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Previous issue date: 2015-09-30 / Objectives: To assess the effect of chest physiotherapy associated with bronchoalveolar lavage with surfactant on the arterial blood gases analysis and radiological findings in an experimental model of meconium aspiration syndrome. Methods: Twelve newborn piglets with experimentally induced meconium aspiration syndrome were randomized into two groups according to the treatment to be given: the control group (which underwent bronchoalveolar lavage with surfactant, associated with change of decubitus and additional dose of surfactant); and the physical therapy group (subjected to the same procedures and added chest physiotherapy with the bag squeezing technique). Measurements of the arterial partial pressure of oxygen, partial pressure of carbon dioxide, and pH were performed before treatment and at 90 minutes and 150 minutes after treatment in both groups. The radiological examination was done soon after the last measurement of gases, prior to euthanasia. The statistical analysis used the Student t test for independent samples, Kolmogorov-Smirnov, ANOVA and Kruskal-Wallis tests. Differences were considered significant at p <0.05. Results: A good response in blood gases analysis was seen in both groups after treatment, with no differences between the groups throughout the study. Radiological examination revealed hyperinflation in 46.7% of lung lobes in the group receiving physiotherapy and in no lobe in the control group (p<0.001). The other radiological findings did not differ between the two groups. Conclusions: Chest physiotherapy did not provide additional benefits, when associated with bronchoalveolar lavage with surfactant, change of decubitus and additional dose of surfactant, in the treatment of experimentally induced meconium aspiration syndrome in newborn piglets. / Objetivos: Avaliar o efeito da fisioterapia respirat?ria associada ao lavado broncoalveolar com surfactante sobre o exame gasom?trico e os aspectos radiol?gicos, em modelo experimental de s?ndrome de aspira??o de mec?nio. M?todos: Doze su?nos rec?m-nascidos com s?ndrome de aspira??o de mec?nio induzida experimentalmente foram randomizados em dois grupos, conforme o tratamento a ser feito: grupo controle (submetido a lavado broncoalveolar com surfactante, associado ? mudan?a de dec?bito e dose adicional de surfactante); e grupo fisioterapia (submetido aos mesmos procedimentos, adicionados de fisioterapia respirat?ria com t?cnica de bag squeezing). Medidas de press?o parcial de oxig?nio arterial, press?o parcial de di?xido de carbono arterial e pH foram realizadas antes do tratamento e aos 90 minutos e 150 minutos ap?s o tratamento nos dois grupos. O estudo radiol?gico foi feito logo ap?s a ?ltima aferi??o da gasometria, antes da eutan?sia. A an?lise estat?stica utilizou os testes t de Student para amostras independentes, Kolmogorov-Smirnov, ANOVA e Kruskal-Wallis. As diferen?as foram consideradas significativas quando p<0,05. Resultados: Houve uma melhora gasom?trica ap?s o tratamento em ambos os grupos, sem que tenham ocorrido diferen?as entre os mesmos ao longo do estudo. O exame radiol?gico identificou hiperinsufla??o em 46,7% dos lobos pulmonares no grupo que recebeu a fisioterapia e em nenhum lobo do grupo controle (p<0,001). Os outros achados radiol?gicos n?o foram diferentes entre os dois grupos. Conclus?es: A fisioterapia respirat?ria n?o trouxe benef?cios adicionais quando associada ao lavado broncoalveolar com surfactante, mudan?a de dec?bito e dose adicional de surfactante, no tratamento da s?ndrome de aspira??o de mec?nio induzida experimentalmente em su?nos rec?m-nascidos.
| Identifer | oai:union.ndltd.org:IBICT/oai:tede2.pucrs.br:tede/6668 |
| Date | 30 September 2015 |
| Creators | Stivanin, Jaqueline Basso |
| Contributors | Fiori, Humberto Holmer, Mattiello, Rita |
| Publisher | Pontif?cia Universidade Cat?lica do Rio Grande do Sul, Programa de P?s-Gradua??o em Medicina/Pediatria e Sa?de da Crian?a, PUCRS, Brasil, Faculdade de Medicina |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/doctoralThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da PUC_RS, instname:Pontifícia Universidade Católica do Rio Grande do Sul, instacron:PUC_RS |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 3098206005268432148, 600, 600, 600, -8624664729441623247, -969369452308786627 |
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