<p>This dissertation describes the effects of a <i>de novo</i> mutation of CaMKII found in children with learning disabilities and describes its effect on catalytic activity. We develop a malachite green assay for the measurement of CaMKII activation and use it for high-throughput chemical screening to identify CaMKII inhibitors and enhancers. We also propose a new mechanism of regulation of CaMKII activity by ADP.</p><p><br></p>
| Identifer | oai:union.ndltd.org:purdue.edu/oai:figshare.com:article/23751231 |
| Date | 07 August 2023 |
| Creators | Walter Saide (16650807) |
| Source Sets | Purdue University |
| Detected Language | English |
| Type | Text, Thesis |
| Rights | CC BY 4.0 |
| Relation | https://figshare.com/articles/thesis/DISTINCT_ROLES_OF_THE_aD_HELIX_IN_aCAMKII_ACTIVATION_CHARACTERIZED_USING_A_DE_NOVO_MUTATION_FROM_CHILDREN_WITH_LEARNING_DISABILITIES/23751231 |
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