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Previous issue date: 2014-03-28 / Introduction: the cognitive decline (DC) has a multifactorial etiology. Some studies have suggested that inflammation, oxidative stress and physical activity are associated with the DC. However, evidence of this issue are still controversial. Objective: to compare and verify the association of inflammatory, redox metabolism markers and caloric expenditure between older people with and without cognitive deficit assisted by the Family Health Strategy of the municipality of Porto Alegre. Methods: Cross-sectional study. The sample consisted of 424 older adults (224 with normal cognitive function and 220 with cognitive impairment) patients of the Family Health Program in Porto Alegre, Rio Grande do Sul, Brazil. The variables investigated were: sociodemografia, biochemical markers, inflammatory (CRP, IL - 6) and oxidation (TBARS, AOPP and FRAP), energy expenditure and cognitive function. The instruments used were the following: for the assessment of physical activity was used the Minnesota Leisure Time Physical Activity Questionnaire and the measurement of energy expenditure (METs) Compendium of physical activities was used: classification of energy costs of human physical activities, and used for final analysis of the converted values in Kcal. For the assessment of cognitive ability Bateira one of neuropsychiatric instruments was applied. Results: significant statistical differences were observed between the groups with respect to biochemical, (except to HDL-C, p=0,006) inflammatory, oxidative and antioxidant power markers investigated. Statistical differences were found in age (p=0,002), IL-6 (p=0,020) and time spent in physical activity (< 0.001) with respect to energy expenditure in the elderly. No association was found between caloric expenditure and cognition (p=0,282). To do so, when considering the statistical treatment using logistic regression, this study showed only association of cognitive impairment with age and HDL-C. Conclusions: the results suggest that biochemical (except to HDL-C), inflammatory, oxidative, antioxidant power markers and energy expenditure are not associated with cognitive deficits in the older individuals. Only age and HDL-C were associated with cognitive impairment in this sample. / Introdu??o: o decl?nio cognitivo (DC) possui uma etiologia multifatorial. Alguns estudos t?m sugerido que a inflama??o, o estresse oxidativo e a atividade f?sica est?o associados ao DC. Todavia, as evid?ncias desta tem?tica ainda s?o controversas. Objetivo: comparar e verificar a associa??o de marcadores inflamat?rios, do metabolismo redox e gasto cal?rico entre idosos com e sem d?ficit cognitivo atendido pela Estrat?gia Sa?de da Fam?lia do Munic?pio de Porto Alegre. M?todos: estudo transversal. A amostragem foi composta de 424 idosos (224 com fun??o cognitiva normal e 220 com d?ficit cognitivo) pacientes da Estrat?gia de Sa?de da Fam?lia em Porto Alegre, Rio Grande do Sul, Brasil. As vari?veis investigadas foram: sociodemografia, marcadores bioqu?micos, inflamat?rios (PCR-us, IL-6) e oxidativos (TBARS, AOPP e FRAP), gasto energ?tico e fun??o cognitiva. Os instrumentos utilizados foram os seguintes: para a avalia??o de atividade f?sica foi utilizado o Minnesota Leisure Time Physical Activity Questionnaire e para a mensura??o de gasto cal?rico (METs) foi utilizado o Comp?ndio de atividades f?sicas: classifica??o de custos energ?ticos de atividades f?sicas humanas, sendo utilizados para an?lise final os valores convertidos em Kcal. Para a avalia??o de habilidade cognitiva foi aplicada uma bateira de instrumentos neuropsiqui?tricos. Resultados: diferen?as estat?sticas significativas n?o foram observadas entre os grupos com rela??o aos marcadores bioqu?micos (exceto para o HDL-C, p=0,006), inflamat?rios, oxidativos e poder antioxidante investigados. Foram encontradas diferen?as estat?sticas na idade (p=0,002), IL-6 (p=0,020) e tempo gasto em atividades f?sicas (< 0,001) com rela??o ao gasto cal?rico dos idosos. Nenhuma associa??o foi encontrada entre gasto cal?rico e cogni??o (p=0,282). Para tanto, quando considerado o tratamento estat?stico pela regress?o log?stica, este estudo evidenciou associa??o do d?ficit cognitivo apenas com idade e HDL-C. Conclus?es: os resultados sugerem que os marcadores bioqu?micos (exceto o HDL-C), inflamat?rios e oxidativos e o gasto cal?rico investigado n?o est?o associados com d?ficit cognitivo nos idosos. Somente a idade e o HDL-C foram associados ao d?ficit cognitivo nesta amostragem.
| Identifer | oai:union.ndltd.org:IBICT/oai:tede2.pucrs.br:tede/2730 |
| Date | 28 March 2014 |
| Creators | Nogueira, Guilherme Marcos |
| Contributors | Gottlieb, Maria Gabriela Valle |
| Publisher | Pontif?cia Universidade Cat?lica do Rio Grande do Sul, Programa de P?s-Gradua??o em Gerontologia Biom?dica, PUCRS, BR, Instituto de Geriatria e Gerontologia |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da PUC_RS, instname:Pontifícia Universidade Católica do Rio Grande do Sul, instacron:PUC_RS |
| Rights | info:eu-repo/semantics/openAccess |
| Relation | 4438661476953179033, 500, 600, 2296420844541114010 |
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