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Previous issue date: 2012-02-29 / The present study evaluated the influence of non-surgical periodontal treatment on the
levels of C- reactive protein (hsCRP) in patients with chronic renal failure (CRF) in pretransplant.
We conducted a controlled and randomized trial to evaluate the periodontal
condition and plasma concentrations of hsCRP, albumin and transferrin in 56 dialysis patients
divided into two groups: experimental and control. The study was conducted at the dental
clinic of Family and Community Health s Unit (USFC), located in Onofre Lopes University
Hospital (HUOL), Federal University of Rio Grande do Norte (UFRN), from December 2010
to November 2011. Severe periodontitis was the type of periodontal disease more common,
affecting 78.6% of patients. Periodontal conditions, evaluated through the means of probing
depth, clinical attachment level, bleeding index and plaque index, proved to be uniform for
both groups at the initial examination. There were no differences in levels of inflammatory
markers between the two groups. The analysis of the concentrations of hsCRP allowed
classifying study participants as at high risk of developing cardiovascular disease. After
completion of periodontal treatment in the experimental group, there was a statistically
significant reduction of the mean of all periodontal parameters assessed; however this
improvement of periodontal health was not accompanied by changes in the levels of hsCRP,
albumin and transferrin in the evaluation time. Given this, the periodontal treatment did not
promote the reduction of systemic inflammatory burden and risk of cardiovascular
complications in patients with CRF / O presente estudo se prop?s a avaliar a influ?ncia do tratamento periodontal n?o
cir?rgico sobre os n?veis da prote?na C reativa (PCR-US) em indiv?duos com Insufici?ncia
Renal Cr?nica (IRC) em fase de pr?-transplante. Realizou-se um ensaio cl?nico, controlado e
randomizado para avaliar as condi??es periodontais e as concentra??es plasm?ticas de PCRUS,
albumina e transferrina em 56 pacientes dial?ticos com doen?a periodontal divididos em
dois grupos: Experimental e Controle. O estudo foi realizado no ambulat?rio odontol?gico da
Unidade de Sa?de Familiar e Comunit?ria (USFC), localizada no Hospital Universit?rio
Onofre Lopes (HUOL), Universidade Federal do Rio Grande do Norte (UFRN), no per?odo
de dezembro de 2010 a novembro de 2011. A periodontite severa foi o tipo de doen?a
periodontal mais frequente, acometendo 78,6% dos pacientes. As condi??es periodontais,
avaliadas atrav?s das m?dias da profundidade de sondagem, n?vel de inser??o cl?nica, ?ndice
de sangramento e ?ndice de biofilme se mostraram uniformes para os dois grupos no exame
inicial. Tamb?m n?o foram encontradas diferen?as nos n?veis dos marcadores inflamat?rios
entre os grupos. A an?lise inicial das concentra??es da PCR-US permitiu classificar os
participantes do estudo como de alto risco para o desenvolvimento de doen?as
cardiovasculares. Ap?s a realiza??o do tratamento periodontal no grupo Experimental, houve
redu??o estatisticamente significante das m?dias de todos os par?metros periodontais
avaliados, entretanto esta melhora das condi??es de sa?de periodontal n?o foi acompanhada
pela altera??o dos n?veis da PCR-US, albumina e transferrina no tempo de avalia??o da
pesquisa. Diante disto, o tratamento periodontal n?o promoveu a redu??o da carga
inflamat?ria sist?mica e o risco de desenvolvimento de complica??es cardiovasculares nos
indiv?duos com IRC
| Identifer | oai:union.ndltd.org:IBICT/oai:repositorio.ufrn.br:123456789/17152 |
| Date | 29 February 2012 |
| Creators | Amorim, Adriana Gomes |
| Contributors | CPF:41291824472, http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4794937Z9, Silveira, Ericka Janine Dantas da, CPF:02869049420, http://lattes.cnpq.br/2186658404241838, Castro, Jurema Freire Lisboa de, CPF:13133845420, http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4788258E1&dataRevisao=null, Pereira, Karuza Maria Alves, CPF:78033977353, http://buscatextual.cnpq.br/buscatextual/visualizacv.do?id=K4742973Y0&dataRevisao=null, Freitas, Roseana de Almeida, CPF:28444361453, http://lattes.cnpq.br/9512014003639405, Galv?o, H?bel Cavalcanti |
| Publisher | Universidade Federal do Rio Grande do Norte, Programa de P?s-Gradua??o em Patologia Oral, UFRN, BR, Odontologia |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/doctoralThesis |
| Format | application/pdf |
| Source | reponame:Repositório Institucional da UFRN, instname:Universidade Federal do Rio Grande do Norte, instacron:UFRN |
| Rights | info:eu-repo/semantics/openAccess |
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