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Previous issue date: 2010-04-30 / O metal é o material classicamente usado na confecção de implantes cirúrgicos para reparação de fraturas. Na tentativa de se evitar problemas de biocompatibilidade e osteoindução, o emprego de biomateriais tem sido proposto na confecção de implantes como placas e parafusos por apresentarem as mesmas funções de um enxerto ósseo, ou seja, serem osteoindutores, osteocondutores e possuiren células osteoprogenitoras. Objetiva-se com esse trabalho avaliar a osteoindução, osteocondução e osteointegração de placa óssea produzida a partir osso bovino na reparação de fratura de tíbia de coelhos. / The objective of this study was to evaluate the mechanical strength of bone plates yielded from bovine cortical bone, conserved in different solutions, and the efficiency of these solutions in the inhibition of microorganism’s growth. 168 plates yielded from bovine tibiae were conserved in 98% glycerin (n=28)
, 150% saline solution (n=28) , 300% sugar solution (n=28), Dakin solution (n=28), frozen in LN2 at - 196°C (n=28), or sterilized in ethylene oxide gas (n=28). After rehydratated in NaCl 0.9% solution for six hours, plates were subjected to tensile, compression, bending and twisting testing. Bone plates microbiological evaluation was carried out before and immediately after rehydratation, with or without enrofloxacin 0.5% addition. There was no significant difference (P<0.01) on resistance to the rupture point in
plates conserved in the different solutions, frozen -
thawed or sterilized. Microorganisms were isolated from plates conserved in satured salt solution, sugar satured solution, Dakin solution or frozen in LN2, before and after rehydratation.
However, after the use of NaCl 0.9% solution added enrofloxacin 0.5%, microorganisms were not isolated. Therefore, bovine bone plates conserved in sugar or salt satured solution, 98% glycerin, Dakin solution, frozen in LN2 or sterilized in ethylene oxide
gas present similar biomechanical tests results, and NaCl 0.9%
solution added enrofloxacin 0.5% rehydratation inhibits microbial growth
.
| Identifer | oai:union.ndltd.org:IBICT/oai:dspace2.ufes.br:10/5085 |
| Date | 30 April 2010 |
| Creators | Melo Filho, Edson Vilela de |
| Contributors | Costa, Fabiano Séllos, Melo, Eliane Gonçalves de, Freitas, Patrícia Maria Coletto |
| Publisher | Universidade Federal do Espírito Santo, Mestrado em Ciências Veterinárias, Programa de Pós-Graduação em Ciências Veterinárias, UFES, BR |
| Source Sets | IBICT Brazilian ETDs |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/masterThesis |
| Format | text |
| Source | reponame:Repositório Institucional da UFES, instname:Universidade Federal do Espírito Santo, instacron:UFES |
| Rights | info:eu-repo/semantics/openAccess |
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