Design, synthesis and study of myeloperoxidase inhibitors in the series of 3-alkylindole

Description

The deleterious effects of MPO make it a new target for medicinal research. The aim of our study is to find promising inhibitors of MPO for using them as starting point of new anti-inflammatory drugs. Depending on previous researches on MPO inhibitors, we selected 5-fluorotryptamine as starting compounds. Using docking experiments, we designed a series of compounds derived from 5-fluorotryptamine. Two modifications were proposed: <p>& / Doctorat en Sciences biomédicales et pharmaceutiques / info:eu-repo/semantics/nonPublished

Links & Downloads

1. local/bictel.ulb.ac.be:ULBetd-10212013-010642
2. local/ulbcat.ulb.ac.be:994814
3. https://dipot.ulb.ac.be/dspace/bitstream/2013/209402/1/819b424d-b73d-41bc-ba4a-aac2805f146e.txt
4. http://hdl.handle.net/2013/ULB-DIPOT:oai:dipot.ulb.ac.be:2013/209402

Tags

Sciences pharmaceutiques

Serotonin

Chemical inhibitors

Low density lipoproteins

Anti-inflammatory agents

Serotonin

Inhibiteurs

Lipoprotéines de basse densité

Antiinflammatoires

3-alkylindole

docking

medicinal chemistry

LDL

atherosclerosis

MPO

Myeloperoxidase

serotonine

HDL

inflemmation

anti inflammatory drugs

depression

Additional Fields

Identifer	oai:union.ndltd.org:ulb.ac.be/oai:dipot.ulb.ac.be:2013/209402
Date	09 October 2013
Creators	Soubhye, Jalal
Contributors	Dufrasne, François, Neve, Jean, Amighi, Karim, Pincemail, Joël, Meyer, Franck, Li, Xiaoli, Pochet, Stéphanie, Kauffmann, Jean-Michel
Publisher	Universite Libre de Bruxelles, Université libre de Bruxelles, Faculté de Pharmacie, Bruxelles
Source Sets	Université libre de Bruxelles
Language	English
Detected Language	English
Type	info:eu-repo/semantics/doctoralThesis, info:ulb-repo/semantics/doctoralThesis, info:ulb-repo/semantics/openurl/vlink-dissertation
Format	1 full-text file(s): application/pdf
Rights	1 full-text file(s): info:eu-repo/semantics/openAccess