Yes / Ynamide, is an understudied but attractive class of alkynes, activated by the donating ability of the nitrogen adjacent to alkynes. With the nucleophilicity on β-carbon and the electrophilicity on α-carbon of ynamides, this review summarizes the syntheses of ynamides and miscellaneous reactions - oxidation, rearrangement, cyclization, and cycloaddition to construct complicated heterocyclic rings. The synthetic methodologies were further applied into natural products synthesis, e.g. marinoquinolines A and C, aplidiopsamine A, rigidin A, and 7-azaserotonin derivative. / We thank National Science Foundation of China (NSFC) (21462004), State Key Laboratory for the Chemistry and Molecular Engineering of Medicinal Resources (CMEMR2014-A04), 2015 GXNSFBA (139032), GXNU, and Newton International Fellowship granted by Royal Society.
| Identifer | oai:union.ndltd.org:BRADFORD/oai:bradscholars.brad.ac.uk:10454/18435 |
| Date | 30 March 2021 |
| Creators | Siyu, Y., Wu, Na (Anna) |
| Source Sets | Bradford Scholars |
| Language | English |
| Detected Language | English |
| Type | Book chapter, Accepted manuscript |
| Rights | Unspecified |
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