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Previous issue date: 2009-04-29 / The mite Demodex canis is a resident of the hair follicles and when overgrowth cause an
inflammatory parasitic disease called demodectic mange. The diagnosis is based on the
visualization of the mite under microscope, especially by skin scrapings, hair plucks or
histopathologic exam. A large number of drugs has been used on the treatment of demodectic
mange, demonstrating varied efficacy numbers, side effects that can prohibit the conclusion of
treatment and difficulties to owners. The objective of the present study was to evaluate the
efficacy of the fluazuron 2.5% pour on and ivermectin on different therapeutic protocols on
the treatment of canine demodectic mange. For this, 31 dogs were divided into five groups,
the first four with six animals and the last one with seven. All with positive skin scrapings.
The dogs were treated on each 14 days, during 84 days. The first group used fluazuron 2.5%
pour on at 20mg/kg, the second used this same drug associated to ivermectin 0.5% pour on at
0.6mg/kg and, the third one, only the ivermectin 0,5% pour on. The fourth and fifth groups
were treated with long-acting ivermectin 3.15% on subcutaneous administration at 0.6 and
1.5mg/kg, respectively. The evaluation and follow up of treatments were realized through
skin scrapings on each 14 days, clinical evaluation with photos of dogs on every visit for a
compare of the lesions. And the histopathologic exam at the end of the therapeutic protocol.
The success rate was defined as the percentage of dogs on each group with negative skin
scrapings. The reduction in mite numbers reached the efficacy levels of 67.66; 88.99; 84.29;
84.90 and 87.86%, for groups 1, 2, 3, 4 e 5, respectively. And the success rates at the end of
treatment were 16.67% for the first group and 50% for the other four. By Wilcoxon test the
reduction of the infestation on the histopathologic exam, before and after treatment, had no
significance for all groups. Remission of lesions did not occur with the dogs of the first group.
On groups 2 and 3, on each one was observed two dogs clinically cured and one with an
improvement of the lesions. And on groups 4 and 5, 4 and 5 dogs were cured, respectively
and also, there was one with an improvement on the lesions. The fluazuron 2.5% pour on did
not show efficacy on the treatment of canine demodectic mange. But the ivermectin 0.5%
pour on associated or not to fluazuron 2.5% pour on and the ivermectin 3.15% on both
dosages, showed good efficacy on the reduction in mite numbers at the end of the protocols. / O ?caro Demodex canis ? um habitante dos fol?culos pilosos, que quando se prolifera causa
uma dermatopatia de cunho inflamat?rio denominada sarna demod?cica. O diagn?stico ? feito
atrav?s da visualiza??o do parasito sob microscopia ?ptica, especialmente atrav?s do exame
parasitol?gico de raspado cut?neo, dos p?los, ou exame histopatol?gico. Muitas drogas t?m
sido utilizadas no tratamento da sarna demod?cica, mas demonstrando n?veis de efic?cia
variados, ocorr?ncia de efeitos colaterais que impossibilitam a conclus?o da terapia ou
empecilhos ? ades?o dos propriet?rios. O objetivo do presente estudo foi avaliar a efic?cia do
fluazuron e da ivermectina em diferentes protocolos terap?uticos no controle da sarna
demod?cica canina. Foram avaliados 31 c?es divididos em cinco grupos, os quatro primeiros
com seis animais e o ?ltimo com sete, positivos para o ?caro D. canis atrav?s do raspado
cut?neo. Todos os c?es foram tratados a cada 14 dias, durante 84 dias. No primeiro grupo foi
utilizado fluazuron 2,5% pour on na dosagem de 20mg/kg, no segundo este f?rmaco
tamb?m foi empregado, mas associado a ivermectina 0,5% pour on na dosagem de 0,6mg/kg
e no terceiro, somente a ivermectina 0,5% pour on . Os c?es do quarto e quinto grupos
foram tratados com ivermectina 3,15% longa a??o por via subcut?nea nas dosagens de 0,6 e
1,5mg/kg, respectivamente. A avalia??o e acompanhamento do tratamento foram feitos
atrav?s dos exames parasitol?gicos de raspado cut?neo a cada 14 dias, da avalia??o cl?nica,
inclusive fotografando os c?es para uma melhor compara??o dos quadros lesionais e, do
exame histopatol?gico ao final de cada protocolo terap?utico. A taxa de sucesso foi definida
pela porcentagem de c?es em cada grupo que apresentaram raspados negativos. A redu??o na
contagem no n?mero de ?caros alcan?ou n?veis de efic?cia de at? 67,66; 88,99; 84, 29; 84,90
e 87,86%, nos grupos 1, 2, 3, 4 e 5, respectivamente. E as taxas de sucesso ao final do
tratamento foram de 16,67% para o grupo 1 e 50% para os outros quatro. Pelo do teste de
Wilcoxon a redu??o da infesta??o atrav?s do exame histopatol?gico antes e depois do
tratamento n?o foi significativa para nenhum grupo. Clinicamente, n?o ocorreu remiss?o das
les?es nos c?es do primeiro grupo. Nos grupos 2 e 3, em cada um se observou 2 c?es
considerados curados clinicamente e 1 com melhora. J? nos grupos 4 e 5, evidenciou-se 4 e 5
animais curados, respectivamente e, tamb?m um com n?tida melhora do quadro cl?nico. O
fluazuron 2,5% pour on n?o demonstrou efic?cia no tratamento da sarna demod?cica
canina. J? a ivermectina 0,5% pour on associada ao fluazuron ou como terapia ?nica e, a
ivermectina 3,15% por via subcut?nea nas duas dosagens diferentes, foram eficazes na
redu??o do n?mero de ?caros ao final dos protocolos terap?uticos.
| Identifer | oai:union.ndltd.org:IBICT/oai:localhost:tede/840 |
| Date | 29 April 2009 |
| Creators | Souza, Clarissa Pimentel de |
| Contributors | Scott, Fabio Barbour |
| Publisher | Universidade Federal Rural do Rio de Janeiro, Curso de P?s-Gradua??o em Ci?ncias Veterin?rias, UFRRJ, Brasil, Parasitologia Veterin?ria |
| Source Sets | IBICT Brazilian ETDs |
| Language | Portuguese |
| Detected Language | English |
| Type | info:eu-repo/semantics/publishedVersion, info:eu-repo/semantics/doctoralThesis |
| Format | application/pdf |
| Source | reponame:Biblioteca Digital de Teses e Dissertações da UFRRJ, instname:Universidade Federal Rural do Rio de Janeiro, instacron:UFRRJ |
| Rights | info:eu-repo/semantics/openAccess |
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