Exploration and Production (E&P) project costs within the oil industry are continuously increasing reflecting a reality of more harsh environments, remote locations with minimal existing infrastructure and cost increases for materials and skilled resources. The significant capital expenditures translate to a number of projects either for new or revamped production facilities. Successful project completion requires a series of correct decisions throughout the project life-cycle namely design, construction, operations, maintenance and decommissioning. Using a Reliability, Availability and Maintainability (RAM) model as part of the project decision process is an E&P industry best practice that recently gained acceptance in Hess Corporation. This paper presents the RAM methodology and the gains from its application in a capital project. / text

The software that operates mobile and embedded devices, the embedded operating system, has evolved to adapt from the traditional desktop environment, where processing horsepower and energy supply are abundant, to the challenging resource-starved embedded environment. The embedded environment presents the software with some difficult constraints when compared to the typical desktop environment: slower hardware, smaller memory size, and a limited battery life. Different embedded OSs tackle these constraints in different ways. We survey two of the more popular embedded OSs: Linux and Windows CE. To reveal their strengths and weaknesses, we examine and compare each of the OS’s process management and scheduler, interrupt handling, memory management, synchronization mechanisms and interprocess communication, and power management. / text

This report examines the state of research regarding the psychological impact of war on American soldiers deployed in military operations in Afghanistan (Operation Enduring Freedom) and Iraq (Operation Iraqi Freedom). Particular focus is given to examination of marital and relationship satisfaction within the Hispanic soldier and veteran population. A wide range of research examines the traumatic aftereffects of wartime service with predominant themes of posttraumatic stress, depression, anxiety, and substance abuse appearing across the literature. Examination of the Hispanic population is disputed with researchers producing conflicting findings: some researchers have indicated an increased risk of psychological disturbances in Hispanic wartime veterans while other have found no such difference between the Hispanic and majority groups. Attempts to explain these discrepant results have ranged from differences in acculturation, to potentially increased traumatic exposure, or to underlying feelings of persecution and alienation. However, consistent results were found in regards to the negative relationship between traumatic exposure and romantic relationship satisfaction. Younger males of lower socioeconomic status with increased trauma exposure and comorbid mental health diagnoses consistently reported less relationship satisfaction than their peers. Given the nature of family and the importance of close relationships within the Hispanic culture, it is increasingly necessary for clinicians working with Hispanic veterans to be aware of these findings. This author purposes that future researchers explore this concept of relationship satisfaction within the Hispanic veteran population with attention given to potentially mediating variables such as level of acculturation and traumatic experience exposure. / text

The foundation of Luecke’s course M: 396 Geometry and Topology is that collaboration amongst mathematicians and biologists caused tremendous gains in DNA research. The field of topology has led to significant strides in understanding of the topological properties of the genetic molecule DNA. Through the integration of biological phenomena and knowledge of topology and Euclidean geometry, biologists can describe and quantize enzyme mechanisms and therefore determine enzyme mechanisms causing the changes. Understanding mathematical applications in contexts outside of mathematics on any level helps to explain why mathematics is a core content area in primary and secondary education. Requiring secondary educators to take such a course could result in mathematics taught with real world application on the secondary level as well as on the graduate level, as shown in Luecke’s course. / text

Training is a powerful and required method to equip human resources with tools to keep their organizations competitive in the markets. Typically at the end of class, trainees are asked to give their feelings about or satisfaction with the training. Although there are various reasons for conducting training evaluations, the common theme is the need to continuously improve a training program in the future. Among training evaluation methods, post-training surveys or questionnaires are the most commonly used way to get trainees’ reaction about the training program and “the forms will tell you to what extent you’ve been successful.” (Kirkpatrick 2006) A higher satisfaction score means more trainees were satisfied with the training. A total of 40 prediction models grouped into 10-GIQs prediction models and 6-GIQs prediction models were built in this work to predict the total training satisfaction based on trainees’ general information which included a trainee’s desire to take training, a trainee’s attitude in training class and other information related to the trainee’s work environment and other characteristics. The best models selected from 10-GIQs and 6-GIQs prediction models performed the prediction work with the prediction quality of PRED (0.15) >= 99% and PRED (0.15) >= 98%, separately. An interesting observation discovered in this work is that the training satisfaction could be predicted based on trainees information that was not related to any training experience at all. The dominant factors on training satisfaction were the trainee’s attitude in training class and the trainee’s desire to take the training which was found in 10-GIQs prediction models and 6-GIQs prediction models, separately. / text

This report discusses the history, use, and future of elliptic curves. Uses of elliptic curves in various number theory settings are presented. Fermat’s Last Proof is shown to be proven with elliptic curves. Finally, the future of elliptic curves with respect to cryptography and primality is shown. / text

The present study is a retrospective cohort analysis which sought to examine adherence to medications used in managing painful diabetic peripheral neuropathy (PDPN) and to determine their association with oral antidiabetic (OAD) medication adherence using the Texas Medicaid prescription claims database. The study objectives were to: 1) provide a description of PDPN and OAD medication use among the study subjects; 2) determine if PDPN medication adherence differs among individual PDPN agents (i.e., tricyclic antidepressants, gabapentin, pregabalin and duloxetine); 3) determine if pre-index OAD and post-index OAD medication adherence differs among mono, dual, and triple OAD therapies; and 4) determine if PDPN medication adherence is related to post-index OAD medication adherence while controlling for covariates. Study participants were adult (≥18 years) Medicaid beneficiaries prescribed OAD and PDPN medications. The index date was the first PDPN prescription. Data were extracted from June 1, 2003 to October 31, 2009 and prescription claims were analyzed over an 18-month study period (i.e., 6 months pre-index and 12 months post index period). Medication possession ratio (MPR) was used as a proxy measure of medication adherence. An MPR less than 80 percent was regarded as being non-adherent to prescribed medication, while an MPR greater than or equal to 80 percent was regarded as being adherent to prescribed medication. Objective 1 was addressed using descriptive statistics (i.e., mean, standard deviation, frequency). Univariate analysis (ANOVA) was employed to address Objectives 2 and 3. Multivariate analyses (i.e., multiple linear regression and logistic regression) were conducted to address Objective 4. For the logistic regression MPR was dichotomized at the cut-off value of 80 percent. A total of 4,277 patients met the study’s inclusion criteria. The overall mean MPR (±SD) for PDPN medications was 75.4 percent (±23.9). Mean MPR (±SD) was highest for duloxetine (85.6% ±18.2) and was lowest for pregabalin (69.4% ±24.9). Mean MPR differed significantly among individual PDPN medications (p<0.0001). The overall mean MPR (±SD) for OAD medications in the pre and post-index period was 73.0 percent (±24.3) and 64.5 percent (±25.6) respectively. In both pre and post-index periods, mean MPR differed significantly among mono, dual, and triple OAD therapies (p<0.0001). In the pre-index period, mean MPR (±SD) was highest for monotherapy users (75.4% ±24.7) and was lowest for triple therapy users (63.9% ±22.9). Similarly, mean MPR (±SD) was highest for monotherapy users (69.0% ±26.1) and was lowest for triple therapy users (52.9% ±21.8) in the post-index period. After controlling for the covariates, PDPN adherence (i.e., MPR) was statistically significant (p<0.0001) and positively related to post-index OAD adherence (i.e., MPR). PDPN patients who were non-adherent (i.e., MPR<80%) to their PDPN medications (or neuropathic pain medications), compared to those who were adherent (MPR≥80%), were significantly less likely to be adherent to their OAD medications [Odds Ratio (OR) = 0.626, 95% CI=0.545-0.719]. In addition, post-index OAD adherence (i.e., MPR) did not differ significantly (p>0.05) when pregabalin, duloxetine and gabapentin users were individually compared to tricyclic antidepressants users. In conclusion, PDPN patients who were adherent (i.e., MPR≥80%) to their PDPN medications, compared to those who were not adherent (i.e., MPR<80%), were more adherent to their OAD medications. Also, adherence to OAD medications was independent of the type of PDPN medication used. PDPN patients need to be educated regularly that neuropathic pain medications only relieve the pain associated with the neuropathy but achieving adequate glycemic control remains the only established approach for slowing down the progression of the neuropathy and other complications associated with the diabetes. / text

Human trafficking is an international crime affecting all countries that continues to grow. The crime operates as part of an illicit underground network, starting with traffickers who manipulate, deceive, and exploit victims. Victims are both male and female, but the crime disproportionally affects women more than men. Latin American women are especially vulnerable to being trafficked due to societal and cultural norms that demand they be subordinate. Additionally, these women lack many educational and job opportunities, and face mental and physical abuse at home and in their communities. These factors make them vulnerable, and the traffickers use these vulnerabilities to deceive and exploit them. This report will argue that in order to effectively prevent victimization, women need to be empowered, not only access to education but also job opportunities. Furthermore, a societal transformation needs to occur that gives more value and significance to women, where they are viewed as powerful beings instead of submissive and subordinate human beings. / text

Multidrug-resistant (MDR) Acinetobacter baumannii have caused nosocomial infections worldwide. Nowadays, there are no effective regimens to treat MDR- A. baumannii. Therefore, this study’s objective was to find out an effective antimicrobial combination against MDR-A. baumannii. This project consisted of four parts. Part 1 was an in vitro antimicrobial susceptibility test of MDR-A. baumannii collected from Thailand. Minimum inhibitory concentrations (MICs) were performed according to the Clinical and Laboratory Standards Institute (CLSI) guidelines using a broth microdilution technique. This study found that colistin was the most active against MDR-A. baumannii (MIC50 0.5µg/mL, MIC90 1µg/mL). In addition, 77% of MBL -producing A. baumannii were reported using the MBL Etest strips. This prevalence was higher than previously reported. Part 2 was conducted to compare antimicrobial susceptibility profiles of pre- and post-colistin exposure A. baumannii isolates. After colistin exposure, A. baumannii isolates became resistant to colistin but more susceptible to cefepime, doxycycline, meropenem and rifampicin. These findings suggested the potential of a synergistic activity of colistin combinations. Part 3 was a time-kill study that compared activity of colistin alone and in combination against MDR-A. baumannii. Time-kill assays were performed using a standard inoculum. Colistin monotherapy was rapidly bactericidal against these isolates; however, regrowth occurred at 24 hrs. On the other hand, colistin in combination with cefepime, doxycycline, meropenem or rifampicin demonstrated synergy and maintained bactericidal activity over 24 hrs (100%). Part 4 was designed to optimize meropenem dosing regimens using a PK-PD model. Three MDR-A. baumannii with colistin MICs (0.5-1µg/mL) and meropenem MICs (32-128µg/mL) were tested. The antimicrobial regimens alone and in combination evaluated were: colistin 2.5mg/kg every 12 hrs, meropenem 3g and 6g continuously infused (CI) over 24 hrs. Colistin monotherapy was rapidly bactericidal but regrowth did occur. Both combinations express synergy (100%). Nevertheless, colistin and high dose meropenem (6g CI over 24 hrs) was bactericidal and prevented regrowth over 24 hrs. In conclusion, MBL-producing A. baumannii is more prevalent than previously thought and colistin combined with a high dose meropenem (6g/day) has good potential to overcome multidrug- and carbapenem-resistant A. baumannii. These findings should be further evaluated in animal models and clinical practices. / text

This thesis describes the development and testing of the Combustive Sound Source (CSS), which is a broadband underwater sound source. The CSS is being developed as a clean, safe, and cost effective replacement to underwater explosive charges, which exhibit an inherent danger to marine life and researchers using the charges. The basic operation of the CSS is as follows. A combustible mixture of gas is held below the surface of the water in a combustion chamber and ignited with an electric spark. A combustion wave propagates through the mixture and converts the fuel and oxidizer into a bubble of combustion products, which expands due to an increase in temperature, and then ultimately collapses to a smaller volume than before ignition, producing a high intensity, low frequency acoustic signal. The thesis begins by discussing the background, history, and purpose of developing the CSS. It continues by describing the current apparatus and the essential components and convenient features added to the latest mechanical design. The general operation is discussed along with a description of an experiment conducted to determine the acoustic output and robustness of the current CSS. The results of this experiment are presented in terms of the effect of volume, ignition depth, oxidizing gas, combustion chamber size, and repeatability of acoustic signatures. Discussion of apparatus robustness is presented to suggest improvements for future CSS designs. / text