by Lo Ping Fai. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1987. / Includes bibliographical references.

Lee Po Yuk. / Thesis (M.Ph.)--Chinese University of Hong Kong, 1987. / Bibliography: leaves 75-81.

by Ng, Shuet Fai. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1990. / Bibliography: leaves 118-137. / ACKNOWLEDGEMENTS --- p.i / ABSTRACT --- p.ii / CONTENTS --- p.iv / Chapter CHAPTER 1: --- GENERAL INTRODUCTION / Chapter I. --- The History of Gossypol --- p..4 / Chapter II. --- The Chemistry of Gossypol --- p..7 / Chapter A. --- Enantiomers of Gossypol --- p.10 / Chapter B. --- Analysis of Gossypol --- p.11 / Chapter III. --- Metabolism and Distribution of Gossypol in Body --- p.12 / Chapter IV. --- The Effect of Gossypol --- p.14 / Chapter A. --- Effect of Gossypol on Different Animal Species --- p.14 / Chapter B. --- Effect of Gossypol on Male Reproductive Organs --- p.16 / Chapter 1. --- Testis and Epididymis --- p.16 / Chapter 2. --- Spermatozoa and Spermatogenic Cells --- p.18 / Chapter C. --- Effect of Gossypol on Reproductive Hormones --- p.20 / Chapter D. --- Effect of Gossypol on Enzymes --- p.22 / Chapter 1. --- Enzymes in Capacitation --- p.23 / Chapter 2. --- The Metabolic Enzymes --- p.24 / Chapter a. --- On Glycolysis --- p.24 / Chapter b. --- On TCA Cycle --- p.26 / Chapter c. --- On Oxidative Phosphorylation --- p.26 / Chapter 3. --- Adenyl Cyclase --- p.26 / Chapter 4. --- Na+/K+-ATPase --- p.28 / Chapter E. --- Other Effects of Gossypol --- p.29 / Chapter V. --- Toxicity of Gossypol --- p.30 / Chapter A. --- General Toxic Effect --- p.30 / Chapter B. --- The Mutagenicity --- p.32 / Chapter VI. --- Clinical Trials of Gossypol --- p.33 / Chapter VII. --- The Purpose of This Study --- p.35 / Chapter A. --- Gossypol and LDH-X --- p.35 / Chapter B. --- Effect of Gossypol on Antioxidant Defense Systems / Chapter C. --- The Influence of Gossypol on Zinc Metabolism --- p.37 / Chapter CHAPTER 2: --- EFFECT OF GOSSYPOL ON LDH-X OF COCK AND DRAKE / Chapter I. --- Introduction --- p.39 / Chapter A. --- General Description of Lactate Dehydrogenase --- p.39 / Chapter B. --- Discovery of LDH-X --- p.40 / Chapter C. --- Properties of LDH-X --- p.41 / Chapter D. --- Role of LDH-X in the Spermatozoa --- p.42 / Chapter E. --- Gossypol and LDH-X --- p.43 / Chapter II. --- Materials and Methods --- p.44 / Chapter A. --- Reagents --- p.45 / Chapter B. --- Methods --- p.45 / Chapter 1. --- The Effect of Gossypol on the Spermatozoa of Cock and Drake --- p.45 / Chapter 2. --- "Measurement of LDH-X Activities in Cock, Drake, Mouse and Rat" --- p.46 / Chapter a. --- Preparation of Samples --- p.46 / Chapter b. --- Enzyme Assay --- p.47 / Chapter III. --- Results / Chapter A. --- Effect of Gossypol on the Spermatozoa of Cock and Drake --- p.48 / Chapter 1. --- Cock --- p.48 / Chapter 2. --- Drake --- p.49 / Chapter B. --- "The LDH-X Activities of Cock, Drake, Rat and Mouse" --- p.51 / Chapter IV. --- Discussion --- p.54 / Chapter CHAPTER 3: --- "THE EFFECT OF GOSSYPOL ON THE METABOLISM OF ZINC IN THE TESTIS, HAIR AND RETINA OF HAMSTER AND MOUSE" / Chapter I. --- Introduction --- p.57 / Chapter A. --- The Physiological Role of Zinc in Animals --- p.57 / Chapter B. --- The Relationship Between Gossypol and Divalentions --- p.58 / Chapter II. --- Materials and Methods --- p.60 / Chapter A. --- Reagents --- p.60 / Chapter B. --- Treatment of Animals for the Zinc Content Study / Chapter 1. --- Detection of Zinc Content in Hamster Hair --- p.61 / Chapter 2. --- "Detection of Zinc Distribution in the Hair, Testis, and Retina in Hamster and Mouse" --- p.62 / Chapter C. --- Determination of Zinc and Iron --- p.63 / Chapter III. --- Results --- p.63 / Chapter A. --- Amount of Zinc in Hamster's Hair --- p.63 / Chapter B. --- "The Distribution of Zinc Content in Hair, Testis and Retina of Hamster and Mouse" --- p.69 / Chapter IV. --- Discussion --- p.71 / Chapter CHAPTER 4: --- EFFECT OF GOSSYPOL ON THE ANTIOXIDANT DEFENSE SYSTEM IN THE TESTIS OF HAMSTER / Chapter I. --- Introduction --- p.73 / Chapter A. --- Oxygen Radicals in Living Cells --- p.75 / Chapter B. --- Oxygen Damage of Spermatozoa --- p.76 / Chapter C. --- Antioxidant Defense System --- p.77 / Chapter 1. --- Enzymatic Antioxidants --- p.78 / Chapter 2. --- Non-Enzymatic Antioxidants --- p.78 / Chapter II. --- Materials and Methods --- p.81 / Chapter A. --- Reagents --- p.81 / Chapter B. --- Experimental Animals --- p.82 / Chapter C. --- The Effect of Scavengers on the Antifertility of Gossypol --- p.83 / Chapter 1. --- Vitamin C --- p.83 / Chapter 2. --- Selenium --- p.84 / Chapter 3. --- Vitamin E --- p.85 / Chapter D. --- Chemical Interaction of Gossypol with Vitamin C and Sodium Selenite --- p.85 / Chapter E. --- Malonaldehyde Assay --- p.85 / Chapter F. --- The Effect of Gossypol on the Antioxidant Defense Enzymes --- p.86 / Chapter 1. --- Drug Treatment --- p.86 / Chapter 2. --- Preparation of Samples for Enzyme Determination --- p.87 / Chapter 3. --- Enzyme Assays --- p.87 / Chapter a. --- Se-GSH-Px --- p.88 / Chapter b. --- Glutathione-S-Transf erase --- p.88 / Chapter c. --- Catalase --- p.89 / Chapter d. --- Superoxide Dismutase --- p.90 / Chapter III. --- Results --- p.90 / Chapter A. --- The Effect of Scavengers on the Antifertility of Gossypol --- p.90 / Chapter B. --- Chemical Interaction of Gossypol with Vitamin C and sodium selenite --- p.91 / Chapter C. --- The MDA Concentration of the Testis of Hamster after Gossypol and Scavengers Injection --- p.101 / Chapter D. --- The Antioxidant Defense Enzymes --- p.101 / Chapter IV. --- Discussion --- p.109 / Chapter CHAPTER 5: --- CONCLUSION AND GENERAL DISCUSSION --- p.113 / REFERENCES --- p.118 / Chapter APPENDIX I --- THE INFLUENCE OF DIETARY LARD ON THE ANT I FERTILITY EFFECT OF GOSSYPOL --- p.138 / Chapter APPENDIX II --- PROTOCOL FOR GOSSYPOL DETERMINATION --- p.158

by Josephine Wing Sze Lau. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1999. / Includes bibliographical references (leaves 84-112). / Abstracts in English and Chinese. / Acknowledgment --- p.iii / Abstract --- p.iv / List of Abbreviations --- p.viii / Chapter CHAPTER ONE: --- INTRODUCTION / Chapter 1.1 --- Methamphetamine (METH) --- p.1 / Chapter 1.1.1 --- Historical Background and Epidemiology --- p.1 / Chapter 1.1.2 --- Physical Effects of METH --- p.4 / Chapter 1.1.3 --- Neurochemical Alternation of METH --- p.6 / Chapter 1.2 --- Mechanisms of METH Toxicity / Chapter 1.2.1 --- Oxidative Stress --- p.8 / Chapter 1.2.1.1 --- Superoxide (O2-) and Superoxide Dismutase (SOD) --- p.10 / Chapter 1.2.1.2 --- "Hydrogen Peroxide (H202), Catalase and Glutathione (GSH)" --- p.11 / Chapter 1.2.1.3 --- Hydroxyl Radical (OH.) --- p.12 / Chapter 1.2.1.4 --- Nitric Oxide (NO) --- p.13 / Chapter 1.2.2 --- Apoptosis --- p.16 / Chapter 1.2.3 --- Excitotoxicity --- p.17 / Chapter 1.2.4 --- Mitochondrial Dysfunction --- p.18 / Chapter 1.2.5 --- Hyperthermia --- p.21 / Chapter 1.2.5.1 --- Cyclooxygenase-2 (COX-2) --- p.23 / Chapter 1.2.5.2 --- Heme-oxygenase-1 (HO-1) --- p.25 / Chapter 1.2.5.3 --- The Effects of Nitric Oxide (NO) on COX-2 and HO-1 Expressions --- p.27 / Chapter 1.3 --- Astrocytes / Chapter 1.3.1 --- Characteristics of Astrocytes --- p.29 / Chapter 1.3.2 --- Astrocyte Functions --- p.30 / Chapter 1.3.3 --- The Role of Astrocytes in METH-induced Neurotoxicity --- p.34 / Chapter 1.4 --- Aim of Project --- p.37 / Chapter CHAPTER TWO: --- MATERIALS AND METHODS / Chapter 2.1 --- Cell Cultures / Chapter 2.1.1 --- Astrocyte Cultures --- p.42 / Chapter 2.1.2 --- CATH.a Cell line and Astrocytes Co-cultures --- p.43 / Chapter 2.2 --- Treatment / Chapter 2.2.1 --- METH Treatment --- p.44 / Chapter 2.2.2 --- Inhibition of Cyclooxygenase-2 (COX-2) and Inducible Nitric Oxide Synthase (iNOS) --- p.44 / Chapter 2.3 --- Lactate Dehydrogenase (LDH) Assay --- p.45 / Chapter 2.4 --- Assay for Reactive Oxygen Species (ROS) Formation --- p.47 / Chapter 2.5 --- Assay for Adenosine Triphosphate (ATP) Content --- p.48 / Chapter 2.6 --- Determination of Mitochondrial Membrane Potential (Δ Ψm) --- p.50 / Chapter 2.7 --- Determination of Nitrite Levels in Cultured Astrocytes --- p.51 / Chapter 2.8 --- Western Blot Analysis --- p.52 / Chapter 2.8.1 --- COX-2 --- p.53 / Chapter 2.8.2 --- HO-1 --- p.53 / Chapter 2.9 --- Viability Assay of CATH.a-Astrocyte Cocultures --- p.54 / Chapter 2.10 --- Statistics --- p.55 / Chapter CHAPTER THREE: --- RESULTS / Chapter 3.1 --- The Effects of METH Treatment on Cultured Astrocytes / Chapter 3.1.1 --- Lactate Dehydrogenase (LDH) Activities --- p.56 / Chapter 3.1.2 --- Morphological Changes --- p.56 / Chapter 3.1.3 --- The Production of Reactive Oxygen Species / Chapter 3.1.3.1 --- Rate of change (0-120 min) --- p.57 / Chapter 3.1.3.2 --- Time course (0 - 48 h) --- p.57 / Chapter 3.1.4 --- Change in ATP Content --- p.58 / Chapter 3.1.5 --- Change in Mitochondrial Membrane Potential (Δ Ψm) --- p.59 / Chapter 3.1.6 --- Nitrite levels after METH treatment / Chapter a) --- Striatal astrocytes --- p.59 / Chapter b) --- Mesencephalic astrocytes --- p.60 / Chapter c) --- Cortical astrocytes --- p.60 / Chapter 3.1.7 --- The Effects of Aminoguanidine (AG) on Nitrite Levels / Chapter a) --- Striatal astrocytes --- p.61 / Chapter b) --- Mesencephalic astrocytes --- p.62 / Chapter c) --- Cortical astrocytes --- p.62 / Chapter 3.1.8 --- The Effects of Indomethacin (INDO) on Nitrite Levels / Chapter a) --- Striatal astrocytes --- p.63 / Chapter b) --- Mesencephalic astrocytes --- p.64 / Chapter c) --- Cortical astrocytes --- p.64 / Chapter 3.1.9 --- Change in Cyclooxygenase-2 (COX-2) Protein Levels / Chapter a) --- Striatal astrocytes --- p.65 / Chapter b) --- Mesencephalic astrocytes --- p.65 / Chapter c) --- Cortical astrocytes --- p.66 / Chapter 3.1.10 --- Change in Heme-oxygenase-1 (HO-1) Protein Levels / Chapter a) --- Striatal astrocytes --- p.66 / Chapter b) --- Mesencephalic astrocytes --- p.66 / Chapter c) --- Cortical astrocytes --- p.67 / Chapter 3.2 --- Cell Viability on CATH.a-Astrocyte Cocultures After METH Treatment --- p.67 / Chapter CHAPTER FOUR: --- DISCUSSION AND CONCLUSION --- p.69 / REFERENCES --- p.84

by Chu Chi Yuen, Andrew. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1999. / Includes bibliographical references (leaves 140-153). / Abstract also in Chinese. / ABSTRACT --- p.i / Chapter 1 --- INTRODUCTION --- p.3 / Chapter 1.1 --- Using Low density lipoprotein (LDL) as a drug carrier --- p.4 / Chapter 1.1.1 --- The structure of Low density lipoprotein (LDL) --- p.4 / Chapter 1.1.2 --- The metabolic pathway of LDL in human bodies --- p.4 / Chapter 1.1.3 --- The rationale for using LDL as a drug carrier --- p.7 / Chapter 1.1.4 --- Reconstitution of LDL with cytotoxic drugs --- p.9 / Chapter 1.1.5 --- Up and down regulation of LDL receptors --- p.11 / Chapter 1.2 --- Doxorubicin (DOX) --- p.12 / Chapter 1.2.1 --- Characteristics of DOX --- p.12 / Chapter 1.2.2 --- Drug actions of DOX --- p.14 / Chapter 1.2.3 --- The adverse side effects of DOX --- p.15 / Chapter 1.3 --- Multidrug resistance phenomenon in tumor cells --- p.17 / Chapter 1.3.1 --- The possible mechanisms of multidrug resistance --- p.19 / Chapter 1.3.2 --- The structure of P-glycoprotein --- p.20 / Chapter 1.3.3 --- The mechanisms of the P-glycoprotein --- p.22 / Chapter 1.3.4 --- Our aim in dealing with multidrug resistance --- p.22 / Chapter 2 --- MATERIALS AND METHODS --- p.23 / Chapter 2.1 --- Materials --- p.23 / Chapter 2.1.1 --- Animals --- p.23 / Chapter 2.1.2 --- Buffers --- p.24 / Chapter 2.1.3 --- Culture media --- p.25 / Chapter 2.1.4 --- Chemicals --- p.26 / Chapter 2.1.5 --- Culture of cells --- p.27 / Chapter 2.2 --- Methods --- p.29 / Chapter 2.2.1 --- In vitro studies --- p.29 / Chapter 2.2.2 --- In vivo studies --- p.44 / Chapter 3 --- RESULTS --- p.51 / Chapter 3.1 --- In vitro studies --- p.51 / Chapter 3.1.1 --- Preparation of LDL-DOX --- p.51 / Chapter 3.1.2 --- Comparison of the cytotoxicity of DOX and LDL-DOX on HepG2 cells --- p.59 / Chapter 3.1.3 --- Modulation of LDL receptors on HepG2 cells and ECV304 cells… --- p.63 / Chapter 3.1.4 --- The effect of combined treatment of LDL-DOX and hyperthermia on HepG2 cells --- p.84 / Chapter 3.1.5 --- The effect of LDL-DOX on resistant cell line R-HepG2 cells --- p.90 / Chapter 3.2 --- In vivo studies --- p.105 / Chapter 3.2.1 --- The comparison of organ distribution of LDL-DOX and DOXin BALB-c mice after administration --- p.105 / Chapter 3.2.2 --- The comparison of organ distribution of LDL-DOX and DOX in nude mice bearing HepG2 cells after adminstration --- p.108 / Chapter 3.2.3 --- Histological studies of heart of nude mice bearing HepG2 cells treated with DOX and LDL-DOX --- p.111 / Chapter 3.2.4 --- Myocardial injury measured by Lactate dehydrogenase (LDH) activity in nude mice bearing HepG2 treated with DOX and LDL- DOX --- p.117 / Chapter 3.2.5 --- The comparison of DOX and LDL-DOX on reducing the tumor sizes and weight in nude mice bearing HepG2 cells --- p.119 / Chapter 4 --- DISCUSSION --- p.122 / Chapter 4.1 --- In vitro studies --- p.122 / Chapter 4.1.1 --- Preparation of LDL-DOX complex --- p.122 / Chapter 4.1.2 --- The cytotoxicity ofLDL-DOX --- p.125 / Chapter 4.1.3 --- The combined treatment of hyperthermia and LDL-DOX --- p.129 / Chapter 4.1.4 --- The ability of LDL-DOX to circumvent muiltidrug resistance --- p.131 / Chapter 4.2 --- In vivo studies --- p.134 / Chapter 5 --- CONCLUSION --- p.136 / Chapter 5.1 --- Conclusion --- p.136 / Chapter 5.2 --- Future pospective --- p.139 / BIBLIOGRAPHY --- p.140

Leung Yiu Fai Ivan. / "July 2000." / Thesis (Ph.D.)--Chinese University of Hong Kong, 2000. / Includes bibliographical references (p. 83-101). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Mode of access: World Wide Web. / Abstracts in English and Chinese.

Yue Gar-Lee Grace. / Thesis (M.Phil.)--Chinese University of Hong Kong, 2003. / Includes bibliographical references (leaves 113-120). / Abstracts in English and Chinese. / Abstract (English version) --- p.i / Abstract (Chinese version) --- p.iii / Acknowledgements --- p.v / Table of contents --- p.vi / List of figures --- p.x / List of tables --- p.xiii / List of abbreviations --- p.xiv / Chapter Chapter I: --- Introduction --- p.1 / Chapter 1.1. --- Transepithelial electrolyte transport in colon --- p.1 / Chapter 1.1.1. --- Intestinal fluid secretion --- p.1 / Chapter 1.1.2. --- Cellular mechanism of chloride secretion --- p.3 / Chapter 1.2. --- Biological activities of flavonoids --- p.6 / Chapter 1.2.1. --- Classification and general activities of flavonoids --- p.6 / Chapter 1.2.2. --- Bioavailability and pharmacokinetic properties of flavonoids --- p.8 / Chapter 1.3. --- "What is Scutellariae radix""?" --- p.9 / Chapter 1.3.1. --- Usage in Traditional Chinese Medicine --- p.9 / Chapter 1.3.2. --- Relationship with Coptidis rhizoma --- p.9 / Chapter 1.4. --- Effect of flavonoids on gastrointestinal activities --- p.12 / Chapter 1.4.1. --- Genistein and quercetin --- p.12 / Chapter 1.4.2. --- Baicalein --- p.12 / Chapter 1.5. --- Possible intracellular signaling pathway involved in the secretory response by Scutellariae radix (SR) in T84 cells --- p.14 / Chapter 1.5.1. --- Human colonic T84 cell --- p.14 / Chapter 1.5.2. --- Intracellular signaling pathway --- p.14 / Chapter 1.6. --- Aim of study --- p.17 / Chapter Chapter II : --- Methods and Materials --- p.18 / Chapter II.1. --- Culture technique of the T84 cells --- p.18 / Chapter II.2. --- Simultaneous measurement of short-circuit current (Isc) and intracellular calcium ([Ca2+]i) --- p.21 / Chapter II.2.1. --- Experimental setup --- p.21 / Chapter II.2.2. --- Preparation of the permeable supports --- p.23 / Chapter II.2.3. --- Cell seeding --- p.27 / Chapter II.2.4. --- Dye loading --- p.27 / Chapter II.2.5. --- Simultaneous measurement of Isc and [Ca2+]i- --- p.30 / Chapter II.3. --- Conventional short-circuit current (Isc) measurement --- p.34 / Chapter II.3.1. --- Experimental setup --- p.34 / Chapter II.3.2. --- Preparation of the permeable supports --- p.36 / Chapter II.3.3. --- Cell seeding --- p.36 / Chapter II.3.4. --- Measurement --- p.38 / Chapter II.4. --- Measurement of cAMP --- p.39 / Chapter II.5. --- Solutions and chemicals --- p.40 / Chapter II.6. --- Statistical analysis --- p.42 / Chapter Chapter III : --- Results --- p.43 / Chapter III. 1. --- Effects of baicalein and its interaction with calcium and cAMP-dependent secretagogues --- p.43 / Chapter III. 1.1. --- Effects of baicalein on baseline Isc and [Ca2+]i --- p.43 / Chapter III. 1.2. --- Ionic basis of baicalein-evoked Isc --- p.43 / Chapter III. 1.3. --- Effect of baicalein on carbachol-evoked Isc --- p.47 / Chapter III. 1.4. --- "Effect of baicalein on Isc stimulated by another calcium mobilizing agonist, histamine" --- p.58 / Chapter III. 1.5. --- Effect of carbachol on Isc response stimulated by baicalein --- p.61 / Chapter III. 1.6. --- Chronic effect of baicalein on carbachol-evoked increase in Isc --- p.63 / Chapter III.1.7. --- Interaction of baicalein with forskolin --- p.65 / Chapter III.2. --- Effects of baicalein on cAMP generation in T84 cells --- p.69 / Chapter III.2.1. --- Effects of baicalein on cAMP production --- p.69 / Chapter III.2.2 --- Effects of baicalein on forskolin-induced cAMP production --- p.70 / Chapter III.3. --- Effects of Scutellariae radix extract on ion transport activities in T84 cells --- p.73 / Chapter III.3.1. --- Effects of Scutellariae radix extract (SRE) on baseline Isc --- p.73 / Chapter III.3.2. --- Ionic basis of SRE-evoked Isc --- p.77 / Chapter III.3.3. --- Effects of adenylate cyclase inhibitor and PKA inhibitor --- p.77 / Chapter III.3.4. --- PKC modulation --- p.86 / Chapter III.3.5. --- Involvement of intracellular calcium --- p.86 / Chapter III.3.6. --- Involvement of cAMP --- p.94 / Chapter Chapter IV : --- Discussion --- p.98 / Chapter IV. 1. --- Effects of baicalein on ion transport in human colonic T84 cells --- p.98 / Chapter IV. 1.1. --- Roles of baicalein in chloride secretion in intestinal epithelial cells --- p.98 / Chapter IV. 1.2. --- Potentiation effect of baicalein on calcium-mediated chloride secretion --- p.100 / Chapter IV. 1.3. --- Potentiation effect of carbachol on baicalein-stimulated chloride secretion --- p.102 / Chapter IV. 1.4. --- Interaction between baicalein and forskolin --- p.104 / Chapter IV.2. --- Effects of Scutellariae radix extract on ion transport in human colonic T84 cells --- p.107 / Chapter IV.2.1 --- Characteristcs of Isc induced by Scutellariae radix extract --- p.107 / Chapter IV.2.2. --- Possible signaling mechanism involved in Isc induced by Scutellariae radix extract --- p.108 / Chapter IV.3. --- Comparison of the effects on ion transport in human colonic T84 cells produced by baicalein and Scutellariae radix extract --- p.110 / Chapter IV.3.1. --- Properties of baicalein- and Scutellariae radix extract- induced Isc response --- p.110 / Chapter IV.3.2. --- Summary --- p.111 / Chapter Chapter V : --- References --- p.113 / Publications --- p.120

Wang Xiansong. / "February 2004." / Thesis (Ph.D.)--Chinese University of Hong Kong, 2004. / Includes bibliographical references (p. 247-285). / Electronic reproduction. Hong Kong : Chinese University of Hong Kong, [2012] System requirements: Adobe Acrobat Reader. Available via World Wide Web. / Mode of access: World Wide Web. / Abstracts in English and Chinese.

by Carrie Au-Yeang. / Thesis (M.Phil.)--Chinese University of Hong Kong, 1997. / Includes bibliographical references (leaves 45-54). / Abstract also in Chinese. / Chapter I. --- Abstract --- p.iii / Chapter II. --- Acknowledgements --- p.iv / Chapter III. --- Table of Contents --- p.v / Chapter IV. --- List of Abbreviations --- p.vii / Chapter V. --- List of Figures --- p.viii / Chapter VI. --- List of Tables --- p.ix / Chapter VII. --- Introduction --- p.1 / Chapter VIII. --- Literature Review --- p.3 / Chapter A. --- Mycobacterium tuberculosis Infections - clinical importance --- p.3 / Chapter B. --- Treatment of M. tuberculosis Infections - the past & present --- p.3 / Chapter C. --- Laboratory Supports for Treatment of Tuberculosis --- p.5 / Chapter D. --- The Postantibiotic Effects (PAE) --- p.6 / Chapter E. --- PAE of Antituberculosis Drugs Against Mycobacteria --- p.15 / Chapter F. --- Radiometric Measurement of growth --- p.16 / Chapter IX. --- Materials and Methods --- p.17 / Chapter A. --- Bacterial Strains and Their Maintenance --- p.17 / Chapter B. --- Antimicrobial Agents --- p.17 / Chapter C. --- Antimicrobial Susceptibility Testing --- p.18 / Chapter D. --- Assessment of PAE and KI In Vitro --- p.20 / Chapter E. --- Assessment of PAE and KI Ex Vivo --- p.22 / Chapter F. --- Determination of Drug Uptake --- p.25 / Chapter X. --- Results --- p.29 / Chapter A. --- In Vitro Susceptibility Testing of the M. tuberculosis Strains --- p.29 / Chapter B. --- PAE In Vitro - the Classical Viable Count Method --- p.29 / Chapter C. --- PAE Measured by the Bactec Method --- p.30 / Chapter D. --- PAE In Vitro - the Bactec Method --- p.30 / Chapter E. --- Postantibiotic Effects Ex Vivo by the Bactec Method --- p.31 / Chapter F. --- Bactericidal Activities In Vitro and Ex Vivo --- p.32 / Chapter XI. --- Discussion --- p.34 / Chapter A. --- Selection of M. tuberculosis isolates and Drug Susceptibility --- p.34 / Chapter B. --- PAE and KI In Vitro & Ex Vivo - the study methods --- p.34 / Chapter C. --- PAE In Vitro & Ex Vivo - single drug --- p.36 / Chapter D. --- PAE Ex Vivo - drug combinations --- p.38 / Chapter E. --- KI In vitro & Ex vivo --- p.39 / Chapter F. --- PAE and Clinical Therapeutic Regimens --- p.41 / Chapter G. --- Conclusion & Future Studies --- p.44 / Chapter XII. --- Literature Cited --- p.45 / Chapter XIII. --- Figures --- p.55 / Chapter IVX --- Tables --- p.68

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