This thesis work presents a study on the impact of mutual coupling among antenna arrays on the performance of the multipath simulator (MPS) system. In MIMO systems, it is a wellknown fact that the mutual coupling significantly affects their system performance. The impact of mutual coupling on MIMO system performance is an important consideration for compact antenna arrays. Hence, it is very important to investigate the impact of mutual coupling on the accuracy of measurements in a MPS system. In this project, the impact of coupling within the MPS array antennas is addressed by performing simulations based on the proposed MPS scattering model which fulfills the far-field (Fraunhoferdistance) boundary conditions. The coupling phenomenon within the MPS array antennas is studied by designing a uniform circular array (UCA) of radius,R consisting of NMPS antennas with single device under test (DUT) antenna at the center. The elements of the array are matched half-wave dipole antennas and the phase of the array elements is kept constant throughout. In this work it is assumed that all the elements in the array are identical and located in the far-field region. This study is carried out by performing MPS simulations in HFSS at the LTE-A band of 2.6GHz. The approach used to model the entire system is by comparing the S-parameters (S21: Forward transmission coefficient parameter) between various array configuration. The simulation results suggest that the impact of mutual coupling increases with the number of MPS antennas and decreases with the radius of the MPS ring. Theradiated power is also measured with and without mutual coupling. Finally, it is concluded that the impact of coupling within the MPS antennas is best countered by designing a large MPS system (preferably R = 10λ or greater), despite the higher incurred costs.

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Aberrationen in der DNA-Kopienzahl sind häufige genetische Veränderungen bei malignen Lymphomerkrankungen. Zugewinne sowie Deletionen stellen dabei Mechanismen zur Onkogen-Aktivierung sowie Tumorsuppressorgen-Inaktivierung dar und tragen somit zur Pathogenese der Erkrankung bei. Array-CGH und SNP-Array sind Messplattformen, die die genomweite Bestimmung von Kopienzahlaberrationen in einem Experiment ermöglichen. Die bei der Analyse entstehenden Datensätze sind komplex und erfordern automatische Methoden zur Unterstützung der Analyse und Interpretation der Messergebnisse. In dieser Promotionsarbeit wurden Methoden entwickelt, welche die Analyse von Array-CGH- und SNP-Array-Messungen ermöglichen. Diese Methoden wurden für die Auswertung umfangreicher Datensätze von malignen Non-Hodgkin-Lymphomen verwendet. Dabei wurden Lymphome der Entitäten Burkitt-Lymphom, diffus großzelliges B-Zell-Lymphom, Mantelzelllymphom, primäres ZNS-Lymphom und peripheres T-Zell-Lymphom – nicht anderweitig spezifiziert – analysiert. Für die untersuchten Lymphom-Entitäten konnten hierbei zahlreiche neue rekurrente Kopienzahlaberrationen sowie uniparentale Disomien gezeigt werden, die neue Einblicke in die Pathogenese der jeweiligen Erkrankungen erlauben. Darüber hinaus erfolgte ein Vergleich beider Messplattformen anhand eines Datensatzes mit gepaarten Array-CGH- und SNP-Array-Daten. Für die eingesetzten Plattformen (2800k-BAC-Array vs. Affymetrix 250k-Sty-SNP-Array) konnte eine circa zwölffach höhere effektive Auflösung der SNP-Array-Plattform gezeigt werden. Die wesentlichen Ergebnisse dieser Arbeit sind in sieben Publikationen eingeflossen.

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This thesis presents optofluidic nanostructures for analyte transport, concentration and sensing. This work was part of a larger collaborative project between the BC Cancer Agency and the departments of Chemistry, Electrical and Mechanical Engineering at the University of Victoria. In this work, arrays of nanoholes are used as optofluidic platforms for sensing, combining the characteristics of these nanostructures for both fluidic transport and plasmonic (optical) sensing. Two different modes are considered: flow-over mode, where the sample solution containing the analyte flows on top of the nanohole arrays, and a novel flow-through mode, where the nanoholes are used as nanochannels, enabling solution transport and analyte sieving. Flow-through nanohole array operation and sensing is first demonstrated, offering a six-fold improvement in sensor response compared to established flow-over sensing formats. Through a subsequent theoretical scaling analysis and computational analyses, the benefits of the flow-through nanohole sensing format are further quantified. A first analysis is dedicated to study the enhancement offered by the flow-through operation mode using a mass transport approach. A second analysis offers an ample study of benefits and limitations of the flow-through nanostructure operation using the combination of mass transport and binding kinetic parameters for different analytes with characteristics of clinical relevance. The mass transport analysis indicates much higher analyte collection efficiency (~ 99%) offered by the flow-through mode, compared to the flow-over platform (~ 2%). The analysis including both mass transport and binding kinetics demonstrate up to 20-fold improvement in response time for typical biomarkers. This thesis also presents the use of the flow-through optofluidic platform as an active analyte concentrator. In combination with a pressure bias, an electric field is used to concentrate electrically charged analyte for subsequent sensing. Fluorescein enrichment of 180-fold in 60 s was achieved, and 100-fold enrichment and simultaneous surface plasmon resonance (SPR) sensing of a protein (bovine serum albumin, BSA) was demonstrated. These experiments represent the first active utilization of a nanohole metallic layer as an electrode, and the first demonstration of a photonic nanostructure achieving both concentration and sensing of analytes. Towards the integration of optofluidic nanostructures into microfluidic environments for portable lab-on-chip diagnostic systems, this dissertation also includes the development of two nanohole array based sensing systems with simple flow-over operation. The first system consisted of a hand-held device with a dual-wavelength light source to increase the spectral diversity. The second system consisted of nanohole arrays integrated with a microfluidic concentration gradient generator for the detection and quantification of ovarian cancer antibody and antigen. Additionally, this dissertation includes a novel technique to actuate liquids in microchannels through ground-directed electric discharges. Experiments demonstrate average fluid velocities on the order of 5cm/s and applicability of the technique in serpentine channels, for on-demand fluid routing, to initiate a mixing process, and through an on-chip integrated microelectrode. / Graduate