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Graduation date: 1992

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The greatest advances in medicine during the last century have been in the control of infectious diseases. These successes were based fundamentally upon the discoveries of bacteriologists and others of the relation of micro-organisms to disease processes. On the other hand most of the chronic diseases such as, muscular dystrophy, arthritis, cancer and atherosclerosis have not as yet been shown to have any comparable unifying thread to connect them. [...]

Cancer is a disease that is caused by mutations in somatic cells. Metastasis is the major cause of death from cancer and often complicates treatment. Malignant tumours secrete degradative enzymes such as cathepsin L which degrade the extracellular matrix to facilitate tumour invasion and metastasis. The immune system does not normally recognize and eradicate tumours because they arise from self tissues to which the immune system is tolerant. Self antigens are poorly immunogenic because they lack T cell help. In this study, a foreign glucosidase was conjugated to self rabbit cathepsin L using glutaraldehyde to specifically provide T helper cell epitopes. The conjugate was used to immunise two male rabbits. A second pair of rabbits (male and female), was primed with sheep cathepsin L (to induce T helper cell activation) and received rabbit cathepsin L boosters. A third pair of rabbits which served as a control was immunised with sheep cathepsin L. The two pairs of test rabbits made high avidity antibodies against rabbit cathepsin L, showing a similar response to control rabbits when antibodies were tested in an ELISA. Western blot analysis showed that these anti-cathepsin L autoantibodies were specific for rabbit cathepsin L. Rabbits which were immunised with the conjugate were · inoculated with sheep cathepsin L nine weeks after the final inoculation with the conjugate. Analysis of antibodies in an ELISA showed that antibody responses against rabbit cathepsin L were augmented in a manner that is characteristic of memory responses. Low titre antibodies against sheep cathepsin L were also produced. / Thesis (M.Sc.)-University of KwaZulu-Natal, Pietermaritzburg, 2005.

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Darbo tikslas: ištirti juodųjų serbentų (Ribes nigrum L.) produktų, pasižyminčių antioksidantinėmis savybėmis įtaką triušių virškinimo procesams ir produktyvumui. Darbo tikslas įgyvendintas sprendžiant šiuos uždavinius: 1) aukštos apykaitynės energijos gautos iš padidinto riebalų kiekio racionų sudarymas, žolės miltus pakeičiant juodųjų serbentų išspaudomis; 2) nustatyti triušių kūno svorio, priesvorio, pašarų sąnaudų su juodaisiais serbentais sąveiką; 3) ištirti juodųjų serbentų išspaudų įtaką atskirų virškinimo trakto segmentų turinio pH ir sausųjų medžiagų kiekiui;4) nustatyti juodųjų serbentų išspaudų įtaką klubinės žarnos turinio klampumui, aklosios žarnos turinio amoniako kiekiui; 5) ištirti trumpųjų grandinių riebalų rūgščių (TGRR) koncentraciją ir sudėtį aklojoje žarnoje; 6) nustatyti juodųjų serbentų išspaudų įtaką aklosios ir gaubtinės žarnų turinio baltymų, bakterijų fermentiniams (α- ir β-galaktozidaziniams, gliukozidaziniams, α- ir β-gliukozidaziniams ir β-gliukuronidazidaziniams) aktyvumams ir lakiųjų riebalų rūgščių (LRR) kiekiams; 7) nustatyt ipoveikį triušių antioksidantinio aktyvumo rodikliams; 8) nustatyti poveikį biocheminiams kraujo rodikliams; 9) ištirti triušių aterogeniškumo ir atsparumo insulinui rodiklius. Išvados: 1) Juodųjų serbentų išspaudų naudojimas pakeičiant žolės miltus, patvirtino hipotezę, kad jos gali būti laikomos veiksminga ir prieinama pašarų sudedamąją dalimi triušių racionuose. 2) Raciono papildymas juodųjų serbentų išspaudomis... [toliau žr. visą tekstą] / Researches were conducted in the Animal Husbandry Department of the Veterinary Academy of Lithuanian Health Sciences University, also in the vivarium of Lithuanian Veterinary Academy and in the Institute of Animal Reproduction and Food Research of the Polish Academy of Sciences. New Zealand rabbits were used for the researches. All rabbits were calved over one cycle of reproduction (50 percent were male and 50 percent were female). All rabbits were assigned to four groups of five individuals each. The rabbits of the control group (K) were fed a standard diet; the group KP was fed a standard diet with increased fat volume. The rabbits of the group E were subjected to a standard diet with the addition of blackcurrant polyphenolic extract (1,5 percent), the animals of the group EP were fed a standard diet with increased fat volume + blackcurrant extract (1,5 percent). Duration of the research was 45 days. Rabbits were stored in the individual flat-bottomed wire cages in closed room. Over the research all rabbits were fed and watered ad libitum. The research included observation of rabbit growth dynamics, level of ammonia in the substance of cecum, activity of microbe ferments, short-chain fatty acids, and research of overall wellness. Thegoalofthepaper: to investigate the effect of blackcurrant (Ribes nigrum L.) products distinguishing for antioxidant features on digestive processes and productivity of rabbits. The goal of the paper has been achieved by solving the following... [to full text]

After European settlement, Australian rangelands especially in South Australia underwent significant changes because of the main land use of pastoralism. Many studies have revealed that the plant communities are negatively effected by herbivory mainly by sheep. The main aim of this study is to separate the different effects of sheep, rabbits and kangaroos. This was examined by survey supported by experimental and modelling research. / A 32,000 km² area previously surveyed by Tiver and Andrew (1997) in eastern South Australia was re-surveyed to monitor populations of perennial plant species at sites of various intensity of grazing by sheep, rabbits and kangaroos (goats populations are low in the study area), the most important vertebrate herbivores. Plant population data were collected in both sheep paddocks and historically ungrazed by sheep (road reserves) by using the Random Walk method and analysed using Generalized Linear Modelling (GLM) to separate the effects of sheep and rabbits on plant regeneration and their regeneration in response to grazing. These data were also compared to similar data collected by Tiver and Andrew in 1992 (1997) to ascertain if the reduction in rabbit numbers through introduction of RCV had allowed increased regeneration. Regeneration of many species inside paddocks were negatively affected and species in roadside reserves did not significantly increase from 1992 to 2004. However, some species showed increase of populations in spite of sheep grazing, with some species being less susceptible than others. This research also indicates kangaroo grazing impact on some plant species. Reduction in rabbit numbers following the 1995 release of calicivirus has not been effective in restoring regeneration. Another experiment was conducted at Middleback Field Station near Whyalla to identify herbivore grazing pressure on the arid zone plant species Acacia aneura using unfenced, sheep fenced and rabbit fenced grazing exclosures. This experiment was set up with seedlings in exclosures, ten replicates of each treatment, at plots four different distances from the watering point to identify the survivorship of seedlings. Data were collected by recording canopy volumes of seedling over an 18 month period and analysed by Residual Maximal Likelihood (REML). Seedlings both near and far from the watering point were severely affected by large herbivores, either sheep, kangaroos or both, and in a separate experiment kangaroo grazing effects on the seedling were also identified. Seedlings browsed by the rabbits recovered better than the seedlings grazed by the large herbivores. Decreasing kangaroo activities has been noticed when the rabbit movements increased. Computer modelling was conducted to predict the future plant population structure over 500 years using a matrix population model developed by Tiver et al. (2006) and using data collected in the survey as a starting point. Extinction probabilities of populations of Acacia aneura near watering points, far from watering points and under pulse grazing scenarios were compared. Sheep grazing was found to cause eventual extinction of populations in all parts of sheep paddocks. Together, the results indicate that sheep are the major herbivore suppressing regeneration of perennial plant species. Kangaroo and rabbits have an identifiable but lesser effect. The results have implications for conservation and pastoral management. To achieve ecological sustainability of arid lands a land-use system including a network of reserves ungrazed by sheep and with control of both rabbit and kangaroo numbers will be required. / Thesis (PhD)--University of South Australia, 2006.

Thesis (Ph. D.)--University of Western Sydney, 2002. / "This thesis is submitted in fulfilment of the requirements of the degree of Doctor of Philosophy to the University of Western Sydney School of Biological Sciences."t.p. Includes bibliographical references (leaves 138-150).

Thesis (Ph. D.)--Uniformed Services University of the Health Sciences, 2007. / Typescript (photocopy).