Muscle weakness is one of the major causes of post-stroke disability. Stroke rehabilitation programs now often incorporate the same type of resistance training that is used for healthy subjects; however, the training effects induced from these training strategies are often limited for stroke patients. An important resistance training principle is that an optimal level of stress is exerted on the neuromuscular system, both during concentric (shortening) and eccentric (lengthening) contractions. One potential problem for post-stroke patients might be difficulties achieving sufficient levels of stress on the neuromuscular system. This problem may be associated with altered muscular function after stroke. In healthy subjects, maximum strength during eccentric contractions is higher than during concentric contractions. In individuals with stroke, this difference in strength is often increased. Moreover, it has also been shown that individuals with stroke exhibit alteration with respect to how the strength varies throughout the range of motion. For example, healthy subjects exhibit a joint specific torque-angle relationship that normally is the same irrespective of contraction mode and contraction velocity. In contrast, individuals with stroke exhibit an overall change of the torque-angle relationship. This change, as described in the literature, consists of a more pronounced strength loss at short muscle length. In individuals with stroke, torque-angle relationships are only partially investigated and so far these relationships have not been analysed using testing protocols that include eccentric, isometric, and concentric modes of contraction.   This thesis investigates the torque-angle relationship of elbow flexors in subjects with stroke during all three modes of contractions – isometric, concentric, and eccentric ­– and the relative loading throughout the range of movement during a resistance exercise. In addition, this thesis studies possible central nervous system mechanisms involved in the control of muscle activation during eccentric and concentric contractions.   The torque-angle relationship during maximum voluntary elbow flexion was examined in stroke subjects (n=11), age-matched healthy subjects (n=11), and young subjects (n=11) during different contraction modes and velocities. In stroke subjects, maximum torque as well as the torque angle relationship was better preserved during eccentric contractions compared to concentric contractions. Furthermore, the relative loading during a resistance exercise at an intensity of 10RM (repetition maximum) was examined. Relative loading throughout the concentric phase of the resistance exercise, expressed as percentage of concentric torque, was found to be similar in all groups. However, relative loading during the eccentric contraction phase, expressed as the percentage of eccentric isokinetic torque, was significantly lower for the stroke group. In addition, when related to isometric maximum voluntary contraction, the loading for the stroke group was significantly lower than for the control groups during both the concentric and eccentric contraction phases. Functional magnetic resonance imaging was used to examine differences between recruited brain regions during the concentric and the eccentric phase of imagined maximum resistance exercise of the elbow flexors (motor imagery) in young healthy subjects (n=18) and in a selected sample of individuals with stroke (n=4). The motor and premotor cortex was less activated during imagined maximum eccentric contractions compared to imagined maximum concentric contraction of elbow flexors. Moreover, BA44 in the ventrolateral prefrontal cortex, a brain area that has been shown to be involved in inhibitory control of motor activity, was additionally recruited during eccentric compared to concentric conditions. This pattern was evident only on the contralesional (the intact hemisphere) in some of the stroke subjects. On the ipsilesional hemisphere, the recruitment in ventrolateral prefrontal cortex was similar for both modes of contractions.    Compared to healthy subjects, the stroke subjects exhibited altered muscular function comprising a specific reduction of torque producing capacity and deviant torque-angle relationship during concentric contractions. Therefore, the relative training load during the resistance exercise at a training intensity of 10RM was lower for subjects with stroke. Furthermore, neuroimaging data indicates that the ventrolateral prefrontal cortex may be involved in a mechanism that modulates cortical motor drive differently depending on mode of the contractions. This might partly be responsible for why it is impossible to fully activate a muscle during eccentric contractions. Moreover, among individuals with stroke, a disturbance of this system could also lie behind the lack of contraction mode-specific modulation of muscle activation that has been found in this population. The altered neuromuscular function evident after a stroke means that stroke victims may find it difficult to supply a sufficient level of stress during traditional resistance exercises to promote adaptation by the neuromuscular system. This insufficiency may partially explain why the increase in strength, in response to conventional resistance training, often has been found to be low among subjects with stroke. / Muskelsvaghet är en av orsakerna till funktionshinder efter stroke. I rehabiliteringsprogram för personer som drabbats av stroke förekommer det numera att styrketräning används i syfte att öka muskelstyrkan. Effekten av styrketräning har dock ofta visat sig vara begränsad. En viktig styrketräningsprincip är att muskulaturen belastas tillräckligt nära maximal styrka under både koncentriska kontraktioner (när man lyfter en vikt) och excentriska kontraktioner (när man kontrollerat sänker en vikt). Ett potentiellt problem skulle kunna vara att personer med stroke inte belastas optimalt under träning på grund av förändrad muskelfunktion. Efter stroke är muskelfunktionen ofta förändrad såtillvida att styrkenedsättningen är mer uttalad under koncentriska kontraktioner. Därutöver har man funnit att styrkenedsättningen är mest uttalad när muskeln är i sitt mest förkortade läge. Detta fenomen har dock inte studerats för alla tre kontraktionstyper, det vill säga excentriska, koncentriska och isometriska kontraktioner, hos personer med stroke.   Denna avhandling undersöker sambandet mellan styrka och ledvinkel över armbågsleden hos personer med stroke under alla tre kontraktionstyper – excentrisk, koncentrisk och isometrisk, samt relativ belastning genom rörelsebanan under en styrketräningsövning. Därutöver undersöker denna avhandling också hjärnans aktiveringsmönster under excentriska och koncentriska kontraktioner.   Sambandet mellan styrka och ledvinkel undersöktes hos personer med stroke (n = 11), åldersmatchade (n = 11) och unga försökspersoner (n = 11). Jämfört med kontrollgrupperna var maximal styrka för personer med stroke mest nedsatt, samt även den oproportionerligt stora styrkenedsättningen vid kort muskelängd som mest uttalad, under koncentriska kontraktioner. Denna avvikelse var minst uttalad vid excentriska kontraktioner. Vidare studerades hur hög belastningen på muskulaturen var i jämförelse med muskelns maximala styrka under en styrketräningsliknande övning för armbågsflexorer vid en träningsintensitet på 10RM. Den uppmätta belastningen under den koncentriska fasen av styrketräningsövningen, uttryckt som procent av den genomsnittliga koncentriska styrkan, var densamma för alla grupperna. Under den excentriska fasen av övningen var dock belastningen, uttryckt som procent av den maximala excentriska styrkan, signifikant lägre för personer med stroke. Träningsbelastningen utgjorde också en lägre andel av den maximala isometriska styrkan för personer med stroke, både under den koncentriska och under den excentriska fasen.   Funktionell magnetresonanstomografi (fMRI) användes för att undersöka hjärnans aktiveringsmönster hos unga försökspersoner (n = 18) och hos individer med stroke (n = 4) när de föreställde sig att de utförde maximal styrketräning för armbågsflexorer (motor imagery). Resultatet visade att primära motorbarken och premotoriska barken var mindre aktiverade när unga friska försökspersonerna föreställde sig utföra maximala excentriska, jämfört med maximala koncentriska kontraktioner. Dessutom var en region i ventrolaterala prefrontala barken, som i tidigare studier visat sig vara inblandat i reglering och hämning av muskelaktivering, mer aktiverade under föreställda excentriska kontraktioner. Detta aktiveringsmönster i den prefrontala barken återfanns dock endast i den icke skadade hjärnhalvan hos personer med stroke.   Jämfört med kontrollgrupperna uppvisade försökspersonerna med stroke en förändrad muskelfunktion som bestod av en specifik nedsättning av styrkan under koncentriska kontraktioner samt också ett mer avvikande samband mellan styrka och ledvinkel under koncentriska kontraktioner. Den relativa belastningen under utförandet av en styrketräningsövning med en intensitet på 10RM var på grund av dessa avvikelser lägre för försökspersoner med stroke. Hjärnavbildnings-studierna indikerade att ventrolaterala prefrontala barken verkar vara involverat i ett kortikalt moduleringssystem som reglerar muskel-aktivering olika beroende på kontraktionstyp under maximala kontraktioner. Detta skulle kunna vara en underliggande mekanism bakom den hittills obesvarade frågan varför det är omöjligt att aktivera muskulaturen maximalt under excentriska kontraktioner. En störning av detta moduleringssystem hos personer med stroke verkar också kunna ligga bakom den förändrade regleringen av muskelaktivering som visat sig förekomma hos personer med stroke. Neuromuskulär funktion efter stroke är förändrad i flera avseenden vilket verkar medföra att muskulaturen inte belastas optimalt under konventionell styrketräning. Detta kan vara en delförklaring till varför styrkeökningen som svar på träning ofta är liten hos personer med stroke.

The purpose of this study is to examine the effects and persuasive mechanisms of expository and narrative HPV vaccine messages targeted toward young men. The researcher used the Centers for Disease Control and Prevention’s HPV facts for men as a framework for the expository message condition. He also created two similar but distinct narratives that focused on HPV and men. The first narrative was informed by narrative persuasion studies in the social sciences and was labeled the academic narrative. The second narrative incorporated important elements of storytelling from literary theory and was labeled the classic narrative. A comparison condition, which presented a testimonial from a testicular cancer survivor, was also employed to compare against the effectiveness of the three experimental conditions. In the experiment, 258 men ages 18-26 were assigned randomly to the expository, academic narrative, classic narrative, or comparison conditions. Outcome measures related to the persuasive effects of the messages were attitudes toward talking to healthcare providers about the HPV vaccine and receptiveness to the HPV vaccine. Outcome measures related to the persuasive mechanisms of expository messages were argument strength, source credibility, and emotional arousal. Outcome measures related to the persuasive mechanisms of narrative messages were perceived realism, transportation, identification, and emotional arousal. Hypotheses predicted that argument strength and source credibility would predict changes in knowledge, attitudes, and vaccine receptiveness in the expository condition, whereas perceived realism, transportation, and identification would predict similar changes in the narrative conditions. An additional hypothesis predicted that emotional arousal would affect the persuasion process differently in the expository and narrative conditions. Results indicated that transportation, identification, and emotional arousal were stronger in the narrative conditions, but these variables did not predict persuasive outcomes. Conversely, perceived realism and source credibility had unexpected persuasive effects in both expository and narrative conditions. Implications of the findings and directions for future research are discussed.

Increased interest in value-added traits of soft winter wheat (SWW; Triticum aestivum L.), such as white-seed coat and gluten strength, has resulted from economic incentives for these traits. The first objective of this study was to determine whether differences existed between red- and white- seeded progeny of 17 populations. When abiotic and biotic stresses were negligible, significant differences were not detected between red- and white-seeded progeny, except for yield: red-seeded progeny had a significantly higher yield than the white-seeded progeny. However, when abiotic and biotic stresses were larger, the yield of white-seeded progeny was not significantly different from red-seeded progeny and the white-seeded progeny accumulated a significantly greater amount of deoxynivalenol (DON) than red-seeded progeny. Therefore, Kentucky producers should be cautious when considering production of white-seeded cultivars. The second objective of this study was to determine whether early- or late- generation selection for white-seeded progeny produced a higher frequency of superior white-seeded lines. Three selection methods were studied. Late-generation bulk selection produced a significantly lower frequency of superior white-seeded lines (1.7%) than single seed descent (SSD; 13.9%); the early-generation bulk (9.6%) did not differ statistically from either method. Although SSD produced the most superior lines, the utility of SSD breeding will have to be assessed by SWW breeders to justify additional labor and space requirements. The final objective was to determine whether early-generation selection of wheat quality, as determined by wheat meal-based assays, was effective. A cross between a strong gluten soft red winter and a weak gluten soft white winter wheat was examined. Significant correlations and regressions between wheat meal assays and flour-based assays were found. High heritability and realized genetic gains were also observed. Therefore, early-generation selection for quality characteristics appears to be effective.

Self-compacting concrete (SCC) was first developed in Japan about two decades ago. Since then, it has been offered as a solution to various challenges inherently associated with traditional concrete construction; i.e. quality and speed of construction, impact of unskilled labour force and noise pollution etc. SCC flows into a uniform level under its own weight and fills in all recesses and corners of the formwork even in highly congested reinforcement areas. In recent years the interest in using SCC in structural members has increased manifold; therefore many researchers have started investigating its characteristics. Nevertheless, before this special concrete is widely accepted and globally used in structures, its structural performance under different conditions should be investigated. This research focuses on investigating the behaviour of high strength self-compacting concrete (HSSCC) in reinforced concrete (RC) structures through a systematic approach in order to bridge part of an existing gap in the available literature. The dissertation is comprised of four main stages; namely, mix design development and mechanical properties of HSSCC, bond performance of deformed bars in HSSCC, experimental investigation on interior RC beam-column joints (BCJs) cast with HSSCC under reversed cyclic excitations, and finally finite element (FE) modelling and analysis of interior BCJs. First, a HSSCC mix proportion yielding compressive strength greater than 100 MPa was developed in the laboratory using locally available materials in New Zealand. Two benchmark concrete mixes of conventionally-vibrated high-strength concrete (CVHSC) and normal-strength conventionally vibrated concrete (CVC) were also designed for comparison purposes. Material characteristics (such as compressive, splitting tensile and flexural strengths as well as modulus of elasticity, shrinkage and microstructural properties) of all mixes were evaluated. It was found that, once the lower quality of material in normal strength concrete is offset by achieving a denser mix in high-strength concrete, mechanical properties of HSSCC are equivalent to or higher than those in CVHSC. Given that the performance of RC structures (and in specific BCJs) is highly dependent on bond between reinforcement and concrete, understanding the bond behaviour in HSSCC was an imperative link between the first and third phases of this research. Therefore, the second phase focused on scrutinizing bond properties of deformed bars in HSSCC using monotonic pull-out and innovative cyclic beam tests. Processing of the pull-out results revealed that a shorter development length may be utilized in HSSCC. In addition, the grade (or ductility) of reinforcing steel was found to substantially influence the post-yield bond performance. Important modifications to the bond model used in the CEB-FIP model code and Maekawa’s bond-slip-strain relationship were suggested from the results of this phase. An innovative cyclic beam specimen and test setup were also designed such that a more realistic bond performance could be observed in the laboratory tests compared to that in real RC structures. Deleterious impact of cyclic loading and buckling of reinforcement on bond performance were investigated using this testing protocol. The third phase of this research focused on the design, fabrication and testing of seven full-size BCJs. BCJs are one of the most critical parts in RC frame structures and their response substantially affects the overall behaviour of the structure. In seismically active regions like New Zealand, the criticality of BCJs is exacerbated with the complexities involved in seismic resistance. The already congested intersection of RC beam and column looks more like a solid steel connection after consideration of earthquake requirements, and placement of concrete becomes problematic in such areas. At the same time, in many of the high-rise structures, normal strength concrete does not meet the capacity requirements; this requires the usage of high-strength concrete. Therefore, once the seismic performance of HSSCC is guaranteed, it can possibly be a solution to both the capacity and compaction problems. Variables such as axial load, concrete type, steel grade, casting direction, and joint shear reinforcement were considered variable in the experimental investigations. It was found that HSSCC has similar seismic performance to that of CVHSC and it can also be incorporated in the joint area of CVC for an enhanced performance. Finally, DIANA (a nonlinear FE program) was used to simulate the experimental results obtained in the third phase of this research. All BCJs were successfully modelled using their relevant attributes (such as the mechanical properties of HSSCC, steel stress-strain response, test setup and loading protocol) and nonlinear FE analyses (FEA) were performed on each model. FE results were compared to those obtained in the laboratory which showed a reasonable agreement between the two. The capabilities of the FEA were scrutinized with respect to the hysteresis loops, energy dissipation, joint shear deformations, stress development in the concrete and steel, and drift components. Integrating the results of all stages of this research provided better understanding of the performance of HSSCC both at the material and structural levels. Not only were none of the seismically important features compromised by using HSSCC in BCJs, but also many other associated benefits were added to their performance. Therefore, HSSCC can be confidently implemented in design of RC structures even in seismically active regions of the world.

No description available.

Fractures are a major public health concern and there is an urgent need to identify high-risk individuals. This study used novel approaches in bone imaging to characterize optimal skeletal development in girls and enhance our understanding of the structural and functional deficits that contribute to skeletal fragility and fracture risk during growth. The findings indicate that fracture in girls is associated with lower trabecular bone density, but not bone macro-architecture at metaphyseal regions of weight-bearing bones, which is consistent with findings reported in children at the distal radius. These findings suggest that lower trabecular density at metaphyseal regions of long bones track throughout the appendicular skeleton and may be an early marker of skeletal fragility.Obese children are overrepresented in childhood fracture cases. Nevertheless, the effects of fat on bone during growth remain unclear. This study showed that skeletal muscle was a stronger determinant of bone parameters in girls than total body adiposity, although fat mass had a persistent, albeit weak association with bone parameters. Furthermore, fatty infiltration of skeletal muscle, which is associated with type 2 diabetes mellitus, was inversely associated with bone strength in girls. These findings are consistent with the proposed functional model of bone development which posits that forces from muscle contractions are the main mechanical challenges to which bones adapt.Physical activity during growth is critical for optimal bone development. The findings from this study support this premise and suggest that regular physical activity enhances bone strength in girls. Nevertheless, for exercise to be accepted as an important public health osteoporosis prevention strategy, lasting adaptations must be shown. Plausible biological explanations have been offered in support of the peri-pubertal years as a "window of opportunity" for maximizing the response to exercise. Findings from this study suggest that a two year school-based high-impact jumping intervention was not an effective means to enhance bone parameters in girls. Controlled dose-response trials will be necessary to test questions regarding the types, bouts, and durations of exercise required to define the "dose" of exercise needed to elicit meaningful skeletal adaptations during growth.

This research focuses on the spall properties of aluminum-magnesium (Al-Mg)alloys.Aluminum alloy 5083 (Al 5083) was used as a model alloy for the work performed in this study. Al-Mg alloys represent a light-weight and corrosion resistant alloy system often used in armor plating. It is desirable to process armor plate material to yield a microstructure that provides maximum resistance to spall failure due to blast and projectile impacts. The blast and impact resistance has often been quantified based on the measurement of the spall strength and the Hugoniot elastic limit (HEL). The spall properties of Al-Mg alloys were measured for four different microstructural states resultant from varying processing conditions. The four microstructures include: (a) textured grain structure from a rolled Al 5083-H116 plate, (b) sub-micron grain structure produced using equi-channel angular pressing (ECAP),(c) equiaxed grain structure, and (d) precipitation hardened microstucture from an Al-9wt.% Mg alloy. The overall results show that grain size is not the most dominant microstructural feature affecting spall strength in aluminum alloys, when the impact conditions are the same. Texture, especially if brittle inclusions align along the grains, appears to have the most dominant effect resulting in decreased spall strength. Furthermore, one-dimensional modeling shows that the inclusion size and distribution is the controlling factor for void formation during spalling. Grain size does affect the decompression rate dependence of each microstructure, whereby smaller grain sizes result in a larger power law exponent for fits of spall strength versus decompression rate. Unlike the spall strength, the HEL shows an increasing trend with decreased grain size, as would be expected from a Hall-Petch type effect, indicating that a smaller grain size is best for penetration resistance. Samples processed using ECAP alone provide the best combination of spall strength and HEL and therefore the most promise for improved blast and penetration resistance of aluminum-magnesium alloy armor plates.

Abstract Post-activation potentiation (PAP) is a phenomenon where force output is acutely enhanced following muscular contraction. Previous research has documented enhanced performance in power-type light exercise following a heavy pre-load, such as vertical jumps following heavy squats. To date, the effect of PAP on moderately heavy exercise following a heavy pre-load has not been investigated. Purpose: The purpose was to examine whether PAP could be elicited in moderately heavy squats following a heavy squat pre-load, and if so, what intensity (as percentage of one repetition-maximum [1RM]) of pre-load elicited the highest PAP effect (measured as mean power, mean force and number of repetitions performed). Subjects: Seventeen resistance-trained males (age 24±2 years, length 182±8 cm, body mass 84.7±13.1 kg, squat 1RM 147.6±29.6 kg) with at least 2 years of experience of the squat exercise. Methods: After testing parallel squat 1RM at a separate session, subjects performed three testing sessions in a randomized order in a cross-over design; performance test at 80% of parallel squat 1RM (control), one repetition at 85% of 1RM followed 8 minutes later by the same performance test (PAP85), and one repetition at 93% of 1RM followed 8 minutes later by the same performance test (PAP93). Sessions were separated by six days. Force and power output was recorded using a linear encoder. Friedman’s test was used to reveal differences between conditions, and a Wilcoxon signed rank test was used to identify these differences. Results: There was an increase in number of repetitions performed for PAP85 (p=0.009) and PAP93 (p=0.001) compared to control, but not for mean power or mean force. There was no significant difference between PAP85 and PAP93 for number of repetitions (p=0.091). Conclusion: PAP can be elicited to improve performance in moderately heavy squats following a heavy squat pre-load in trained subjects, but only measured as number of repetitions performed, not force or power. PAP could therefore be useful not only for designing power training, but also for strength and hypertrophy training. KEYWORDS: squat, post-activation potentiation, PAP, strength, power, hypertrophy.

Eccentric overload in training settings utilizes loads higher than concentric one repetition maximum (1RM). There is no clear definition of eccentric “failure” or 1RM using conventional weights, so eccentric 1RM is estimated to be between 145-190% concentric 1RM. Historically, the highest intensity used for eccentric overload is typically 120% of concentric 1RM despite little research using conventional weights with higher eccentric intensities. The purpose of this study was to conduct an exploratory neuro-mechanical analysis of different intensities of elbow flexors eccentric overload using free weights by examining angular kinematics during contraction. Twenty male participants with weight training experience had unilateral concentration curl isometric peak torque assessed on a Humac Norm Dynamometer and concentric 1RM assessed with dumbbells while biceps brachii electromyography (EMG) and elbow joint angle were recorded. Angles were recorded using a custom made electrogoniometer and elbow joint torque was estimated using inverse dynamics. Participants were randomly assigned in counter balanced order to perform eccentric actions at 120%, 140%, 150%, 160% and 170% concentric 1RM with 4 minutes rest between. Variables included peak torque, angular velocity at peak torque, impulse, power, mean EMG, and EMG normalized to peak. Data were analyzed using repeated measures ANOVA or a Friedman test. Angular velocity at peak torque was significantly lower for 120% (65.3 ± 40.8°/s) compared to all other conditions (range: 65.3 ± 40.8 to 162.1 ± 75.2°/s; p<0.01). Peak torque for all conditions (range: 98.2 ± 16.2 to 108.2 ± 21.6 Nm) was significantly higher than isometric peak torque (77.4 ± 16.8Nm; p<0.05). Peak torque at 160% (108.2 ± 21.6Nm) was significantly higher than at 120% (98.2 ± 16.2Nm; p<0.05). Power for 140-170% (range: 166.2 ± 85.7W to 265.8 ± 111.3W) was significantly higher than power at 120% (79.9 ± 66.8W; p<0.05). Impulse was highest at 120% (56.1 ± 54.6Nms) compared to all other conditions (range: 56.2 ± 54.6 to 9.6 ± 3.8Nms; p≤0.05). Impulse at 140% (20.6 ± 11.8Nms) was significantly higher than 170% (9.6 ± 3.8Nms; p<0.05). Isometric mean EMG (0.792 ± 0.285 mV) was significantly higher than all eccentric conditions (range: 0.654 ± 0.313 to 0.533 ± 0.259mV; p<0.05) with no difference between eccentric conditions for mean EMG or EMG normalized to peak. It was concluded that compared to 120%, eccentric overload with intensity ranging from 140-170% concentric 1RM involves minimal increases in peak torque and no change in EMG activation. Intensities above 120% enhance power and decrease impulse. This research has implications on future training prescription of eccentric exercise.

No description available.