Many in the Christian tradition accept three theological affirmations: (TA1) That bodily resurrection is not a superfluous hope of afterlife; (TA2) There is immediate post-mortem existence in Paradise; and (TA3) There is numerical identity between pre-mortem and post-resurrection human beings. Many of the same Christians also accept a robust doctrine of The Intermediate State, a paradisiacal disembodied state of existence following the biological death of a human person. I say The Intermediate State makes TAs 1 – 3 an inconsistent set. So, given these TAs, I say that there is no such thing as The Intermediate State and, therefore, it should be jettisoned from Christian theology. Chapter 1 aims to show that, if the TAs are true, Christian theology should jettison The Intermediate State. This is because The Intermediate State specifically undermines TA1. Along with The Intermediate State, Christian theologians should jettison the metaphysics of substance dualism. This is because substance dualism, a metaphysics that The Intermediate State requires, is either false or unmotivated. Substance dualism is false because, minimally, it conflicts with an argument St. Paul lays out in 1 Corinthians 15. And, even if it did not, it lacks motivation for Christian theology because there is no The Intermediate State. In Chapter 1, I advance theological arguments along these lines. If the arguments go through, Christian theology needs a way coherently to speak about afterlife that does not make use of these errant views. If TAs 1 – 3 are true, substance dualism is either false or unmotivated, and The Intermediate State does not obtain, Christian theology requires an amended metaphysics of human persons and an amended metaphysics of time. I attempt to offer such things in Chapters 2 – 5. Chapters 2 and 3 are given over to investigating physicalist and constitution metaphysics of human persons. I find the range of views wanting for a number of philosophical and theological reasons. Chapter 4 is an explication and defense of a hylemorphic metaphysics of human persons and a sustained argument against some leading hylemorphic conceptions that insist the soul of a biologically dead human person can survive the death of the body. Lastly, Chapter 5 offers a theory of time that completes the project’s goal: a coherent metaphysics within which a human person’s death is immediately followed by her eschatological (future) bodily resurrection so that the three TAs are an affirmed and consistent set.

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Double-exposure lithography has shown promise as potential resolu- tion enhancement technique that is attractive because it is much cheaper than double-patterning lithography and it can be deployed on existing imaging tools. However, this technology is not possible without the development of new materials with nonlinear response to exposure dose. Several materials have been proposed to implement a nonlinear response to exposure including re- versible contrast enhancement layers (rCELs), two-photon materials, interme- diate state two-photon (ISTP) materials, and optical threshold layers (OTLs). The performance of these materials in double-exposure applications was inves- tigated through computer simulation using a custom simulator. The results from the feasibility studies revealed that the ISTP and OTL types of materials showed much more promise than the rCEL and two-photon types of materi- als. Calculations show that two-photon materials will not be feasible unless achievable laser peak power in exposure tools can be signi¯cantly increased. Although rCEL materials demonstrated nonlinear behavior in double-exposure mode, only marginal image quality and process window improvements were ob- served. Using the results from the simulation work described herein, materials development work is currently ongoing to enable potential ISTP and OTL materials for manufacturing. A new biochip platform named \Mesoscale Unaddressed Functional- ized Features INdexed by Shape" (MUFFINS) was developed in the Willson Research Group at the University of Texas at Austin as a potential method to achieve a new low-cost biosensor system. The platform uses poly(ethylene glycol) hydrogels with bioprobes covalently cross-linked into the matrix for detection. Each sensor is shape-encoded with a unique pattern such that the information of the sensor is associated with the pattern and not its position. Large quantities of individual sensors can be produced separately and then self- assembled to form random arrays. Detection occurs through hybridization of the probes with °uorescently labeled targets. The key designs of the system include parallel batch fabrication using photolithography and self-assembly, in- creased information density using multiplexing, and enhanced shape-encoding with automated pattern recognition. The development of two aspects of the platform { self-assembly mechanics and pattern recognition algorithm, and a demonstration of all the key design elements using a single array are described herein. / text

The field of organic chemistry is divided into many subfields, which include polymer design and synthesis, transition metal catalysis and organocatalysis among a variety of others. Challenges in polymer design and synthesis can be highlighted pointedly in the use of photoresists for lithographic processing. Recent challenges in development of shorter wavelength sources has led to the need to develop new photoresist materials that can be exposed twice without any development steps in between. Two methods for addressing double exposure materials will be presented. Additionally, the areas of catalysis, whether transition metal or organic in nature, are important methods in organic synthesis. The mechanism of the addition of Gilman reagents to enones has been the subject of debate, and efforts to elucidate this mechanism will be presented. Finally, organocatalysis has expanded its scope into a variety of reactions previously only conducted with transition metal catalysts. Work towards an enantioselective allylic amination reaction using organocatalysis as well as absolute stereochemistry of the product will be explored. / text

The aim of this study is to prove that neither 1 Peter 3:19 nor 1 Peter 4:6 refers to the Christian doctrine the ‘Descensus Christi ad Inferos’. The meaning of these two verses has long been debated (cf. Dalton 1989:27-28), and is very often seen as a reference to Christ’s descent into Hades (cf. Feinberg 1986:309). This study will be done by means of a parallel study. The first part of this study will involve the doctrine of the ‘Descensus’; looking at its origin and its development. It will be argued in this section that the roots of this doctrine can be found in Jewish-Christianity and not pagan mythology as has been suggested (cf. Bousset 1907:224ff&Beare 1945:145). The discussion of the doctrine is necessary, since we do need to know more about the doctrine to see whether it is the referent in 1 Peter. The second part of the study will then engage in the meaning of 1 Peter 3:19 and 4:6. This section will be very context driven. We will start with an introduction to 1 Peter, discussing all the preliminary questions (i.e. author, date, audience&form). This will be followed by a structural analysis of 1 Peter. Here it will be argued that the letter should be understood in terms of metaphors, with the ‘Diaspora’ as the controlling metaphor (cf. Martin 1992). The verses under discussion, form part of the third metaphor-cluster namely the ‘Sufferers of the Dispersion’, while the name of our subsection is’ The Righteous Sufferer’. By means of the grammatical analysis, and the influence of the pseudepigraphal book 1 Enoch, it will be shown that these verses do not allow themselves to be interpreted as references to the Descent of Christ into Hades. / Dissertation (MA)--University of Pretoria, 2008. / Ancient Languages / unrestricted

This master thesis is focused on temperature dependence of magnetization curves and susceptibility of thin films of type-I superconductor. A model for susceptibility of type-I superconductor in intermediate state is presented. This model is compared with experimental data yielding temperature dependence of critical magnetic field of superconductor. Furthermore it is shown that sufficiently thin film of superconductor which is type-I in bulk can exhibit type-II behaviour in perpendicular magnetic field. Susceptibility measured on such a film is therefore compared to susceptibility calculated for Bean model for type-I superconductors.

[pt] A escatologia de Joseph Ratzinger é o tema principal dessa dissertação. Busca-se através da análise dos escritos escatológicos do autor apresentar parte de suas contribuições aos recorrentes debates sobre a escatologia do século XX. Para isso, foi necessário estudar e apresentar uma panorâmica histórica da escatologia e de seus característicos desdobramentos ao longo dos séculos. Posteriormente se analisou os escritos e as homilias de Ratzinger que se relacionavam diretamente com a doutrina das últimas coisas com destaque para as suas formulações teológicas mais importantes a partir dos tais. Nessas análises, buscou-se focar nos posicionamentos adotados por Ratzinger à medida que suas investigações se intensificavam. Dedicou-se, também ao exame da relação de Ratzinger e o desenvolvimento histórico da matéria com espaço para observação da evolução do seu pensamento. Foram apresentados aspectos distintivos e as contribuições do autor ao debate sobre escatologia. / [en] Joseph Ratzinger s eschatology is the main theme of this dissertation. It seeks through the analysis of the author s eschatological writings to present part of his contributions to the recurring debates on eschatology in the 20th century. To do this, it was necessary to study and present a historical overview of eschatology and its characteristic developments over the centuries. Subsequently, the writings and homilies of Ratzinger that were directly related to the doctrine of the last things were analyzed, with emphasis on his most important theological formulations from these. In these analyses, the focus was on the positions adopted by Ratzinger as his investigations intensified. It was also dedicated to examining the relationship between Ratzinger and the historical development of the subject, with space for observing the evolution of his thought. The author s distinctive aspects and contributions to the debate on eschatology were presented.

HU est une protéine bactérienne de type histone impliquée dans de nombreuses fonctions biologiques telles que la compaction, la transcription, la réplication et la réparation de l'ADN. Chez E. coli, il existe trois espèces dimériques de HU (HUα2, HUβ2 et HUαβ) ayant des rôles biologiques distincts. La formation de l'hétérodimère repose sur un échange de chaines peptidiques entre les homodimères. Un mécanisme modèle a été proposé par Ramstein et collaborateurs (J.M.B. 331, 101-121 2003) et a servi de point de départ a ce travail. Dans ce modèle, les homodimères transitent d'une conformation native (N2) vers une conformation intermédiaire (I2). Les homodimères sous forme I2 s'associent ensuite dans un hétérotetramère transitoire qui se redissocie en formant des hétérodimères. L'objectif principal de ce travail de thèse a été de caractériser chaque étape du mécanisme d'échange du point de vue structural et cinétique. Parmi les principaux résultats de ce travail, deux structures originales, HUβ2 de E. coli et HU de L. lactis, ont été obtenues par diffraction des rayons X et complètent la caractérisation structurale des protéines HU sous leur forme N2. Un modèle de la conformation I2, partiellement désordonnée, a été élaboré à partir des résultats obtenus en RMN et en simulation de dynamique moléculaire. De plus, l'existence de la conformation tétramérique a été mise en évidence en faible concentration par spectrométrie de masse en conditions natives. Des protocoles de production/purification/oxydation ont été mis au point pour l'introduction de ponts disulfure afin de stabiliser la conformation tétramérique en vue de sa caractérisation structurale. L'ensemble des données acquises par ces différentes méthodes biophysiques affine la compréhension du mécanisme d'échange de chaines d'un point de vue structural et cinétique et met en lumière le rôle clef de la conformation I2 dans le contrôle de la composition des dimères de HU. / HU is a histone like protein of bacteria involved in numerous biological functions such as DNA compaction, transcription, replication and repair. In E. coli, three HU dimers types are present (HUα2, HUβ2 et HUαβ) and show distinct biological roles. The heterodimer is formed from homodimers through a peptidic chain exchange. A model of this mechanism has been proposed by Ramstein and coworkers (J.M.B. 331, 101-121 2003) and was used as a starting point for this study. In this model, homodimers undergo a conformationnal change from a native state (N2) toward an intermediate state (I2). Then, I2 homodimers associate to form a transient heterotetramer which then dissociate into heterodimers. The main aim of this work was to characterize the structure and kinetic of each step of this mechanism. Major results of this work include the elucidation of two original crystal structures : HUβ2 from E. coli and HU from L. lactis in N2 states. A model of the partially disordered I2 state has also been proposed for HUβ2 and HUα2, and is consistent with results obtained from both NMR and molecular dynamics experiments. In addition, the existence of a low concentration tetrameric conformation has been evidenced by native mass spectrometry experiments. A protocol of production/purification/oxydation as been developped for the introduction of disulfide bridges in order to stabilize this conformation and characterize its structure. Together, results obtained from these different biophysical means refine our understanding of the chain exchange mechanism at the molecular level and highlight the role of the I2 conformation in controlling HU dimers composition.

La propriété d’être réversiblement commutable de certaines protéines fluorescenteshomologues à la GFP ouvre un vaste champ d’applications possibles: notamment le biostockagede données à haute densité et la microscopie à super résolution. Parmi ces protéines,on trouve plusieurs variantes de la GFP, notamment la protéine jaune YFP, et des protéinesfluorescentes issues d'espèces marines Anthozoaires, comme Dronpa ou Padron. Plusieursétudes structurales indiquent que ces protéines fluorescentes photochromiques commutent parisomérisation et protonation couplées du chromophore. Cependant, la synchronisation entreces deux événements, le détail des mécanismes de photo-commutation, et le rôle de ladynamique conformationelle restent incomplètement compris. Par l'utilisation combinée de lacristallographie cinétique et de la spectroscopie optique in cristallo à basse température, nousavons comparé le comportement des protéines YFP, Dronpa et IrisFP, et nous avons étudié endétail le mécanisme photo-physique de commutation chez la protéine Padron. Contrairement àDronpa et IrisFP, la photo-commutation d’YFP est plus efficace à basse température qu’àtempérature ambiante. Nos résultats suggèrent que le mécanisme de commutation d’YFPn'implique pas de changement conformationel majeur, mais plutôt une protonation photoinduitedu chromophore ne nécessitant pas d'isomérisation. Au contraire, les études réaliséessur la protéine Padron nous ont permis de montrer que, dans ce cas, l’isomérisation duchromophore peut se produire indépendamment de sa protonation, et, étonnamment, àtempérature cryogénique. De plus, deux états intermédiaires ont pu être caractérisés au coursdu processus de photo-commutation. La protéine Padron a permis de mettre à jour le premiermarqueur codable génétiquement qui soit efficacement photo-commutable à températurecryogénique. / The property to be reversible switchable of some homologues fluorescents protein ofGFP open a large field for possible applications: such as, high-density data bio-storage andsuper-resolution microscopy. Between these proteins, we find several variants of GFP, such asyellow fluorescent protein, YFP, and fluorescents protein from marine Anthozoary species, asDronpa or Padron. Several structural studies suggest that these fluorescent proteins switch viaisomerization coupled with the protonation of the chromophore. However, thesynchronization between these processes, the detail about the photo-switching mechanism,and the role of conformational dynamics remains unclear. In combination of the kineticcrystallography and the optic spectroscopy in cristallo at low temperature, we have comparedthe YFP behavior, Dronpa and IrisFP, and we have studied in detail the photo-physicmechanism of Padron switching. In contrast to Dronpa and IrisFP, the YFP photoswitching ismore efficient at low temperature than at room temperature. Our results suggest that theYFPswitching is not associated to large structural rearrangements, but mostly a photo-inducedprotonation of the chromophore without isomerization. On the contrary, the studies done withPadron allowed us to show, in this case, the chromophore isomerization can be producedindependently of the protonation, at cryo-temperatures. Moreover, two intermediate stateswere revealed in the photo-pathway. Padron fluorescent protein allows to advance the firstgenetically inserted dye, being photo-switchable at cryogenic temperature

The thesis explores the subject of purgatory and its relative value for modern people. It summarises: 1. The manner in which biblical texts used to underpin the doctrine; 2. The history of the doctrine within the Roman Catholic Church and the reaction to it during the Reformation and beyond; and 3. Contemporary formulations of purgatory and purgatory-like ideas. The thesis argues, from several perspectives, that a modern formulation of the doctrine is: 1. Reasonable; 2. Biblically consistent; 3. Meets the criteria of an established Tradition at practice within the Church; and 4. Is capable of assisting people in understanding and appreciating the existential questions of death and the after life. The thesis is approached from the angle of a Legal Counsel presenting an argument for acceptance of the thesis. / SYS THEOLOGY & THEOL ETHICS / MTH (SYSTEMATIC THEOLOGY)