Variability between oncologists in defining the tumor during radiation therapy planning can be as high as 700% by volume. Robust, automated definition of tumor boundaries has the ability to significantly improve treatment accuracy and efficiency. However, the information provided in computed tomography (CT) is not sensitive enough to differences between tumor and healthy tissue and positron emission tomography (PET) is hampered by blurriness and low resolution. The textural characteristics of thoracic tissue was investigated and compared with those of tumors found within 21 patient PET and CT images in order to enhance the differences and the boundary between cancerous and healthy tissue. A pattern recognition approach was used from these samples to learn the textural characteristics of each and classify voxels as being either normal or abnormal. The approach was compared to a number of alternative methods and found to have the highest overlap with that of an oncologist's tumor definition.

Thesis (Ph. D.)--Oregon State University, 2002. / Typescript (photocopy). Includes bibliographical references (leaves 168-171). Also available on the World Wide Web.

Thesis supervisor: Alberto Maria Segre. Includes bibliographic references (p. 145-151).

Thesis (Ph. D.)--University of Washington, 2001. / Vita. Includes bibliographical references (p. 96-105).

Reinforcement Learning (RL) offers a promising approach towards achieving the dream of autonomous agents that can behave intelligently in the real world. Instead of requiring humans to determine the correct behaviors or sufficient knowledge in advance, RL algorithms allow an agent to acquire the necessary knowledge through direct experience with its environment. Early algorithms guaranteed convergence to optimal behaviors in limited domains, giving hope that simple, universal mechanisms would allow learning agents to succeed at solving a wide variety of complex problems. In practice, the field of RL has struggled to apply these techniques successfully to the full breadth and depth of real-world domains. This thesis extends the reach of RL techniques by demonstrating the synergies among certain key developments in the literature. The first of these developments is model-based exploration, which facilitates theoretical convergence guarantees in finite problems by explicitly reasoning about an agent's certainty in its understanding of its environment. A second branch of research studies function approximation, which generalizes RL to infinite problems by artificially limiting the degrees of freedom in an agent's representation of its environment. The final major advance that this thesis incorporates is hierarchical decomposition, which seeks to improve the efficiency of learning by endowing an agent's knowledge and behavior with the gross structure of its environment. Each of these ideas has intuitive appeal and sustains substantial independent research efforts, but this thesis defines the first RL agent that combines all their benefits in the general case. In showing how to combine these techniques effectively, this thesis investigates the twin issues of generalization and exploration, which lie at the heart of efficient learning. This thesis thus lays the groundwork for the next generation of RL algorithms, which will allow scientific agents to know when it suffices to estimate a plan from current data and when to accept the potential cost of running an experiment to gather new data. / text

The overall purpose of this study was to find a way to identify incorrect data in Sida’s statistics about their contributions. A contribution is the financial support given by Sida to a project. The goal was to build an algorithm that determines if a contribution has a risk to be inaccurate coded, based on supervised classification methods within the area of Machine Learning. A thorough data analysis process was done in order to train a model to find hidden patterns in the data. Descriptive features containing important information about the contributions were successfully selected and used for this task. These included keywords that were retrieved from descriptions of the contributions. Two Machine learning methods, Adaboost and Support Vector Machines, were tested for ten classification models. Each model got evaluated depending on their accuracy of predicting the target variable into its correct class. A misclassified component was more likely to be incorrectly coded and was also seen as an anomaly. The Adaboost method performed better and more steadily on the majority of the models. Six classification models built with the Adaboost method were combined to one final ensemble classifier. This classifier was verified with new unseen data and an anomaly score was calculated for each component. The higher the score, the higher the risk of being anomalous. The result was a ranked list, where the most anomalous components were prioritized for further investigation of staff at Sida.

Activities of DNA are to a great extent controlled epigenetically through the internal struc- ture of chromatin. This structure is dynamic and is influenced by different modifications of histone proteins. Various combinations of epigenetic modification of histones pinpoint to different functional regions of the DNA determining the so-called chromatin states. How- ever, the characterization of chromatin states by the DNA sequence properties remains largely unknown. In this study we aim to explore whether DNA sequence patterns in the human genome can characterize different chromatin states. Using DNA sequence motifs we built binary classifiers for each chromatic state to eval- uate whether a given genomic sequence is a good candidate for belonging to a particular chromatin state. Of four classification algorithms (C4.5, Naive Bayes, Random Forest, and SVM) used for this purpose, the decision tree based classifiers (C4.5 and Random Forest) yielded best results among those we evaluated. Our results suggest that in general these models lack sufficient predictive power, although for four chromatin states (insulators, het- erochromatin, and two types of copy number variation) we found that presence of certain motifs in DNA sequences does imply an increased probability that such a sequence is one of these chromatin states.

Twitter with its rising popularity as a micro-blogging website has inevitably attracted attention of spammers. Spammers use myriad of techniques to lure victims into clicking malicious URLs. In this thesis, we present several novel features capable of distinguishing spam accounts from legitimate accounts in real-time. The features exploit the behavioral and content entropy, bait-techniques, community-orientation, and profile characteristics of spammers. We then use supervised learning algorithms to generate models using the proposed features and show that our tool, spAmbush, can detect spammers in real-time. Our analysis reveals detection of more than 90% of spammers with less than five tweets and more than half with only a single tweet. Our feature computation has low latency and resource requirement. Our results show a 96% detection rate with only 0.01% false positive rate. We further cluster the unknown spammers to identify and understand the prevalent spam campaigns on Twitter.

No description available.

No description available.