Magister Artium - MA / This study aims to investigate the extent to which the increasing demand for medicinal plant and the resulting pressure on local cultivators to meet the demand impact upon cultivation and gathering practices of such plants. The specific focus is on the social practices of cultivation and gathering of medicinal plants in Ebenhaezer, a small-scale peri-urban town in Matzikama in the Western Cape Province in South Africa. This study will utilize survey and in-depth interviews techniques complemented with a focus group discussion on observed cultivation and gathering practices.

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Magister Scientiae - MSc / This study aimed to evaluate the antimicrobial efficacy of medicinal hemp plant extracts to determine the antibacterial effects of indigenous Sansevieria species and exotic Cannabis sativa phytotherapy varieties. This study also assessed whether aqueous o / South Africa

Magister Scientiae - MSc / The incidence of cardiovascular diseases, including hypertension, is on the increase worldwide. Medicinal plants played an important role in the treatment of hypertension for centuries. Very few scientific studies have, however, been done to validate the use of these phytotherapies. O africana is on of the many phytotherapies that has been use indigenously for years to treat hypertension. The objectives of this study were to determine the most effective does of O africana aqueous extract which will reduce blood pressure; to determine whether chronic administration of O africana can be used to prevent and treat hypertension; to determine whether O africana exert its effects by modulation of the renin-angiotensin system. / South Africa

Magister Artium - MA / This study falls within the framework of the larger multidisciplinary university health initiative (MUTHI) objectives to investigate and document the use of local medicinal plants for the treatment of HIV and symptoms of related opportunistic infections such as tuberculosis, thrush and shingles in the Western Cape. The study stems from twelve months fieldwork in Strand, Western Cape and the collection of plants from Mpoza, Eastern Cape for a variety of reasons. The study ethnographically documents when, under which circumstances and where plants are collected for use.As far as I am aware this is the first anthropological study which "follows" traditional healers in the Western Cape to a site in the Eastern Cape where they collect plants. Seventeen plants were collected from different genera which traditional healers reported to use as treatment for suspected HIV and related symptoms. For each plant I describe the medicinal uses,preparatory techniques and plant parts used as suggested by traditional healers. I also explore healer's aetiologies concerning plants, treatments and the social-material relations which are prevalent in my research settings.

Magister Artium (Development Studies) - MA(DVS) / Medicinal plants remain a very important natural resource used as traditional medicines for health needs in many developing countries. In the current deepening economic and political crises in Zimbabwe a significant number of the population has inevitably relied more on natural resources which has led to receding population and scarcity of many medicinal plant species in their natural habitat. It is against this background that this research, using Rural Eastern Zimbabwe that this study explored the extent to which use values of medicinal plants increased since the Zimbabwean crises and the different use values of these species among men and women. The rational choice theory, use value approach and concept of utility constituted a theoretical grounding of the research process. The study essentially used qualitative research methods with some quantitative data. A mix of interviews and focus group discussions were employed for this study. Interviews were conducted with community leaders, traditional healers, NGOs in the similar field and Government stakeholders eliciting their views on use values of medicinal plants and sustainable interventions that can be enacted in conserving these species. The findings of the study were shown through using tables, charts and the quantitative data was presented using STATA. The calculated total usevalues of the 11 medicinal plants showed that Kirkia ancuminata Oliv, Dicoma anomala Sond, Syzgium guineense DC, Zingiber offinale, Acacia Karoo Hayne were found to have “high total use-values” and Lannea edulis Engl, Aloe, Lippia javanica Spreng, Virtex payos merril, parinari curatelli and Coleochloa setiflora have “low total use-values”

Please read the abstract (Summary) in the section, 00front of this document / Thesis (DPhil)--University of Pretoria, 2008. / Pharmacology / DPhil / Unrestricted

Please read the abstract in the 00front of this document / Dissertation (MSc (Pharmacology))--University of Pretoria, 2006. / Pharmacology / unrestricted

This research examines an edible and medicinal plant species, Balsamorhiza sagittata Pursh (Nutt) (balsamroot, or spring sunflower). Included are: 1) a study of literature concerning previous uses and potential agronomic applications of B. sagittata; 2) an ecological study to assess the general habitat requirements of B. sagittata at three populations in the Northwestern Plateau of British Columbia; and 3) an agronomic study of B. sagittata, the main purpose of which is to explore the development of the species in a cropping system or as a horticulture plant. Ethnobotanical literature confirms that B. sagittata has a long tradition as a highly significant food and medicinal resource on the Northern plateau. A review of botanical and range literature indicates that the species is an ecologically important forb in sagebrush ecosystems. Ecological data collectci:l was significantly different between the field sites. The only variable that was statistically similar at the Pavilion Mountain, Hat Creek Valley and Botanie Valley research locations was the number of blooms on the B. sagittata plants. Furthermore the data did not indicate significant correlations to explain variation in the number of B. sagittata plants between sample plots. Preliminary agronomic experiments indicate that B. sagittata can be propagated by seed, both in a greenhouse and at a field location. Treating seeds with ethylene before stratification significantly increased seed germination. / Graduate

Type II diabetes is becoming a growing problem in developed countries worldwide. The median age for diagnosis was around sixty, but recent surveys have shown that the entire age distribution curve shifting left. The incidence of type II diabetes is thought to be parallel with the growing rate of obesity associated with an unhealthy western diet. Type II diabetes is an expensive disease to manage, it is for this reason that cheaper medication needs to be investigated in the form of traditional plants, such as Sutherlandia frutescens. Prescription medication, such as tricyclic antidepressants, may also increase body weight thereby playing a role in obesity. The cause of weight gain in such cases may go unrecognized or lead to cessation of the medication with or without the practitioner’s knowledge or approval. It is therefore necessary to investigate the causative agents responsible for the excessive weight gain. Drinking water containing extracts of S. frutescens or metformin was administered to two groups of eleven insulin resistant male Wistar rats. The insulin resistant control group received water without any medication. Rats were sacrificed after 8 weeks allowing for fasting blood glucose, insulin and tissue glycogen content determination. Glucose uptake was also determined using [3H] deoxyglucose. The effect of the medication and the diet on muscle post receptor insulin signaling proteins was determined through Western blots. Liver proteomics was also performed using 2-D electrophoresis. In a separate experiment 26 male Wistar rats were exposed to strepotozotocin toxin, 7 of these rats received intravenous insulin treatment, 7 rats received S. frutescens extract and 7 rats received a combination of both medications, the remaining 5 received no treatment and served as the control. Rats were sacrificed after 6 days allowing for fasting blood glucose, insulin and tissue glycogen content determination. Two groups of 14 male Wistar rats received amitriptyline or trimipramine (common tricyclic antidepressants) in their drinking water, the control group (30 rats) received water without any medication. The rats’ weight and food consumption was monitored throughout the trial and their oxygen consumption was also determined. Rats were sacrificed after 6 weeks or 14 weeks of medicinal compliance allowing for fasting blood glucose, insulin and tissue glycogen content determination. Glucose uptake was also determined using [3H] deoxyglucose. S. frutescens treatment normalized circulating serum insulin levels and significantly increased the rate of glucose clearance. Certain post receptor insulin signaling proteins were also significantly increased relative to the insulin resistant control group. 2-D electrophoresis identified the normalization of protein levels associated with the urea cycle. S. frutescens was also able to, independently; maintain normoglycaemic levels in the strepotozotocin treated group. The tricyclic antidepressants significantly increased blood glucose levels while significantly reducing tissue glycogen levels for both sacrifice periods. Serum insulin remained unchanged while a significant increase in insulin degradation and insulin degrading enzyme levels were found for both antidepressants. S. frutescens shows promise as a low cost antidiabetic medication for future use. Although the antidepressants did not promote weight gain, the increase in blood glucose levels may be cause for concern in patients with a pre-disposition toward developing diabetes.