Fatores de transcrição (FT) são proteínas que se ligam em sequências específicas e bem conservadas de nucleotídeos no DNA, denominadas sítios de ligação dos fatores de transcrição (SLFT), localizadas em regiões de regulação gênica conhecidas como módulos cis-reguladores (CRM). Ao reconhecer o SLFT, o fator de transcrição se liga naquele sítio e influencia a transcrição gênica positiva ou negativamente. Existem técnicas experimentais para a identificação dos locais dos SLFTs em um genoma, como footprinting, ChIP-chip ou ChIP-seq. Entretanto, a execução de tais técnicas implica em custos e tempo elevados. Alternativamente, pode-se utilizar as sequências de SLFTs já conhecidas para um determinado fator de transcrição e aplicar técnicas de aprendizado computacional supervisionado para criar um modelo computacional para tal sítio e então realizar a predição computacional no genoma. Entretanto, a maioria das ferramentas computacionais existentes para esse fim considera independência entre as posições entre os nucleotídeos de um sítio - como as baseadas em PWMs (position weight matrix) - o que não é necessariamente verdade. Este projeto teve como objetivo avaliar a utilização de gramáticas regulares estocásticas (GRE) como técnica alternativa às PWMs neste problema, uma vez que GREs são capazes de caracterizar dependências entre posições consecutivas dos sítios. Embora as diferenças de desempenho tenham sido sutis, GREs parecem mesmo ser mais adequadas do que PWMs na presença de valores mais altos de dependência de bases, e PWMs nos demais casos. Por fim, uma ferramenta de predição computacional de SLFTs foi criada baseada tanto em GREs quanto em PWMs. / Transcription factors (FT) are proteins that bind to specific and well-conserved sequences of nucleotides in the DNA, called transcription factor binding sites (TFBS), contained in regions of gene regulation known as cis-regulatory modules (CRM). By recognizing TFBA, the transcription factor binds to that site and positively or negatively influence the gene transcription. There are experimental procedures for the identification of TFBS in a genome such as footprinting, ChIP-chip or ChIP-Seq. However, the implementation of these techniques involves high costs and time. Alternatively, one may utilize the TFBS sequences already known for a particular transcription factor and applying computational supervised learning techniques to create a computational model for that site and then perform the computational prediction in the genome. However, most existing software tools for this purpose considers independence between nucleotide positions in the site - such as those based on PWMs (position weight matrix) - which is not necessarily true. This project aimed to evaluate the use of stochastic regular grammars (SRG) as an alternative technique to PWMs in this problem, since SRGs are able to characterize dependencies between consecutive positions in the sites. Although differences in performance have been subtle, SRGs appear to be more suitable than PWMs in the presence of higher base dependency values, and PWMs in other cases. Finally, a computational TFBS prediction tool was created based on both SRGs and PWMs.

Os atuais avanços na área das Tecnologias da Informação e da Comunicação (TIC) estão mudando a Educação, com a disponibilização de sistemas educativos para apoiar as atividades no processo de ensino e de aprendizagem. Embora o tópico de combinatória seja relevante para o ensino médio e para os cursos de Ciências Exatas, este tópico tem sido desconsiderado nos avanços da Informática na Educação, principalmente ao se considerar o uso de ambientes de aprendizagem via Web. Atualmente, o iComb é, no melhor de nosso conhecimento, o único sistema Web integrável a tais ambientes. Ele é um Módulo de Aprendizagem Interativa (iMA) integrável ao Sistema Gerenciador de Cursos (SGC) Moodle, por meio do plugin iTarefa. O iComb oferece atividades de autoria de exercícios, bem como, sua avaliação automática. No entanto, considerando sua usabilidade, foram detectados alguns problemas na interface. O foco deste trabalho está relacionado ao reprojeto do sistema iComb e seu impacto na aprendizagem de combinatória. Para a reconstrução do iComb adotou-se o método de design de interação, buscando-se a participação efetiva de usuários finais do sistema, em todas as atividades desse processo, com (i) sessões de teste de usabilidade utilizando a versão Java do iComb para identificar problemas e guiar o redesenho do sistema, e (ii) prototipagem e avaliação da interface do sistema redesenhado. Esse processo permitiu implementar uma nova versão do iComb utilizando tecnologias associadas ao HTML5, que será brevemente disponibilizado como software livre. / Current advances in Information and Communication Technologies (ICT) are changing Education with delivering software to support learning/teaching activities. Although being relevant for Science, Technology, Engineering, and Mathematics (STEM) courses, Combinatorial Analysis is almost disregarded in these advances, mostly if we consider their integration with earning Management Systems. Currently, iComb is, at the best of our knowledge, the only system with such a possibility. It is an interactive Learning Module (iLM) that can be integrated to Moodle, through the iAssign plugin. iComb provides authoring activities as well as their automatic assessment. Nevertheless, considering the system usability, several interaction problems were detected during sessions with teachers and students. In this work it is described the process of redesigning the iComb system by adopting Interactive Design, to conduct controlled sessions of system use for (i) identifying usability issues for guiding the system redesign; and (ii) prototyping and evaluate the redesigned system interface, with end-users. This process allowed to implement new version of iComb using HTML5 related technologies that will be sooner available as free software, in order to reach a larger audience. Preliminary results on the interface evaluation indicate that both students and teachers felt more comfortable using the new interface of iComb and found it easier to execute common tasks.

Les oxydes non-stoechiométriques de type Ruddlesden-Popper, tel que Pr2NiO4+δ, peuvent être dopés en trous par substitution du strontium au praséodyme ou par insertion d’oxygène. Ces modes de dopage s’accompagnent de mises en ordre complexes impliquant la distribution des ions oxygène excédentaires, des ordres de charge et/ou de spin. Le diagramme de phase de Pr2-xSrxNiO4+δ a été exploré par diffraction des rayons X (en laboratoire et par rayonnement synchrotron) ainsi que neutronique. Pour la phase Pr2NiO4.25, nous avons mis en évidence une sur-structure incommensurable avec des réflexions satellites au 6ème ordre, produisant un spectre de diffraction très complexe avec 4 individus et 8 domaines incommensurables. Par diffractions synchrotron et neutronique, un ordre de charge de type échiquier a été identifié dès la température ambiante, suivi en dessous de 170 K par un ordre de type rubans ; un ordre de spin incommensurable s’établit au-dessous de 99 K. Ce travail a permis de révéler un ensemble complexe de phases ordonnées structuralement et électroniquement, gouvernées par des variations subtiles de stoechiométrie en strontium et oxygène. / Non-stoichiometric oxides from the Ruddlesden-Popper series, such as Pr2NiO4+δ, can be hole-doped by substituting strontium to praseodymium or by oxygen insertion. This leads to complex structural ordering involving oxygen-, charge- and spin ordering. The complex phase diagram of Pr2-xSrxNiO4+δ was explored using X-ray (laboratory and synchrotron) as well as neutron diffractions. For the doped phase of highest oxygen content (Pr2NiO4.25), we could evidence an incommensurate structure with satellite reflections of 6th order, yielding a very complex diffraction pattern of up to four twin-individuals and eight incommensurate domains. Checkerboard-type charge ordering was identified already at ambient temperature, while stripe charge ordering was observed below 170 K by synchrotron and neutron diffraction; incommensurate spin ordering appears below 99 K. This thesis reveals the existence of many complex oxygen and electronically ordered phases going along with small variations of the oxygen/strontium stoichiometry.

This master's thesis describes the problems of SELinux, and the methods of creation of a proper security policy with a focus on the SELinux reference policy and its mechanisms. It designs the methodics of formulation of specific security rules, supplemented with the practical example of its application. Furthermore, it describes the available security rules commonly used for http, ftp and ssh services securing, their modification and practical utilization. According to the proposed methodology, these services are protected with their own security rules and both security methods are mutually compared and evaluated.

Issues of this thesis are focused on side-channel cryptanalysis. Particularly attention is paid to differential power analysis, when is simulated an attack on the cryptographic module for different conditions and for different structural features of this module. As the cryptographic module is used a PIC microcontroller, which is operating with AES symmetric encryption algorithm. For this purpose, a design of experimental printed circuit board was created. Then, this PCB was equipped only with the necessary components for the function of the cryptographic module. Cryptanalysis is aimed on current consumption of crypto module that is caused by execution of AddRoundKey instructions. Power consumption of PIC microcontroller is measured in depending on the size of power supply voltage, size of serial resistor, size of bypass capacitor, and this thesis also examines the influence of ambient temperature on power consumption of PIC. The measured values are graphically presented and then discussed.

Der Bologna-Prozess hat umfangreiche Reformbewegungen mit dem Ziel einer Harmonisierung des Europäischen Hochschulraums initiiert. Des Weiteren hat die universitäre Lehre in Europa und international fächerübergreifend vielschichtige Veränderungen erfahren und wird zunehmend studierendenzentriert und kompetenzorientiert ausgerichtet. Um mit diesen Entwicklungen Schritt zu halten, war das Ziel dieser Arbeit, ein flexibles und innovatives Lehrkonzept für Fach Kieferorthopädie an der Universität Leipzig zu erarbeiten. Grundlage dafür war die Erstellung eines Lernzielkatalogs, der sowohl allgemeine als auch spezifisch auf die lokalen Gegebenheiten zugeschnittene Anforderungen definiert. Anhand dieses Katalogs wurden vier Module erstellt. Sie halten sich in ihrem strukturellen und inhaltlichen Aufbau sowohl an die Vorgaben der Approbationsordnung als auch an die europäischen und nationalen Empfehlungen. Durch die Einbeziehung traditioneller und moderner Lehr-, Lern- und Prüfungsformen wurde die Lehre studierendenzentriert und kompetenzorientiert gestaltet. Diese Arbeit kann als Muster für die Implementierung eines modernen Lehrkonzepts in der Kieferorthopädie dienen. Eine Verknüpfung mit anderen Fachrichtungen im Sinne einer interdisziplinären Studentenausbildung ist durch die transparente Gestaltung des Lernzielkatalogs und der Module ebenso möglich wie eine Anpassung an zukünftige geänderte Rahmenbedingungen.:1. Einleitung 2. Literaturübersicht 2.1. Entwicklungen bei der Lehrplangestaltung 2.2. Der Bologna-Prozess 2.2.1. Hintergründe 2.2.2. Erläuterungen zu spezifischen Zielen des Bologna-Prozesses 2.2.2.1. Diploma Supplement 2.2.2.2. Einheitliche Studienstrukturen 2.2.2.3. European Credit Transfer and Accumulation System (ECTS) 2.2.2.4. Mobilität 2.2.2.5. Qualitätssicherung 2.2.3. Stand der Umsetzung in Deutschland 2.2.3.1. Diploma Supplement 2.2.3.2. Einheitliche Studienstrukturen 2.2.3.3. European Credit Transfer and Accumulation System 2.2.3.4. Mobilität 2.2.3.5. Qualitätssicherung 2.2.4. Das Staatsexamen als deutsche Besonderheit in der Hochschullandschaft 2.2.5. Kritische Wertung und Ausblick 2.3. Rahmenbedingungen 2.3.1. Der Nationale Qualifikationsrahmen 2.3.2. Die zahnmedizinische Ausbildung in Deutschland 2.3.3. Die zahnmedizinische Ausbildung in Leipzig 2.4. Lernziele und Kompetenzen des Zahnarztes: Richtlinien und Kataloge 2.4.1. Empfehlungen des Wissenschaftsrats 2.4.2. Globalisierung und medizinische/zahnmedizinische Ausbildung 2.4.3. Profil und Kompetenzen des europäischen Zahnarztes 2.4.4. Lernzielkatalog Kanada 2.4.5. Lernzielkatalog Schweiz 2.4.6. Nationaler Kompetenzbasierter Lernzielkatalog Zahnmedizin (NKLZ) 2.5. Akademische Lehrformen 2.5.1. Vorlesungen 2.5.2. Praktika/Hospitation 2.5.3. Kurse 2.5.4. Seminare 2.5.5. Problemorientiertes Lernen 2.5.6. Weitere Lehrmethoden 2.6. Leistungsnachweise 2.6.1. Schriftliche Prüfungen 2.6.2. Mündliche Prüfungen 2.6.3. Schriftliche Arbeiten/Erfahrungsberichte 2.6.4. Referate/mündliche Präsentationen 2.6.5. Weitere mündliche Prüfungsformen 2.6.6. Posterpräsentationen 2.6.7. Portfolio 2.6.8. Self and Peer Assessment 3. Material und Methode 3.1. Problemidentifikation und allgemeine Bedarfsanalyse 3.2. Gezielte Bedarfsanalyse 3.3. Verfassen von Lernzielen 3.4. Lehrstrategien 3.5. Modulentwicklung 3.5.1. Modulplanung 3.5.2. Lernzielerstellung 3.5.3. ECTS-Punkte-Vergabe 3.5.4. Leistungsnachweise 3.5.5. Studienführer/Modulbeschreibung 4. Ergebnisse 4.1. Problemidentifikation und Bedarfsanalyse 4.2. Gezielte Bedarfsanalyse 4.2.1. Auswertung der Evaluationsergebnisse 4.2.1.1. Auswertung „Vorlesung Kieferorthopädie“, 7. Semester 4.2.1.2. Auswertung „Kurs kieferorthopädische Technik“, 7. Semester 4.2.1.3. Auswertung „Kurs Kieferorthopädie I“, 8. Semester 4.3. Verfassen von Lernzielen – Lernzielkatalog für das Fach Kieferorthopädie 4.3.1. Zahnarztbild, Leitbild der sächsischen Zahnärzte 4.3.2. Rollen des Zahnarztes 4.3.2.1. Medizinischer Experte 4.3.2.2. Kommunikator 4.3.2.3. Interprofessioneller Partner 4.3.2.4. Verantwortungsträger und Manager 4.3.2.5. Professionelles Vorbild 4.3.2.6. Gesundheitsberater und Fürsprecher 4.3.2.7. Wissenschaftler und Lehrer 4.3.3. Fachspezifische Kompetenzen 4.3.4. Fachspezifische Lernziele 4.4. Lehrstrategien 4.4.1. Modul I: „Normale und gestörte Schädel- und Gebissentwicklung und kieferorthopädische Technik“ 4.4.2. Modul II: „Kieferorthopädische Diagnostik“ 4.4.3. Modul III: „ Kieferorthopädische Therapie“ 4.4.4. Modul IV: „POL-Kurs Kieferorthopädie und praktische Übungen“ 4.5. Leistungsnachweise 4.5.1. Modul I: „Normale und gestörte Schädel- und Gebissentwicklung und kieferorthopädische Technik“ 4.5.2. Modul II: „Kieferorthopädische Diagnostik“ 4.5.3. Modul III: „Kieferorthopädische Therapie“ 4.5.4. Modul IV: „POL-Kurs Kieferorthopädie und praktische Übungen“ 4.5.5. Modulübergreifender Leistungsnachweis (Portfolio) 4.6. ECTS-Credit-Vergabe 4.7. Modulplanung 4.7.1. Modul I: „Normale und gestörte Schädel- und Gebissentwicklung und kieferorthopädische Technik“ 4.7.2. Modul II: „Kieferorthopädische Diagnostik“ 4.7.3. Modul III: „Kieferorthopädische Therapie“ 4.7.4. Modul IV: „POL-Kurs Kieferorthopädie und praktische Übungen“ 5. Diskussion 5.1. Ressourcen identifizieren 5.2. Unterstützung einholen 5.3. Verwaltungsstrukturen schaffen 5.4. Hürden erkennen und abbauen 5.5. Evaluation und Feedback 5.6. Weiterentwicklung des Curriculums 5.7. Erfahrungsberichte anderer Fakultäten 5.8. Schlussfolgerungen 6. Zusammenfassung 7. Literaturverzeichnis 8. Anlagen

Building industry contributes to massive amounts of harmful emissions. This trend will continue to rise unless appropriate measures are taken. This master thesis aims to calculate the environmental impact during the whole life time of a prefabricated cross-laminated timber (CLT) modular building. The environmental impacts from the end-of-life stage and the benefit of the most of the building material beyond the system boundary is also included. Life cycle assessment (LCA) is used as a tool to assess the environmental impacts following the standard SS-EN 15978:2011. Since there is a lack of environmental data about CLT in general and about prefabricated CLT volumetric modules buildings in particular the results from this work will enhance the understanding of the environmental performance of this kind of building system. This work is done with Size AB, a company that only produces CLT modular multi-storeys buildings.  The studied object is three storeys building located in Nykvarn in Sweden. The total emissions during the building life cycle are at least 377 kg CO2-eq/m2 of the gross floor area (GFA), 0,296 kg PO43--eq/m2 of GFA and 1,1 kg SO2-eq/m2 of GFA for global warming potential (GWP), eutrophication potential (EP) and acidification potential (AP) respectively. The result shows that the share of the AP and EP during the end-of-life stage is only 1% for each, whereas CO2-eq emission is accounted for 14% during this stage. The material production stage accounts for more than 50% for all environmental indicators.  This study provides fundamental data to perform LCAs in this area and to carry out climate declarations. Through sensitivity analysis it was discovered inter alia that high production intensity in the modules fabrication factory plays a significant role in reducing the environmental impacts during the construction stage. It was also found that modification of the LCA’s system boundary is recommended to present a transparent LCA of modular buildings.

Quasi-hereditary algebras are an important class of algebras with many appli-cations in representation theory, most notably the representation theory of semi-simple complex Lie-algebras. Such algebras sometimes admit an exact Borel sub-algebra, that is a subalgebra satisfying similar formal properties to the Borel sub-algebras from Lie theory. This thesis is divided into two parts. In the first part we classify quasi-hereditary algebras with two simple modules over perfect fields up to Morita equivalence, generalizing a similar result by Membrillo-Hernandez for thealgebraically closed case. In the second part, we take a poset X, a certain set M of constants, and a finite set ρ of paths in the Hasse-diagram of X and construct analgebra A(X, M, ρ) that generalizes the twisted double incidence algebras originally introduced by Deng and Xi. We provide necessary and sufficient conditions for this algebra to be quasi-hereditary when X is a tree, and we show that A(X, M, ρ) admits an exact Borel subalgebra when these conditions are satisfied. Following this, we compute the Ext-algebra of the standard modules of A(X, M, ρ).

<p>The only datasets used in my thesis work are from TUDatasets, <a href="https://chrsmrrs.github.io/datasets/">TUDataset | TUD Benchmark datasets (chrsmrrs.github.io)</a>, a collection of public benchmark datasets for graph classification and regression.</p><p><br></p>

Diploma project develops the intention to build up an ecological project based on renewable resources utilization of energy and materials recycling in Zábřeh. The study is engaged in possible area extension and tries to divide it into functional zones, when zone of main production remains the same (already elaborated project) and the zone of extension where there is settled production storages, alt.production hall extension. Third zone, so-called green zone, is developed in more detail. The green zone is a belt of plot separating the production area from second-class road nr.315, and also creates entrance gateway and lungz of the whole area. The green belt is conceived as a sojourn park with water elements(biotopes, lake, water basin), which is intersected by wooden footbridge, that connects object of multifunction pavilion and office building and ends at articifial island, or more precisely as a torso in the lake waters, symbolizing the science, which´s end is far away for human beings. The footbridge is also an axis between planned science-technological centres for the direct processing of waste materials. Administration building and pavilion are conceived as a „second nature“, purely human artifact, whih is also clearly expressed in „non-natural“ materials used. Their concept tries to saturate client´s requests and use the renewable resources of energy with observance of building biology principles (author´s request) at the same time.