The purpose of this research was to examine the patterns and themes of litigation in Americans with Disabilities Act (ADA) disability discrimination cases charged under the theory of disparate impact. Specifically, this study used Computer Assisted Legal Research (CALR) to identify and review all U.S. Appellate Court ADA disparate impact cases as reported by Westlaw, a commercial electronic case law reporting system owned by Thomson Reuters. This study used a two-step, mixed methods approach to analyze the data relevant to the research questions and sub-questions. First, the researcher employed content analysis (Hall & Wright, 2008) to identify and characterize patterns and trends of litigation in all reported U.S. Appellate Court ADA cases charged under the theory of disparate impact from 1992 through 2012. Cases were analyzed chronologically, and variables included number of published and unpublished cases, distribution of jurisdiction, distribution of ADA titles, EEOC involvement, case fact patterns, and characteristics of charging and opposing parties. Frequency analyses were conducted on these data. Second, the researcher identified a subset of the ADA disparate impact cases analyzed in the first step: Title I, or employment discrimination cases. Qualitative analysis employing the constant comparative method (Strauss & Corbin, 1990) was used to identify and characterize patterns and themes of the judicial opinions in the Title I disparate impact cases. The researcher developed a framework for analysis based on a review of the literature of the sociopolitical perspective of disability to guide the analysis of the judicial opinions in the subset of disparate impact cases. The results of the frequency analyses conducted on these data revealed four trends: (a) Precedent, (b) Circuit and Judge Effects, (c) Equal Employment Opportunity Commission (EEOC) Successes, and (d) Sutton Case Effect. The results of the qualitative analysis of the text of the judicial opinions produced four themes and three relationships among the themes. The four themes were accommodation(s); workplace culture, norms, and policies; judicial process; and policy space. The three relationships were gap-filling, weighing and balancing, and maintaining status quo versus effecting social change. The themes and relationships are depicted in a concept map that visually displays the conceptual framework revealed in the study. The findings in this study may inform disability and rehabilitation scholars about ADA disparate impact cases, a body of law about which little is known. The patterns and trends identified in ADA Title I disparate impact cases may provide information about the types of policies and practices that are most frequently litigated. Rehabilitation practitioners may be able to use the results of this research to develop education and outreach strategies for employers on best practices for hiring, accommodating, and promoting employees with disabilities. Because the workplace policies and procedures identified in the cases that comprise this study are neutral on their face rather than intentionally discriminatory, employers may benefit from information that assists them in evaluating their policies and procedures proactively, which may avoid costly and time-consuming litigation. Finally, workplace policies and procedures that fairly represent the essential functions of the job and are applied uniformly to workers with and without disabilities will contribute to a more diverse workforce.

Hundreds of thousands of students earn credit toward both high school and college each year through dual credit programs. This research project used qualitative methods to elicit the story, the shared reality, of faculty who spend their time with these students. It is an important story to tell as legislators, community college and public school administrators, parents, and students are motivated to see these programs not only continue, but grow. System influence diagrams (SIDs) depicting the dual credit teaching experience on high school and college campuses were developed for two separate groups of community college faculty. The models were used for comparing the high school and college dual credit teaching environments. The results of this study support other research, suggesting there are important differences between the high school and college environments when teaching dual credit students. From an overall perspective, faculty found the community college campus environment superior to teaching on the high school campus for reasons related to facilities and technology, a sense of belonging in the larger organization, and the integration of dual credit students into a more traditional college environment. / text

EDUCATIONAL IDEALS VS. ARCHITECTURAL EXPRESSION: THE GENESIS OF BUILDING EXCELLENCE Brenda Sisco Vaughan, Ph.D. The University of Texas at Austin, 2011 Supervisor: William F. Lasher How education is articulated, understood or comprehended, in the vocabulary (i.e. the expressive techniques or devices) of architecture provokes a certain fascination and intrigue for those interested in methods of pedagogy and cognition at institutions of higher education. This research entered the discussion about architectural expression in the university setting with a focus on the educational aspects in the programming, planning, and design of new buildings on campus. Educational ideals refer to concepts of perfection or models of excellence at institutions of higher education. Architectural expression refers to design or the determination of form which includes every aspect of every quality of a building (size, shape, materials, texture, color, ornamentation, etc.), while supporting the function and intended use of the building. This research examined the processes by which educational ideals translate into architectural expression. Analyses of the processes or systems used in planning and designing new buildings provided data to understand influences on the system. Qualitative data were analyzed in this study from a systems point of view utilizing Interactive Qualitative Analysis, IQA methodology. Following IQA protocol, the problem of how educational ideals translate into architectural expression produced and named the factors (affinities) influencing the processes on university campuses; identified relationships between these factors in cause-and-effect terms; provided the forum to compare and contrast similarities and differences in the systems; and identified similarities and differences in the processes utilized in planning and designing new buildings at private vs. public institutions. In this study, focus groups of higher education administrators and professional architects explored the case study of The University of Texas at Austin. After the data were analyzed, a theoretical model was produced to explore the case study of Rice University. Research synthesis provides information, guidance, and recommendations for educational administrators and professional architects in leadership and decision-making roles guiding the direction of new building projects on campuses. / text

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Regenerative medicine (RM) has the potential to develop new treatments for chronic disease and injury that are desperately needed in developing countries. Several emerging economies are actively participating in RM, producing new knowledge and initiating clinical trials. This thesis presents case studies of RM in China and Brazil and a comparative analysis of RM across Brazil, China and India. I aim to better understand the state of RM, how it has developed and what is needed for RM innovation to succeed within these countries. Case studies were conducted using face-to-face in-depth semi-structured interviews with RM experts from different areas including research institutes, hospitals, firms, educational institutes, government, policy agencies, and bioethics groups. Interviews were analysed using thematic analysis and triangulated with the analysis of research articles, government reports, laws and other primary and grey literature. China is now the 5th most prolific publisher on stem cells in the world. Chinese RM benefits from permissive regulations and the expertise of Chinese returnees that have trained abroad, but the field’s reputation is challenged by a weak regulatory system and the clinical availability of untested stem cell therapies. Brazil has created a small but strong RM program, but needs to address challenges to the field including inconsistent funding, slow importation of materials, and weak linkages between stake-holders. Comparative analysis of the three countries identifies several common elements that support RM, including linkages between stake-holders, government support, infrastructure, human resources, and good governance. RM capacity is clustered in large urban centres, which could exacerbate socio-economic and health disparities unless measures are taken to ensure equitable distribution of benefits. RM does not adhere to classical views of southern innovation, suggesting that new models are needed to describe innovation in emerging technologies, where countries are keeping up instead of catching up.

Regenerative medicine (RM) has the potential to develop new treatments for chronic disease and injury that are desperately needed in developing countries. Several emerging economies are actively participating in RM, producing new knowledge and initiating clinical trials. This thesis presents case studies of RM in China and Brazil and a comparative analysis of RM across Brazil, China and India. I aim to better understand the state of RM, how it has developed and what is needed for RM innovation to succeed within these countries. Case studies were conducted using face-to-face in-depth semi-structured interviews with RM experts from different areas including research institutes, hospitals, firms, educational institutes, government, policy agencies, and bioethics groups. Interviews were analysed using thematic analysis and triangulated with the analysis of research articles, government reports, laws and other primary and grey literature. China is now the 5th most prolific publisher on stem cells in the world. Chinese RM benefits from permissive regulations and the expertise of Chinese returnees that have trained abroad, but the field’s reputation is challenged by a weak regulatory system and the clinical availability of untested stem cell therapies. Brazil has created a small but strong RM program, but needs to address challenges to the field including inconsistent funding, slow importation of materials, and weak linkages between stake-holders. Comparative analysis of the three countries identifies several common elements that support RM, including linkages between stake-holders, government support, infrastructure, human resources, and good governance. RM capacity is clustered in large urban centres, which could exacerbate socio-economic and health disparities unless measures are taken to ensure equitable distribution of benefits. RM does not adhere to classical views of southern innovation, suggesting that new models are needed to describe innovation in emerging technologies, where countries are keeping up instead of catching up.

No description available.

DNA-binding proteins (DBPs) such as repair proteins, DNA polymerases, re- combinases, transcription factors, etc. manifest diverse stochastic behaviours dependent on physiological conditions inside the cell. Now that multiple independent in vitro studies have extensively characterised different aspects of the biochemistry of DBPs, computational and mathematical tools that would be able to integrate this information into a coherent framework are in huge demand, especially when attempting a transition to in vivo characterisation of these systems. ChIP-Seq is the method commonly used to study DBPs in vivo. This method generates high resolution sequencing data { population scale readout of the activity of DBPs on the DNA. The mathematical tools available for the analysis of this type of data are at the moment very restrictive in their ability to extract mechanistic and quantitative details on the activity of DBPs. The main trouble that researchers experience when analysing such population scale sequencing data is effectively disentangling complexity in these data, since the observed output often combines diverse outcomes of multiple unsynchronised processes reflecting biomolecular variability. Although being a static snapshot ChIP-Seq can be effectively utilised as a readout for the dynamics of DBPs in vivo. This thesis features a new approach to ChIP-Seq analysis { namely accessing the concealed details of the dynamic behaviour of DBPs on DNA using probabilistic modelling, statistical inference and numerical optimisation. In order to achieve this I propose to integrate previously acquired assumptions about the behaviour of DBPs into a Markov- Chain model which would allow to take into account their intrinsic stochasticity. By incorporating this model into a statistical model of data acquisition, the experimentally observed output can be simulated and then compared to in vivo data to reverse engineer the stochastic activity of DBPs on the DNA. Conventional tools normally employ simple empirical models where the parameters have no link with the mechanistic reality of the process under scrutiny. This thesis marks the transition from qualitative analysis to mechanistic modelling in an attempt to make the most of the high resolution sequencing data. It is also worth noting that from a computer science point of view DBPs are of great interest since they are able to perform stochastic computation on DNA by responding in a probabilistic manner to the patterns encoded in the DNA. The theoretical framework proposed here allows to quantitatively characterise complex responses of these molecular machines to the sequence features.

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The main topic of this diploma thesis is the development of Mrs. Dagmar Damková media image between 2003-2017. Mrs. Damková is a former football referee and became the first woman who managed a football match in the Czech 1st Men's League in 2003. She has been professionally successful and popular with the public and the media in a purely male environment. She has become one of the world's best female referee and has been managing the prestigious games of the biggest foreign events. She ended her career as a referee in 2011 and began her new career path as a functionary. Besides this, she became a chairwomen of the Committee of the Referees of the Football Association of the Czech Republic. She was directly responsible for the actions of the referees, and was therefore often criticized by the media. Her relationship with the influential but controversial functionary Roman Berbr was also known to the public at that time, which has increased the interest of her person from the media. Mrs. Damková had withdrawn from the public after leaving the Refereeing Commission and the media did not refer to her so often. The research part of the thesis includes qualitative analysis of the media texts which were published in five periods of professional career Dagmar Damková. This diploma thesis also includes interviews...