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Call number: LD2668 .T4 1986 C443 / Master of Science / Chemistry

published_or_final_version / Chemistry / Doctoral / Doctor of Philosophy

While the market for “green” building materials has been expanding rapidly, no rigorous framework exists for evaluating the chemical and biological reactivity of these building materials. The objective of this research was to assess the ozone reactivity, primary and secondary VOC emission rates and mold resistance of selected green building materials. Two different sets of experiments were conducted. The first set focused on reactive consumption of ozone by ten common green materials. A screening assessment of secondary emissions of C6 and greater carbonyls was also completed for selected green materials. The second set was completed to evaluate the relative resistance of selected green building materials and their conventional analogs to surface fungal growth in moist interior environments. Ozone reactivity varied considerably between test materials. The ozone deposition velocity for inorganic ceiling tiles, for example, was two times higher than cabinetry materials and approximately fifty times higher than UV-coated bamboo. Experimental results were used as input to a simple mass balance model which predicted that the ratio of indoor to outdoor ozone concentrations was not significantly affected by green building materials. The green materials used in this study emitted less primary and secondary VOCs than did their non-green counterparts, although the difference was not significant and the material sample set was relatively small. Also, the green materials tested were not prone to either less or more mold growth than their conventional counterparts. Instead, materials composed of organic materials with high equilibrium moisture contents (EMC) were more prone to mold growth than inorganic materials with low EMC. Perlite-based (inorganic) ceiling tiles that consumed relatively large amounts of ozone without corresponding by-product formation were also resistant to mold growth. Such findings should facilitate the selection of future green building materials, both explicitly and by defining a protocol for future testing of green materials. / text

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This study examined how smoking and stress interact to affect the reactivity of the cardiovascular system. Findings revealed that subjects who smoked first and who were then exposed to stress showed less cardiovascular reactivity (CVR) to stress compared to non-smoking subjects exposed only to stress. However, the combination of smoking and stress led to higher absolute levels and greater reactivity for all cardiovascular measures compared to stress alone. The ability for trait hostility, state angry affect and state anxious-affect to predict CVR to smoking and stress was also examined. State anxious-affect was the only affect-related variable that predicted CVR across experimental phases for both smokers and non-smokers. None of the affect-related variables were able to predict CVR during smoking. Trait hostility and state anxious-affect predicted CVR to stress for smokers and non-smokers. Trait hostility was negatively associated with CVR to stress, while state anxious-affect was positively associated with CVR to stress. State angry affect did not predict CVR to stress after accounting for the effects due to trait hostility.

Background: Clopidogrel is commonly prescribed to cats with perceived increased risk of thromboembolic events, but little information exists regarding its antiplatelet effects. ObjectiveTo determine effects of clopidogrel on platelet responsiveness in cats with or without the A31P mutation in the MYBPC3 gene. A secondary aim was to characterize variability in feline platelet responses to clopidogrel. AnimalsFourteen healthy cats from a Maine Coon/outbred mixed Domestic cat colony: 8 cats homozygous for A31P mutation in the MYPBC3 gene and 6 wild-type cats without the A31P mutation. MethodsEx vivo study. All cats received clopidogrel (18.75 mg PO q24h) for 14 days. Before and after clopidogrel treatment, adenosine diphosphate (ADP)-induced P-selectin expression was evaluated. ADP- and thrombin-induced platelet aggregation was measured by optical aggregometry (OA). Platelet pVASP and ADP receptor response index (ARRI) were measured by Western blot analysis. ResultsPlatelet activation from cats with the A31P mutation was significantly (P = .0095) increased [35.55% (18.58-48.55) to 58.90% (24.85-69.90)], in response to ADP. Clopidogrel treatment attenuated ADP-induced P-selectin expression and platelet aggregation. ADP- and PGE(1)-treated platelets had a similar level of pVASP as PGE(1)-treated platelets after clopidogrel treatment. Clopidogrel administration resulted in significantly lower ARRI [24.13% (12.46-35.50) to 11.30% (-7.383 to 23.27)] (P = .017). Two of 13 cats were nonresponders based on OA and flow cytometry. Conclusion and Clinical ImportanceClopidogrel is effective at attenuating platelet activation and aggregation in some cats. Cats with A31P mutation had increased platelet activation relative to the variable response seen in wild-type cats.

Thesis (MTech (Chemistry))--Cape Peninsula University of Technology, 2009 / The host compound 9-(4-methoxyphenyl)-9H-xanthen-9-01 (AI) forms inclusion compounds with the solid guests l -naphthylamine (NAPH), 8-hydroxyquinoline (HQ). acridine (ACRI), 1,4 - diazabicyclo[2.2.2]octane (DABCO) and a liquid guest benzaldehyde (BENZAL). All four structures AI·YzNAPH, AI· Y,HQ AI·ACRI and AI ·Y,DABCO were successfully solved in the triclinic space group P I . The structure of AI·Y,BENZAL was successfully solved in the monocl inic space group P2dn . Similar packin g motifs arise for the NAPH and HQ inclusion compounds where the main interaction is of the fonm (Host)-OH····O-(Host). Both the DABCO and the ACRI guests hydrogen bond to the host molecule. The host: guest ratios for A I·ACRI. AI· Y,NAPH. A I· Y,DABCO and A I· YzHQ were found using nuclear magnetic resonance (NMR) spectroscopy. The host:guest ratio for AI·YzBENZAL was found using thenmogravimetric analysis. Enthalpy changes of the inclusion compounds were monitored using differential scanning calorimetry (DSC). Kinetics of desolvation for AI·Y,BENZAL were conducted using a non - isothenmal method where we have obtained an activation energy range of 74 k J morl - 86 k J mor' . The solid - solid reaction kinetics for A I·Y,NAPH, A I· Y,HQ, AI·ACRI and AI ·Y,DABCO were determined at room temperature using powder X-ray diffraction (PXRD).

This Thesis is concerned with the synthesis of post-metallocene group 4 amidinate complexes as pre-catalysts for the polymerisation and oligomerisation of α-olefins. Activation of half-sandwich group 4 amidinate complexes with 1,3-conjugated dienes is also investigated and their underlying chemistry is explored. <strong>Chapter 1</strong> introduces homogeneous Ziegler-Natta catalysis, with a specific focus on group 4 compounds. A review of metallocene and post-metallocene complexes of group 4 will also be presented and their behaviour in olefin polymerisation will be discussed. <strong>Chapter 2</strong> describes the synthesis and characterisation of _K1-amidinate supported titanium complexes. Base-free activation of the titanium cyclopentadienyl-amidinate dialkyl complexes will be investigated and the resulting cationic species will be further explored with commonly applied trapping agents. The synthesis and characterisation of new titanium cyclopentadienyl-amidinate diene complexes and their corresponding tri(pentafluorophenyl)borane-activated zwitterionic compounds will also be described and their performance in the co-polymerisation of ethylene and propylene will be discussed. <strong>Chapter 3</strong> explores the addition of 1,3-conjugated diene reagents to titanium cyclopentadienyl-amidinate and guanidinate alkyl cations. Mechanistic and computational studies of allyl and diene formation will also be described. The polymerisation capabilities of the newly formed complex will be discussed and compared to previously reported dialkyl complexes. <strong>Chapter 4</strong> describes the synthesis and characterisation of aminopyridinato titanium complexes and _K1-_K2-bis(amidinate) titanium complexes. The activation chemistry of the newly formed dialkyl complexes will be investigated. Furthermore, the synthesis of a new bis(aminopyridinato) titanium complex will also be discussed alongside their activity in EPM and EPDM polymerisation. <strong>Chapter 5</strong> describes the performance of the aminopyridinato titanium complexes (synthesised in Chapter 4) in EPDM polymerisation. The sensitivity of the aforementioned complexes towards hindered phenols will also be discussed and their behaviour in ethylene oligomerisation will be explored. <strong>Chapter 6</strong> presents full experimental procedures and characterising data for the new complexes reported in this Thesis.