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451	The role of socioeconomic factors in the succesful completion of matric education among young mothers in the Soutpansberg East circuit, Limpopo Province, South Africa Hatuugari, Livingstone 08 1900 (has links) This dissertation was carried out to try to describe the role of socio-economic factors in the successful completion of schooling up to matriculation level (matric), among young mothers in the Soutpansberg East Circuit in Limpopo Province, South Africa. The researcher used the social capital theoretical framework. A questionnaire was administered to 128 young mothers, aged 18 and above, after a pilot survey had been carried out. The data was captured, exported and analysed The data was then exported to the latest model of the Statistical Package for the Social Sciences (SPSS) version 25 where it was analysed. The research used independent T-test analysis, analysis of variance (ANOVA) and correlation analysis. The independent T- test was used to determine if the views of young mothers differed by the number of children, form of support from father, school policy and presence of educators as counsellors. A one-way analysis of variance (ANOVA) was done to determine whether the views on the role of socioeconomic factors in the successful completion of matric among young mothers in the Soutpansberg East Circuit, Limpopo Province, South Africa differed by age, grade, type of family and who takes care of the child. The findings showed that there were several socioeconomic factors that assisted young mothers to complete matric, among them were, family supports, child support grants, intra-school environment and policies. They provided critical support to the young mother in different forms among others taking care of children while they were at school, financial support, encouragement. The study also found other that schools in the Soutpansberg East Circuit also provided a significant amount of support to young mothers. The study also found a general trend of absentee fatherhood in the caring of children. The study found out that there was a complicated interplay of different socioeconomic factors to the completion of matric among the young mothers. The researcher, therefore, concluded that socio-economic factors are critical for the successful completion of schooling up to matric level in the Soutpansberg East Circuit. The study found out the need for more empirical study in the role of socioeconomic factors to the complication of matric among young mothers. / Sociology / M.A. (Sociology) Young mothers Socioeconomic factors Soutpansberg East Circuit Role Matirc Intra-school policies Social capital Child support grant 370.1150968257
452	Characteristics Associated with Neonatal Carnitine Levels: A Systematic Review & Clinical Database Analysis Sutherland, Sarah C. 28 January 2013 (has links) Newborn screening programs measure analyte levels in neonatal blood spots to identify individuals at high risk of disease. Carnitine and acylcarnitine levels are primary markers used in the detection of fatty acid oxidation disorders. These analytes may be influenced by certain pre/perinatal or newborn screening related factors. The primary objective of this study was to explore the association between these characteristics and levels of blood carnitines and acylcarnitines in the newborn population. The study was composed of two parts: a systematic review and a clinical database analysis of existing newborn screening data. The systematic review results suggested considerable variability across studies in the presence and directionality of associations between analyte levels and birth weight, gestational age, age at time of blood spot collection, type of sample, and storage time. Sex was not significantly associated with carnitine or acylcarnitine levels in neonatal blood. We identified a need to more fully investigate a potential interaction between gestational age and birth weight in regard to analyte levels. The secondary data analyses indicated a statistically significant relationship between analyte levels and all perinatal / infant and newborn screening related factors of interest, but effect sizes were generally small. The interaction between gestational age and birth weight was significant in all models; when further explored through graphical analysis with conditional means, extremely premature neonates stood out as having distinct analyte patterns in relation to birth weight. Variation in the ratio of total acylcarnitine to free carnitine was better accounted for by the perinatal and newborn factors than was variation in any individual carnitine or acylcarnitine, indicating that proportions of carnitine and acylcarnitines may be more important in understanding an individual’s metabolic functioning than individual analyte levels. A low proportion of variation was explained in all multivariate models, supporting the use of universal algorithms in newborn screening and suggesting the need for further large scale empirical research targeted at previously unaccounted for perinatal factors such as birth stress. newborn screening neonatal screening carnitine acylcarnitine mass screening inborn errors of metabolism lipid metabolism fatty acid oxidation fatty acid oxidation disorders free carnitine octanoylcarnitine C8 short chain acylcarnitine medium chain acylcarnitine long chain acylcarnitine birth weight gestational age sex age at collection age of collection blood spot heel prick socioeconomic status feeding breast milk formula transit time transfusion false positive Newborn Screening Ontario Ontario Newborn Screening Program database analysis systematic review
453	Characteristics Associated with Neonatal Carnitine Levels: A Systematic Review & Clinical Database Analysis Sutherland, Sarah C. 28 January 2013 (has links) Newborn screening programs measure analyte levels in neonatal blood spots to identify individuals at high risk of disease. Carnitine and acylcarnitine levels are primary markers used in the detection of fatty acid oxidation disorders. These analytes may be influenced by certain pre/perinatal or newborn screening related factors. The primary objective of this study was to explore the association between these characteristics and levels of blood carnitines and acylcarnitines in the newborn population. The study was composed of two parts: a systematic review and a clinical database analysis of existing newborn screening data. The systematic review results suggested considerable variability across studies in the presence and directionality of associations between analyte levels and birth weight, gestational age, age at time of blood spot collection, type of sample, and storage time. Sex was not significantly associated with carnitine or acylcarnitine levels in neonatal blood. We identified a need to more fully investigate a potential interaction between gestational age and birth weight in regard to analyte levels. The secondary data analyses indicated a statistically significant relationship between analyte levels and all perinatal / infant and newborn screening related factors of interest, but effect sizes were generally small. The interaction between gestational age and birth weight was significant in all models; when further explored through graphical analysis with conditional means, extremely premature neonates stood out as having distinct analyte patterns in relation to birth weight. Variation in the ratio of total acylcarnitine to free carnitine was better accounted for by the perinatal and newborn factors than was variation in any individual carnitine or acylcarnitine, indicating that proportions of carnitine and acylcarnitines may be more important in understanding an individual’s metabolic functioning than individual analyte levels. A low proportion of variation was explained in all multivariate models, supporting the use of universal algorithms in newborn screening and suggesting the need for further large scale empirical research targeted at previously unaccounted for perinatal factors such as birth stress. newborn screening neonatal screening carnitine acylcarnitine mass screening inborn errors of metabolism lipid metabolism fatty acid oxidation fatty acid oxidation disorders free carnitine octanoylcarnitine C8 short chain acylcarnitine medium chain acylcarnitine long chain acylcarnitine birth weight gestational age sex age at collection age of collection blood spot heel prick socioeconomic status feeding breast milk formula transit time transfusion false positive Newborn Screening Ontario Ontario Newborn Screening Program database analysis systematic review
454	Characteristics Associated with Neonatal Carnitine Levels: A Systematic Review & Clinical Database Analysis Sutherland, Sarah C. January 2013 (has links) Newborn screening programs measure analyte levels in neonatal blood spots to identify individuals at high risk of disease. Carnitine and acylcarnitine levels are primary markers used in the detection of fatty acid oxidation disorders. These analytes may be influenced by certain pre/perinatal or newborn screening related factors. The primary objective of this study was to explore the association between these characteristics and levels of blood carnitines and acylcarnitines in the newborn population. The study was composed of two parts: a systematic review and a clinical database analysis of existing newborn screening data. The systematic review results suggested considerable variability across studies in the presence and directionality of associations between analyte levels and birth weight, gestational age, age at time of blood spot collection, type of sample, and storage time. Sex was not significantly associated with carnitine or acylcarnitine levels in neonatal blood. We identified a need to more fully investigate a potential interaction between gestational age and birth weight in regard to analyte levels. The secondary data analyses indicated a statistically significant relationship between analyte levels and all perinatal / infant and newborn screening related factors of interest, but effect sizes were generally small. The interaction between gestational age and birth weight was significant in all models; when further explored through graphical analysis with conditional means, extremely premature neonates stood out as having distinct analyte patterns in relation to birth weight. Variation in the ratio of total acylcarnitine to free carnitine was better accounted for by the perinatal and newborn factors than was variation in any individual carnitine or acylcarnitine, indicating that proportions of carnitine and acylcarnitines may be more important in understanding an individual’s metabolic functioning than individual analyte levels. A low proportion of variation was explained in all multivariate models, supporting the use of universal algorithms in newborn screening and suggesting the need for further large scale empirical research targeted at previously unaccounted for perinatal factors such as birth stress. newborn screening neonatal screening carnitine acylcarnitine mass screening inborn errors of metabolism lipid metabolism fatty acid oxidation fatty acid oxidation disorders free carnitine octanoylcarnitine C8 short chain acylcarnitine medium chain acylcarnitine long chain acylcarnitine birth weight gestational age sex age at collection age of collection blood spot heel prick socioeconomic status feeding breast milk formula transit time transfusion false positive Newborn Screening Ontario Ontario Newborn Screening Program database analysis systematic review
455	Time trends in childhood cancer : Britain 1966-2005 Kroll, Mary Eileen January 2009 (has links) Increasing time trends in the recorded incidence of childhood cancer have been reported in many different settings. The extent to which these trends reflect real changes in incidence, rather than improvements in methods for diagnosis and registration, is controversial. Using data from the National Registry of Childhood Tumours (NRCT), this thesis investigates time trends in cancer diagnosed under age 15 in residents of Britain during 1966-2005 (54650 cases), and considers potential sources of artefact in detail. Several different methods are used to estimate completeness of NRCT registration. The history of methods for diagnosis and registration of childhood cancers in Britain is described, and predictions are made for effects on recorded incidence. For each of the 12 main diagnostic groups, Poisson regression is used to fit continuous time trends and ‘step’ models to the annual age-sex-standardised rates by year of birth and year of diagnosis. Age-specific rates by period, and quinquennial standardised rates for diagnostic subgroups, are shown graphically. For three broad groups (leukaemia, CNS tumours and other cancer), geographical variation is compared by period of diagnosis. The results of these analyses are discussed in relation to the predicted artefacts. The evidence for a positive association between affluence and recorded incidence of childhood leukaemia is briefly reviewed. A special form of diagnostic artefact, the ‘fatal infection’ hypothesis, is proposed as an explanation of both this association and the leukaemia time trend. This hypothesis is examined in a novel test based on clinical data. The recorded incidence of childhood cancer in Britain increased in each of 12 diagnostic groups during 1966-2005 (from 0.5% per year for bone cancer to 2.5% for hepatic cancer, with 0.7% for leukaemia). Evidence presented here suggests that these increases are probably artefacts of diagnosis and registration. The potential implications for epidemiological studies of childhood cancer should be considered. 610.21

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