Increasing of human life comfort and safety requires development and application of new chemical substances, which, unfortunately, cannot be completely removed by WWTPs. Thus, these compounds, their metabolites and TPs formed during human/animals/bacteria metabolism, wastewater treatment and natural environmental processes are tend to contaminate all the environmental compartments. Appearance of advanced analytical instrumentation and techniques enable to perform research on emerging environment contaminants fate. This thesis was focused on application of high resolution mass spectrometer and new generation of triple quadrupole for analysis of the environmental pollutants. All studies were mainly devoted to such a group of contaminants as pharmaceuticals because of their high consumption, frequent occurrence in all environmental matrices and potential to cause adverse effects for non-targeted organism due to their biological activity. The first part of the thesis is related to method development for identification and quantification of metabolites in the different tissues of rainbow trout exposed to diltiazem. As a result, 17 diltiazem metabolites were tentatively identified by HRMS and spectral interpretation software. The complex metabolic pathway in metabolic phase I for diltiazem and tissue specific bioconcentration in fish were proposed in the study. The second part of the work is mainly focused on investigation of pharmaceuticals fate in the soil environment. The transformation of several pharmaceuticals, such as atenolol, metoprolol, carbamazepine, sulfamethoxazole, trimethoprim, and clindamycin in 13 different soils was studied under laboratory conditions. The parent compounds were analyzed in all studied soils and dissipation curves were plotted. Finally, 15 known and new metabolites were detected and identified. Moreover, identity of 6 of them was confirmed by available analytical standards. It was shown that almost the same metabolites profile was observed in all soils, but formed amount and degradation rate of all detected metabolites were soil type dependent. Several parent compounds and metabolites were shown to be persistent in the soils. Consequently, pharmaceuticals can be transported via ground water to plant. Further fate of pharmaceuticals must be studied as it can have adverse effect on crop consumers. The third part of the dissertation dealt with an important issue of pharmaceuticals transport between different aquatic environmental compartments. Water, sediments and fish from a pond affected with TWW from a local WWTP were analyzed within this project. 18 pharmaceuticals and 7 their metabolites were found in all studied matrices. Solid water distribution coefficients for sediments and bioaccumulation factors for fish liver were obtained in this study under real conditions. Seasonal variations in all studied parameters were investigated for one year period. This study help to extend a limited available information on fate of wide range of compound, especially metabolites in the aquatic environment affected by treated wastewater.

The Master Thesis "Set v proměně životního stylu" is divided into two parts, the theoretical and the practical one. The theoretical part deals with the life style of different social groups and the dining culture in particular historical periods of time. Further it explores the historical events that have impacted the development of the 20th century life style and also the way that the design has been formed as a independend creative discipline. The origin of Bauhaus was a milestone of a great importance and is covered in the next chapter. A quick look at the contemporaty production is followed. The practical part is concerned with the history of fondue, where it was found and what are the kinds of nowaday´s preparation. It will be introduced what sorts of containers are used for given kinds of fondue . The target of the practical part is to make a fondue set for a group of six people. This will be conducted partly by a graphical visualisation and partly by a ceramic realization.

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This dissertation presents theoretical and empirical research on the agoraphobia. The theoretical part outlines the history and diagnosis of agoraphobia since the mid- nineteenth century to the present through selected theories of this disorder. Concept of normality and diagnosis of agoraphobia disorder according to ICD -10, DSM IV and DSM V are also addressed. Space is also devoted to the philosophical concept of anxiety and body in relation to space. In the empirical part of the thesis the life story narrative analysis as well as analysis of narrative interviews with women suffering from agoraphobia was carried out. Ten women represent the sample. Received research data were analysed using the categorial- formal analysis. Following research objectives were set: to analyse importance of the disease in lives of participants, to describe the individual specific form of the disease, to analyse individual meaning and purpose attributed by the participants to their disease, to describe diverse aspects of life depicting. The aim was also to learn about the ways participants manage their disease including the use of therapy. Life story narrative analysis of female agoraphobia proved to be a suitable method for understanding the very meaning of agoraphobia disorder and also the meaning that is being...

Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Botany Candidate: Gabriela Tkáčová Supervisor: RNDr. Jitka Vytlačilová, Ph.D Title of diploma thesis: The occurence of pharmaceuticals in the environment I. Drugs are biologically active substances used for treatment and prophylaxis of human and animal illnesses. Some drugs, however, remain biologically active even after they are excreted from the organism. By various means these substances can appear in the environment and can be detected in wastewater, surface water, seawater, groundwater, drinking water, sediments and soil. Chronic presence of low concentrations of drugs in the environment can negatively affect non-target organisms. Aim of this diploma thesis is to study presence of SSRI, statins and hypoglycemic drugs in the environment. Drugs from these farmacodynamic groups were detected in the environment in concentrations ranging from ng/l to μg/l. Selected drugs from SSRI group were fluoxetine, citalopram, fluvoxamine, sertraline, paroxetine and escitalopram. In water samples they were detected in concentration ranging from tens to hundreds ng/l, they were also detected in soils and sediments. Toxicity for water biota was also proven. Fluoxetine caused changes in secondary sexual characteristics of fish...

This master thesis focuses on values and life satisfaction of young adults. Theoretical part defines the concept of the terms "values", "life satisfaction", and "early adulthood". After that, results of the existing research on the topic of values and life satisfaction are introduced. Quantitative section of the empirical part examines the correlation between the level of importance of 23 values and the level of satisfaction in 23 different areas of life. Data sample consisted of 726 young adults. Quantitative section is followed by a qualitative research to compensate for deficiencies of the quantitative method. Results showed that 19 out of 23 areas have a statistically significant correlation between the level of value's importance and the level of satisfaction in the relevant area of life. One area of life manifested a statistically significant negative correlation. This research initiates a challenge to examine the relationship between the level of values' importance and the level of satisfaction in the respective areas of life more thoroughly. Keywords: values, life satisfaction, early adulthood

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Angl. resumé