本研究的主要目的在於運用靜息態功能性磁振造影技術來探討高社會焦慮的自我參照處理腦區的功能聯結。根據Clark和Wells(1995)的模型，高社會焦慮者的負向自我心象只透過自我相關的在線索來建構；然而根據Rapee和Heimberg(1997)的模型則假設高社會焦慮者還會納入他人外在訊息，做自我與他人參照訊息的處理。本研究企圖透過神經影像的發現來檢測上述兩個模型。 本研究篩選出四十名大學生分為高社會焦慮組與低社會焦慮組，所有受試者都會進行靜息態功能性磁振造影的掃描，並使用MPFC、PCC、ACC、VMPFC、DMPFC作為種子進行全腦的功能聯結分析並獲得功能聯結圖譜做比較。 研究結果發現高社會焦慮者的MPFC、PCC、ACC都有增加的功能聯結，顯示他們比一般人更容易做自我參照處理，而VMPFC、DMPFC同時有增加的功能聯結，代表高社會焦慮者的自我參照處理除了自我內在的相關訊息外，還會包含他人外在相關訊息的處理，研究結果較支持Rapee和Heimberg(1997)的說法。最後並提出本論文研究限制，與對社會焦慮症的臨床理論與實務上之建議。 / The purpose of the present study was to utilize the resting-state functional magnetic resonance imaging(RS-fMRI) technique to investigate the brain regions in functional connectivity of self-referential processing in socially anxious individuals. According to Clark and Wells’ (1995) view, socially anxious individuals were hypothesized to construct their negative self-image with self-related internal information. However, according to Repee and Heimberg’ s (1997) model, they supposed that socially anxious individuals also brought other-related external information to make other-related external information self-referential and other-referential be processed. The present study was designed to use finding of neuroimaging to examine the two models Forty undergraduate students were assigned to either high or low social-anxiety group. All subjects were asked to be scanned with RS-fMRI. MPFC, PCC, ACC, VMPFC, DMPFC were used as seeds to proceed the whole-brain functional connectivity analysis and acquired functional connectivity maps for comparison. The results revealed that functional connectivity of MPFC, PCC, ACC of high social anxiety group increased, it displayed that they were more easily to do self-referential processing. Besides, functional connectivity of VMPFC and DMPFC also increased simultaneously, which means that the self-referential processing of high social anxiety group not only included self-related internal information but also included other-related external information. The result supported Repee and Heimberg’ s model. The limitations of this study and the suggestions for the theories and clinical treatment of social anxiety disorder were advanced in the end.

本研究的目的是初步探索Wang等人(2012)的模式中各因子的生理基礎，在該模式當中，社會焦慮疾患與憂鬱疾患間的結構關係，可透過高負向情感因子、低正向情感因子、害怕負向評價因子與害怕正向評價因子良好說明，然目前主要研究發現多來自問卷法研究，本研究以靜息態磁振造影做為生理方面的初探工具，以功能聯結網絡找出與因子對應的生理佐證。本研究邀請共邀請50位大學生，其中有25位是高社會焦慮傾向者，另外25位則是低社會焦慮傾向者，每位參與者都須填寫問卷與接受約15分鐘的磁振造影掃描。本研究分別以杏仁核、腦島、依核與眶額葉皮質為種子區域形成的功能聯結網絡，結果發現高社會焦慮傾向組與低社會焦慮傾向組在四組功能聯結網絡均有顯著差異；進一步分析具差異的功能聯結與量表的關係，可觀察到與負向情感因子有關的聯結同時和社會焦慮傾向及憂鬱傾向達顯著正相關，與正向情感因子有關的聯結則同時和社會焦慮傾向及憂鬱傾向達顯著負相關；分別排除社會焦慮傾向與憂鬱傾向的影響後，仍可發現和害怕正向評價因子與害怕負向評價因子具顯著相關的功能聯結。本研究的發現顯示Wang等人(2012)的模式中各因子的確有對應的腦部功能聯結，可見該模式具有生理實質性，且可良好論述與釐清心理疾患間關係，然本研究受限於種子與參與者的選擇，無法呈現該模式中因子間的關係，未來可進一步採用作業態等方法，以利更加確立腦部功能聯結與模式中各因子的關係。