published_or_final_version / Medical Sciences / Master / Master of Medical Sciences

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The stopping of an earlier intended action is best explained in a race between a go process and a stop process (Logan & Cowan, 1984). The finish line, to which each process races, has been likened to a point of no return, specifically one that marks the onset of a final ballistic (unstoppable) process. Of note is the typical relation of reduced go probabilities and faster go latencies at shorter signal onset asynchronies (SOAs). (The SOA is the time interval between presentation of the go signal and presentation of the stop signal.) We report, in some cases, sub-maximal surface electromyograms (EMGs) at onset when trying to stop a maximal speeded action. These data indicate reduced synaptic drive to reach the motor pools as a result of earlier stopping effects and, as such, hold important implications for a theory of control. First, we interpret these data to suggest that the point of no return is phantom. Sub-maximal EMGs indicate a point in the control stream beyond which some EMG will be later observed but, importantly, they fail to mark the onset of a final ballistic process if, once breached, the same process remains subject to further effects of stopping. The alternative interpretation, however, that of a final ballistic process that receives sub-maximal input which results in sub-maximal output (i.e., EMG onset) cannot be ruled out from these data. We used the Hoffmann (H) reflex to probe further the mechanism of control for stopping a voluntary action. The H-reflex, an involuntary reflex that is taken as an index of spinal control, is relevant to the control of stopping because it is typically facilitated a short time before EMG onset. In other words, it provides a window of control within which a final ballistic process would otherwise be expected to locate. Thus, we interpret the effects of stopping on the H-reflex before EMG onset as strong evidence against a final ballistic process. Second, while the race model can explain the relation between the go probabilities, the go latencies and the SOAs, it fails to explain the sub-maximal EMG onsets that describe that same action in some cases. We submit a mechanism of excitatory-inhibitory interaction at all times up to the motor pool to explain both sets of empirical data. The viability of this theory is demonstrated using computer analyses.

Knee osteoarthritis (OA) is a progressive disease and a leading cause of morbidity in older adults, resulting in severe mobility limitations. While the osteoligamentous and neuromuscular systems are altered in knee OA, little data is available to illustrate an association among these systems. The objective of this dissertation was to improve our understanding of how muscle activation patterns during gait are altered across the knee OA severity spectrum and to examine how factors related to the OA process are associated with these alterations. Three independent but related studies were conducted. Muscle activation of the medial and lateral orientations of the gastrocnemii, quadriceps and hamstrings were recorded during gait using surface electromyography for all three studies. Key activation features were identified using principal component analysis. First, participants selected from a large group (n=272) of individuals classified as asymptomatic, ii) moderate ii) severe knee OA were matched for walking velocity. Significant amplitude and temporal activation characteristics were found, supporting that differences among OA severities exist and were not the result of walking velocity only. Secondly, individuals with moderate OA were sub-grouped based on structural severity determined using Kellgren-Lawrence radiographic scores (II-IV) and were compared to a velocity-matched asymptomatic group. Medial gastrocnemius, lateral hamstring and quadriceps amplitudes and temporal patterns were significantly altered by structural severity where significant activation imbalances between the lateral:medial gastrocnemii and hamstrings were found with greater structural impairment (score>II). Thirdly, individuals with moderate OA were prospectively evaluated and divided into knee effusion and no effusion groups, based on a positive bulge test. A significantly higher knee flexion angle during mid-stance, higher quadriceps amplitudes and prolonged hamstrings amplitudes were found when effusion was found. These studies showed that muscle activation patterns during walking were related to i) OA presence and severity based on functional, symptoms and radiographic evidence, ii) structural severity and iii) knee joint effusion. These findings improve our understanding of the interrelationships between alterations in joint structure and function associated with knee OA and muscle activation patterns during gait. These data can contribute to the development of gait-based metrics that can facilitate knee OA diagnosis and monitor progression.

Healthy aging is associated with an increased incidence of injuries such as low back pain and falling. Age-related changes in trunk neuromuscular activation patterns could potentially explain uncontrolled trunk motion, a risk factor for these injuries. The purpose of this study was two-fold: i) to establish if trunk neuromuscular activation patterns differ between older and younger adults, and ii) to identify if increased cognitive load can alter the activation patterns used by older adults. Participants performed a controlled dynamic transfer task known to challenge trunk musculature by continuously changing the external moment experienced by the spine. In this thesis, the transfer task was altered by increasing the external moment and cognitive load to address purpose i) and ii) respectively. Three dimensional trunk and pelvis motion and surface electromyograms for 24 trunk muscle sites were collected in two experiments. In the first experiment 26 younger adults, and 17 older adults, performed the transfer task at two physical task intensities. In a second experiment, eight of these older adults performed the dynamic transfer task while performing a simultaneous cognitive dual-task. An analysis of amplitude and temporal characteristics of EMG waveforms, using principal component analysis, showed that older adults had altered trunk neuromuscular activation patterns compared to younger adults. In particular, after accounting for physical task intensity, older adults have increased antagonist co-activation, less temporal variation to changing external moments, and changes in the synergistic relationships between trunk muscle sites. Increasing the cognitive load had no influence on the trunk neuromuscular activation patterns used by healthy active older adults. However, as cognitive performance was not measured in the dual-task it cannot be excluded that i) the cognitive task did not represent enough challenge to result in competition of cortical resources, or ii) the cognitive resources necessary for the successful completion of the transfer task were prioritized in older adults.

This thesis is an investigation of the neurophysiologic mechanism, central sensitization, underlying pain and dysfunction in osteoarthritis. Central sensitization is an important mechanism in the pathophysiology of osteoarthritis but, to our knowledge, its influence on motoneurone excitability is unknown. Our primary hypothesis states that increasing central sensitization within a spinal segment will cause a greater increase in the excitability of motoneurones in subjects with osteoarthritis when compared to healthy controls. To test this hypothesis, we experimentally induced central sensitization in individuals and monitored the recruitment threshold force of the motor units in the first dorsal interosseous muscle using indwelling electromyography. Findings from this study suggest that central sensitization lowers the motor unit recruitment threshold in osteoarthritis compared to healthy individuals. Motoneurone excitability might be inhibited in healthy individuals with persistent sensitization as well. Thus, central sensitization is an important consideration in the biomechanical dysfunction seen in osteoarthritis. / Canadian Arthritis Network

Present day manufacturing assembly relies extensively on a variety of fasteners for the assembly of sub-systems, components and trim. Speed Fastening (SF) is one commonly used non-structural assembly fastening method. The primary limitation of SF is the lack of continuously fed rivets. One path to productivity improvement for SF is the development of a continuously feed tool that would eliminate the non-value added time currently scheduled for reloading in the work cycle. In preparation for the design of a new tool, a proactive ergonomic investigation was carried out to examine differences in muscular effort, upper-body posture, as well as subjective ratings of perceived exertion and discomfort across three different work rates for a simulated SF task conducted in a laboratory setting. The purpose of this investigation was to characterize the ergonomic consequences that an increase in work rate would have on SF operators. Twelve healthy female subjects participated in simulated SF work over four test-sessions. The first test session familiarized subjects with the SF tasks as well as the data collection protocol. Subsequent test days, which were scheduled 24 hours apart, were block randomized to one of three work rates (7, 14 and 21 fasteners/min.) with subjects required to complete 120 minutes of a simulated SF task at both waist and shoulder height using a 50% work to rest duty cycle. The results of this study show significant increases in the amount of muscular activity required to complete the simulated SF, particularly for the 21 fasteners per minute work rate, with increases in peak sEMG amplitudes ranging from 3-12% MVIC. Specifically these increases were most marked in the forearm extensor muscles. In addition, significantly deviated postures were found in upper-limb joint ROM data, particularly when SF work was completed at shoulder height. Overall, based on the increased exposure to risk factors known to be precursors for workplace injury (i.e. repetition and awkward posture), it is inferred that an increase in work rate will put SF operators at an elevated risk of musculoskeletal injury. It is expected that this risk would be even more pronounced for work completed at shoulder height. / Thesis (Master, Kinesiology & Health Studies) -- Queen's University, 2009-09-02 00:01:36.701

The present study quantifies electromyographic variables in one and two degree of freedom elbow movements involving flexion/extension and pronation/supination, in order to understand the associated central commands. Agonist burst magnitude varied with motion in a second degree of freedom for some muscles but not for others. In movements for which a biarticular muscle acted as agonist in two degrees of freedom, agonist burst magnitudes were approximately the sum of the magnitudes in the component movements. Agonist burst magnitude varied with motion in a second degree of freedom for some, but not all, monoarticular muscles. When biarticular muscles acted as agonist in one degree of freedom and antagonist in the other, the muscle often displayed both components simultaneously. The additivity of EMG burst magnitudes in two degree of freedom movements and the presence of both agonist and antagonist bursts in a muscle suggest that central commands associated with motion in individual degrees of freedom are superimposed in producing two degree of freedom movements.

Resistance exercise using weights typically offers constant external load during coupled shortening (concentric) and lengthening (eccentric) muscle actions in sets of consecutive repetitions until failure. However, the constant external load and the inherent capability of skeletal muscle to produce greater force in the eccentric compared with the concentric action, would infer that most actions are executed with incomplete motor unit involvement. In contrast, use of the inertia of flywheels to generate resistance allows for maximal voluntary force to be produced throughout the concentric action, and for brief episodes of greater eccentric than concentric loading, i.e. “eccentric overload”. Thus, it was hypothesized that acute flywheel resistance exercise would induce greater motor unit and muscle use, and subsequent fatigue, compared with traditional weight stack/free weight resistance exercise. Furthermore, it was hypothesized that flywheel training would induce more robust neuromuscular adaptations compared with training using weights. A total of 43 trained and untrained men were investigated in these studies. Knee extensor muscle activation, fatigue response and muscle use were assessed during exercises by recording electromyographic signals and by means of functional magnetic resonance imaging, respectively. Flywheel resistance exercise provoked maximal or near maximal muscle activation from the first repetition, induced robust fatigue, and prompted more substantial motor unit and muscle use than weight stack/free weight resistance exercise in both novice and resistance trained men. Both prior to and following five weeks of unilateral knee extension training, the eccentric muscle activation was greater with flywheel than weight stack training. Furthermore, weight stack training generated greater increases of dynamic strength and neural adaptations, while flywheel training generated more prominent hypertrophy of individual quadriceps muscles and greater improvement of maximal isometric strength. Hence, due to the preferential metabolic cost of the concentric rather than eccentric actions, the maximal activation through the entire range of the concentric action within each repetition of a set during flywheel resistance exercise probably evoked the marked fatigue, and prompted more substantial muscle use than resistance exercise using weights. Furthermore, while any cause‐effect relationship remains to be determined, results of the pesent study suggest that brief episodes of “eccentric overload” amplify muscular adaptations following concentriceccentric resistance training.

The primary purpose of this study was to determine the ratio of activation between the VMO and the VL during an open chain knee exercise (dynamic knee extension) and a closed chain knee exercise (lateral step-up). A secondary purpose of this study was to compare muscle activation during the concentric and eccentric phase of the exercises. The data obtained during the knee extension exercise was further analyzed to compare the activity of the VMO and VL during three ranges of knee flexion: 0° - 30°, 30° - 60°, and 60° - 90°. Electromyographic (EMG) data was collected while 20 Ball State University students, who were asymptomatic for Patellofemoral Pain Syndrome, performed the two selected exercises. A one way ANOVA showed no statistically significant difference between the VMO: VL ratio of the two exercises, but the lateral step-up did produce a ratio greater than 1.0. A one-way ANOVA indicated a significant difference between the RMS values of the VL for the concentric and eccentric phase of the knee extension exercise. Based on the results of this study, the lateral stepup and eccentric training could be used to selectively strengthen the VMO for the treatment of PFPS. / School of Physical Education