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The Global ETD Search service is a free service for researchers
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Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Showing 61 to 68 of 68 (0.018 seconds)Spelling suggestions: "subject:"14333"" "subject:"1433.3""
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Mechanisms Underlying the Regulation and Functions of HDAC7Gao, Chengzhuo 22 July 2008 (has links)
No description available.
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Protein 14-3-3 (YWHA) isoforms and their roles in regulating mouse oocyte maturationDe, Santanu 02 July 2014 (has links)
No description available.
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| 63 |
Steroid-responsive Enzephalopathie bei Autoimmunthyreoiditis als Differentialdiagnose der Creutzfeldt-Jakob-Krankheit / Steroid-responsive encephalopathy in autoimmune thyroiditis as a differential diagnosis of Creutzfeldt-Jakob diseaseOsmanlioglu, Seyma 23 March 2016 (has links)
No description available.
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Development of microarray techniques for the study of gene expression in the European eel (Anguilla anguilla) during silvering and migration to seawaterMcWilliam, Iain Stuart January 2008 (has links)
The European eel, Anguilla anguilla, has a complex life-cycle involving migrations between the Sargasso Sea and the river systems of Europe and North Africa. The requirement to move across large salinity gradients presents a significant physiological challenge and the developmental stages of the eel are closely linked to these migrations. Microarrays were created to elucidate gene expression changes occurring during; i. The transition from juvenile yellow to the adult sexually maturing, migrating silver eel and; ii. Salinity adaptation during the migration from freshwater to seawater. Groups (n = 6) of freshwater-acclimated yellow or silver eels were transferred to seawater for between 6 hours and 5 months and complementary control groups were transferred to freshwater. Brain, kidney, intestine and gill cDNA libraries were constructed using suppression subtractive hybridisation (SSH) techniques and a novel protocol based on Invitrogen's Gateway cloning system. The latter technique produced a low redundancy (~4 %) EST bank with a wide range of insert sizes (0.5 – 10 kb). Two microarray types were produced; one comprised 5760 clones from the two brain libraries whilst the other was a multi-tissue microarray incorporating 6144 clones from the SSH libraries. Pooled RNA samples were probed against the microarrays to highlight differentially expressed genes. Real-time quantitative PCR (QPCR) was used to validate the observed expression changes of selected genes in the tissues of individual fish. Following yellow to silver transformation of freshwater-adapted eels, the expression of tyrosine 3-mono-oxygenase/tryptophan 5-mono-oxygenase activation protein (14-3-3) and vaccinia related kinase 3 was shown to be consistently elevated. Prolactin expression increased in the brains of silver eels following two-day seawater-acclimation but QPCR analysis revealed high variation amongst freshwater-adapted eels. This is the first eel microarray study and the expression profiles highlighted herein will provide new avenues for research into the sexual development and salinity acclimation of A. anguilla.
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Rôle des protéines 14-3-3 dans la régulation de la longévité par la voie DAF-2/Insuline/IGF-1 chez Caenorhabditis elegansAraiz, Caroline 01 July 2008 (has links) (PDF)
Les protéines 14-3-3 sont des protéines ubiquitaires conservées chez tous les eucaryotes. Elles interagissent avec de multiples partenaires, dont elles modulent la fonction et la localisation, et interviennent de ce fait dans de nombreux processus cellulaires. FTT-1 et FTT-2 sont les deux orthologues de 14-3-3 présents chez Caenorhabditis elegans. En utilisant l'approche de RNA interférence, nous avons montré que les protéines FTT sont impliquées dans la voie DAF-2/Insuline/IGF-1, régissant la longévité, la résistance au stress et le métabolisme chez C. elegans, et dont l'effecteur majeur est le facteur de transcription DAF-16, orthologue de Forkhead chez les mammifères. Ce travail de thèse a permis de caractériser les fonctions de chacune des protéines FTT dans la régulation des différents phénotypes engendrés par cette voie et de mettre en évidence le rôle prépondérant de FTT-2. D'autre part, nos données ont révélé la contribution supplémentaire de FTT-2 dans la régulation de la longévité et du métabolisme lipidique et de FTT-1 et FTT-2 dans la résistance au stress, à travers un mécanisme parallèle à la voie DAF-2/Ins/IGF-1 et ne mettant pas en jeu DAF-16. Les résultats de notre étude soulignent la complexité des fonctions des protéines FTT et démontrent leur participation à plusieurs processus importants pour la survie de C. elegans lors d'une exposition à un stress mais aussi lors du vieillissement physiologique du nématode.
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Large tumor suppressor 1 (LATS1) and stress stimuli regulate mixed lineage kinases (MLKs) in ovarian cells.Kasturirangan, Srimathi January 2021 (has links)
No description available.
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| 67 |
EXPLORING THE MOLECULAR MECHANISM OF ROOT-MEDIATED RESPONSES TO <i>RALSTONIA</i>Katherine Rivera-Zuluaga (17552421) 06 December 2023 (has links)
<p dir="ltr">Bacterial Wilt, caused by <i>Ralstonia solanacearum</i>, is among the most devastating plant diseases in the world. This pathogen causes significant loss in crops such as tobacco, potato, and tomato. <i>R. solanacearum</i> root infection and xylem colonization determine disease outcome. To date, little is known about the defense mechanism mediated by roots to prevent <i>R. solanacearum</i> vascular colonization during the initial infection stages. Plant early responses are important since they may impact disease outcomes<i>.</i><i> </i>Here, we report the formation of root hairs and primary root growth inhibition in tomato seedlings as <i>Ralstonia</i>-induced phenotypes that depend on tomato genotype and <i>Ralstonia</i> species. The <i>Ralstonia</i>-induced root phenotypes are independent of a functional type III secretion system and exopolysaccharide production (EPS). We also found that <i>R. solanacearum</i><i> </i>K60 infection increased auxin levels throughout the root meristem in wilt-susceptible tomato roots. Our data suggest proper auxin signaling and transport are important for susceptibility to <i>R. solanacearum</i> K60. Blocking auxin transport pharmacologically or genetically led to fewer wilting symptoms, suggesting that auxin is important during early infection stages and disease outcomes in tomato. We previously found that a tomato mutant defective in auxin transport and signaling, known as <i>diageotropica</i> (<i>dgt</i>), has enhanced resistance to <i>R. solanacearum</i> K60. We characterized the resistant response in the <i>dgt</i> mutant, and we found that the resistant response in the <i>dgt</i> mutant may be due to increased lignin content preventing pathogen vasculature colonization. <i>DGT</i> encodes a cyclophilin protein that regulates auxin transport and signaling. Mutations in the cyclophilin DGT promote resistance to <i>R. solanacearum</i> K60. DGT has been reported to regulate auxin transport and signaling. However, the molecular mechanism regarding how DGT mediates these processes is still unknown. We used Yeast Two-Hybrid to identify candidate protein interactors, and we found that SlbZIP1/SlbZIP29, Sl14-3-3, and SlMYB110 may interact with DGT to regulate both development and defense responses. Understanding the role of DGT, auxin, and lignin in defense responses to <i>R. solanacearum</i> K60 in tomato is necessary for Solanaceae crop improvement.</p>
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Über die differentielle Regulation von Ionenkanälen in spezifischen Nanodomänen atrialer und ventrikulärer Kardiomyozyten / Differential Regulation of Ion Channels in Specific Nanodomains of Atrial and Ventricular CardiomyocytesBrandenburg, Sören 29 June 2017 (has links)
No description available.
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