Flutter is one of the most important phenomena in which aerodynamic surfaces become unstable in certain flight conditions. Since the 1930&amp / #8217 / s many studies were conducted in the areas of flutter prediction in design stage, research of design methods for flutter prevention, derivation and confirmation of flutter flight envelopes via tests, and in similar subjects for aircraft wings. With the use of controllers in 1960&amp / #8217 / s, studies on the active flutter suppression began. First the classical controllers were used. Then, with the improvement of the controller synthesis methods, optimal controllers and later robust controllers started to be used. However, there are not many studies in the literature about fully movable control surfaces, commonly referred to as fins. Fins are used as missile control surfaces, and they can also be used as a horizontal stabilizer or as a canard in aircraft. In the scope of this thesis, controllers satisfying the performance and flutter suppression requirements of a fin are synthesized and compared. For this purpose, H2, Hinf, and mu controllers are used. A new flutter suppression method is proposed and used. In order to assess the performance of this method, results obtained are compared with the results of another flutter suppression method given in the literature. or the purpose of implementation of the controllers developed, aeroelastic model equations are derived by using the typical section wing model with thin airfoil assumption. The controller synthesis method is tested for aeroelastic models that are veloped for various flow regimes / namely, steady incompressible subsonic, unsteady incompressible subsonic, nsteady compressible subsonic, and unsteady compressible supersonic.

On aura essayé, dans notre période où des actes meurtriers sont commis au nom de Dieu, de réévaluer la compréhension de celui-ci dans la philosophie contemporaine de Kant à Lévinas. En effet, là où autrefois Dieu réglait le régime de signification de la vie et de la mort, jusqu'à déterminer le sens du sacrifice de cette vie, la philosophie contemporaine tente de dégager – c'était du moins notre thèse principale – un Dieu déceptif et non plus tout-puissant. Ce Dieu ne justifierait ainsi plus le sens de la vie, mais décevrait le sens de celle-ci en l'ouvrant non pas à la promesse d'une vie après la mort, mais à la finitude comme telle. Cette ouverture divine à la finitude, ouvre en cela même à des injonctions éthiques et politiques. Si « Dieu est mort », ainsi, c'est en tant que, dans sa mort, il ouvre également l'instant de la mort en général : la mienne et celle de l'Autre – a fortiori –, en intimant chacun et chaque autre à se veiller dans une Bien-veillance soucieuse de la mortalité d'Autrui. A la conséquence de quoi, on aura dernièrement voulu penser, contre notre tradition métaphysique patriarcale, non plus un Dieu-le-Père, mais un Dieu comme Mère, dont la maternité, selon Lévinas, serait accueil inconditionnel de l'Autre, responsabilité infinie pour sa vie et pour sa mort. / We would have try, in our area where murderous acts are committed in the name of God, to reevaluate his understanding in contemporary philosophy from Kant to Levinas. In point of fact, there were formerly God solved the meaning regime of life and death, up to determine the sense ofthis life's sacrifice, the contemporary philosophy tempts to clarify - it is at the very least our mainthesis - a deceptive God ( Kant ) and neither all-mighty. This God thus wouldn't justify the meaning of life, but deceived it's meaning in opening it not to the promise of life after death, but to a finiteness as such. This divine opening to finiteness, opens in itself ethical and political injunctions. If "God is dead", so, it is a such that, is his death, he also opens the instant of death in general : mine and others - all the more so - ordering each and everyone to attend to a Good-attending, mindful of Other's morality. In the consequence of what, we would lately have wanted to think, asour metaphysic patriarchal tradition, not anymore a God-the-Father, but a God as a Mother, whosemotherhood, according to Levinas, would be an unconditional welcome of the Other, infinite responsibility for it's life and death.

Studies have been conducted to highlight the anti-inflammatory and immunosuppressive properties of cannabinoids and also their potentials for cartilage repair and regeneration. Various wound healing techniques can be used to investigate the mechanisms of chondrocyte repair in monolayers or three dimensional tissue constructs. The effect of different concentrations of the synthetic cannabinoids WIN55, 212-2 (WIN-2), URB602 and HU-308 with and without their antagonists on the wound healing of chondrocyte monolayers was investigated using a simple scratch assay model. The three cannabinoids were found to increase wound healing of chondrocyte monolayers, but at different rates. WIN55, 212-2 at a concentration of 1μM had the highest effect of increasing both migration and proliferation of chondrocytes cultured in a chondrogenic media, which increased the rate of wound closure. It was also found that treating the cells with 2μM of any of the cannabinoids lead to a decrease in cell proliferation and the rate of wound closure. These findings were further investigated, by studying the effect of WIN-2 on nitric oxide (NO) and matrix metalloproteinase-2 (MMP-2) expressed by wounded chondrocyte monolayers. Moreover, expression of collagen type-I, collagen type-II, fibronectin and S100 proteins were detected using immunofluorescence and verified quantitatively using ELISA based techniques, following treatment with 1μM and 2μM of WIN-2, for both 2D monolayers and 3D sheets. Treating chondrocytes with 1μM of WIN-2 significantly increased collagen type-II, fibronectin and S100, and significantly reduced collagen type-I compared to control groups in monolayers and chondrocyte cell sheets. On the other hand, both concentrations of WIN-2 significantly reduced the expression of the inflammation markers NO, and MMP-2, in a dose dependent manner. These findings highlight the potential use of the synthetic cannabinoid for improving the rate of wound closure as well as acting as an antiinflammatory agent, which could be used to enhance tissue engineering protocols aimed at cartilage repair. / Egyptian Government

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Yes / Studies have been conducted to highlight the anti-inflammatory and immunosuppressive properties of synthetic cannabinoids as well as their potential for cartilage repair. Various wound healing techniques can be used to investigate the mechanisms of chondrocyte repair in monolayers or three dimensional tissues constructs. In this work the effect of WIN55, 212-2 (WIN-2) on nitric oxide (NO) and matrix metalloproteinase-2 (MMP-2) expressed by wounded chondrocyte monolayers was investigated. Moreover, expression of collagen type-I and type-II, fibronectin and S100 proteins were detected using immunofluorescence and quantitatively verified using ELISA based techniques following treatment with 1 μM and 2 μM of WIN-2. Treating chondrocytes with 1 μM of WIN-2 significantly increased expression of collagen type-II, fibronectin and S100, and significantly reduced collagen type-I expressions as compared to the control groups. On the other hand, both concentrations of WIN-2 significantly reduced the expression of the inflammation markers NO and MMP-2 in a dose dependent manner. These findings highlight the potential use of the synthetic cannabinoids for improving cartilage healing properties as well as acting as an anti-inflammatory agent which could be used to enhance tissue engineering protocols aimed at cartilage repair.

The potential antitumor activity of mixed CB1/CB2 cannabinoid receptor agonists, such as the aminoalkylindole WIN55,212-2 (WIN2), has been extensively studied, but little information is available as to their potential interaction with conventional cancer therapies, such as ionizing radiation (IR). In the present work, we investigated the effects of WIN2 on the antiproliferative effects of radiation in human (MCF-7 and MDA-MB-231) and murine (4T1) breast cancer cells, as well as an immortalized human breast epithelial cell line (MCF-10A). WIN2 or radiation alone inhibited breast tumor growth, while the combination of WIN2 and radiation was more effective than either agent alone in breast cancer cells. WIN2 showed lower potency in MCF-10A cells than MCF-7 cells, but was still able to augment the effects of radiation at higher doses. The stereoisomer of WIN2, WIN55,212-3 (WIN3) failed to inhibit growth or potentiate the growth-inhibitory effects of radiation, indicating stereospecificity in all cell lines tested. The combination of WIN2 and IR was examined in vivo but the results were inconclusive. Interestingly, while other aminoalkylindoles, pravadoline and JWH-015, enhanced the antiproliferative effects of radiation, this was not the case for other synthetic cannabinoids (i.e., nabilone, CP55,940 and methanandamide) or phytocannabinoids (i.e., ∆9-tetrahydrocannabinol and cannabidiol). The antiproliferative actions of WIN2 were not ameliorated by CB1, CB2, TRPV1, or PPAR receptor antagonists, suggesting the possibility of a novel site of action. Studies utilizing sphingosine-1-phosphate (S1P) agonists and estradiol suggest that WIN2 interferes with S1P signaling in cell proliferation, but agonist stimulated [³⁵S]GTPγS binding assays show that this antagonism is not occurring at the level of S1P receptors. In addition, WIN2 did not alter radiation-induced DNA damage or the rate of DNA repair based on γH2AX staining. Treatment with WIN2 and radiation promoted both autophagy and senescence, but not apoptosis or necrosis. Time course studies combined with senescence and cell death data suggest that radiation-induced senescence, while WIN2 induced classical growth arrest and the WIN2/IR combination produced parallel mechanisms of both senescent growth arrest and classical growth arrest. Taken together, these findings raise the possibility that aminoalkylindole compounds targeting a novel site of action represents a potential strategy to augment the effectiveness of radiation treatment in breast cancer.

In this thesis, control and guidance algorithms for unmanned sea surface vehicles are studied. To design control algorithms of different complexity, first a mathematical model for an unmanned sea surface vehicle is derived. The dynamical and kinematical equations for a sea surface vehicle are obtained, and they are adapted to real life conditions with necessary additions and simplifications. The forces and torques effecting on the vehicle are investigated in detail. Control algorithms for under-actuated six degrees-of-freedom model are designed. PID and LQR controllers are implemented to attain desired surge speed and yaw position. The autopilots are designed and their performances are compared. Based on the autopilots, a guidance algorithm is implemented to achieve desired motions of the vehicle. An obstacle avoidance algorithm is proposed for safe motion among the obstacles. A next-point generation algorithm is designed to direct the vehicle to the most appropriate next way-point if the one ahead is missed. The effects of disturbances on the motion of the vehicle are studied thoroughly on simulation results. PID controller for an unmanned sea surface vehicle is implemented on ArduPilot Mega v1.4 cart controlling a Traxxas Spartan model boat. The performance of the controller is validated. Simulations and experimental results are provided.

Most engineering systems are highly nonlinear in nature and thus one could not develop efficient mathematical models for these systems. Artificial neural networks, which are used in estimation, filtering, identification and control in technical literature, are considered as universal modeling and functional approximation tools. Unfortunately, developing a well trained monolithic type neural network (with many free parameters/weights) is known to be a daunting task since the process of loading a specific pattern (functional relationship) onto a generic neural network is proven to be a NP-complete problem. It implies that if training is conducted on a deterministic computer, the time required for training process grows exponentially with increasing size of the free parameter space (and the training data in correlation). As an alternative modeling technique for nonlinear dynamic systems / this thesis proposed a general methodology for structured neural network topologies and their corresponding applications are realized. The main idea behind this (rather classic) divide-and-conquer approach is to employ a priori information on the process to divide the problem into its fundamental components. Hence, a number of smaller neural networks could be designed to tackle with these elementary mapping problems. Then, all these networks are combined to yield a tailored structured neural network for the purpose of modeling the dynamic system under study accurately. Finally, implementations of the devised networks are taken into consideration and the efficiency of the proposed methodology is tested on four different types of mechanical systems.

Conformal airborne antennas have several advantages compared to externally mounted antennas, and they will play an important role in future aircrafts. However, they are subjected to vibration induced deformations which degrade their electromagnetic performances. With the motivation of suppressing such vibrations, use of active vibration control techniques with piezoelectric actuators is investigated in this study. At first, it is aimed to control the first three bending modes of a cantilever beam. In this scope, four different modal controllers / positive position feedback (PPF), resonant control (RC), integral resonant control (IRC) and positive position feedback with feed-through (PPFFT) are designed based on both reduced order finite element model and the system identification model. PPFFT, is a modified version of PPF which is proposed as a new controller in this study. Results of real- time control experiments show that PPFFT presents superior performance compared to its predecessor, PPF, and other two methods. In the second part of the study, it is focused on controlling the first three modes of a rectangular plate with four clamped edges. Best location alternatives for three piezoelectric actuators are determined with modal strain energy method. Based on the reduced order finite element model, three PPFFT controllers are designed for three collocated transfer functions. Disturbance rejection performances show the convenience of PPFFT in multi-input multi-output control systems. Performance of the control system is also verified by discrete-time simulations for a random disturbance representing the in-flight aircraft vibration characteristics.

In fin actuation systems, the performance of classical linear control systems is not satisfactory due to uncertainty of the system parameters and disturbances of the working medium. For this reason, sliding mode, H2 or H&infin / robust controllers are widely used in literature for such systems. However, use of such controllers results in very conservative system responses. Based on this fact, in this thesis, development of a more effective robust controller is aimed via integration of the optimum properties of the existent pure H2 and H&infin / type robust controllers. To achieve this, during the controller synthesizing procedure, some of the optimization parameters are weighted according to H2 norm minimization, and parameter uncertainties and other variables are weighted according to H&infin / theorem. First, the system set up to be controlled is physically constructed and performed system identification processes. Then, two different types of robust controllers H2 and H&infin / controllers are designed and tested over both the real system and simulation. Finally an H2/H&infin / mixed type controller synthesized and the results are compared with the outputs of the robust controllers of the previous step.