The master thesis is undertaking marketing research for company XXX, Ltd. which is providing hobby groups for children in kindergartens. This master thesis is specifically focused on marketing research of a new market Hodoninsko. This thesis is including analysis of external and internal environment, comparison of the plan with reality and proposals of how to improve the company operations.

Les membres du genre Morbillivirus, famille Paramyxoviridae sont responsables de graves maladies chez l'homme et les animaux, comme la rougeole, la peste bovine (RP) et la peste des petits ruminants (PPR). Malgré l'existence de vaccins efficaces contre ces maladies, des traitements spécifiques sont souhaitables. L'inhibition de la réplication de ces virus peut-être acquise par interférence ARN (ARNi), un mécanisme d'inhibition post-transcriptionnel déclenché par des séquences courtes d'ARN double-brin (siARN). Le CIRAD a précédemment identifié 3 siARNs ciblant des régions conservées du gène de la nucléoprotéine virale capables d'inhiber au moins 80% de la réplication in vitro des virus de la rougeole, de la RP et de la PPR. Cependant, un problème majeur dans la stratégie d'ARNi est le risque d'apparition de virus résistants. Dans cette étude, nous avons évalué le risque d'apparition de mutants d'échappement du virus de la PPR sous pression de sélection de 3 siARNs appliqués seul ou en association après plusieurs transfections successives in vitro. Excepté pour la combinaison des 3 siARNs, le virus a échappé à l'ARNi après 3 à 20 passages consécutifs, avec des mutations simples ou multiples (synonymes ou pas) ou une délétion de 6 nucléotides dans la zone cible des siARN. Ces résultats mettent en évidence une plasticité génomique inattendue des morbillivirus surtout illustrée par cette délétion non-délétère d'une partie significative d'un gène viral essentiel, qui devrait être considérée comme un obstacle à l'utilisation de l'ARNi comme thérapie antivirale. Cependant, l'utilisation combinée de 3 siARNs peut être proposée pour diminuer le risque d'échappement aux siARNs. / Viruses in the genus Morbillivirus, within the family Paramyxoviridae are responsible for severe humans and animal diseases, including measles, rinderpest (RP) and peste des petits ruminants (PPR). In spite of the existence of efficient vaccines against these diseases, specific treatments to be applied when the infection is already present are desirable. Inhibition of morbillivirus replication can be achieved by RNA interference (RNAi), a mechanism of post-transcriptional gene silencing triggered by small double-stranded RNA (siRNA). The CIRAD previously identified three siRNAs that target conserved regions of the essential gene encoding the viral nucleoprotein and are able to prevent in vitro at least 80% of the replication of measles, RP and PPR viruses . However, a major problem in RNAi is the important risk of emergence of escape mutants. In this study, we investigated the ability of PPR virus to escape the inhibition conferred by single or multiple siRNAs after several consecutive transfections in vitro. Except with the combination of the three different siRNAs, the virus systematically escaped RNAi after 3 to 20 consecutive passages. The mutations were characterized by either single or multiple punctual nucleotide mutations (synonymous or not) or a deletion of a stretch of 6 nucleotides into the siRNA target. These results demonstrate that the genomic plasticity of morbilliviruses, illustrated maily by this significant and no-deleterious deletion in an essential viral gene, should be considered as an obstacle to the use of RNAi in antiviral therapy. However, the combined use of three siRNAs can be proposed to prevent treatment failure with siRNAs.

Diploma thesis is focused on creating suitable marketing strategy for the firm of KOMÁNEK, s.r.o. based on external and internal environment analysis and own research. Thesis is divided into two parts. In the first part there is summarized existing theoretical knowledge so far and basic concepts of marketing. In the second part there is a description of the firm KOMÁNEK, s.r.o. and analysis of its external and internal environment using PESTE and SWOT analysis. At the end there are suggestions of marketing strategy based on the results.

The main aim of Diploma Thesis is management system analysis and sugestion of chosen company, according to a management functions. Strategic analysis is a part of company analysis. It includes the proposals and recommendations of management system which gives a support for a company position at the market and helps to improve company economic result.

The object of this diploma thesis is the composition of marketing plan for company MORAVOSTAV Brno, a.s. The theoretic part presents the basic information from the section of a marketing planning and methods. Next follows the characteristics of the set company and the analysis processing of the company present state. Acquired data are evaluated and applied in the particular concept of marketing plan for the year 2009.

The diploma thesis aims at analyzing Miss Claire Ltd., a distributor of perfumes and cosmetic goods. The situation of external and internal environment is described based on Porter Value Chain, indicators of financial analysis, PESTE and SWOT matrix. GE model and BCG matrix serve as complementary tools. All suggested strategies fulfill SMART criteria as well as strategic goal of Miss Claire Ltd, which is achievement of profitability and stabilization of market position.

The goal of the submitted thesis "Evaluation of the financial situation and proposals for its improvement" is based on economic analysis, assessment of the performance of the selected enterprises Montáže inženýrských sítí spol. s r.o. and identify the weaknesses of the company and then propose solutions to eliminate them. The first part is defined to theoretical and methodological bases of economic analysis. In the second part are then selected methods applied to a specific company. In this work are used to evaluate the economic performance of enterprises methods of financial analysis, PEST analysis, Porter’s five forces analysis and SWOT analysis. The results of the calculations is the synthetic part of the work assessed and management measures designed to improve the financial situation of the company.

This master’s thesis is focused on creation of business plan for creation of new company which offers services to seniors and employment of students at the same time. The base for formulation of SWOT analyse is analyse of external environment and branch analyse. Set up of strategy and the concrete business plan follow. Its practicability is supported by finance plan processed in variant.

Židlíková, E. Corporate Marketing Strategy. Diploma Thesis. Brno: Brno University of Technology, 2014. The thesis focuses on a marketing analysis of the Victoria company, a travel agency located in Brno. Its principal objective is to create a corporate marketing strategy based on a marketing research and analyses that determine preferences and interests of consumers in the area of tourism. The thesis is subdivided into two sections – theoretical and practical. The theoretical section comprises chapters describing various theoretical bases of marketing as well as the manner of drafting a marketing plan. The practical section presents practical findings related to the thesis.

The diploma thesis is focused on a preparation of a business plan for the establishment of a new home furnishing fabrics and decorations e-shop. It examines the present market and competition state. It contains a project implementation draft including a financial budget.