Purpose Lower serum vitamin D levels have been associated with an increased risk of aggressive prostate cancer. Among men with localized prostate cancer, especially with low-or intermediate-risk disease, vitamin D may serve as an important biomarker of disease aggression. The aim of this study was to assess the relationship between adverse pathology at the time of radical prostatectomy and serum 25-hydroxyvitamin D (25-OH D) levels. Methods This cross-sectional study was carried out from 2009 to 2014, nested within a large epidemiologic study of 1,760 healthy controls and men undergoing prostate cancer screening. In total, 190 men underwent radical prostatectomy in the cohort. Adverse pathology was defined as the presence of primary Gleason 4 or any Gleason 5 disease, or extraprostatic extension. Descriptive and multivariate analyses were performed to assess the relationship between 25-OH D and adverse pathology at the time of prostatectomy. Results Eighty-seven men (45.8%) in this cohort demonstrated adverse pathology at radical prostatectomy. The median age in the cohort was 64.0 years (interquartile range, 59.0 to 67.0). On univariate analysis, men with adverse pathology at radical prostatectomy demonstrated lower median serum 25-OH D (22.7 v 27.0 ng/mL, P = .007) compared with their counterparts. On multivariate analysis, controlling for age, serum prostate specific antigen, and abnormal digital rectal examination, serum 25-OH D less than 30 ng/mL was associated with increased odds of adverse pathology (odds ratio, 2.64; 95% CI, 1.25 to 5.59; P = .01). Conclusion Insufficiency/deficiency of serum 25-OH D is associated with increased odds of adverse pathology in men with localized disease undergoing radical prostatectomy. Serum 25-OH D may serve as a useful biomarker in prostate cancer aggressiveness, which deserves continued study. (C) 2016 by American Society of Clinical Oncology

Bakgrund Syftet med denna avhandling är att få veta mer om hur elever skapar mening i mötet med innehållet i skolans naturvetenskap. De resultat som presenteras i avhandlingen är resultat som visar hur eleverna uttrycker sig under utvalda interaktioner från naturvetenskaplig undervisning. Elevernas uttryck för meningsskapande jämförs också med vad som tidigare forskning rapporterat som svårt i skolans naturvetenskap. Lärandet betraktas genomgående som en sociokulturell aktivitet. Metoder För att kunna besvara frågan om hur ett meningsskapande uttrycks har elevernas uttalanden under interaktioner karaktäriserats kvalitativt och med objektet för undervisningen i förgrunden. Datainsamlingen har gjorts med ljud- eller videoinspelningar. Ämnesinnehållet i interaktionerna är i fokus och hur eleverna samtalar om genetik, cellandning, blodomlopp eller genomförandet av en laboration är centralt i avhandlingens delstudier. De deltagande eleverna är från grundskolans årskurs fem, årskurs nio och från gymnasiet. Resultat Resultaten visar en variation i hur ofta elever diskuterar och uttrycker någon egen mening om de naturvetenskapliga förklaringsmodellerna. När elever konstruerar begreppskartor med utvalda begrepp uttrycker gruppen sitt meningsskapande på sätt som många gånger närmar sig det vetenskapliga. En undervisningsfilm presenterar många vetenskapliga förklaringsmodeller av blodomloppets funktion, men få av dem används av eleverna i det efterföljande samtalet. I interaktioner under laborationer uttrycker elever inte så ofta ett meningsskapande av de naturvetenskapliga förklaringsmodellerna. Sammanfattning Avhandlingens delstudier ger prov på flera tillfällen när eleverna diskuterar ett meningsskapande av de naturvetenskapliga förklaringsmodellerna. Det finns också exempel när förklaringsmodellerna inte diskuteras, även om de för en skolad naturvetare helt uppenbart presenteras. En viktig faktor för att elevernas naturvetenskapliga meningsskapande ska ske är i studierna om undervisningen uppmärksammar hur naturvetenskapliga förklaringsmodeller knyter samman synliga fenomen med molekylära förklaringar och symboler. En annan faktor är om undervisningen lyfter fram naturvetenskapens sätt att kommunicera. Ytterligare en viktig faktor för att de naturvetenskapliga förklaringsmodellerna ska bli ett verktyg för elevernas meningsskapande är om det nya innehållet knyter an till elevernas tidigare vardagserfarenheter eller erfarenheter från tidigare undervisning.

Music therapists use songwriting interventions to address a variety of goals with several populations. Nevertheless, limited research exists regarding the use of songwriting interventions with individuals who are grieving. The purpose of this study was to examine practices and perceptions of board-certified music therapists working with clients who are grieving, specifically: (a) common interventions used to address grief (b) use of songwriting intervention; (c) perceived effectiveness of songwriting; and (d) music therapists’ comfort levels and training in implementing songwriting interventions. An online survey was sent to 6,292 board-certified music therapists, 324 of whom completed the survey. Participants reported that they use counseling techniques, singing, and songwriting with individuals who are grieving. Respondents indicated that songwriting was most effective in increasing emotional expression of clients who are grieving. All participants (N = 324, 100%) believed that songwriting could be an effective intervention for clients who are grieving. Music therapists expressed a need for further training in implementing songwriting interventions.

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Estuaries are unique coastal bodies of water where water derived from land meets the sea. In order to preserve estuaries and minimise the effects of human interference in these sensitive areas, an understanding of the hydrodynamics is essential. South Africa has 259 estuaries, of which approximately 70% are temporary open. The aim of the project was to provide data to analyse the effect of different flow scenarios on the frequency, timing and duration of mouth closure for temporary open estuaries. To achieve the project aim, two case studies were undertaken, namely Mhlanga and Mdloti Estuaries. Achieving the terms of reference required monitoring of the mouth state, water level, flow rates and developing an understanding of breaching mechanisms. Observations of the mouth were used to monitor its state and initially photographs were used to monitor the water level within each estuary. During 2003 a continuous water level monitor was developed and placed in each estuary. Velocity readings were taken upstream of the estuaries at discrete time intervals and converted to flow rates using the velocity area method. A photographic survey of the berm at Mhlanga Estuary was used to observe the effect of beach processes on the mouth area. The survey observed the estuary as it shifted from closed through to open, then partially open and finally closed again, providing information on mouth mechanisms. The continuous water level monitoring provides useful information for Mhlanga Estuary in terms of breaching patterns, tidal exchange when in the open state and an indication of the time scales involved in mechanisms which change the mouth state. Similar information for Mdloti Estuary was not available as the estuary did not breach since the installation of the water level monitors, however salinity profiles from 2002 provided qualitative information on the existence of a saline intrusion into the estuary. The relationship between flow and mouth state is complex and relies on other influences such as water level and systems losses. In general estuaries will breach under high flows and remain closed under low flows, however in between these two regimes the estuary mouth state is less predictable based on flow alone. Mhlanga Estuary repeatedly breached at low tide. During the open phase tidal influence was both observed and captured by water level monitors despite the perched nature of the estuary. Closure generally occurred at high tide trapping saline water within the estuary. The two case studies provided a good basis for exploring the affects of different flow conditions on estuaries, with Mdloti Estuary experiencing the effects of the Hazelmere Dam and abstractions, while Mhlanga Estuary has increased flow due to the discharge of treated effluent to the system. / Thesis (M.Sc.Eng.)-University of Natal, Durban, 2004.

SourceURL:file://localhost/Users/ClaesAct/Dropbox/LNU%20psykologi/Uppsats/Examensarbete_ClaesLilja_HT16_2PS600.doc Physical exercise has been associated with various health benefits, including improved cognitive functioning, well-being and life satisfaction. Other variables that have been found to explain these areas include gender, age, dispositional optimism, meditation practice, and videogame habits. The aim of the present study was to explore whether physical exercise on its own has benefits for visuospatial rotation abilities and life satisfaction. It was also the intention to examine how other known factors of age, gender, dispositional optimism, meditation, and videogames may help predict visuospatial rotation abilities and satisfaction with life. The results showed no significant explanation for visuospatial performance while finding some exercise measurements and physical activity level to have significant correlations with life satisfaction. Dispositional optimism was found to be the strongest indicator of life satisfaction, while gender was determined to not hold explanatory power for either of the criterion variables.

In this study an attempt has been made to explore the role of technology transfer in the economic growth of Iraq, through the change in the technology itself for the period 1960-1978. For this purpose the economy was disaggregated into seven sectors. The experience of developed countries has shown that technical change is one of the most important factors of economic growth alongside, or even overshadowing, such factors as labour and capital. In the light of technology transfer, developing countries have the advantage of introducing high levels of advancement of knowledge which can be used to induce domestic technical change at later stages. Technical change is normally defined as a shift in the production function, and for this reason two forms of production function were estimated and tested, i. e. the constant elasticity of substitution and the Cobb-Douglas function. Also two specifications (constant and variable) were assigned to technical change. To validate the use of these, statistical tests were conducted to establish the optimum fit. Then the selected form was used to simulate output levels for comparison with actual figures. The techniques used for estimation are both linear and non-linear. Data used are time series in real terms of capital stock and output, as well as number of persons employed. Furthermore in order to judge the importance of technical change to the growth of output on aggregate and sectoral levels, as regards economic growth, comparisons were drawn with existing data from other developed and developing countries, including centrally planned economies.

Previous research examining the impact of training and practice effects on modifying performance of fluid intelligence tasks (Gf) and crystallized intelligence tasks (Gc) were extended to include self-rated performance attributions among non-depressed and depressed older persons. The following general questions were addressed. How does level of depression affect performance on Gf and Gc measures and performance attributions? How does level of depression and degree of benefit from either training or practice relate to changes in attributional styles? The framework used for predicting shifts in attributional styles was the reformulated learned helplessness model. Three hundred twenty-five community-dwelling older persons completed the Gf/Gc Sampler, Beck Depression Inventory, and Attributions for Success/Failure Questionnaire at pretest, posttest (one week), and follow-up (one month). Between the pretest and posttest sessions, subjects participated in one of three experimental conditions; (a) cognitive (induction) training, (b) stress inoculation training, and (c) no-contact control groups. The results from univariate and multivariate analysis of covariance procedures provided partial support for the hypotheses. At pretest, both non-depressed and depressed older persons had internal attributional styles, although based on differential performance outcomes. The depressed persons were found to have more failure experiences as a result of their significantly poorer performance on Gf tasks, versus the non-depressed. Specific Gf training effects were documented regarding attributional shifts for the non-depressed, while there were no changes on their attributional style due to practice on either Gf or Gc tasks. In contrast, only differential practice effects were documented for depressed subjects across Gf and Gc tasks. The importance of assessing personality dimensions in older persons and their xelationship to training and practice effects were discussed, in addition to limitations of the study and suggestions for future research.

The rotational microwave spectra of the three isotopes (^13CH_3^12C^15N, ^12CH_3^13C^15N, and ^13CH_3^13C^15N) of the methyl cyanide molecule in the v_8=3, v_8=2, v_7=1 and v_4=1 vibrational energy levels for the rotational components 1£J£5 (for a range of frequency 17-95 GHz.) were experimentally and theoretically examined. Rotational components in each vibration were measured to determine the mutual interactions in each vibration between any of the vibrational levels investigated. The method of isotopic substitution was employed for internal tuning of each vibrational level by single and double substitution of ^13C in the two sites of the molecule. It was found that relative frequencies within each vibration with respect to another vibration were shifted in a systematic way. The results given in this work were interpreted on the basis of these energy shifts. Large departure between experimentally measured and theoretically predicted frequency for the quantum sets (J, K=±l, ϑ=±1), Kϑ-l in the v_8=3 vibrational states for the ^13c and ^15N tagged isotopes of CH_3CN showed anomalous behavior which was explained as being due to Fermi resonance. Accidently strong resonances (ASR) were introduced to account for some departures which were not explained by Fermi resonance.

The purposes of this study were to analyze (1) the changes over time in the state anxiety level of children in a computer-assisted program of reading instruction and in classroom reading instruction, (2) the changes in state anxiety patterns as related to gender, achievement level, and ethnicity, and (3) the difference in anxiety levels of the students while in computer-assisted reading instruction and classroom reading instruction.