Motivation Impairments of attention and memory are detectable in early psychosis, and often result in severe, longstanding functional impairments. Pharmacological interventions for cognitive impairments have been largely unsuccessful. The current study aims to explore the effects of aerobic exercise and mind-body exercise (yoga) on cognitive functioning and clinical symptoms in female patients with early psychosis. The potential neuromechanism underlying the clinical consequences was also investigated. Methods Female patients (n=120) diagnosed with schizophrenia spectrum disorders, brief psychosis, psychosis NOS, or delusional disorder (according to SCID) were recruited from three hospital/clinic sites. They were randomized into integrated yoga therapy group, aerobic exercise programme group, and waiting list as the control group. Both interventions were held three times weekly. At baseline and at 12 weeks, clinical symptoms, cognitive functions, quality of life and fitness levels were assessed in all participants, and completed structural MRI data were collected in 58 patients. Repeated measures ANOVA and ANCOVA analyses of the clinical, cognitive, quality of life and fitness data were compared between baseline and at 12 weeks among the three groups. Post-hoc Bonferroni test was used for comparing between two groups. Structural MRI data was analyzed by FreeSurfer V5.1 and Qdec V1.4 to calculate the brain volume and cortical thickness. Results Completed clinical and cognitive data were collected in 85 patients, and completed MRI imaging data of good quality were collected in 39 patients. No significant differences in age, education years, and duration of the illness at baseline were observed among the three groups. Both yoga and aerobic exercise groups demonstrated significant improvements in verbal encoding (p<0.01), short-term memory (p<0.05), long-term memory (p<0.01), and working memory (p<0.01) with moderate to large effect sizes compared to control groups. The yoga group showed significantly enhanced attention and concentration (p<0.05). Both yoga and aerobic exercise significantly improved overall clinical symptoms (p<0.05) and depressive symptoms (p<0.05) after 12 weeks. Significant increases were observed in the thickness of the left superior frontal gyrus and the right inferior frontal gyrus (pars triangularis) in the aerobic exercise group. Significant increases were observed in the volume of the postcentral gyrus and the posterior corpus callosum in the yoga group. There was a statistically significant correlation between improvements in working memory and changes in the postcentral gyrus (r=0.54, p<0.01) after controlling for the multiple comparisons with a Bonferroni adjusted alpha level. Discussion Both types of exercise improved memory in early psychosis patients, with yoga having a superior effect on attention than aerobic exercise. Observed increments in the cortical thicknesses and volume may indicate improved neurogenesis. Significance There have been few systematic clinical trial studying exercise and psychosis, and none of them has explored the effects of exercise in female patients with early stage psychosis. The present study indicates possible interventions for cognitive impairments in the patients with early psychosis, which are non-invasive and mostly safe. The application of yoga and aerobic exercise as adjunct treatments to treat psychosis in the clinical setting should be advocated. / published_or_final_version / Psychiatry / Doctoral / Doctor of Philosophy

Study Objectives. Sleep is regulated by internal mechanisms that respond to environmental cues. Physical activity is one external cue that can affect sleep. It has been suggested that exercise affects sleep in a variety of ways, including influencing neurotransmitter levels and altering circadian rhythms. The purpose of this study was to examine self-reported sleep quality both before and after a well- defined exercise protocol. Design, Setting, and Participants. The TIGER study involves a 15-week aerobic exercise intervention conducted in young adults (n=2,027, mean age 21.8 ± 5 y). Participants were required to engage in 30 minutes of aerobic exercise at 65-85% maximal heart rate reserve three times/week. Multivariate regression was used to identify factors associated with sleep quality and duration. Measurements and Results. Multiple measures of body size/composition, heart rate (HR), and blood pressure (BP) were obtained on all participants. Sleep quality and duration were accessed via a condensed sleep quality profile (SQP). Prior to exercise, age (p<0.001), gender (p<0.008) and overweight/obesity status (p<0.001), but not race/ethnicity, were all significantly associated with SQP score. Age (p<0.002), and race/ethnicity (p<0.05) were significantly associated with sleep duration, with African Americans and Hispanics having significantly shorter sleep times compared to non-Hispanic whites. SQP score was not significantly different following chronic exercise training. Conclusions. Although overweight/obesity groups had significantly different sleep quality scores before and after exercise, sleep quality did not change for subjects after 15 weeks of aerobic exercise intervention. / text

Proliferating tissues, including embryonic and tumour tissues, preferentially employ aerobic glycolysis to support cell growth. This reliance on glycolysis even in the presence of oxygen, referred to as the “Warburg Effect”, may confer a proliferative, survival and invasive advantage and be exploited therapeutically. In this thesis, we demonstrate that the glycolytic enzyme Hexokinase 2 (HK2) is crucial for the “Warburg Effect” in human Glioblastoma Multiforme (GBM), the most common and therapeutically resistant malignant brain tumour. In contrast to normal brain and low-grade gliomas, GBMs exhibited a marked increase in HK2 expression, but not HK1, particularly in perinecrotic, hypoxic regions and its expression predicted poor overall survival of GBM patients. Stable loss of HK2 in GBM cells restored oxidative phosphorylation (OXPHOS)-mediated glucose metabolism, with increased oxygen consumption and decreased lactic acid production, an effect not seen with loss of glycolytic enzymes HK1 or PKM2. Furthermore, HK2 depletion resulted in decreased proliferation in vitro and in vivo and increased sensitivity to apoptotic inducers such as radiation and chemotherapy, both common adjuvant therapies of GBMs. Intracranial xenografts of GBM cells with reduced HK2 demonstrated significantly increased survival with decreased proliferation and angiogenesis yet enhanced invasiveness. In contrast, exogenous HK2 expression in GBM cells promoted proliferation, therapeutic resistance and intracranial growth. This was dependent partly on the PI3K/AKT dependent translocation of HK2 to the mitochondrial membrane. Stable loss of glycolytic enzymes HK2, HK1 and PKM2 reduced GBM proliferation but differentially altered the PI3K/AKT/mTOR and AMPK signaling pathways, the extent to which may influence whether a cell preferentially undergoes autophagy or apoptosis as the primary mode of cell death. Collectively, targeting enzymes employed by the tumour to modulate its energy metabolism, such as HK2 in GBMs, may favourably alter its therapeutic sensitivity to radiation and both classical and novel chemotherapeutic agents.

Aerobic capacity of aerobic gymnasts while testing in specific and non-specific conditions The aim of the study: to determine an aerobic capacity of aerobic gymnasts while testing in specific and non-specific conditions. Objectives: · To compare submaximum heart rate and respiratory indices during treadmill and step tests. · To compare maximum heart rate and respiratory indices during treadmill and step tests. · To evaluate step test’s using opportunities for testing an aerobic capacity of aerobic gymnasts. Methods: 1. Continuously increasing step test. 2. Continuously increasing treadmill test 3. Measurement of respiratory gas exchange. 4. HR monitoring and recording. 5. Measurement of blood lactate concentration. 6. Anthropometrical measurements. The hypothesis of the study. Incremental increasing step test is able for evaluation of an aerobic capacity, heart rate and respiratory indices, especially submaximum, while testing under specific conditions, i. e. performing physical exercises on the aerobic platform dosing physical load according to the tempo of music. Practical application. The results access the physiological knowledges about aerobic gymnasts aerobic capacity. These data can be used for individualization of the physical loads in aerobic gymnastics. Originality of the study. First time using respiratory gas exchange telemetric system was performed an incremental increasing step test, while the physical load was dosed by music rhythm. The aerobic capacity of... [to full text]

In this study the stability and nutrient removal performance of aerobic granules under variable operating pH and variable growth medium was investigated. The results indicated that alkaline pH (pH=9) inhibited nitrogen and phosphorus removal. Moreover, high pH induced granules breakage and resulted in an increased biomass concentration in the effluent. On the other hand, acidic pH (pH=6) did not have significant impacts on stability and nutrient removal efficiency of granules. Changing the growth medium from acetate-based wastewater to municipal wastewater resulted in loss of biological phosphorus removal while ammonium and COD removal stayed the same. The granules disintegrated during the first two weeks after changing the feed; re-granulation of the biomass was observed after the acclimation of bacteria to the new growth medium. However, the granules breakage did not exert significant impact on settling property of biomass.

Proliferating tissues, including embryonic and tumour tissues, preferentially employ aerobic glycolysis to support cell growth. This reliance on glycolysis even in the presence of oxygen, referred to as the “Warburg Effect”, may confer a proliferative, survival and invasive advantage and be exploited therapeutically. In this thesis, we demonstrate that the glycolytic enzyme Hexokinase 2 (HK2) is crucial for the “Warburg Effect” in human Glioblastoma Multiforme (GBM), the most common and therapeutically resistant malignant brain tumour. In contrast to normal brain and low-grade gliomas, GBMs exhibited a marked increase in HK2 expression, but not HK1, particularly in perinecrotic, hypoxic regions and its expression predicted poor overall survival of GBM patients. Stable loss of HK2 in GBM cells restored oxidative phosphorylation (OXPHOS)-mediated glucose metabolism, with increased oxygen consumption and decreased lactic acid production, an effect not seen with loss of glycolytic enzymes HK1 or PKM2. Furthermore, HK2 depletion resulted in decreased proliferation in vitro and in vivo and increased sensitivity to apoptotic inducers such as radiation and chemotherapy, both common adjuvant therapies of GBMs. Intracranial xenografts of GBM cells with reduced HK2 demonstrated significantly increased survival with decreased proliferation and angiogenesis yet enhanced invasiveness. In contrast, exogenous HK2 expression in GBM cells promoted proliferation, therapeutic resistance and intracranial growth. This was dependent partly on the PI3K/AKT dependent translocation of HK2 to the mitochondrial membrane. Stable loss of glycolytic enzymes HK2, HK1 and PKM2 reduced GBM proliferation but differentially altered the PI3K/AKT/mTOR and AMPK signaling pathways, the extent to which may influence whether a cell preferentially undergoes autophagy or apoptosis as the primary mode of cell death. Collectively, targeting enzymes employed by the tumour to modulate its energy metabolism, such as HK2 in GBMs, may favourably alter its therapeutic sensitivity to radiation and both classical and novel chemotherapeutic agents.

Thesis (PhD)--University of South Australia, 1995

Thesis (M.A. (Psychology)) - Rhodes University, 2007.

Thesis (Ed.D.) -- Teachers College, Columbia University, 1991. / Typescript; issued also on microfilm. Sponsor: John P. Allegrante. Dissertation Committee: Bernard Gutin. Includes bibliographical references (leaves 171-185).

Theses (M.S.)--Marshall University, 2005. / Title from document title page. Includes abstract. Document formatted into pages: contains ix, 69 pages. Bibliography: p. 41-45.