Orientador: Lourenço Sbragia Neto / Dissertação (mestrado) - Universidade Estadual de Campinas, Faculdade de Ciencias Medicas / Made available in DSpace on 2018-08-07T00:05:25Z (GMT). No. of bitstreams: 1 Montanha_LucianeZanussoPagnossim_M.pdf: 1646758 bytes, checksum: 0ab1371fc4a273bbc0497f525a5b8c19 (MD5) Previous issue date: 2006 / Resumo: Este estudo foi realizado visando avaliar a evolução clinica do torcicolo congênito (TC) em 47 pacientes e comparar a eficácia da fisioterapia como tratamento para estes casos. O método utilizado foi o estudo retrospectivo onde as informações colhidas foram referentes a: antecedentes maternos como idade, tipo de parto e ser primigesta ou multigesta; antecedentes pessoais como sexo, data de nascimento, idade ao diagnóstico, ser primogênito, raça e doenças associadas; achados clinicos como distúrbio visual, plagiocefalia, existência de rotação cervical, presença de nódulo intramuscular, localização do nódulo no pescoço e complicações evolutivas e os dados referentes ao tratamento fisioterapêutico como data da \- consulta (Dl), data da última consulta (DU), data do início da melhora (DM), tratamento intensivo, tratamento mínimo, necessidade de intervenção cirúrgica, tempo total de tratamento e de cura. A classificação do tratamento foi definida em dois diferentes tempos, de acordo com a freqüência das sessões fisioterapêuticas: o intensivo, realizado diariamente, e o mínimo, 1 vez por semana. Na análise estatística aplicada, os testes utilizados foram o Chi-Quadrado e o Exato de Fisher, adotando os valores significantes para o valor p<0,05. Como resultado, pode ser observado que a evolução clínica foi satisfatória em ambos os grupos de tratamento e todas as crianças que aderiram à fisioterapia obtiveram a cura do TC. Conclui-se, portanto, que o tratamento fisioterapêutico é recomendado a crianças portadoras de TC, mesmo nos casos em que não é possível a realização diária da fisioterapia / Abstract: This study was carried out with 47 patients in order to assess the clinical evaluation of congenital torticollis and compare the effectiveness of physiotherapy as treatment. The applied method was a retrospective analysis of the clinical record of the patients where the picked up information referred to: maternal antecedents like age, birth type and being prime or multi birth; personal antecedents like sex, birth date, age at diagnosis, being prime birth, race and associated diseases, clinical findings like eyes defects, facial hemihypoplasia, neck rotation, presence of sternocleidomastoid tumor, tumor position in the neck and evolutive complications and the data referred to physiotherapy treatment like first consultation date (Dl), last consultation date (DU), begin of improvement date (DM), intensive treatment, minimal treatment, necessity of surgical intervention, time of treatment and the cure. The classification of the treatment was defined in two different times, according to the frequency of physiotherapy sessions, daily as intensive treatment and once a week as minimal. The tests used for statistical analysis were the Chi squared and the Fisher exact, with p < 0,05 as significant value. As result, it can be observed that the clinical evolution was satisfactory in both groups of treatment and all newborns who adopted the any treatment obtained the cure. Therefore, it can be concluded that the physiotherapy treatment is recommended to the children with TC, even in the cases where it was not possible the daily treatment / Mestrado / Pesquisa Experimental / Mestre em Cirurgia

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The study of signaling pathways that modulate multidrug resistance The theme of cancer cell resistance to anti-cancer drugs including the common mechanisms of resistance development and the theory of cancer stem cells was introduced in the Introduction to the doctoral thesis. The theoretical part was focused more deeply on the two topics - the role of ATP-binding cassette (ABC) transport proteins and chromosomal abnormalities in the development of cancer chemoresistance. The possible therapeutic potential for the treatment of cancer was stressed for both topics. The Results were composed of the commentaries on the five published works, which the author of the thesis conducted as the main author. The first work brought the evidence supporting the hypothesis of the existence of ABC gene expression profiles (signatures), which are common to multiple types of tumors and are associated with significant clinical consequences. These general ABC gene expression profiles could possibly form a new hallmark of cancer. The second work studied more closely a group of acute myeloid leukemia patients, who did not achieve complete cytogenetic remission after two attempts to maintain remission of the malignant disease. The new entity, consisting of patients with the translocation t(2;11)(p21;q23) without the...

The study of signaling pathways that modulate multidrug resistance The theme of cancer cell resistance to anti-cancer drugs including the common mechanisms of resistance development and the theory of cancer stem cells was introduced in the Introduction to the doctoral thesis. The theoretical part was focused more deeply on the two topics - the role of ATP-binding cassette (ABC) transport proteins and chromosomal abnormalities in the development of cancer chemoresistance. The possible therapeutic potential for the treatment of cancer was stressed for both topics. The Results were composed of the commentaries on the five published works, which the author of the thesis conducted as the main author. The first work brought the evidence supporting the hypothesis of the existence of ABC gene expression profiles (signatures), which are common to multiple types of tumors and are associated with significant clinical consequences. These general ABC gene expression profiles could possibly form a new hallmark of cancer. The second work studied more closely a group of acute myeloid leukemia patients, who did not achieve complete cytogenetic remission after two attempts to maintain remission of the malignant disease. The new entity, consisting of patients with the translocation t(2;11)(p21;q23) without the...

The extraction and analysis of human gait characteristics using image sequences and the subsequent classification of these characteristics are currently an intense area of research. Recently, the focus of this research area has turned to the realm of computer vision as an unobtrusive way of performing this analysis. With such systems becoming more common, a gait analysis system that will quickly and accurately determine if a subject is walking normally becomes more valuable. Such a system could be used as a preprocessing step in a more sophisticated gait analysis system or could be used for rehabilitation purposes. In this thesis a system is proposed which utilizes a novel fusion of spatial computer vision operations as well as motion in order to accurately and efficiently determine if a subject moving through a scene is walking normally or abnormally. Specifically this system will yield a classification of the type of motion being observed, whether it is a human walking normally or some other kind of motion taking place within the frame. Experimental results will show that the system provides accurate detection of normal walking and can distinguish abnormalities as subtle as limping or walking with a straight leg reliably. / Master of Science

The implementation of data mining techniques in the medical area has generated great interest because of its potential for more efficient, economic and robust performance when compared to physicians. In this paper, we focus on the implementation of Multiple-Instance Learning (MIL) in the area of medical image mining, particularly to hard exudates detection in retinal images from diabetic patients. Our proposed approach deals with the highly noisy images that are common in the medical area, improving the detection specificity while keeping the sensitivity as high as possible. We have also investigated the effect of feature selection on system performance. We describe how we implement the idea of MIL on the problem of retinal image mining, discuss the issues that are characteristic of retinal images as well as issues common to other medical image mining problems, and report the results of initial experiments. / Singapore-MIT Alliance (SMA)

Syftet med studien är att undersöka hur en population av potentiellt blivande föräldrar i åldrarna 20-40 år önskar att handläggning av informationen kring ultraljudsmarkörer bör se ut. Studien utformades som en pilotstudie med bekvämlighetsurval, och en enkät med parametrar fördelade på 11 scenarion utarbetades. Enkäten delades ut på föreläsningar i och omkring Stockholm i april 2012. 49 kvinnor och 36 män deltog i undersökningen. Potentiellt blivande föräldrar vill ofta få information om upptäckta softmarkers. Dock svarar en betydande del av försökspersonerna att de för vissa scenarion inte vill ta del av all tillgänglig information. Flest vill ha information vid obotliga tillstånd och när markören sitter i fostrets hjärna eller hjärta. De scenarion där flest svarar att de inte vill bli informerade är då markören sitter i fostrets tarm eller skelett samt när tillståndet är bortbart. Signifikanta skillnader uppmättes mellan olika gruppers svar. Kvinnor svarar oftare än män att de inte vill ha information om funna softmarkers. Detsamma gäller för sambos/gifta när man jämför dem med de som är singlar. De som hade barn vill oftare inte veta om att en softmarker har upptäckts jämfört med de som inte har barn. / The aim of the study was to investigate how potential new parents aged 20-40 would prefer the information about soft markers to be handled. The study was designed as a pilot study, and a questionnaire was made with parameters divided into 11 scenarios. The questionnaire was handed out at lectures in the Stockholm area in April of 2012. Answers were analyzed in SPSS with chi-2 tests. 49 women and 36 men participated in the study. Potential new parents often wish to be informed of discovered soft markers. However, a significant portion of the participants say they prefer not to know about soft markers in their foetus in some scenarios. Scenarios where the condition is incurable or where the soft marker is placed in the brain or heart of the foetus are the ones where the most people say they want the information. A soft marker placed in the foetus’ intestines or skeleton is when the most people answer that they do not wish to recieve this information. Significant differences are seen between different groups. Women more often than men say they do not want information about a discovered soft marker. The same is true for those who are married or cohabitating when compared to singles. Those who are already parents want information about a soft marker to a lower degree than those who do not have children.

Thesis (Ph. D.)--University of Hong Kong, 2007. / Title proper from title frame. Also available in printed format.