Bulls of various breedtypes including Angus (Bos taurus), Bonsmara (Sanga X Bos taurus), Brahman (Bos indicus), Romosinuano (Criollo), Tuli (Sanga) and Wagyu (Japanese Bos taurus) were utilized to evaluate the influence of tropical adaptation on adrenal and testicular function. The objectives were to determine if tropical adaptation influenced: a) response to management stressors, b) organ and gland weights, adrenal and testis StAR and P450 content and total adrenal, medullary and cortical areas, c) basal and hCG-induced testosterone and d) testis and epididymal sperm concentrations. Blood samples were obtained within 5 min before and after transportation and during restraint every 15 min for 6 h to evaluate cortical response. Angus, Brahman and Romosinuano bulls were slaughtered following sexual maturity. Cortical responses to transportation and restraint were not influenced by tropical adaptation. Response to these stressors could be categorized into high responders (Angus, Brahman), intermediate responders (Romosinuano, Tuli) and low responders (Wagyu, Bonsmara). Tropically-adapted breedtypes were not categorized into a single group; therefore, cortical responses to management stressors were influenced by breedtype, but not by tropical adaptation. Most organ and gland weights (actual weight and weight corrected for BW) and the steroid precursors, StAR and P450, were not influenced by tropical adaptation, but were by breedtype. Paired adrenal gland weight, total adrenal area, medullary and cortical areas were influenced by tropical adaptation. Tropically-adapted breedtypes had lighter glands and smaller areas than the temperate Bos taurus breedtypes. All breedtypes except Wagyu had similar basal concentrations of plasma testosterone prior to hCG administration; therefore, basal testosterone was not influenced by tropical adaptation, but only by breedtype. Wagyu had greater basal concentrations of testosterone than other breedtypes. Testosterone concentrations following hCG administration was similar between adaptation groups and breedtypes. As expected, testis and epididymal sperm concentrations were influenced by tropical adaptation. Tropically-adapted breedtypes had greater testicular and epididymal sperm concentrations than the temperate Bos taurus breedtypes during the summer months. In summary, adrenal weight and area and testicular and epididymal sperm concentrations were influenced by tropical adaptation. Cortical response to management stressors, basal testosterone and StAR and P450 content were influenced by breedtype, not tropical adaptation.

The discussion about 4P’s marketing mix covers two aspects. On the one hand, marketing mix activities are used to apply product into market and attract customers. Its activities are matched with every single market in different way. Managers are focused on country specification, customers’ demands and potential competitors. They analyse all factors, which can influence on future product’s adaptation. Enterprise’s success is measured by amount of selling as well as customer satisfaction and behaviour. On the other hand, it is not obviously that companies need to change their marketing strategies every time, when they want to expand their market to being more international. From this point of view differentiation among marketing mix activities are useful for at first gain new target group and meet their requirements. Subsequently, product can be customized. This thesis concludes theories about marketing mix components and its practical application.

This thesis deals with TV advertising strategies, namely adaptation and standardization, and with the impact of cultural homogenization on these strategies. Indeed, globalization generates the convergence of world cultures and especially of young Europeans’ cultures. This relative convergence in people’s habits, behaviour and values could allow advertisers to use more standardized advertisements without losing too much impact on the consumer. The use of standardized advertisements is interesting to create a uniform brand image, appeal to cross-border segments and, of course, make economies of scale. This thesis surveys young Europeans, represented by Swedes and Belgians, to examine their degree of cultural homogenization, i.e., if they are culturally similar enough for standardization to be effective on this group. Moreover, it compares the impact of both adapted and standardized commercials on this young European audience. This study comes to two main findings. First, the young Swedish and Belgian cultures have similarities, which standardized commercials can exploit, but also differences. This shows that we can speak about cultures’ convergence but not about a complete homogenization. Second, standardization seems to be effective - as effective as adaptation - in its appeal to young Swedes and Belgians. This shows that, given its advantages, standardization is certainly the most adequate method for targeting a young European audience. The findings for Sweden and Belgium should be valid for the whole EU. The thesis also discusses the generalization of the findings to the rest of the world and other age ranges as well as the future of commercials.

The essay investigates the film adaptation The Remains of the Day. The novel and film are used to give examples of ways the story of a novel can change when it is adapted for film. The theoretical framework is based on Linda Hutcheon's concept of orginality and fidelity.

Vasopressin (VP) is an antidiuretic hormone that is synthesized and released by osmosensitive magnocellular neurosecretory cells (MNCs) to regulate water homeostasis in the body. The rate and firing pattern of MNCs determines the amount of VP release, which is elevated during physiological stress particularly dehydration. During acute osmotic changes the MNCs shrink and swell due to hypertonic and hypotonic stimuli, respectively. In contrast to hippocampal neurons, which display regulatory volume increases (RVI) and regulatory volume decreases (RVD) in response to hypertonic and hypotonic stimuli, MNCs do not have compensatory mechanisms. The MNCs undergo hypertrophy as a part of their physiological structural and functional plasticity during chronic dehydration. These changes are thought to be important during long term osmotic changes for the sustained and high level releases of hormone. However, the mechanism of hypertrophy is still unclear and it is difficult to address this issue in vivo. We therefore undertook studies on acutely isolated MNCs to test hypertrophy in MNCs. We observed that acutely isolated MNCs treated with hyperosmolar solution (325 mOsmol kg-1) for 150 minutes in vitro showed hypertrophy (a 9% increase in CSA) and recovered their original size when returned to isotonic solution (295 mOsmol kg-1) for another 60 minutes. Whole cell patch clamp experiments showed a 34% increase in cell membrane capacitance following treatment with hypertonic solution for 90-150 minutes. The osmotically-evoked hypertrophic response was blocked by using a TAT (human immunodeficiency virus transactivator of transcription) peptide (TAT-NSF700) that prevents SNARE-mediated exocytotic fusion by blocking the function of NSF (N-ethylmaleimide-sensitive factor). The hypertrophic response did not appear to be altered by a scrambled version of the peptide, showing that osmotically-evoked hypertrophy depends on SNARE-mediated exocytotic fusion. The VP and OT-MNCs exposed to hyperosmolar solution for two hours showed increased immunofluorescence for L-type Ca²⁺ channels (both Cav1.2 and Cav1.3). Our data suggest that the osmotically-evoked hypertrophy is associated with an increase in the total membrane surface area due to the exocytotic fusion of intracellular granules with the plasma membrane and with increased expression of L-type Ca2+ channels. This study will be helpful in understanding of the adaptation that MNCs undergo during long term dehydration and pathological conditions that lead to increased plasma osmolality.

In May 2003, the first case of bovine spongiform encephalopathy (BSE) was identified in Alberta, and the impact was immediately devastating on farmers and rural communities across Canada. Not only were farmers faced by the impacts of BSE, they were also contending with record low farm incomes, changing commodity prices, and overall rural depopulation. One grassroots adaptation to this rural crisis is the adoption of Holistic Management (HM) by farmers in western Canada. Although growing in popularity, HM has yet to be systematically assessed in the literature. The overall objectives of this study were to characterize HM; to assess to what degree it simultaneously addresses environmental, economic, and social priorities; to examine the impacts caused by the BSE crisis on HM and non-HM producers; and to explore the potential of HM for adapting and dealing with future crises. This was carried out through a questionnaire that was mailed to 784 HM producers across western Canada. Qualitative and quantitative analysis of survey data showed that HM allowed producers to systematically address all three pillars of sustainability (environment, economic, and social). In particular, the social aspect emphasized in the practice of HM was unique compared to other approaches to agricultural sustainability that focus on economic and/or environmental priorities. When comparing HM producers to non HM producers, the HM producers were less impacted by the BSE crisis. Indeed, holistic managers described how the occurrence of BSE and subsequent consequences to the entire industry actually made them more resilient. The key factors that helped HM producers adapt to the BSE crisis were community involvement, within the family and larger community, and farm management. New farm practices, such as rotational grazing, and the HM clubs to support these new farm innovations/practices also aided producers in adapting to the BSE crisis. The results of this study demonstrate the value of alternative community based approaches that address agricultural challenges in a truly holistic and sustainable manner. / October 2008

Adaptation from literature to film has always been a much criticized enterprise, with fidelity criticism, or an attempt to discredit fidelity criticism, often driving the critical discussion. However, this type of thinking is somewhat limited, becoming circular and going nowhere productive. Instead, taking into account what has come before, this thesis attempts to settle on a method of examination that moves away from fidelity criticism and towards an approach that aligns itself with cultural studies. Adaptations, then, can be seen as products of the historical, cultural, political and general socio-economic framework out of which they emerge, owing perhaps more to their context of production than to their source material. In order to provide a case study that reflects this idea, this paper looks to an author who has been adapted on multiple occasions, Jane Austen, and examines her as a cultural construct. Looking at Austen’s most popular novel, Pride and Prejudice, and using Robert Z. Leonard’s Pride and Prejudice (1940), Cyril Coke’s Jane Austen ‘s Pride and Prejudice (1980), Simon Langton’s Pride and Prejudice (1995), Andrew Black’s Pride and Prejudice: A Latter Day Comedy (2003), Gurinder Chadha’s Bride and Prejudice (2004) and Joe Wright’s Pride & Prejudice (2005), the thesis argues that the appeal of Austen is a result of her cult status and economic viability, and also the malleability of her text, which allows filmmakers to use it in a number of different contexts, while still embodying the source material.

Successful adaptation to changes is of great importance to today’s workforce and for organizations. Built on the I-ADAPT theory (Ployhart & Bliese, 2006), this dissertation research explored the relationships among ability and personality factors, adaptability, and adaptive performance. Using a relatively simple skill acquisition task, the noun-pair lookup task, this research examined whether those relationships would be affected by the skill acquisition stages at which a change is introduced. As such, unexpected changes were introduced at different performance stages of the noun-pair lookup task. In one condition, participants experienced an unexpected change to the varied mapping (VM) version of the noun-pair lookup task at early stages of consistent mapping (CM) task learning. In the other condition, the change from the CM task to the VM task was introduced at late stages of the CM task learning. Two hundred and twenty five participants completed the noun-pair lookup task in one of two conditions. They also completed measures of two Big Five factors (openness to experience at the construct level and conscientiousness at the facet level), the I-ADAPT-M measure of adaptability, and tests of working memory capacity and perceptual speed. It was found that the timing of introducing a change did matter. Controlling for pre-change performance, participants had greater performance decrements when the change was introduced at late stages of the CM task practice than when it was introduced at early stages of the CM task practice. Ability factors and personality traits were found to be predictive of strategy choice in the CM task. There was no evidence of the moderating effect of the performance stage at which a change was introduced on the relationship between ability factors and adaptive performance. The mediation effect of adaptability on the relationship between ability and personality factors and adaptive performance was not supported. Adaptability as measured by I-ADAPT-M was also correlated with personality traits but not with ability factors or performance on the noun-pair lookup task. In conclusion, this dissertation showed the importance of making a clear distinction between adaptability and adaptive performance, and taking into consideration skill acquisition stages in task-related adaptive performance.

A fundamental challenge in evolutionary biology and medical genetic research is to connect the phenotype (a disease in humans or an adaptive trait in animals or plants) with the genotype. Using a classical example of an adaptive trait with a strong Mendelian genetic basis - warfarin resistance in the Norway rat (Rattus norvegicus), my dissertation tests the main hypothesis that speculated ‘simple’ adaptive trait has a more complex genetic architecture. Warfarin is an anticoagulant rodenticide used since the 1950s, and also is a widely prescribed blood-thinning drug in human. As a rodenticide, warfarin has initially been very effective. However, resistant rodents have evolved quickly and Vkorc1 (vitamin K epoxide reductase complex subunit 1) is the known resistance gene. As a popular drug, warfarin has a narrow therapeutic window with several genes VKORC1, CYP2C9, CYP4F2 established as biomarkers predicting warfarin dose in humans, suggesting a complex genetic architecture of warfarin resistance in rodents. In my thesis I performed network-guided genomic association studies (NetGWAS) and gene expression analysis to identify candidate genes involved in warfarin resistance based on a sample of ~600 wild rats from 19 populations in Germany. My thesis work revealed that the resistance mutation in Vkorc1 likely is under balancing selection and was recently introduced to the rat population in our study area. A key innovation of my thesis is adopting a NetGWAS approach to prioritize true associations and conducting co-expression network analysis to detect expression changes related to warfarin. My work shows that additional candidate genes are connected to the vitamin K pathway of which Vkorc1 is an essential component. While the validation of identified genes remains a challenge, the value of my thesis for future investigation is shown: one candidate gene Calu (Calumenin) is associated with warfarin resistance in multiple populations and is an essential part of the vitamin K cycle. Finally, my thesis briefly examines the genetics underlying a newly postulated cost of resistance, arterial calcification. This dissertation provides us an innovative framework in which we learned the genetic architecture of an adaptive trait in multiple dimensions: nucleotide or expression variation, genomic distribution and gene-gene interactions.

The purpose of this essay is, from a narratological point of view and also by employing film adaptation theory, to compare the novel The Golden Compass to its film adaptation and examine the narrative elements they have in common and those that are distinct for each medium. The aim is also to critically comment on these elements and to discuss to what extent the changes made affect the story and how it is perceived. The analysis that I have carried out shows that changes have been made regarding the plot order, i.e. sequences have been moved around or even removed in the film adaptation. The portrayal of the characters differs as well; some characters have been condensed while others have been extended to fit into the new frame of narrative. There are also differences in pacing between the original work and the adaptation. However, the changes do not affect the perception of the story and the story works very well in the new narrative structure.