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The treatment of alcoholism has had a unique historical development in the United States. This study provides a chronology of how the problem of alcoholism was defined and handled during various time periods in United States history. The process that evolved resulted in an abstinence based, comprehensive, multidisciplinary approach to the treatment of alcoholism as a primary disease based on the principles of Alcoholics Anonymous. This treatment modality, that developed outside of established medicine, is currently used by the majority of treatment providers. Seven individuals who have been actively involved in alcoholism treatment were interviewed. In addition to archival research, biographies and autobiographies were examined to gain a broad perspective. Because alcoholism is both a collective and an individual problem an effort was made to include a microsociological frame of reference within a broad sociological view. Alcoholism, or inebriety, was first perceived as a legal and moral problem. By the end of the 19th century, inebriety was recognized as an illness differing from mental illness, and separate asylums were established for its treatment. Alcoholism is currently accepted and treated as a primary disease by the majority of social institutions, but the legal and moral implications remain. National Prohibition in the early part of the 20th century targeted alcohol instead of the alcoholic delaying any progress toward treatment which was made in the 19th century. The advent of Alcoholics Anonymous brought the first widely accepted hope for alcoholics. The treatment process that developed utilized the principles of Alcoholics Anonymous in a setting of shared recovery which has been difficult to quantify. In 1970 the allocation of federal funds for treatment and research brought the involvement of new disciplines creating both conflicts and possibilities. Alcoholism recovery has elucidated the connection of mind, body, and spirit.

Thesis (M.Dev.) --University of Limpopo, 2009 / There is dearth of information about the extent of alcohol abuse by teenagers, focusing mainly on the volume and the frequency of alcohol intake by teenagers especially in a rural setting. Most notable contributions are descriptive in nature and rely on cross-sectional analysis, with little specific focus on rural teenage alcohol abuse. To bridge the gap, this study quantifies the extent of alcohol abuse by teenagers in rural areas by means of a case study in Lebitso Senior Secondary School situated in Mopani District of Limpopo Province. STUDY DESIGN A mixed approach was used with the quantitative method taking the upper hand because of the nature of the variables for the hypotheses formulated which required statistical procedures. Simple random sampling was used as the study was characterized by the representation of the learners of one senior secondary school to represent the homogeneous nature of teenagers in a similar setting, in Limpopo Province. RESULTS The study population consisted of 251 male and female teenage learners of Lebitso Senior Secondary School. In the exploration of alcohol abuse by teenagers, the availability of liquor outlets in respect of the teenagers’households, and the socio-economic status of their families were revealed to have a bearing on their abuse of alcohol. 93% of teenagers had liquor outlets near their places of residence. The study has also shown that 87% of male learners and 13% of female learners had access to finances, which influenced their behaviour towards the abuse of alcohol. CONCLUSION Among the recommendations were that Education, Health, Safety and Security Sectors were to join hands in order to come up with preventative measures to deal with this problem.

Department of Psychology. Bibliography : leaves 72-76.

Police culture often valorises 'hard' drinking, and in NSW police label their heavy drinkers 'heroes'. It is queried if there is some relationship between occupational culture and drinking style.It is found that much of the current theorising about the origins and nature of problem drinking, such as psychological theorising about stress, is inadequate to explain and address the extraordinary level of high-risk drinking among police.This thesis explores alternative views such as critical and feminist perspectives on police culture, constructions of masculinity, and mechanisms of 'enabling', to discover whether these might prove more applicable and more productive. The research also explores the matter of whether a case can be made for taking alternative ideas and theories into account in designing intervention programmes for specific occupation contexts, and whether they raise any policy and practical implications for addressing problem drinking within the NSW Police Service. / Master of Science (Hons)

The primary focus of the present thesis is the exploration of factors that influence the dopamine (DA) neuron by examining the expression of the dopamine transporter (DAT), a marker of the DA neuron. The secondary focus of this thesis is on the serotonin neuron and in particular the serotonin transporter (SERT), a marker of the serotonin neuron. To this end three distinct and separate models have been employed. The goals of this thesis were: (1) to test the hypothesis that monoamine oxidase inhibition during development alters serotonergic innervation in the cortex and raphe, while not affecting relative DA innervation of nigrostriatal pathway, (2) to test the hypothesis that elevated brain levels of hypoxanthine (Hx) deleteriously affect the DA neuron, and (3) to test the hypothesis that densities of DAT and SERT in brainstem cell body regions distinguish alcohol-preferring vervet monkeys with different behavioral patterns of ethanol consumption. / Alterations in the activity of monoamine oxidase (MAO), a degradative enzyme that plays an important role in regulating levels of monoamine transmitters, may have a profound effect on brain development. The present study investigates relative DA and serotonin innervation of cortical and subcortical areas, measured by DAT and SERT densities, following MAO inhibition (A or B or A+B) in mice throughout gestation and early post-natal development. DAT binding was unaltered within the nigrostriatal pathway. The most significant finding reported here is that the combined MAO-A+B inhibition significantly reduced SERT binding by 25% in both the cortex and raphe nucleus. Lower levels of SERT binding were apparent during the early post-natal period (PND 14), a period during which pups were still exposed to MAO inhibitors in the dam's milk, but also persisted into later life (PND's 35 and 90) after inhibitors were no longer being administered. Persistent effects were restricted to cortex and raphe, suggesting a relative vulnerability of these regions to alterations in monoamine transmitter levels during development. / The second study presents data demonstrating that Hx delivered intracerebroventricularly significantly reduces the number of tyrosine hydroxylase immunoreactive cells (TH-ir) in the substantia nigra by 22% and 30%, at 7 and 21 days, respectively. After 3 days of Hx administration, striatal DA and serotonin were elevated over control levels by 22% and 25%, respectively, but returned to control levels by 7 days. The serotonin metabolite 5-HIAA was elevated after 3 days of Hx, but levels of DA metabolites were not different from control. Locomotion, a behavior thought to be related to DA transmission, was elevated following Hx treatment, as were presynaptic markers of the DA system such as DAT and TH protein levels. The persistent reduction in TH positive cell numbers suggests that Hx damages or kills DA neurons. The increase in intracellular DA at early time points suggests that Hx might interfere with DA release, possibly by temporarily inactivating DA neurons. These findings are consistent with the hypothesis that Hx, a purine significantly elevated in blood and CSF of Lesch-Nyhan patients, maybe involved in DA dysfunction. / Studies on alcohol abuse have focused on the mesolimbic DA pathway and the serotonergic influence within this pathway. Here we report that abstinent binge-drinking monkeys have significant reductions of SERT binding, and to a lesser extent, DAT binding in the midbrain region, while abstinent heavy-drinking subjects have elevated levels of DAT binding, as compared to controls. Both mesolimbic and nigrostriatal pathways are affected. CSF levels of both HVA and 5-HIAA substantiate the neuroanatomical differences between binge- and heavy-drinking vervets. Taken together, these findings provide a neurochemical profile with which to further distinguish subtypes of alcohol-preferring vervet monkeys.

This thesis encompasses studies that examine autonomic reactivity and neuropsychological function in preadolescent boys who are at-risk for developing alcoholism and conduct disorder. The literature suggests an association between cognitive impairments and behavioural undercontrol, and that autonomic hyperreactivity may facilitate the use of alcohol to dampen stress. Thus, either factor may contribute to early alcohol use. In the first study, preadolescent sons of male multigenerational alcoholics were found to be cardiovascularly reactive during cognitive stress, and impaired on tests of executive function. Furthermore, reactivity was correlated with anxiety, and executive function deficits with conduct problems. In the second study, reactivity during a laboratory aggression task was monitored and cognitive functions (attentional or memory processes and executive functions) were assessed among aggressive boys rated as disruptive, or anxious-disruptive. During the aggression task, anxious-disruptive boys, unlike disruptive boys or controls, moderated their aggression when their opponent engaged in retaliatory behaviour. Anxious-disruptive boys were more highly aroused throughout the task, and the neuropsychological assessment found they were impaired on tests of executive function, independent of attention and memory. In the third study, anxious-disruptive boys exhibited greater cardiovascular, electrodermal, and muscle tension reactivity than disruptive or control boys during cognitive stress, while disruptive boys were electrodermally underaroused. These studies suggest it is possible to delineate specific neuropsychological profiles among at-risk youth, using either a behavioural genetics model, or selecting for personality traits. There were consistent autonomic reactivity patterns across tasks among groups defined by similar behavioural profiles. Thus, while cognitive impairments and hyperreactivity may comprise a vulnerability among sons of alcoholics, thes

This study identifies the alcohol intaKe patterns of 274 white patients attending an Urban General Practice. The average consumption rate was 6.5 drinKs per person per weeK (d/p/w). 40X of the surveyed group did not consume any alcohol. The drinkers averaged 11 dIp/wo 72X of the males drank and 501: of the females dranK. 4.31: of the population surveyed were drinking more than 28 dIp/wo Marital status made no real difference to consumption rates but unemployment (16 d/p/w) and being a manual labourer (11.7 d/p/w) did. People who had lost either their occupation (11.7 d/p/w) or a close family member (9.3 d/p/w) in the preceeding year had higher than average (6,5 d/p/w) consumption levels and these were increased further if they had identified an alcohol abuser in their family. This study also identifies the useful supportive services available to this particular community and its health care worKers with a brief discussion of the type of service prOVided and method of access to the service. The appendix contains a list of the services with the relevant address. telephone number and where possible the name of a contact person. / Thesis (M.Prax.Med.)-University of Natal, Durban, 1986.

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