Bibliography: pages 158-170. / A randomised, placebo-controlled double-blind crossover design was employed in assessing the effects of piracetam treatment on the functional capacities of abstinent chronic alcoholics. A sample of 63 subjects, selected for reliability (to counteract an anticipated high drop-out rate) and for a minimum period of abstinence from problem drinking of three months was drawn from the William Slater Hospital, Rondebosch and commenced the trial. The trial consisted of two 8-week periods, with daily dosages of 4,8gm of piracetam or placebo. Subjects were assessed on a psychometric battery yielding a total of 31 scores at baseline, crossover (8 weeks) and trial termination (16 weeks). The final sample size was 48 after drop-outs and noncompliance had been taken into account. Scoring of test data for these subjects was completed before breaking protocols. Results were analysed by means, of two way analysis of variance with repeated measures on the trials variable. Only two of the 31 analyses yielded significant differences between piracetam and the placebo. These yielded opposed results, and as this number of significant results could be expected due to chance alone, it was concluded that they were probably chance results and that no differences existed between the effects of piracetam and placebo on the functional capacities of chronic alcoholics.

For a number of years a history of sudden onset of coma, followed later by death, was noted amongst Africans at King Edward VIII hospital, Durban. Necropsy, where performed, revealed no cause in many of these patients. In 1957 after cerebrospinal fluid had been examined in some of the cases it was seen that the only abnormality present was a low cerebrospinal sugar. Hypoglycaemia was suspected and blood sugar estimation confirmed it. Further investigation failed to reveal the cause of the hypoglycaemia and in some cases because of a "flat" glucose tolerance curve organic hyperinsulinism was suspected. In one case total pancreatectomy was performed but thorough macroscopical and histological investigation failed to reveal a tumour or hyperplasia, and the patient subsequently suffered from diabetes. In August 1958, I admitted an African female patient, of 26 years, to the ward in coma.

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Thesis (Ph.D.)--Boston University / PLEASE NOTE: Boston University Libraries did not receive an Authorization To Manage form for this thesis or dissertation. It is therefore not openly accessible, though it may be available by request. If you are the author or principal advisor of this work and would like to request open access for it, please contact us at open-help@bu.edu. Thank you. / Traditionally, alcoholism research focusing on the brain included only men. Recently, inclusion of women in brain-based alcoholism research has shown that gender differences in physiology and drinking habits contribute to unique profiles of cognitive, emotional, and neuropsychological dysfunction, as well as dimorphic patterns of structural brain damage and recovery. The present study employed functional and structural magnetic resonance imaging (MRI) of alcoholic men and women and demographically-similar control participants to explore how gender and alcoholism interact to influence: (1) interference by reward-salient distractor stimuli on working memory, (2) emotional processing and memory, and (3) drinking pattern associations with structural brain abnormalities. [TRUNCATED] / 2999-01-01

Thesis (M.A.) -- University of Texas at Arlington, 2008.

Thesis (Ph. D.)--West Virginia University, 2001. / Title from document title page. Document formatted into pages; contains x, 137 p. : ill. Vita. Includes abstract. Includes bibliographical references (p. 104-114).

Thesis (Ph. D.)--University of Florida, 1982. / Description based on print version record. Typescript. Vita. Includes bibliographical references (leaves 92-111).

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