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  • About
  • The Global ETD Search service is a free service for researchers to find electronic theses and dissertations. This service is provided by the Networked Digital Library of Theses and Dissertations.
    Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
31

Aromatic Amino Acid Studies

Sullivan, Patrick Timothy 12 1900 (has links)
Pyridine ring analogs of the aromatic amino acids phenylalanine and tyrosine were synthesized and studied in microbiological and mammalian systems.
32

Some nutritional and metabolic effects of histidine toxicity in the rat

Steele, Robert Darryl, 1946- January 1973 (has links)
No description available.
33

Amino acid metabolism and requirement in teleost during their early life stages and implications in fish formulated diets

Zhang, Yongfang, January 2007 (has links)
Thesis (Ph. D.)--Ohio State University, 2007. / Title from first page of PDF file. Includes bibliographical references (p. 145-153).
34

Regulation in aromatic amino acid biosynthesis in Saccharomyces cerevisiae

Brown, Judy Forsyth January 1987 (has links)
No description available.
35

Growth studies on mycobacterium BCG

Moore, David Franklyn January 1981 (has links)
No description available.
36

An investigation into mechanisms underlying the regulation of nitric oxide synthesis in the rat cerebellum

Toms, Nicholas Jeremy January 1994 (has links)
No description available.
37

Synthesis and pharmacological characterisation of novel agonists for AMPA and kainate receptors based on the natural product willardiine

Troop, Helen Marie January 2000 (has links)
No description available.
38

Synthesis of #beta#-carboxyaspartic acid derivatives and studies on 3-methoxycarbonylmethylene-3,4,5,6-tetrahydro- 2H-1,4-oxazine-2-one derivatives

Laughton, Peter January 1997 (has links)
No description available.
39

Synthesis of methionine and conformationally restricted tryptophan analogues and their incorporation into neuropeptides

Nichols, Paul David January 1994 (has links)
No description available.
40

POLYAMINE-MEDIATED DEGRADATION OF ORNITHINE DECARBOXYLASE IN CHINESE HAMSTER OVARY CELLS.

GLASS, JAMES RUSSELL. January 1987 (has links)
The objective of this research was to identify specific mechanisms involved in the regulation of ornithine decarboxylase, the first enzyme in the polyamine biosynthetic pathway. Immunochemical techniques were used to study post-translational modifications of the ODC protein in relation to activity alterations. Initial experimentation showed that Chinese hamster cells maintained in a defined medium express an ODC protein stable to intracellular degradation. Treatment of these cells with exogenous ornithine or polyamines resulted in a rapid loss of enzyme activity, without detectable changes in the enzyme specific activity. The loss of enzyme activity was a result of accelerated ODC degradation, as determined by immunoprecipitation of pre-labeled protein. In addition, spermidine, but not ornithine, totally inhibited new ODC synthesis. The mechanism of accelerated ODC degradation was investigated and found to occur by an apparent novel mechanism. Degradation of ODC was both ubiquitin-independent and non-lysosomal, and there was also no detectable accumulation of a modified form of ODC protein. In addition, it was found that a component of protein synthesis is required for this process, as inhibitors (cycloheximide, emetine, puromycin) blocked polyamine-accelerated degradation. ODC cDNA was used to synthesize both ODC specific mRNA and protein using in vitro synthesis. These systems may allow the generation of sufficient quantities of material which can be used to recreate in vitro the specific components involved in polyamine inhibition of ODC synthesis and the protease(s) responsible for degradation. The major finding of this work is the direct demonstration that ODC is a stable intracellular protein in the absence of putrescine and spermidine depleted cells (Chapter 2). In addition, that degradation occurs by a novel mechanism, with a requirement for some component of protein synthesis (Chapter 3). Finally, these studies describe the in vitro production of ODC protein and mRNA, which should facilitate further studies of polyamine regulation of ODC degradation and synthesis (Chapter 4).

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