Anorexia Nervosa (AN) and Bulimia Nervosa (BN) are diseases with considerable individual variation. Genetic background plays an important role in disease susceptibility and severity. To evaluate the relationship between certain genetic loci and diseases subtypes we genotyped and analysed evolution of selected clinical parameters. We investigated a group of 75 pacients with AN (1. study), 127 DSM-4 and ICD-10 diagnosed patients with AN and BN (2. study), and contributed to sample of 2907 AN patients in large GWAS study. Results from the 1st study support association of polymorphism -1438G/A in serotonine receptor 5-HT2A with AN and compare the results from other studies with metaanalyses. In next, polymorphism responsible for the serotonine neurotransmission (serotonine transporter 5-HTT, polymorphisms LPR and VNTR) the study shows different association trend of LPR with AN in Czech population compared to other studies. 5-HTT VNTR polymorphism had no observed association. The second study investigated the role of hemeoxygenase 1 (plays a pivotal role in metabolic stress protecting cells) in eating disorders, in interaction with enviromental stress. We investigated the usefulness of an aggregate measure of the risks of AN and BN that is based on genetic susceptibility loci and the added effect of...

Essstörungen sind prävalente psychische Störungen mit schwerwiegenden, oftmals langfristigen Auswirkungen auf die psychische und körperliche Gesundheit. Eine zunehmende Anzahl von klinischen Studien dokumentiert die Wirksamkeit verschiedener psychotherapeutischer Ansätze für spezifische Essstörungen. Im vorliegenden Themenheft 5 werden die Wirksamkeit von neuen Ansätzen zur Einzeltherapie und zur internet-basierten Rückfallprophylaxe, die Patientensicht auf die Therapie sowie die Relevanz von Faktoren des therapeutischen Prozesses bei verschiedenen Essstörungen beleuchtet. Weiterer Forschungsbedarf besteht insbesondere hinsichtlich des Prozesses und der Dissemination evidenzbasierter Psychotherapie für Essstörungen. / Eating disorders are prevalent psychiatric disorders with severe and longstanding 15 implications for mental and physical health. An increasing number of clinical studies documents the efficacy of certain psychotherapeutic approaches for specific eating disorders. This special issue addresses the efficacy of novel approaches in face-to-face individual therapy and Internet-based relapse prevention, patient views of treatment, and the relevance of therapeutic process factors for diverse eating disorders. Further research is particularly 20 warranted regarding the process and dissemination of evidence-based psychotherapy for eating disorders.

Objective: For eating disorders, a vast number of investigations have demonstrated the efficacy of psychological treatments. However, evidence supporting the impact of therapeutic process aspects on outcome (i.e., process-outcome research) has not been disentangled. Method: Using the Generic Model of Psychotherapy (GMP) to organize various process aspects, a systematic literature search was conducted on psychological treatment studies for anorexia nervosa, bulimia nervosa, binge-eating disorder, and eating disorders not otherwise specified. Results: Improved outcomes resulted for family-based treatment compared to individual treatment, for individual compared to group treatment, booster sessions, and positive patient expectations (GMP contract aspect); for nutritional counseling and exercising but not exposure with response prevention as adjunct interventions (therapeutic operations); for highly motivated patients and, to a lesser extent, for therapeutic alliance (therapeutic bond); as well as for rapid response and longer overall treatment duration (temporal patterns). Regarding other GMP aspects, studies on self-relatedness were completely lacking and in-session impacts were rarely investigated. Discussion: As most studies assessed only a limited number of process aspects, the ability to draw conclusions about their overall impact regarding outcome is rather limited. Therefore, future process-outcome research is needed beyond investigations of treatment efficacy for eating disorders.

Thesis (M.A.)--East Carolina University, 2009. / Presented to the faculty of the Department of Psychology. Advisor: Susan McCammon. Title from PDF t.p. (viewed May 3, 2010). Includes bibliographical references.

Thesis (M.A)--University of Missouri-Columbia, 2004. / Typescript. Vita. Includes bibliographical references (leaves 82-87). Also available on the Internet.

Thesis (M.A)--University of Missouri-Columbia, 2004. / Typescript. Vita. Includes bibliographical references (leaves 82-87). Also available on the Internet.

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Made available in DSpace on 2016-04-28T20:40:06Z (GMT). No. of bitstreams: 1 Kelly Cristina Arrigatto Goncalves.pdf: 1574036 bytes, checksum: f27be8d55d7bb24392bac96ba062b279 (MD5) Previous issue date: 2009-06-05 / A research about anorexia and bulimia that had its start in the cyberspace and overflowed to the real world, this is the true abstract of what the present paper represents. The research started through a website known as Orkut, where I searched for online communities of anorexic and bulimic girls, and also where I invited them to take part in my research, through an interview using MSN. When I interviewed the young women with eating disorders, I tried to keep as my focus the relationship between the etiology of eating disorders and the family relations. As the research went on, I collected a wide variety of interviews, both of anorexics and bulimics. While I was researching on the internet, I enrolled in an institution that offers psychoanalytic treatment to the youth that suffers from anorexia and bulimia, called CEPPAN, Centro de Estudos e Pesquisas em Psicanálise da Anorexia e Bulimia. Due to CEPPAN and the internet, I was able to achieve clinical experience in cases of anorexia and bulimia. Therefore, my research ended with data that blended clinical experience with a careful statistical analysis of the interviews collected using the internet. The research was successful in confirming some of the major psychoanalytical hypothesis about eating disorders and to offer a new finding, which is the high prevalence of anorexia and bulimia among those which I called the first daughter of the couple, that is, the first woman to be born, regardless of the presence or absence of brothers / Uma pesquisa sobre anorexia e bulimia, que teve início no mundo virtual e acabou transbordando para o real constitui o verdadeiro resumo do que a presente dissertação de mestrado apresenta. A pesquisa teve início através do site de relacionamento Orkut, onde busquei comunidades virtuais de anoréxicas e bulímicas, e as convidei a participar de uma entrevista pelo MSN. Ao entrevistar as jovens com transtornos alimentares, tentei manter o foco na relação entre a etiologia dos transtornos alimentares e as relações familiares. Aos poucos, coletei um amplo número de entrevistas, tanto de anoréxicas quanto de bulímicas. Ao mesmo tempo em que pesquisava pela internet, comecei a freqüentar uma instituição que oferece tratamento psicanalítico para jovens com anorexia e bulimia, o CEPPAN, Centro de Estudos e Pesquisas em Psicanálise da Anorexia e Bulimia. Através do CEPPAN e também da internet acabei tendo experiência clínica com casos de anorexia e bulimia. Portanto, o resultado foi uma pesquisa que misturou experiência clínica com uma análise estatística cuidadosa dos dados coletados através da internet. A pesquisa teve sucesso ao confirmar algumas das principais hipóteses da psicanálise sobre os transtornos alimentares e propor um novo dado, que é a alta prevalência de anorexia e bulimia entre o que chamei de primeira filha do casal, isto é, a primeira mulher que nasce, independentemente da presença ou não de irmãos

Diss. (sammanfattning) Stockholm : Karol. inst., 2006. / Härtill 4 uppsatser.

The most common eating disorders (EDs) according to DSM-5 are anorexia nervosa (AN), bulimia nervosa (BN) and binge eating disorder (BED). These disorders have received increasing attention in psychiatry due to rising prevalence and high morbidity and mortality. The diagnostic category “anorexia nervosa,” introduced by Ernest-Charles Lasègue and William Gull in 1873, first appears a century later in a German textbook of psychiatry, authored by Gerd Huber in 1974. However, disordered eating behavior has been described and discussed in German psychiatric textbooks throughout the past 200 years. We reviewed content regarding eating disorder diagnoses but also descriptions of disordered eating behavior in general. As material, we carefully selected eighteen German-language textbooks of psychiatry across the period 1803–2017. Previously, in German psychiatry, disordered eating behaviors were seen as symptoms of depressive disorders, bipolar disorder or schizophrenia, or as manifestations of historical diagnoses no longer used by the majority of psychiatrists such as neurasthenia, hypochondria and hysteria. Interestingly, 19th and early 20th century psychiatrists like Kraepelin, Bumke, Hoff, Bleuler, and Jaspers reported symptom clusters such as food refusal and vomiting under these outdated diagnostic categories, whereas nowadays they are listed as core criteria for specific eating disorder subtypes. A wide range of medical conditions such as endocrinopathies, intestinal or brain lesions were also cited as causes of abnormal food intake and body weight. An additional consideration in the delayed adoption of eating disorder diagnoses in German psychiatry is that people with EDs are commonly treated in the specialty discipline of psychosomatic medicine, introduced in Germany afterWorld War II, rather than in psychiatry. Viewed from today’s perspective, the classification of disorders associated with disordered eating is continuously evolving. Major depressive disorder, schizophrenia and physical diseases have been enduringly associated with abnormal eating behavior and are listed as important differential diagnoses of EDs in DSM-5. Moreover, there are overlaps regarding the neurobiological basis and psychological and psychopharmacological therapies applied to all of these disorders.