The first essay considers the relative effectiveness of government and non-governmental organizations (NGOs) as channels to allocate resources. I use a catastrophic climate-related shock--Hurricane Mitch--to examine the political economy of these channels of aid distribution at the micro level. I combine extensive data on aid received by Nicaraguan households with data on municipal election outcomes and an exogenous, precipitation-based measure of hurricane impact. I find that the hurricane had long-lasting effects on the aid received by households from both NGOs and the government. In the short term, however, the government did not provide aid according to the objective measure of hurricane damage but instead provided aid along political lines. The second essay presents estimates of a relationship between extreme hot temperatures during gestation and a child's subsequent physical well-being in a sample of children in Peru, thus extending existing evidence constructed from U.S. data. Estimates are constructed using high-resolution gridded climate data and geo-coded household surveys. The results suggest that a period of extreme heat (a month whose average temperature is more than 2 standard deviations above the local average) in the period 1 to 3 months before birth is associated with lower weight at birth and a reduction in height (measured 1 to 59 months after birth) that cannot be fully explained by birth weight. There is no evidence of differential maternal investment, as measured by duration of breastfeeding, according to a child's exposure to extreme heat during gestation. The third essay asks whether improved treatment of HIV/AIDS in Africa can be achieved simply by paying health workers to do more. I present estimates of the impact of financial incentives paid to individual workers at public health facilities in Mozambique. The results suggest that piece-rate incentives increased the delivery of five out of fourteen health services for which treatment effects can be identified, with estimated increases ranging from 34 to 157 percent, depending on the particular service. I find no evidence of a corresponding decrease in the delivery of services that are not financially incentivized, suggesting that there is no "crowding out" of intrinsic motivation.

We investigated the relationship between glucose tolerance and birth weight in a group of 7-year-old black South Africans on whom longitudinal anthropometric data were available. Oral glucose tolerance tests (OGTT’s) were carried out on 152 subjects and inverse correlations were found between birth weight and the total amount of insulin secreted during the first 30 minutes (r= -0.19, p=0.04) and the last 90 minutes (r= -0.19, p=0.04) of the oral glucose tolerance test and also between birth weight and the 30 minute glucose concentrations (r= -0.20, p=0.02). Children born with low birth weights but who had high weights at 7 years, had higher insulin concentrations and indices of obesity compared with those with low birth weights and low weights at 7 years of age. There were also positive correlations between weight velocity and BMI (r=0.24, p=0.02) and weight velocity and postprandial insulin levels (r=0.31, p=0.001). Thus low birth weight in conjunction with rapid childhood gains in weight especially as subcutaneous fat, produces poor glucose tolerance in 7-year-old children and may make them susceptible to the development of Type II diabetes later in life.

Background: Limited epidemiologic studies have investigated the effects of pesticide exposure during pregnancy on low birth weight in offspring in rural China.Methods: A survey of a total of 503 women was conducted in Ling county of Shandong Province of China following delivery from 1 November 2009 to 8 February 2010.Results: After adjustment for confounding and compared with no pesticide exposure, multiple logistic regression showed a non-significant increased likelihood of low birth weight for both children of mothers exposed to pesticides when not pregnant (OR = 1.80, 95% CI: 0.62, 5.22) and mothers exposed to pesticides during pregnancy (OR = 2.42, 95% CI: 0.73, 8.08); multiple linear regression showed a non-significant reduced birth weight for both children of mothers exposed to pesticides when not pregnant (β=–0.59, p=0.28) and mothers exposed to pesticides during pregnancy (β=–0.89, p=0.15).Conclusions: Exposure to pesticides during pregnancy was associated with a non-significant increase in low birth weight in this rural Chinese population. Future studies using larger sample sizes and longer follow-up periods are warranted.

Thesis (Ph. D.)--Michigan State University, 2004. / Includes bibliographical references.

<p>Background: Childrens health, particularly in the early years, forms the basis of future health and development and plays a significant role in predicting individual life and opportunities. Thus, studies which enhance the understanding of the determinants of childrens health status are needed. Previous research on childrens health had focused on the familys and infants characteristics and ignored the potential impact of macro-level influences. The objectives of this thesis were (i) to examine the independent effects of neighbourhood factors on childhood health outcomes, (ii) to explore neighbourhood moderating effects on the associations between some individual risk factors and childhood health outcomes, and (iii) to quantify the contribution of neighbourhood factors to childhood health outcomes.</p><p>Method: The study population included 9,888 children born to women residing in Saskatoon during three years, 1992-1994. The data used in this study were extracted from three sources. The information related to birth outcomes and the mothers characteristics was extracted from the birth registration files maintained by Saskatchewans Vital Statistics Branch. The health services utilization information was generated from Saskatchewan Healths computerized administrative databases. The information related to the neighbourhood characteristics was obtained from Statistics Canadas 1991 Census, from local sources such as the Planning Department of the City, and two specialized neighbourhood surveys. Six domains of neighbourhood were examined in this study: socio-economic disadvantage, social interaction, physical condition, population density, local programs and services, and unhealthy lifestyle norm. This study was divided into two focused topics corresponding to two childrens health outcomes: low birth weight (LBW) and childrens hospitalizations (both incidence and length of stay). Multilevel modelling was employed to examine the independent/moderating impacts of neighbourhood characteristics on these childrens health outcomes. GIS mapping was used to visualize the associations between neighbourhood characteristics and childrens health outcomes.</p><p>Findings of focused topic 1: There was a significant variation across Saskatoon neighbourhoods in the distribution of LBW rate. This significant variation was attributed to both the characteristics of individuals living within the neighbourhoods as well as the characteristics of the neighbourhood of residence. Neighbourhood variables were both independent risk factors for LBW and moderators for the association between maternal characteristics and LBW. Specifically, a greater level of socio-economic disadvantage, a lower level of program availability and accessibility within the neighbourhoods were associated with a higher risk of LBW. A significant interaction between neighbourhood social interaction and single parent status was found. The risk of single parent status on LBW was mitigated by a greater level of social interaction within neighbourhoods. With individual level variables held constant, three neighbourhood variables predicted LBW, together contributing to a change in LBW rate of 7.0%.</p><p>Findings of focused topic 2: This focused topic employed a longitudinal/multilevel design to examine the effects of socio-economic status at multiple levels on childrens hospitalization. The key findings of this focused topic are the following: (i) There was a gradient association between the number of adverse birth outcomes and childhood hospitalization; (ii) There was a significant interaction between family income and adverse birth outcomes (i.e., the effect of adverse birth outcomes on childhood hospitalization was heightened among those children living in low income families); (iii) Neighbourhood characteristics, specifically neighbourhood socio-economic disadvantage, neighbourhood physical condition, and neighbourhood population density had independent effects on childhood hospitalization over and above the effect of family income; (iv) With individual level variables held constant, three neighbourhood variables (i.e., neighbourhood socio-economic disadvantage, physical condition and population density) together accounted for a variation of 40% in the incidence rate of hospitalization, and two neighbourhood variables (i.e., neighbourhood socio-economic disadvantage and physical condition) together accounted for a change in the length of stay per hospitalization from 2.88 days to 5.18 days across neighbourhoods.</p><p>Conclusion: Both individual and neighbourhood characteristics determined childhood health outcomes examined. Neighbourhood factors acted as independent risk factors as well as moderators on the association between individual risk factors and health outcomes. The contribution of neighbourhood factors to childrens health outcomes was quite substantial. The findings suggest that future interventions aimed at improving childrens health status in Saskatoon may be enhanced by targeting both high risk individuals and high risk neighbourhoods. The geographical variations in childrens health outcomes reported in this study are modifiable; they can be altered through public policy and urban planning, and through the efforts of families and children.

Background and aim: Persons sustaining different types of brain injury may experience difficulties with advanced mobility. Both persons with traumatic brain injury (TBI) and persons born with very low birth weight (VLBW) have similar brain abnormalities, such as reduced white matter and connectivity, and may thus experience similar mobility problems. However, few studies have assessed advanced motor abilities, and none have compared mobility functions in adult TBI and VLBW populations. Our aim was to investigate high level mobility functions in adults with TBI and VLBW adults compared to matched controls, and to compare high-level mobility in TBI and VLBW adults. Methods: Participants consisted of 22 subjects (mean age 22.9 ± 2.0 yrs) with chronic traumatic brain injury, and 35 subjects (mean age 22.5 ± 0.7 yrs) born preterm with birth weight (below 1500 grams). Two TBI participants were not able to complete all test items due to pain. The VLBW group included three subjects with cerebral palsy (CP). Each group was matched with its own control group, consisting of 24 subjects each from the same geographical area matched by age and sex. Mean age in the control group was 23.3 ± 1.8 yrs for TBI and 22.8 ± 0.5 yrs for VLBW. Advanced mobility functions were assessed by the High-level Mobility Assessment Tool (HiMAT), which consists of 13 timed mobility tasks, with a maximum total HiMAT score of 54. Results: Mean total HiMAT score in the TBI group was 47.0 ± 7.7 compared to 50.3 ± 3.9 for the controls (U=193, p=0.116). Three of 13 mobility tasks differed significantly from the control group: ‘walking’, ‘walk over obstacle’ and ‘bound non-affected leg’. When the two subjects who reported pain were excluded from the analysis, mean total HiMAT score was 48.9 ± 4.9 (U=193, p=0.264), with ‘walking’ and ‘walk over obstacle’ remaining significantly different from the control group. In the TBI group, nine (40.9%) participants performed at or below the 5th percentile compared to 6 (25%) of the TBI controls. Mean total HiMAT score in the VLBW group was 45.1 ± 7.8 compared to 49.9 ± 3.5 in its control group (U = 256, p=0.011). Five of the 13 mobility task scores were significantly different from the control group: ‘walking backwards’, ‘running’, ‘hop affected leg’, ‘bound affected leg’, and ‘bound non-affected leg’. When the three subjects with CP were excluded, mean total HiMAT score was 46.8 ± 5.5 in the VLBW group (U=256, p=0.033) and three mobility task scores remained significantly different from the controls: ‘walking backwards’, ‘hop affected leg’ and ‘bound non-affected leg’. In the VLBW group, 17 (48.6%) participants performed at or below the 5th percentile compared to 4 (16.7%) of the VLBW controls. When directly compared to the VLBW group, the TBI group had (OR 0.733, CI 0.249 – 2.154) lower risk for performing at or below the 5th percentile, although not significant. Conclusions: Compared to controls, adults with TBI had reduced high-level mobility in specific tasks. Adults born with VLBW had reduced overall high level mobility. Furthermore, the HiMAT seems to be a valuable tool for assessing high-level mobility in VLBW populations, and should be formally tested for further use. Keywords: High-level mobility, high-level mobility assessment tool, traumatic brain injury, very low birth weight

<p>Background: Childrens health, particularly in the early years, forms the basis of future health and development and plays a significant role in predicting individual life and opportunities. Thus, studies which enhance the understanding of the determinants of childrens health status are needed. Previous research on childrens health had focused on the familys and infants characteristics and ignored the potential impact of macro-level influences. The objectives of this thesis were (i) to examine the independent effects of neighbourhood factors on childhood health outcomes, (ii) to explore neighbourhood moderating effects on the associations between some individual risk factors and childhood health outcomes, and (iii) to quantify the contribution of neighbourhood factors to childhood health outcomes.</p><p>Method: The study population included 9,888 children born to women residing in Saskatoon during three years, 1992-1994. The data used in this study were extracted from three sources. The information related to birth outcomes and the mothers characteristics was extracted from the birth registration files maintained by Saskatchewans Vital Statistics Branch. The health services utilization information was generated from Saskatchewan Healths computerized administrative databases. The information related to the neighbourhood characteristics was obtained from Statistics Canadas 1991 Census, from local sources such as the Planning Department of the City, and two specialized neighbourhood surveys. Six domains of neighbourhood were examined in this study: socio-economic disadvantage, social interaction, physical condition, population density, local programs and services, and unhealthy lifestyle norm. This study was divided into two focused topics corresponding to two childrens health outcomes: low birth weight (LBW) and childrens hospitalizations (both incidence and length of stay). Multilevel modelling was employed to examine the independent/moderating impacts of neighbourhood characteristics on these childrens health outcomes. GIS mapping was used to visualize the associations between neighbourhood characteristics and childrens health outcomes.</p><p>Findings of focused topic 1: There was a significant variation across Saskatoon neighbourhoods in the distribution of LBW rate. This significant variation was attributed to both the characteristics of individuals living within the neighbourhoods as well as the characteristics of the neighbourhood of residence. Neighbourhood variables were both independent risk factors for LBW and moderators for the association between maternal characteristics and LBW. Specifically, a greater level of socio-economic disadvantage, a lower level of program availability and accessibility within the neighbourhoods were associated with a higher risk of LBW. A significant interaction between neighbourhood social interaction and single parent status was found. The risk of single parent status on LBW was mitigated by a greater level of social interaction within neighbourhoods. With individual level variables held constant, three neighbourhood variables predicted LBW, together contributing to a change in LBW rate of 7.0%.</p><p>Findings of focused topic 2: This focused topic employed a longitudinal/multilevel design to examine the effects of socio-economic status at multiple levels on childrens hospitalization. The key findings of this focused topic are the following: (i) There was a gradient association between the number of adverse birth outcomes and childhood hospitalization; (ii) There was a significant interaction between family income and adverse birth outcomes (i.e., the effect of adverse birth outcomes on childhood hospitalization was heightened among those children living in low income families); (iii) Neighbourhood characteristics, specifically neighbourhood socio-economic disadvantage, neighbourhood physical condition, and neighbourhood population density had independent effects on childhood hospitalization over and above the effect of family income; (iv) With individual level variables held constant, three neighbourhood variables (i.e., neighbourhood socio-economic disadvantage, physical condition and population density) together accounted for a variation of 40% in the incidence rate of hospitalization, and two neighbourhood variables (i.e., neighbourhood socio-economic disadvantage and physical condition) together accounted for a change in the length of stay per hospitalization from 2.88 days to 5.18 days across neighbourhoods.</p><p>Conclusion: Both individual and neighbourhood characteristics determined childhood health outcomes examined. Neighbourhood factors acted as independent risk factors as well as moderators on the association between individual risk factors and health outcomes. The contribution of neighbourhood factors to childrens health outcomes was quite substantial. The findings suggest that future interventions aimed at improving childrens health status in Saskatoon may be enhanced by targeting both high risk individuals and high risk neighbourhoods. The geographical variations in childrens health outcomes reported in this study are modifiable; they can be altered through public policy and urban planning, and through the efforts of families and children.

No description available.

Thesis (M.P.H.)--University of Hong Kong, 2009. / Includes bibliographical references (p. 43-46).

Thesis (Ph. D.)--University of Washington, 2000. / Vita. Includes bibliographical references (leaves 70-78).