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Spiritual well-being is a well-established predictor of mental health, yet the potential mechanisms of this association are relatively unexplored. We examined the influence of spirituality, including religious and existential well-being, on depressive symptoms, and the potential mediating effect of optimism and pessimism, in a sample of 66 African American female suicide attempters. Participants were recruited from a large, urban hospital and completed the Spiritual Well-Being Scale, Life Orientation Test-Revised, and the Beck Depression Inventory-II. The association between spiritual well-being and depressive symptoms was mediated indirectly through both optimism and pessimism; greater religious and existential well-being was related to more optimism, and less pessimism and, in turn, to fewer depressive symptoms. Historically, spiritual well-being has been important to the African American community, and its beneficial effects on mental health might be explained, in part, by their effect on cognitive-emotional functioning.

The present study examined negative life events (NLEs) and sexual assault victimization as predictors of positive and negative psychological functioning in a sample of 151 female college students. Results obtained from conducting regression analyses indicated several notable patterns. NLEs, compared with sexual assault victimization, were a stronger negative predictor of positive functioning based on indices related to subjective well-being (e.g., life satisfaction, positive affect). Alternatively, sexual assault victimization, compared with NLEs, was a stronger positive predictor of negative functioning based on indices related to posttraumatic stress disorder symptoms (e.g., anxiety) and related conditions (e.g., alcohol use). Furthermore, both NLEs and sexual assault victimization were found to be positive predictors of negative functioning based on indices related to suicide risk (e.g., depressive symptoms, suicidal behaviors). Overall, our findings indicate that both NLEs and sexual assault victimization represent important and distinct predictors of psychological functioning in female college students.

Suicide represents a major problem for all members of society. Findings from studies have shown that suicide risk is among the highest in young adult populations. Although a variety of factors have been identified in trying to predict suicide risk in young adults, one variable that has received considerable attention has been social disconnectedness. For example, according to Joiner’s (2005) theory of suicide, being socially disconnected from others represents a critical factor that heightens a person’s risk for suicide. Consistent with this view, findings from numerous studies have shown a reliable association between loneliness and suicide risk (Hatcher & Stubbersfield, 2013). For example, Chang and his colleagues (Chang et al., 2015; Chang, Muyan, & Hirsch, 2015; Muyan & Chang, 2015) have found a reliable association between loneliness and greater suicide risk (e.g., hopelessness, suicidal behaviors) in diverse cultural groups. Indeed, in one study, Chang, Hirsch, Sanna, Jeglic, and Fabian (2011) found that loneliness was an important predictor of suicide risk in Latina college students. Although these findings are important and point to the potential value of loneliness as a predictor of suicide risk in diverse adult groups, they do not take into account more culture- specific variables. Accordingly, we conducted the present study to examine the extent to which culture- specific (emic) variables might play an important role in predicting suicide risk, and to also determine if the inclusion of a general (etic) explanatory variable would add to the prediction of suicide risk, namely, hopelessness and suicidal behaviors, in a sample of 155 Latino college students. We conducted a pair of regression analyses including demographic variables (viz., age & sex) in the First Step, ethnic identity variables (ethnic affirmation, ethnic identity achievement, ethnic behaviors, & other group orientation; Phinney, 1992) in the Second Step, and loneliness (Russell, Peplau, & Curtrona, 1980) in the final Third Step, in predicting hopelessness and suicidal behaviors. Results of these analyses for both outcomes indicated that demographic variables did not account for significant variance in suicide risk. However, ethnic identity variables, as a set, were found to account for a significant 11% of the variance in hopelessness, and a significant 10% of the variance in suicide behaviors. Noteworthy, the inclusion of loneliness was found to account for an additional 19% of unique variance in hopelessness, and an additional 13% of unique variance in suicidal behaviors. Taken together, our findings underscore the importance of considering both emic and etic factors in trying to identify variables that may place Latinos at heightened risk for suicide. Additionally, our findings also point to the potential value of targeting specific ethnic identity variables (e.g., ethnic identity achievement) as well as loneliness when working with Latinos at risk for suicide.

Depression is a serious public health concern and leading cause of global disability; in the U.S., it is estimated that over 35 million individuals suffer from depression. Health-related dysfunction, including impairment and poor quality of life, are often associated with depressive symptoms; however, little research has examined the interrelationships between these factors. Functional impairment, or the experience of difficulty conducting necessary activities of daily living, may contribute to emotional distress directly but may also impact perceived quality of life. Health-related quality of life (HRQL), which is conceptualized as a holistic and subjective perception of one’s physical and mental quality of life, is a wellestablished indicator of overall general health. Given the dearth of research examining the linkages between these variables, we hypothesized that greater levels of functional impairment would be positively related to depressive symptoms and that physical and mental HRQL would mediate this association, such that greater functional impairment would be associated with poorer mental and physical HRQL and, in turn, to greater depressive symptoms. Our sample (N=100; 70.3% female (N=71); 93% Caucasian (N=94); Mean Age = 42.18, SD = 12.83) was recruited from a rural, Southern Appalachian primary care clinic serving working and uninsured patients. Participants completed self-report measures: Instrumental Activities of Daily Living Scale, World Health Organization Quality of Life Scale - Brief, and the Center for Epidemiological Studies Depression Scale. Simple mediation analyses, consistent with Preacher and Hayes, were conducted covarying age, sex and ethnicity. In support of our hypothesis, the direct effect of functional impairment on depressive symptoms decreased but remained significant (DE=-1.39, SE=.66, p=.03) when mental HRQL was included as a mediator (IE lower 95% CI=-3.27, upper 95% CI=-.877), indicating partial mediation. In addition, the direct effect of functional impairment on depressive symptoms fell out of significance (DE=-1.18, SE=.33, p=.15) when physical HRQL was included as a mediator (IE lower 95% CI=-3.79, upper 95% CI=-.83), indicating full mediation. Our findings suggest that individuals experiencing functional limitations are less likely to report good mental and physical HRQL and, in turn, endorse higher levels of depressive symptoms. Our findings may have clinical implications; therapeutic enhancement of coping skills and problem-solving strategies may reduce psychological distress, whereas engagement with social and instrumental support networks may provide assistance with physical limits, thereby reducing risk for depressive symptoms in individuals experiencing functional impairment.

Objectives: Asthma is a genetic disease that requires an environmental trigger to manifest in predisposed individuals. This study aims to assess the prevalence of asthma among U.S. adolescents and possible environmental triggers to asthma. Methods: This is a secondary analysis of the Youth Risk Behavioral Survey 2015 (YRBS 2015). A total of 15,624 high school students in the U.S. were included in this analysis. The YRBS was established by Center for disease control and prevention (CDC) in 1991 to monitor six priority health risk behaviors among youths and young adults. Data were collected via self-administered questionnaire which was validated by CDC through a two test reliability studies. The Data was analyzed using SAS v 9.4. Results: The overall prevalence of asthma was 23.08% with no significant difference between male (22.84%) and female (23.31%). Simple logistic regression analysis showed that the estimated odds of having asthma among individuals that initiated cigarette smoking before the age of 13 years was about 40% higher than those who did not (Odds Ratio (OR): 1.40, 95% CI: 1.22-1.62, p<0.0001). The odds of having asthma was also significantly higher among individuals who used marijuana before the age of 13 years (OR: 1.25, 95% CI: 1.11-1.46, p<0.001) than those who did not. Furthermore, the estimated odds of having asthma was 25% higher in individuals currently using marijuana (OR: 1.25, 95%CI: 1.14-1.37, p<0.0001) than those who do not and 44% higher among obese individuals (OR: 1.44, 95%CI: 1.29-1.60, p<0.0001) compared to non-obese individuals. Sleeping eight or more hours per day was protective against asthma (OR: 0.81, 95% CI: 0.74-0.88, P<0.0001). After adjusting for age and other factors, multiple logistic regression showed that the odds of having asthma was approximately 26% higher among individuals who initiated cigarette smoking before the age of 13 years (adjusted OR (aOR): 1.26, 95% CI: 1.01- 1.57, P=0.037) than those who did not. Moreover, the odds of having asthma was 18% higher among those who initiated alcohol drinking before the age of 13 years (aOR: 1.18, 95%CI: 1.04-1.35, P=0.014), compared to those who did not. There was no association found between asthma and physical activity, the use of marijuana after adjusting for age and other potential risk factors. Conclusion: While sleeping more than eight hours per day was protective against asthma, early initiation of cigarette smoking, marijuana, and alcohol drinking was positively associated with asthma. Encouraging children to sleep minimum of eight hours per day will potentially decrease asthma prevalence.

As with every U.S. election cycle, the early 2016 election season was a roller-coaster experience, with positive and negative campaign messages emerging from both parties, and with high hopes and dashed hopes for both Democratic and Republican candidates. However, as Donald J. Trump emerged as the Republican candidate to challenge Democrat Hillary R. Clinton for the Office of President, the United States appeared to be equally bemused, horrified and confident in a Democratic victory — after all, how could someone so unorthodox as Donald Trump become the next president? His divisive campaign had become predictive, for many voters, of a clear victory for Clinton. However, those within vulnerable groups, including women, immigrants and the LGBTQ communities, along with many allies, noted the growing normalization of his micro- and macro-aggressions by the mainstream media, and the societal legitimization of his campaign.

Objective: Student mental health may suffer due to unreasonable expectations associated with academic entitlement; permissive parenting may be one source of these expectations. The authors examined the role of academic entitlement as a mediator of the relationship between permissive parenting and psychological functioning. Participants: Participants were 524 undergraduate students at a single institution (52% female; age range = 18–22). Data collection was completed in May 2011. Methods: Cross-sectional design. Participants completed online self-report measures of parenting styles, academic entitlement, stress, depressive symptoms, and well-being. Results: Permissive parenting was associated with greater academic entitlement and, in turn, to more perceived stress and poorer mental health. Mother/father differences were found in some cases. Conclusions: Academic entitlement may partially explain why permissive parenting is detrimentally related to mental health for college students. Implications for academic affairs and counseling include helping students develop an appreciation of the role of self-regulation in college success.

Background: Suicidal young adults often confide their distress to peers. It is unclear, however, what types of assistance a friend may offer in response to various symptoms of distress as well as whether the sex of either individual affects responses. Aims: We examined open-ended responses to e-mail vignettes from a fictitious friend exhibiting depressed, irritable, or overtly suicidal communications. Method: College student participants (n = 106) read e-mail messages from a fictitious friend, to which they composed a reply. Replies were coded to reflect the presence/absence of mention of professional help, problem-oriented (personal) help, and social support. Results: Problem-oriented help was offered the most across conditions; professional help was offered least in response to depressed or irritable vignettes. Women were more likely to offer any type of help than men. Patterns of help-giving and sex differences in help-giving varied by condition. Conclusions: Results indicate students’ preferences for solving peer problems personally rather than professionally. Campus prevention and intervention efforts should focus on enhancing students’ peer support and referral skills.

Substance use disorders are serious health concerns in the United States. Furthermore, the National Survey on Drug Use and Health reports a continuous increase in substance use disorders in the United States during the last 10 years. However, there are not many effective pharmacotherapeutics available for substance use disorders. The current dissertation is focused on research aimed at discovering pharmacotherapeutics for substance use disorders. First part of dissertation focused on discovering methamphetamine (METH) use disorder therapeutics targeting specific mechanism of METH action on dopaminergic neurons. The second part of dissertation focused on opioids and cocaine use disorder therapeutics targeting rewarding pathway commonly activated by opioids and cocaine. With respect to METH, it induces release of dopamine (DA) in neuronal terminals by interacting with the vesicular monoamine transporter-2 (VMAT2) and DA transporter (DAT). VMAT2 inhibitors have been found by our research group to decrease METH-evoked DA release, METH-induced hyperlocomotion, and METH self-administration in rats. However, these VMAT2 inhibitors lacked selectivity and tolerance developed to these pharmacologic effects after repeated administration, thereby limiting their potential as pharmacotherapeutics for METH use disorders. In the current study, analogs from a novel scaffold were found to selectively inhibit VMAT2 and were evaluated using neurochemical and behavioral pharmacological approaches. R- and S-3-(4-methoxyphenyl)-N-(1-phenylpropan-2-yl)propan-1-amine (GZ-11610 and GZ-11608, respectively) exhibited 94- to 3450-fold selectivity for VMAT2 over human-ether-a-go-go (hERG) channel, DAT, serotonin transporter, and nicotinic acetylcholine receptors. GZ-11608 competitively and concentration-dependently inhibited METH-evoked DA release via VMAT2. Also, GZ-11610 (56-300 mg/kg, oral) and GZ-11608 (300 mg/kg, oral; 10-30 mg/kg, s.c.) reduced METH-induced hyperlocomotor activity in METH-sensitized rats. Furthermore, GZ-11608 (1-30 mg/kg, s.c.) inhibited METH self-administration, cue- and METH-induced reinstatement in a dose-dependent manner, and 30 mg/kg (s.c.), 10 mg/kg (s.c.), and 17 mg/kg (s.c.) produced significant effect, respectively. Importantly, the GZ-11608-induced decrease in METH self-administration was not surmounted by increasing the amount of METH available. GZ-11608 did not substitute for METH and did not serve as a reinforcer in rats self-administering METH and drug naïve rats, respectively. Thus, these VMAT2 inhibitors incorporating a new scaffold are novel leads for new pharmacotherapeutics to treat METH use disorders. Substances with high abuse potential including opioids and cocaine elevate extracellular DA concentration in the nucleus accumbens, and this mechanism has long been considered to underly substance-induced reward. DA in the nucleus accumbens originates from DA neuron cell bodies located in the ventral tegmental area in the midbrain. Interestingly, M5 muscarinic acetylcholine receptors (mAChRs) are proteins that are highly expressed on ventral tegmental area DA neurons. Also, studies investigating M5 mAChRs knockout mice showed reduced responding for cocaine in cocaine self-administration and decreased time spent in cocaine-paired and morphine-paired place preference studies. Pharmacological inhibition of M5 mAChRs function via microinfusing mAChR antagonists exhibiting no selectivity among M1-M5 mAChRs subtypes into the ventral tegmental area where expression of M5 mAChRs are dominant, reduced morphine-induced hyperlocomotion and cocaine seeking behaviors in rats. These studies support therapeutic potential of M5 mAChRs selectivity antagonists in opioids and cocaine use disorders. Thus, in the current study, affinity of a series of pethidine and quinuclidinyl N-phenylcarbamate analogs for M5 mAChRs was evaluated using in vitro and ex vivo neuropharmacological assays. Among the pethidine analogs, compound 6a showed the highest binding affinity at M5 (Ki = 0.38 µM), but also high affinity at M1 and M3 mAChRs (0.67 and 0.37 µM, respectively). Among the quinuclidinyl N-phenylcarbamate analogs, compound 13c exhibited the highest affinity at M5 (Ki = 1.8 nM), but also high affinity at M1, M2, M3 and M4 mAChRs (Ki = 1.6, 13, 2.6, 2.2 nM, respectively). Also, 13c acted as an agonist of mAChRs on oxotremorine-induced DA release from rat striatal slices. In addition, compound 13b was found exhibiting the highest selectivity (17-fold) at M3 over M2 mAChRs, suggesting potential of 13b as a chronic obstructive pulmonary disease therapeutics. Taken together, these novel analogs serve as leads for further discovery of subtype-selective M5 mAChR antagonists that may have potential as therapeutics for substance use disorders, as well as for chronic obstructive pulmonary disease.