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Effects of isoflavones in patients with watchful waiting benign prostate hyperplasia. / 異黃酮素治療良性前列腺增生之療效 / Yi huang tong su zhi liao liang xing qian lie xian zeng sheng zhi liao xiaoJanuary 2009 (has links)
Han, Li. / Thesis (M.Phil.)--Chinese University of Hong Kong, 2009. / Includes bibliographical references (leaves 132-140). / Abstract and appendixes also in Chinese. / Chapter 1.1 --- BACKGROUND & SIGNIFICANCE OF THE STUDY --- p.1 / Chapter 1.2 --- STRUCTURE OF THE THESIS --- p.4 / Chapter 2.1 --- BPH --- p.6 / Chapter 2.1.1 --- PREVALENCE OF BPH --- p.6 / Chapter 2.1.2 --- IMPACT OF BPH SYMPTOMS ON PATIENTS --- p.9 / Chapter 2.1.2.1 --- CLINICAL SYMPTOMS OF BPH --- p.9 / Chapter 2.1.2.2 --- IMPACT OF CLINICAL SYMPTOMS ON QUALITY OF LIFE --- p.10 / Chapter 2.1.3 --- IMPACT OF BPH MEDICAL MANAGEMENT ON PATIENTS --- p.11 / Chapter 2.1.3.1 --- MEDICAL MANAGEMENT OF BPH --- p.11 / Chapter 2.1.3.2 --- SIDE EFFECTS OF PHARMACOLOGICAL AND SURGICAL THERAPIES --- p.15 / Chapter 2.1.4 --- USE OF COMPLEMENTARY AND ALTERNATIVE THERAPY AMONG BPH PATIENTS --- p.19 / Chapter 2.1.4.1 --- PREVALENCE --- p.19 / Chapter 2.1.4.2 --- REASONS FOR TURNING TO CAM --- p.20 / Chapter 2.2 --- ISOFLAVONES --- p.43 / Chapter 2.2.1 --- ISOFLAVONES FUNCTION --- p.43 / Chapter 2.2.1.1 --- STRUCTURE --- p.43 / Chapter 2.2.1.2 --- FOOD SOURCES --- p.45 / Chapter 2.2.2 --- APPLICATION OF ISOFLAVONES IN BPH --- p.46 / Chapter 2.2.2.1 --- DOCUMENTED MECHANISM OF BPH --- p.46 / Chapter 2.2.2.2 --- STUDIES IN VITRO --- p.47 / Chapter 2.2.2.3 --- STUDIES IN VIVO --- p.48 / Chapter 2.2.2.4 --- EPIDEMIOLOGIC EVIDENCE --- p.49 / Chapter 2.3. --- RESEARCH GAP IN HUMAN STUDY --- p.50 / Chapter 3.1 --- STUDY DESIGN --- p.51 / Chapter 3.2 --- AIM --- p.51 / Chapter 3.3 --- STUDY POPULATION --- p.52 / Chapter 3.3.1 --- INCLUSION CRITERIA --- p.52 / Chapter 3.3.2 --- EXCLUSION CRITERIA --- p.52 / Chapter 3.3.3 --- SAMPLE SIZE ESTIMATION --- p.53 / Chapter 3.4 --- RANDOMIZATION --- p.54 / Chapter 3.4.1 --- GENERATION THE RANDOM ALLOCATION SEQUENCE AND DETAILS OF RESTRICTION OF RANDOMIZATION --- p.54 / Chapter 3.4.2 --- IMPLEMENTATION OF RANDOMIZATION --- p.54 / Chapter 3.5 --- BLINDING --- p.55 / Chapter 3.5.1 --- WHO WERE BLINDED --- p.55 / Chapter 3.6 --- INTERVENTION --- p.55 / Chapter 3.6.1 --- STUDY MEDICATIONS AND DOSAGE --- p.55 / Chapter 3.6.2 --- STUDY REGIMEN --- p.56 / Chapter 3.7 --- DATA COLLECTION --- p.56 / Chapter 3.8 --- OUTCOME MEASUREMENTS --- p.58 / Chapter 3.8.1 --- PRIMARY OUTCOME --- p.58 / Chapter 3.8.1.1 --- UROFLOWMETRY: PEAK URINE FLOW RATE (QMAX) --- p.58 / Chapter 3.8.2 --- SECONDARY OUTCOMES --- p.59 / Chapter 3.8.2.1 --- BLADDER SCAN: POST-VOIDING RESIDUAL VOLUME (PVR) --- p.59 / Chapter 3.8.2.2 --- SYMPTOMS SCORE (IPSS) --- p.60 / Chapter 3.8.2.3 --- QUALIFY OF LIFE --- p.61 / Chapter 3.8.2.4 --- SERUM PSA LEVEL --- p.62 / Chapter 3.8.2.5 --- URINALYSIS TEST --- p.62 / Chapter 3.8.3 --- AE/SAE --- p.63 / Chapter 3.8.3.1 --- SELF REPORTED AE/SAE --- p.63 / Chapter 3.8.3.2 --- SEXUAL HORMONE LEVEL --- p.64 / Chapter 3.8.3.3 --- SEXUAL RELATED QUALITY OF LIFE --- p.64 / Chapter 3.9 --- STATISTICAL ANALYSIS --- p.65 / Chapter 3.9.1 --- DESCRIPTIVE ANALYSIS --- p.65 / Chapter 3.9.2 --- COMPARATIVE ANALYSIS --- p.65 / Chapter 4.1 --- PARTICIPANTS FLOW --- p.67 / Chapter 4.2 --- DEMOGRAPHICS --- p.69 / Chapter 4.3 --- BASELINE CHARACTERISTICS COMPARISON --- p.70 / Chapter 4.3.1 --- IPSS --- p.72 / Chapter 4.3.2 --- QMAX AND PRV --- p.73 / Chapter 4.3.3 --- QUALITY OF LIFE --- p.73 / Chapter 4.3.4 --- SERUM PSA LEVEL --- p.74 / Chapter 4.4 --- EFFICACY OUTCOMES --- p.74 / Chapter 4.4.1 --- QMAX AND PVR --- p.74 / Chapter 4.4.1.1 --- QMAX --- p.74 / Chapter 4.4.1.2 --- PVR --- p.75 / Chapter 4.4.2 --- IPSS --- p.79 / Chapter 4.4.2.1 --- TOTAL IPSS --- p.79 / Chapter 4.4.2.2 --- IPSS SUB SCORE 1_ INCOMPLETE EMPTYING --- p.79 / Chapter 4.4.2.3 --- IPSS SUB SCORE 2_ FREQUENCY --- p.80 / Chapter 4.4.2.4 --- IPSS SUB SCORE 3_INTERMITTENCY --- p.81 / Chapter 4.4.2.5 --- IPSS SUB SCORE 4_ URGENCY --- p.82 / Chapter 4.4.2.6 --- IPSS SUB SCORE 5_ WEAK STREAM --- p.82 / Chapter 4.4.2.7 --- IPSS SUB SCORE 6_ STRAINING --- p.83 / Chapter 4.4.2.8 --- IPSS SUB SCORE 7_ NOCTURIA --- p.84 / Chapter 4.4.3 --- QOL --- p.90 / Chapter 4.4.3.1 --- QOL IN IPSS Q8_QOL_URINATION --- p.90 / Chapter 4.4.3.2 --- QOL IN SF-36 --- p.91 / Chapter 4.4.3.2.1 --- PHYSICAL FUNCTIONING --- p.91 / Chapter 4.4.3.2.2 --- ROLE-PHYSICAL --- p.92 / Chapter 4.4.3.2.3 --- BODY PAIN --- p.92 / Chapter 4.4.3.2.4 --- GENERAL HEALTH --- p.93 / Chapter 4.4.3.2.5 --- VITALITY --- p.94 / Chapter 4.4.3.2.6 --- SOCIAL FUNCTIONING --- p.95 / Chapter 4.4.3.2.7 --- ROLE-EMOTIONAL --- p.95 / Chapter 4.4.3.2.8 --- MENTAL HEALTH --- p.96 / Chapter 4.4.4 --- SERUM PSA LEVEL --- p.103 / Chapter 4.4.5 --- SUBGROUP ANALYSIS --- p.106 / Chapter 4.4.6 --- SELF-PREFERENCE EFFECT ANALYSIS --- p.107 / Chapter 4.4.7 --- DIARY ANALYSIS --- p.109 / Chapter 4.5 --- ADVERSE EVENTS --- p.113 / Chapter 4.5.1 --- SELF-REPORTED AE/SAE --- p.113 / Chapter 4.5.2 --- SEXUAL HORMONE LEVEL --- p.114 / Chapter 4.5.3 --- SEXUAL RELATED QUALITY OF LIFE --- p.114 / Chapter 4.5.3.1 --- SEXUAL LIFE UNSATISFACTORY --- p.114 / Chapter 4.5.3.2 --- LIBIDO DECREASE --- p.115 / Chapter 5.1 --- PRINCIPAL FINDINGS --- p.116 / Chapter 5.1.1 --- EFFICACY --- p.116 / Chapter 5.1.2 --- SAFETY --- p.117 / Chapter 5.2 --- STRENGH AND LIMITATIOINS --- p.117 / Chapter 5.2.1 --- STRENGTH --- p.117 / Chapter 5.2.1.1 --- BLINDING IS EFFECTIVE --- p.117 / Chapter 5.2.1.2 --- COMPLIANCE IS GOOD --- p.118 / Chapter 5.2.1.3 --- LONG TREATMENT PERIOD --- p.119 / Chapter 5.2.1.4 --- STUDY OUTCOMES INCLUDE BOTH OBJECTIVE OUTCOMES AND SUBJECTIVE OUTCOMES --- p.121 / Chapter 5.2.2 --- LIMITATIONS --- p.121 / Chapter 5.2.2.1 --- INSUFFICIENT SAMPLE SIZE --- p.122 / Chapter 5.2.2.2 --- POSSIBLY LOW DOSE --- p.122 / Chapter 5.2.2.3 --- LACK OF BASELINE DATA ON QUALITY OF SEXUAL LIFE --- p.123 / Chapter 5.2.2.4 --- "LACK OF DATA ON LIFESTY FACTORES INCLUDING DIETARY HABIT, PHYSICAL ACTIVITY, SMOKING STATUS AND ACOHOL CONSUMPTION" --- p.123 / Chapter 5.3 --- INTERPRETATIONS OF THE RESUTLS --- p.124 / Chapter 5.3.1 --- TWO POSIVE RESULTS IN EMPTYING FUNCTION AND QUALITY OF LIFE --- p.124 / Chapter 5.3.2 --- ONE NEGATIVE RESULT IN PEAK URINARY FLOW RATE --- p.127 / Chapter 5.3.3 --- QUALITY OF SEXUAL LIFE --- p.129 / Chapter 6.1 --- CONCLUSIONS --- p.130 / Chapter 6.2 --- IMPLICATIONS --- p.131
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Treatment of Benign Paroxysmalvertigo: Necessity of Post-Maneuver ProhibitionDeBoodt, Jennifer L 01 December 2003 (has links)
Benign paroxysmal positional vertigo (BPPV), characterized by a history of brief attacks of intense positional vertigo and rotary nystagmus, results from otoconial migration into the semicircular canals, making the sensory structures in the canal gravity sensitive. Treatment methods include positioning maneuvers, which return the otoconia back into the otolith, and typically include a variety of activity limitations for the subsequent 24-48 hours. Previous studies suggest BPPV treatment can be successful without any limitations of the patient post- therapy. The purpose of this study was to determine the necessity of post-maneuver restrictions on BPPV patients treated with the Canalith Repositioning Maneuver. Twenty participants were identified as having BPPV of the posterior canal and treated with the Canalith Repositioning Maneuver. During post-maneuver instruction, the ten participants assigned to the restricted group were provided with typical instructions. Ten participants assigned to the non-restricted group were given no post-maneuver restrictions. At the one-week post-treatment follow-up, all patients were free of vertigo and/or nystagmus. Results indicated that given two groups of subjects matched for age, gender, and symptoms, post-maneuver restrictions are not necessary for successful outcome using the CRM to treat posterior-canal BPPV.
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The incidence of positional nystagmus in healthy participants revisited [electronic resource] / by Terri L. Schneider.Schneider, Terri L. January 2002 (has links)
Professional research project (Au.D.)--University of South Florida, 2002. / Title from PDF of title page. / Document formatted into pages; contains 24 pages. / Includes bibliographical references. / Text (Electronic thesis) in PDF format. / ABSTRACT: The purpose of this study was to examine the prevalence of nystagmus found in healthy individuals during the positional testing subtest of the standard vestibular test battery. Positional testing involves moving the patient's head, and sometimes the entire body, into a variety of positions while observing eye movement. The hypothesis of the current study was that a relatively low percentage of participants would display nystagmus during positional testing used routinely in clinical diagnostic procedures. The findings were then compared to those of an earlier study in which 82% of normal, healthy individuals were reported to exhibit nystagmus during this testing. Twenty-five participants were selected that had no known otologic disease and who reported normal hearing sensitivity. / ABSTRACT: In addition, the participants affirmed they had not consumed any alcohol or taken any medications that are known to affect nystagmus. They were then observed in nine different positions. Forty-eight percent of the participants experienced nystagmus in at least one position. Although this percentage was considerably lower than that reported in the earlier study, methodological differences appear to account for the discrepancy. Specifically, the criterion for determining the presence/absence of nystagmus potentially explains the difference in full. / System requirements: World Wide Web browser and PDF reader. / Mode of access: World Wide Web.
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Rausvažiedės ežiuolės Echinacea purpurea (L.) Moench antiandrogeninių savybių eksperimentiniai tyrimai / Experimental studies of antiandrogenic properties of Echinacea purpurea (L.)MoenchSkaudickas, Darius 09 December 2005 (has links)
1. INTRODUCTION
1.1. Work actuality
In recent years the number of males with urination disorders mostly induced by prostate pathology has significantly increased [Gas et al., 1998; Khan, Khan et al., 2005; Amaral, Coeli et al., 2004]. Benign prostate hyperplasia (BPH) affects males at a much younger age making them complain of urination disorders of different types and intensity. It is quite a common pathology among males (which is) conditioned by life style and nutrition [Saga & Sugimura, 2004; Shabbir & Mumtaz, 2004; Cambell, 2005].
Clinical symptoms of BPH are not restricted only to urination complaints. With an increase of age of males, the balance of androgens and estrogens undergoes changes in the male organism, affecting the power of libido. According to C.M.Porth, 2005, two theories related to senility have been created, trying to explain biological processes occurring with age: The first theory is related to the so called genetically programmed changes. This theory affirms that changes brought on by aging, are genetically predetermined. Another theory is called the stochastic theory which says that all changes are of accidental nature, i.e. the body undergoes accidental changes. There is one more theory, the so-called neuroendocrinic theory of senility. This theory involves three basic factors of the process of aging: 1) facilitated degradation of hormones, 2) decreased synthesis and secretion of hormones, 3) diminished sensitivity of “target” receptors to... [to full text]
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DISTRESS AND HEALTH INFORMATION INTERESTS OF WOMEN FOLLOWING A BENIGN BREAST BIOPSYSteffens, Rachel Fancher 01 January 2008 (has links)
Benign breast biopsy (BBB) can be a stressful experience for many women. Few studies have examined the specific aspects of the BBB more and less distressing. However, no research studies have examined demographic and clinical variables as they relate to distress associated with specific aspects of the BBB or the informational interests of women following a BBB. This study evaluated the magnitude of distress associated with each aspect of the BBB (additional mammography, waiting for the results of the mammography, being informed of needing a biopsy, etc.) as well as the clinical (family history of BC in first degree relative, history of BBB, and type of biopsy) and demographic (age and education) variables as correlates of distress associated with each aspect of a BBB. Additionally, we examined health information interests in women following a BBB and the manner in which women preferred to have this health information communicated.
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Prostat kanserli hastalarda leptin düzeylerinin araştırılması /Dilmen, Cem. Perk, Hakkı. January 2004 (has links) (PDF)
Tez (Tıpta Uzmanlık) - Süleyman Demirel Üniversitesi, Tıp Fakültesi, Üroloji Anabilim Dalı, 2004. / Bibliyografya var.
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Impact d'une invalidation de LXRα sur la physiologie prostatique : un dialogue avec la signalisation androgénique / Impact of an invalidation of LXRα on prostate physiology : a dialogue with androgenic signallingViennois, Emilie 06 December 2011 (has links)
L’hypertrophie bénigne de la prostate (HBP) est une pathologie qui affecte 50% des hommes dès l’âge de 60 ans et qui conduit à des troubles de la miction. L’HBP se caractérise par une hypertrophie exclusive ou composite de plusieurs compartiments tissulaires de la prostate que sont l’épithélium, le stroma et les fibres musculaires qui définissent respectivement les composantes glandulaire, fibreuse et musculaire de cette pathologie. Il a récemment été montré que les souris dépourvues en récepteurs nucléaires LXR (Liver‐X‐receptor) α (souris lxrα‐/‐) développent une hypertrophie de la prostate dont les signes histologiques évoquent une HBP de type fibreuse. Par ailleurs, un des traitements de l’HBP, vise à éteindre la signalisation androgénique en inhibant la conversion de la testostérone en son métabolite actif, la dihydrotestostérone (DHT). Le phénotype d’hypertrophie de la prostate pourrait donc également s’expliquer par une altération de la signalisation androgénique dans les souris lxrα‐/‐. Dans ce contexte, notre projet de recherche a été centré sur l’étude du rôle des LXR dans l’apparition de l’HBP dans sa composante glandulaire et l’analyse des relations moléculaires associant les signalisations dépendantes de LXRα et du récepteur des androgènes (AR) au sein de la prostate. Le phénotype d’HBP observé dans les souris lxrα‐/‐ résulte d’altérations importantes de l’homéostasie de l’épithélium qui miment la composante glandulaire : 1) une activité sécrétoire accrue ; 2) une altération des processus de sécrétion associée à une altération de l’expression des gènes codant des protéines du transport vésiculaire ; 3) une réponse altérée de certains gènes androgéno‐dépendants associée à une hypersensibilité aux androgènes ; 4) des modifications du réseau paracrine reliant le stroma et l’épithélium. Au final, ces travaux définissent LXRα comme un acteur clé de l’homéostasie prostatique et ouvrent des pistes intéressantes pour la compréhension de l’étiologie de l’HBP chez l’homme. Ces résultats montrent qu’il est possible de moduler la réponse androgénique de la prostate en ciblant LXRα. Ainsi, à plus long terme, l’activation pharmacologique de LXRα constitue une piste potentielle dans le traitement de l’HBP. / Benign prostate hyperplasia (BPH) is a very common prostatic disorder that affects 50% of men after 60 years. In BPH, prostate enlargement causes urinary disorders. BPH is characterized by a hypertrophy of several tissue compartments such as the epithelium, stroma and/or muscle fibers. Hence, three main forms of BPH have been described : glandular, fibrous and muscular form. It has been recently shown that LXR (Liver‐X‐receptor) α (lxrα‐/‐) mice develop a prostate enlargement with histological signs of fibrous BPH. Inhibition of testosterone conversion into DHT is one the most effective pharmacological treatment of BPH. Thus, the lxrα‐/‐ prostate phenotype could be in part due to an alteration of androgen signaling. In this context, the aim of this work was to study the role of LXR in glandular BPH development and to understand the relationships between LXRα and the androgen receptor (AR) dependent signaling pathway in prostate. The prostate enlargement observed in lxrα‐/‐ mice results from major alterations in epithelium homeostasis mimicking the glandular alteration of BPH : 1) increase of secretory activity ; 2) alteration of the secretory process associated with altered expression of vesicular transport protein encoding genes ; 3) a disruption in the response of androgen‐dependent genes associated with androgen hypersensitivity ; 4) changes in the paracrine network between stroma and epithelium. Finally, this work defines LXRα as a key player in prostate homeostasis and opens interesting way to the understanding of BPH etiology. These results show that targeting LXRα modulate the prostate androgenic response. Thus, pharmacological activation of LXRα could constitute a new option for the treatment of BPH.
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Estudo comparativo entre a administração de toxina botulínica “A” e a orquiectomia no tratamento da hiperplasia prostática benigna do cãoMostachio, Giuliano Queiroz [UNESP] 22 February 2008 (has links) (PDF)
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mostachio_gq_me_jabo.pdf: 1253600 bytes, checksum: c1f946210aa85f9b2c8aa26f7af6e985 (MD5) / Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) / A hiperplasia prostática benigna (HPB) tem início no animal com um a dois anos de idade, sendo que 80% dos cães com cinco anos apresentam evidências histológicas de sua presença. A fisiopatologia da doença não está totalmente compreendida, no entanto, a diidrotestosterona é o principal hormônio envolvido. Recentemente, o efeito da toxina botulínica A (TB-A) foi investigado na próstata, mostrando que esta induz atrofia do parênquima e redução do volume. Como o cão é o único animal doméstico que apresenta esta alteração, este se apresenta como modelo experimental para novos estudos da HPB humana. Com base nisso, este estudo objetivou fornecer informações acerca dos efeitos da TB-A sobre a próstata, libido e qualidade do sêmen, comparando os dados com animais orquiectomizados. Para tanto, 18 cães adultos, com evidências ultra-sonográficas de HPB foram submetidos à castração ou administração de 250 ou 500 U de TB-A, e avaliados durante 16 semanas. A orquiectomia mostrou-se um excelente tratamento para a HPB, promovendo redução de 80% do volume prostático. Aplicação da TB-A não ocasionou alterações significativas na libido, ereção ou qualidade e características seminais. Efeitos locais e sistêmicos também não foram observados. Administração de 250 U da TB-A promoveu redução máxima de 9,4% do volume prostático, entretanto, tal redução não foi significativa. Por outro lado, a administração de 500 U de TB-A reduziu significamente as variáveis comprimento, altura e volume da próstata. Desta forma, o presente ensaio contribui de forma singular e inovadora para o conhecimento dos efeitos desta nova modalidade de tratamento na HPB canina. / Benign prostatic hyperplasia (BPH) starts the development in animals aging about 1 – 2 years. 80% of 5 years-old dogs have histologic evidences of BPH. Despite the little knowledge concerning about this disease, dihydrotestosterone is the main involved hormone. Recently, the effect of botulinum toxin A (BT-A) on rat and human prostate was investigated, and prostatic parenchyma atrophy and decrease in glandular volume were observed. The dog is one of a few animals that can develop BPH spontaneously and is frequently used as an animal model for human prostatic hyperplasia. Based on that, this study aimed to provide information on BT-A effects on prostate, libido and semen quality, in comparison to orchiectomized dogs. For that, 18 adults dogs, with Ultrasonographic evidences of BPH were submitted to orchiectomy or administration of 250 or 500 U of BT-A, and evaluated along 16 weeks. Orchiectomy presented excellent results on BPH, reducing the prostate volume up to 80%. Administration of BT-A did not significantly interfered on libido, erection or semen characteristics. Local and systemic effects also were not observed. Administration of 250 U of BT-A has promoved a maximum decrease of 9,4% on prostatic volume. However, this reduction was not statistically significant. On the other hand, 500 U of BTA administration has shown to significantly reduce the length, height and volume of prostate. This way, the present study is an innovative and singular contribution for the knowledge of the effects of BT-A on canine prostate.
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Avaliação do valor diagnóstico e prognóstico do carboidrato L-fucose e das fucosiltransferases 3 e 6 em tumores prostáticos humanoVASCONCELOS, Juliana Lúcia de Albuquerque January 2012 (has links)
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Previous issue date: 2012 / Câncer é um conjunto de alterações celulares, que leva a uma divisão celular sem controle, podendo invadir tecidos adjacentes através da circulação sanguínea e do sistema linfático. O Câncer de Próstata (CP) é o segundo tumor mais comum entre a população masculina, e é considerado o câncer da terceira idade. A carcinogênese é um mecanismo complexo no qual ocorre mudanças na expressão de proteínas e glicoconjugados. Glicosilação é mediada por glicosiltransferases, enzimas que tem função de inserir resíduos de carboidratos específicos, e é um dos mais importantes processos biológicos pós-tradução de modificações na estrutura final e função de lipídios e proteínas. As fucosiltransferases (FUT) participam da transferência de resíduos de L-fucose, um sacarídeo associado ao câncer e a processos inflamatórios, da GDP-L-fucose. Neste estudo objetivou-se avaliar a expressão dos genes FUT3 e FUT6 através da Imunohistoquímica em Adenocarcinoma Prostático e Hiperplasia Prostática Benigna correlacionando com o padrão de expressão de L-fucose empregando a histoquímica com as lectinas UEA-I (Ulex europaeus) e LTA (Lotus tetragonolobus). As enzimas FUT3 e FUT6 apresentaram-se com uma alta expressão tanto no Adenocarcinoma Prostático como na Hiperplasia Benigna Prostática, principalmente a FUT 6. Os resultados da histoquímica com lectinas mostraram uma baixa distribuição/accessibilidade de L-fucose.
Sugere-se que, as enzimas FUT3 e FUT6 possam representar potenciais biomarcadores para avaliar alterações benignas e malignas prostáticas refletindo uma variação no perfil de L-fucose nestes tumores que podem estar associados às suas características biológicas. / Cancer is a set of cellular changes, leading to uncontrolled cell division that may
invade surrounding tissues via bloodstream and lymphatic system. Prostate
Cancer (PC) is the second most common tumor in men and is considered the
cancer of the elderly. Carcinogenesis is a complex mechanism in which
changes occur in the expression of proteins and glycoconjugates where
glycosylation plays key roles since modulates the carbohydrate moieties in
glycoconjugates being one of the most important biological processes of posttranslational
modifications in the final structure and function of lipids and
proteins. Fucosyltransferases (FUTs) are enzymes that catalyze the transfer of
the L-fucose residues, a saccharide which has been linked to cancer and
inflammation features, from GDP-Fuc. This study the objective to evaluate the
expression of genes FUT 3 and FUT 6 by immunohistochemistry in Prostatic
Adenocarcinoma and Benign Prostatic Hyperplasia and to correlates with the
expression pattern of L-fucose using lectin histochemistry with UEA-I (Ulex
europaeus) and LTA (Lotus tetragonolobus). FUT3 and FUT6 showed a high
expression in both prostatic tissues, especially FUT6. The results of lectin
histochemistry showed a low distribution/accessibility of L-fucose residues. It is
suggested that FUT3 and FUT6 may represent potential biomarkers to evaluate
benign and malignant alterations in prostate reflecting a variation in the profile
of L-fucose residues in these tumors which can be associated to their biological
features.
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Reabilitação vestibular da vertigem postural paroxística benigna de canal posterior em idosos / Vestibular rehabilitation of benign posterior canal postural vertigo in the agedAna Paula do Rego André 15 December 2003 (has links)
A Reabilitação Vestibular (RV) é um programa de tratamento realizado por exercícios, associado a um conjunto de medidas relacionadas à mudança de hábitos e esclarecimentos sobre os sintomas associados à alteração do equilíbrio. É um método de terapia fisiológico, inócuo e coerente, que pretende trabalhar o paciente vertiginoso aliviando os sintomas e aumentando seu limiar de sensibilidade para a vertigem. A Vertigem Postural Paroxística Benigna (VPPB) é a mais comum das vestibulopatias periféricas em adultos, principalmente em idosos do sexo feminino, apresentando como etiologia mais comum a degeneração da mácula utricular. Nos idosos, caracteriza-se por tontura rotatória e nistagmo posicional à mudança de posição da cabeça ou por determinada posição do corpo e, como conseqüência, pode ocorrer quedas e limitações na qualidade de vida dos mesmos, tornando-os limitados físico e emocionalmente. O presente estudo teve como objetivo avaliar prospetivamente a Reabilitação Vestibular como tratamento da VPPB com acometimento de canal semicircular posterior e seu efeito na qualidade de vida em indivíduos idosos. Participaram do estudo 23 voluntários com hipótese diagnóstica otorrinolaringológica de VPPB de canal semicircular posterior por ductolitíase, com faixa etária entre 60 e 91 anos, com média de 70,69 anos e desvio padrão de 9,24. Quanto ao gênero 17 (73,9%) eram do sexo feminino e 6 (26,1%) do masculino. No tratamento da VPPB por meio da reabilitação vestibular em 17 (73,9%) dos voluntários, utilizou-se a manobra de Epley; 6 (26,08%) com manobra de Epley associada ao exercício de Brandt e Daroff . O tempo de tratamento variou de 2 a 6 semanas. Aplicou-se um questionário (Dizziness Handicap Inventory - DHI brasileiro) pré e pós RV para quantificar a tontura quanto aos aspectos: físico, emocional, funcional e geral. Quanto ao aspecto físico, emocional, funcional e geral observou-se diferença estatisticamente significativa (p<0,0001) entre os escores pré e pós RV. Concluímos que os escores dos aspectos avaliados no DHI brasileiro melhoraram após intervenção fonoaudiológica pela RV nos pacientes com VPPB de canal semicircular posterior, havendo um incremento na qualidade de vida dos voluntários estudados. / Vestibular rehabilitation is a treatment?s program based on exercises, associated with a factor?s collection related to changing habits and guidance about symptoms associates to unbalance. It is harmless, coherent and physiologic therapy method that intends to work the dizzy patient, relieving the symptoms and increasing his vertigo?s threshold. The Benign Paroxysmal Positional Vertigo is the one most frequent adult?s pathologies of the peripheral vestibular?s system. It is caused by the utricle?s degeneration. In aged people, is characterize by vertigo and positional nystagmus provoked by certain cephalic movements or body movements and, as sequelae, can take to falls and life quality restriction, physical and emotional. This study?s purpose was evaluate the Vestibular Rehabilitation in posterior canal?s BPPV?s treatment and its effect in the elderly life?s quality. Twenty three volunteers with BPPV ?s posterior canal?s canalith diagnoses pointed out by otorhinolaryngologist, aged between sixty to ninety one years old, average of 70,69 years and deviation of 9,24. Seventeen volunteers (73,9%) were female and six (26,1%) were male. In BPPV?s treatment by vestibular rehabilitation, thirteen (56,52%) were submitted to Epley maneuver, six (26,08%) used the Epley maneuver associated to Brandt- Daroff exercises and four patients (17,39%) were submitted only to the Brandt- Daroff exercises. The treatment?s time lasted from 2 to 6 weeks. A questionnaire (Dizziness Handicap Inventory Portuguese- DHI Portuguese) was used in order to dizziness quantity in the physical, emotional, functional and general aspects, which was observed a significant statistical difference (p<0,001) between the scores previous and after Vestibular Rehabilitation. Concluding that the aspects? scores evaluated improved after Vestibular Rehabilitation therapy in the posterior canal?s BPPV?s patients, occurring an improvement in volunteers? life quality.
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