Understanding the link between the Sun and climate is vital in the current incidence of global climate change, and 10Be in natural archives constitutes an excellent tracer for this purpose. As cosmic rays enter the atmosphere, cosmogenic isotopes like 10Be and 14C are formed. Variations in solar activity modulate the amount of incoming cosmic rays, and thereby cosmogenic isotope production. Atmospherically produced 10Be enters natural archives such as sediments and glaciers by wet and dry deposition within about a year of production. 10Be from natural archives therefore provides information on past solar activity, and because these archives also contain climate information, solar activity and climate can be linked. One remaining question is to what degree 10Be in natural archives reflects production, and to what extent the local and regional environment overprints the production signal. To explore this, 10Be was measured at annual resolution over the last 600 years in a Greenland ice core. Measurement potentials for these samples benefited from the development of a new laboratory method of co-precipitating 10Be with niobium. To diversify geographic location and archive media type, a pioneer study of measuring 10Be with annual resolution in varved lake sediments from Finland was conducted, with samples from the entire 20th century. Pathways of 10Be into lake sediments are more complex than into glacial ice, inferring that contemporary atmospheric conditions may not be recorded. Here, it is shown for the first time that tracing the 11-year solar cycle through lake sediment 10Be variations is possible. Results also show that on an annual basis, 10Be deposition in ice and sediment archives is affected by local environmental conditions. On a slightly longer timescale, however, diverse 10Be records exhibit similar trends and a negative correlation with solar activity. Cyclic variability of 10Be deposition persisted throughout past grand solar minima, when little or no sunspot activity was recorded. 10Be levels indicate that although solar activity has been high during the 20th century, levels are not unprecedented in the investigated 600 years. Aerosol 10Be/7Be values indicate possible influence of stratosphere-troposphere exchange on isotope abundance and the production signal.

The photoionization of the beryllium-like isoelectronic series has been studied. The bound state wave functions of the target ions were built with CIV3 program. The relativistic Breit-Pauli R-matrix method was used to calculate the cross sections in the photon energy range between the ionization threshold and 1s24f7/2 threshold for each ion. For the total cross sections of Be, B+, C+2, N+3, and O+4, our results match experiment well. The comparison between the present work and other theoretical works are also discussed. We show the comparison with our LS results as it indicates the importance of relativistic effects on different ions. In the analysis, the resonances converging to 1s22lj and 1s23lj were identified and characterized with quantum defects, energies and widths using the eigenphase sum methodology. We summarize the general appearance of resonances along the resonance series and along the isoelectronic sequence. Partial cross sections are also reported systematically along the sequence. All calculations were performed on the NERSC system.

The eastern California shear zone (ECSZ) and Walker Lane belt represent an important inland component of the Pacific-North America plate boundary. Current geodetic data indicate accumulation of transtensional shear at a rate of ~9.2 ± 0.3 mm/yr across the region, more than double the total geologic rate (<3.5 mm/yr) for faults in the northern ECSZ over the late Pleistocene [Bennett et al., 2003, Kirby et al., 2006, Lee et al., 2009, Frankel et al., 2007]. Unraveling the strain puzzle of the Walker Lane is therefore essential to understanding both how deformation is distributed through the lithosphere along this transtensional part of the Pacific-North America plate boundary and how the plate boundary is evolving through time. The observed mismatch between geodetic and geologic slip rates in the central Walker Lane is characteristic of other active tectonic settings, including the nearby Mojave segment of the ECSZ [Oskin et al., 2008] and the Altyn Tagh fault in China [Cowgill, 2007]. In each case, lack of fault slip data spanning multiple temporal and spatial scales hinders interpretation of fault interactions and their implications for lithospheric dynamics. The discrepancy between geodetic and geologic slip rates in the central Walker Lane indicates that if strain rates have remained constant since the late Pleistocene [e.g. Frankel et al., in press], then the "missing" strain is distributed on structures other than the two major dextral faults at this latitude (Death Valley-Fish Lake Valley fault and White Mountains fault). Otherwise the region could presently be experiencing a strain transient similar to that of the nearby Mojave section of the ECSZ [e.g., Oskin et al., 2008], or the rate of strain accumulation could actually increasing over the late Pleistocene [e.g. Reheis and Sawyer, 1997; Hoeft and Frankel, 2010]. The Silver Peak-Lone Mountain extensional complex (SPLM), to which the Clayton Valley faults belong, is the prime candidate to account for the "missing" strain. The down-to-the-northwest orientation of the SPLM faults makes them the most kinematically suitable structures to accommodate the regional pattern of NW-SE dextral shear. We use differential GPS to measure fault offset and terrestrial cosmogenic nuclide (TCN) geochronology to date offset landforms. Using these tools, we measure extension rates that are time-invariant, ranging from 0.1 ± 0.1 to 0.3 ± 0.1 mm/yr for fault dips of 30° and 60°. These rates are not high enough to account for the discrepancy between geologic and geodetic data in the ECSZ-Walker Lane transition zone. Based on geologic mapping and previously published geophysical data [Davis, 1981; Zampirro, 2005], deformation through Clayton Valley appears to be very widely-distributed. The diffuse nature of deformation leads to geologic slip rates that are underestimated due to the effects of off-fault deformation and unrecognized fault strands. Our results from Clayton Valley suggest that the discrepancy between geodetic and geologic strain rates at the latitude of the northern ECSZ is a result of long-term geologic rates that are underestimated. If the true geologic rates could be calculated, they would likely be significantly higher and therefore in closer agreement with geodetic data, as is the case everywhere else in the ECSZ north of the Garlock fault [Frankel et al., 2007a, in press; Kirby et al., 2008; Lee et al., 2009a].

Tissue regeneration in salamanders is a robust process that is not easily interrupted or altered. Therefore, inhibiting regeneration provides a means to interrogate the underlying cellular and molecular mechanisms regulating this complex event. Here we show that application of a relatively low concentration of beryllium nitrate solution (100mM) causes a delay in skin regeneration and severely alters normal limb regeneration. We provide evidence showing a beryllium-induced reduction in dermal fibroblast migration in vivo and in vitro. We link this phenomenon to delayed regeneration of the skin and abnormal blastema formation resulting in limb patterning defects during regeneration. Though our results show a slight reduction in fibroblast proliferation during the early stages of limb regeneration, we attribute this to an overall reduction in fibroblast presence at the site of injury. Keratinocytes appeared unresponsive to beryllium treatment with the rates of re-epithelialization and proliferation not significantly different between treatment and control groups. Taken together, these data reinforce a necessary role for fibroblasts during tissue regeneration and show that beryllium nitrate inhibits normal fibroblast behavior.

Thesis (Ph. D.)--West Virginia University, 2007. / Title from document title page. Document formatted into pages; contains xv, 145 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 138-145).

Heidelberg, Univ., Diss., 2007. / Online publiziert: 2008.

Thesis (Ph. D.)--West Virginia University, 2005. / Title from document title page. Document formatted into pages; contains xi, 99 p. : ill. (some col.). Includes abstract. Includes bibliographical references (p. 93-99).

Thesis--University of California, Berkeley, 1958. / "Physics and Mathematics" -t.p. Includes bibliographical references (p. 115-117).

Freie Universiẗat, Diss., 2000--Berlin. / Dateiformat: zip, Dateien im PDF-Format.

Made available in DSpace on 2014-10-09T12:44:28Z (GMT). No. of bitstreams: 0 / Made available in DSpace on 2014-10-09T13:57:11Z (GMT). No. of bitstreams: 1 06874.pdf: 5138428 bytes, checksum: e22d5fad1a78f9c1d2ced36a4c194d23 (MD5) / Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) / Dissertacao (Mestrado) / IPEN/D / Instituto de Pesquisas Energeticas e Nucleares - IPEN/CNEN-SP / FAPESP:97/05621-9