This study aimed to compare  the artificial tears Systane Ultra with Add1 and their performance in NITBUT (Non Invasive Tear Break Up Time). 20 participants between 21-29 years were divided into two groups , one group received Systane Ultra and the other Add1. Once each participant filled out an OSDI survey NITBUT was measured. First without any Artificial tears and then 5, 10, 15 , 20, 30 , 45 and 60 minutes after instillation. The Systane Ultra group and Add1 group differs in this study, however, no significant difference ( P = 0.055 ) in amplitude of NITBUT was obtained. Over time there is no significant difference (P > 0.05). The two drops perform equal at all times. There are advantages to using an instrument like Bon Sirius, for example, to avoid the bias of the observer. This study can be considered as an experimental study for future studies in the field.

Purpose: The purpose of this study was to compare corneal thickness measured both centrally and midperipherally, between two instruments using different measuring principles. The study also looked at correlation between corneal thickness and intraocular pressure (IOP). Methods: Central and midperipheral corneal thickness was measured on the right eyes of 31 subjects with two different instruments. Instruments were Scheimpflug-camera from Bon Sirius and an AS/OCT from Optos. Measurements were taken on central cornea (CCT) and midperipheral (nasal (NCT), temporal (TCT), superior (SCT) and inferior (ICT)) at a distance of 1.75 mm from the apex. Mean age of the subjects was 23.6 ± 4.5 years. (19-44 years). A CT-80A non-contact tonometer (NonCT) from Topcon was used to measure the intraocular pressure (IOP). Results: A mean-value for central corneal thickness was calculated to 542.4 µm and 540.4 µm for Bon Sirius and AS/OCT repectively. Remaining measured points had mean-values for corneal thickness of, NCT: 577.7 µm & 558.5 µm. TCT: 555.0 µm & 545.2 µm. SCT: 585.7 µm & 554.5 µm. ICT: 563.0 µm & 548.9 µm, respectively. Mean-difference for CCT was 2.4 µm and it showed a significant difference between the two instruments with a p-value of 0.007. Remaining measured points all showed a significant difference of p<0.05. NCT: 19.2 µm. TCT: 9.8 µm. SCT: 31 µm. ICT: 14 µm. A correlation between IOP and CCT measured in both Sirius and AS/OCT was positive with r = 0.7 and p<0.05. Conclusion: The results showed that Sirius gives higher values for corneal thickness then ASOCT in all five measurement points. The results show that these instruments can be used interchangeably when measuring central corneal thickness. However, caution should be used when measuring midperipheral corneal thickness as the there is a significant differences between these two instruments.

Purpose: Understanding how pupil size changes under different light conditions is important for refractive surgery, in contact lens fitting, as well as in the development of multifocal contact lenses. It is therefore of great value to have good measurement results and trustworthy methods. The accuracy and repeatability of the instruments used for these measurements are also critical.The purpose of this study was to investigate whether there was a potential relationship between the pupil diameter and the eye's refractive error with the use of the pupilometer incorporated within Sirius. A secondary purpose arose during the study, to evaluate the repeatability of the instrument Sirius. The null hypothesis of this study was; that pupil diameter is greater in myopes than hyperopes and emmetropes - that one would see a decrease in pupil diameter from myopes to emmetropes and also a decrease in pupil diameter from emmetropes to hyperopes. Method: There were 64 participants who took part in this study, aged between 20 to 36 years. Of these, three were excluded because they did not fit the inclusion criteria. The participants were divided into three different groups according to their spherical equivalent refractive errors: there were 26 myopes (range -7.75 D to -0.75 D), 17 emmetropes (range -0.50 D to +0.50 D), and 18 hyperopes (range + 0.75 D to + 5.75 D). Both eyes was measured. Pupil diameter was first measured in Sirius in a darkened room, where the computer was the only light source and the screen's brightness was dimmed. An objective refraction was done with the use of an autorefractor to get an estimated refractive value. Thereafter, retinoscopy was performed in a trial frame with a retinoscopy rack or loose trial lenses. The participants with higher astigmatism were also controlled with the use of the Jackson cross-cylinder. The pupil response was checked in all participants following pupil diameter measurements, to ensure that both eyes did not exhibit pupil defects. The result was analyzed with Excel and GraphPad Prism. Results: Since this study did not find any difference between the right and left eye, the data analysis was performed for right eye only. The mean and standard deviation (SD) of spherical equivalent power for myopes was -2.75 ±1.95 D, emmetropes -0.06 ±0.37 D and hyperopes +1.51 ±1.37 D. This study showed a weak trend between refractive error and pupil diameter, but no significant correlation between pupil diameter and the refractive state of the eye was evident, irrespective of lighting conditions; scotopic (p = 0.38), mesopic (p = 0.17) or photopic (p = 0.16). As expected, a clear decrease in pupil diameter with increased illumination intensity was found. A variance analysis (one-way, repeated measures ANOVA) was performed on the three different measurement in each illumination level, to confirm the repeatability of Sirius. The ICC values were 0.94 for scotopic, 0.87 for mesopic and 0.95 for photopic lighting conditions. Conclusuion: The study shows no significant correlation between pupil diameter and the refractive state of the eye over the range of -7.75 D to + 5.75 D. In this study, we also investigated the repeatability of the measurements values obtained with Sirius using the ICC; this showed that Sirius has a good repeatability in measuring pupil diameter in all three light levels.