In this dissertation, catalytic C-F bond activation mediated by alumenium and silylium species, improved methods for the synthesis of highly chlorinated carboranes and dodecaborates, new type of P2Si= pincer silylene Pt complexes and PBP pincer Rh complexes are presented. In Chapter II, the design and synthesis of P2Si= and PBP ligand precursors is described. BrC6H4PR2 is shown to be a useful building block for PXP type of ligands with o-arylene backbone. RLi reagents displayed high chemoselectivity towards electrophiles, such as Si(OEt)4 and BX3 (X = Hal). In Chapter III, new chlorination methods to synthesize [HCB11Cl11]- and [B12Cl12]2- are presented. [HCB11Cl11]- was obtained via reactions of Cs[HCB11H11] with SbCl5 or via reactions of Cs[HCB11H11] with Cl2 in acetic acid and triflic acid. Heating Cs2[B12H12] in mixtures of SO2Cl2 and MeCN led to the isolation of Cs2[B12Cl12] in high yield. In Chapter IV, Et2Al[HCB11H5Br6] or Ph3C[HCB11H5Br6] were shown to be robust catalysts for sp3 C-F bond activation with trialkylaluminum as the stoichiometric reagent. Trialkylaluminum compounds were also shown to be able to be used as “clean-up” reagent for the C-F bond activation reactions, which led to ultra high TON for the catalytic reactions. In Chapter V, a series of (TPB)M complexes (M = Ni, Pd, Pt) were synthesized and characterized by multinuclear NMR spectroscopy and X-ray crystallography. The resulting metal complexes displayed strong dative M→B interaction and unusual tetrahedral geometry for four-coordinate 16ē species, due to the cage structure of the ligand. In Chapter VI, (PSiHP)PtCl was synthesized via the reaction of the ligand precursor and Pt(COD)Cl2, which was used to obtain a series of (PSiHP)PtX complexes(X= I, OTf, Me, Ph, Mes). After hydride abstraction by Ph3C[HCB11Cl11], the X ligand (X= I, OTf, Me, Ph) migrated from the Pt center to silicon center to give a cationic pincer silyl species. The migration was not observed when mesityl was used as the X ligand, which resulted in the first known pincer complex with central silylene donor. Our approaches towards PNP pincer boryl Rh complexes were summarized in Chapter VII. (PBPhP)Rh pivalate complex underwent C-Ph bond activation to yield the pivalate-bridging Rh borane complex.

“The present work has been approached as a Mission Study. This is a wide enough category, but if I have had a model in mind, it has been E.J. Sharpe's study of the thought of J.N. Farquhar, published in the series, “Studia Missionalia Upsaliensia” ¹⁰ I have tried to take account of J. Kent's appeal, in an essay on “The History of Christian Missions in the Modern Era”, to take secular history more seriously “for its own sake”, than was the case in an earlier generation of mission studies.¹¹ Not that any other study of Andrews would have made much sense, so active and perspicuous a participant was he in that history. I have also suggested that it is helpful to see Andrews within the special context of The Cambridge Mission to Delhi and its distinctive theology of mission, and indeed, my argument that this theology found a new authentication in his work during these years, provides a framework to the thesis. Two omissions ought to be justified, I have not attempted an elaborate review of the 19th century background of “Protestant missionary thought”, desirable as this might have been, because this has been done very thoroughly in the first part of Sharpe's study referred to above. Sharpe's omission, however, of the Cambridge Mission to Delhi and of “the missions of the Catholic tradition” (“with one exception, the Oxford mission to Calcutta”) because they lie to “one side of the dominant Evangelical stream of missionary thought”, provides a convenient space in which to establish the distinctive approach of the Delhi Mission.¹² Another omission is any general survey of the history of the Cambridge Mission, partly because a useful one is already available, by F.J. Western, but partly also because the essential context of Andrews' work was the completely new situation that developed almost immediately after his arrival in India, for which the earlier activities of the Mission provided no precedents. The sources used are exclusively English sources for English was almost exclusively the language in which the matter of Indian nationalism at this stage, and of Hindu reformation and of much of progressive Indian Islam occurred.¹³ For the unpublished sources for this study, I have relied largely on the well-known collections, in particular the archives of the C.M.D. and of S.P.G., the papers of two of the viceroys, Minto and Hardinge, and the correspondence of Tagore, Munshi Ram and Gandhi. The published sources have been in many ways quite as important as the unpublished, for Andrews became, from late 1906, something of a compulsive communicator in the nationalist press, and the evidence for his developing thought is to a considerable extent in print here. Many of these published sources are excessively rare. Thus, for example, there is, in India, only one surviving run of the St. Stephen's College Magazine for these years, and the same is true of the journal, Young Men of India, while there is in Britain only one microfilm copy of the nationalist newspaper, the Tribune, so important for this study. Because of the interest of much of this source material, and a wish to make it more accessible, I have allowed the notes to tend towards the copious. A full account of these sources is given in the Bibliography. Although, as is said above, Andrews' approach to his work, as representing a sort of realization of a distinctive theology of mission, provides a thesis on which this study is constructed, it is perhaps more important simply to claim a profound intrinsic interest in the story of this "gentle, eager and many-sided saint” ¹⁴ and in his perception of the necessities, still far from fulfilled, of a Christian response to the Asian revolution.” – from the Introduction.

Les premiers lecteurs de la « Trilogie de Pan » (1929-1930) puis l’historiographie stylistique tout entière ont systématiquement rapproché l’écriture de Jean Giono de celle de Charles Ferdinand Ramuz, et singulièrement de celle de son roman de 1926, La Grande Peur dans la montagne. Or, quelque soit l’observable linguistique choisi (la référence à la langue orale, la pratique de la répétition, les formes de l’analogie), de nettes différences apparaissent entre les deux pratiques rédactionnelles. C’est que la perception d’une parenté stylistique entre deux écrivains est contrainte par bien autre chose que des faits linguistiques. Dans le cas présent, on a, d’une part, projeté sur des formes langagières dissemblables une évidente communauté d’imaginaire. On a, d’autre part, préjugé de la similarité des formes langagières à partir de la proximité du projet esthétique : les deux oeuvres mettent en effet en tension la revendication d’une fidélité à une langue parlée régionalement inscrite, et une pratique de la langue qui emprunte aux codes « poétiques » conventionnels. / The first readers of the “Trilogie de Pan” (1929-1930) and the whole stylistic historiography havesystematically compared Jean Giono’s style with that of Charles Ferdinand Ramuz, and notably withthe style of his 1926 novel, La Grande Peur dans la montagne. Whatever linguistic criterion one maychoose (the reference to oral speech, the uses of repetition, the forms of analogy), it neverthelessappears that there is not so much in common between these two prose styles. The reason of thatfrequent comparison is simple: one often judges stylistic features from a non linguistic point of view.In the present case, readers have had the impression that both writing styles were similar because theauthors shared a common imaginary backround, but also because they had the same literary project:they both wanted to remain faithful to popular and local manners of speaking and at the same timedecided to resort to the same poetical stylistic conventions.

Chapter 1 gives an introduction on the physical and electronic properties of fluorine and the C-F bond. The application of fluorine in organic chemistry, which is mainly attributed to the electronic properties of fluorine is described. The role of fluorine in neuropsychiatric drug development and for influencing the conformational study of bioactive amines is also illustrated. Chapter 2 of the thesis describes the synthesis of the two fluorinated stereoisomers (2R, 3S) and (2S, 3S) 3-fluoro N-methyl–D-aspartate (NMDA). These were prepared as analogues to study the binding conformation of NMDA on the glutameric NMDA receptor. The (2S, 3S)-3-fluoro NMDA D-72 was successfully prepared from diethyl D-tartrate. The (2S,3R)- stereoisomer was prepared by separation of diastereoisomers generated by reaction of a meso- epoxide with an enantiomerically pure amine, followed by fluorination. Both the (2S,3R)- and (2R,3S)- enantiomers were prepared separately, however assignment of the absolute configuration to each enantiomer could not be unambiguously proven. The fluorinated 3F-NMDA stereoisomers were assessed by dose response analysis and TEVC analysis in the rat glutamate receptor. The biological results show that the (2S, 3S)-3F NMDA D-72 is a good agonist, whereas (2R, 3S)- and (2S, 3R)-3-fluoro NMDA are inactive stereoisomers. The result of this study indicates that (2S, 3S)-3F NMDA D-72 is the only relevant agonist that can access a conformation for binding to NMDA receptor. Chapter 3 describes the preparation of fluorinated analogues of the calcium receptor agonist Cinacalcet. The (2R,1’R)-123 and (2S,1’R)-124 fluoro Cinacalcet diastereoisomers were prepared from 3’-(trifluoromethyl)cinnamic acid and 3’’-SF₅-137 Cinacalcet was synthesized from pentafluorosulfanyl benzyl alcohol. The biological assessment in the calcium receptor (CaR) revealed that both (2R,1’R)-123 and (2S,1’R)-124 fluoro Cinacalcet is slightly lower in potency compared to the non-fluorinated Cinacalcet 117. This suggests that the Cinacalcet 117 adopts an extended conformation when bound to the receptor. The 3’’-SF₅-137 Cinacalcet possesses equipotent activity with Cinacalcet 117.

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Thesis (S.T.M.)--Concordia Theological Seminary, Ft. Wayne, 1999. / Includes bibliographical references (leaves 159-169).

Thesis (S.T.M.)--Concordia Seminary, St. Louis, 1987. / Includes bibliographical references (leaves 171-172).

Techn. Univ., Diss.--Berlin, 2000. / Literaturverz. S. [331] - 354.

Thesis (S.T.M.)--Concordia Theological Seminary, Ft. Wayne, 1999. / Includes bibliographical references (leaves 159-169).

Thesis (S.T.M.)--Concordia Theological Seminary, Ft. Wayne, 1999. / Includes bibliographical references (leaves 159-169).