Critical heat flux (CHF) and post-CHF are two critical phenomena in light water-cooled nuclear power plants regarding safety. Even though the general trends of CHF and post- CHF are known, the exact mechanisms are still unknown. To better understand CHF and post-CHF, experimental flow boiling facilities are constructed around the world. However, these facilities are limited in their experimental conditions and spatial resolution necessary to advance our understanding of two-phase heat transfer. Previous rod surface measurements were collected with thermocouples to measure CHF location and temperature excursion, yet thermocouples provide limited spatial resolution, which leads to significant uncertainties in the CHF prediction. On the other hand, optical fiber temperature sensors can measure the temperature and the CHF propagation with high spatial resolution. Also, the capability of the optical fiber at high temperatures has been proven in previous studies. The current study aims to apply optical fiber at high-pressure and high mass fluxes. The high-Pressure HIgh-temperature annuLUS flow (PHILUS) facility was designed to provide desired working conditions in the test section that uses optical fiber temperature sensors. The PHILUS test section has a length of 1320 mm, with 1000 mm of heated length. The working conditions of the PHILUS are up to 18 MPa, temperatures up to 357◦C, and coolant mass flux from 500 to 3700 kg/m2s. The main components of the loop are a steam separator, two heat exchangers (a condenser and a cooler), a bladder-type accumulator, two bypass lines, and a high-pressure pump. Coolant-Boiling in Rod Arrays-Two Fluids (COBRA-TF) code was used to design the CHF and post-CHF experiments to be performed at the PHILUS facility. / Master of Science / A nuclear power plant produces heat which is transferred from the reactor core through the coolant. The coolant water flows through the reactor core to safely transport the heat that ultimately is used to produce electrical energy. If the balance between the power produced by fission and the energy removed by the coolant is changed, it can lead to potential damage to the reactor core. The maximum heat transfer rate occurs at the point where a vapor blanket covers the surface of the fuel cladding. At this point, known as Critical Heat Flux (CHF), the surface temperature drastically increases. To better understand and better predict the CHF, experimental facilities are needed. Even though there are several facilities worldwide, most of them have limited working conditions and measurement capabilities. Past experiments used thermocouples to measure the surface temperature with a very small spatial resolution, which causes very large uncertainties in the CHF and post-CHF predictions. On the other hand, optical fiber sensors can be used to measure temperature with very high spatial resolution. The high-Pressure HIgh-temperature annuLUS flow (PHILUS) facility was designed in this work to apply optical fibers in the measurement of the rod surface temperature and simulations were performed to show its advantages. The working conditions of the PHILUS are comparable to commercial pressurized water reactors.

Congestive heart failure (CHF) is a growing epidemic that affects more than 50% of the world's population. CHF is a preventable disease, but prevention requires a healthy lifestyle from a young age. Most patients already diagnosed with CHF receive advice and strict instructions for care to prevent further cardiac injury. This quantitative descriptive research study was designed to address walking and jogging as the best exercises for patients diagnosed with CHF and in patients diagnosed with other cardiac problems. The results revealed that walking is the best exercise to improve patients' resting heart rate and overall cardiac function. This study also indicated that cardiac rehabilitation (CR) improved both blood pressure and heart rate, but the findings showed that CR improved heart rate most effectively. The Levine conservation model served as the foundation of the research. The Levine conservation model ensures the safety and the wholeness of a patient by protecting the interaction and adaptations of the patient's health care plan and environment through conserving and balancing energy. The social change plan for this research study is to give health care teams who care for patients with CHF or cardiac problems guidance to educate patients about CR. Increasing CR education among all health care teams could help improve many patients' quality of life, and the autonomy and empowerment given to patients may subsequently increase patients' cooperation with the treatment plan.

No description available.

The Renström mine, Boliden Mineral AB, uses, among other methods, the Transverse long hole stoping method with backfill. The mine uses a cement-stabilized hydraulic fill (CHF), which is a mixture of enrichment sand, cement and water. The most important factor in relation to strength is the water cement ratio. Today, only tests have been performed on the surface and in laboratory tests. The purpose of this work is thus to study the possibility of using other types of methods that can give a better understanding of the strength of the entire filling volume. Studies on backfill containing Portland cement and sulphur have shown that the UCS strength decreases with time, which can cause problems for the mine. A leaching method (MRM leaching test) used to evaluate potential sulphide soils has been used in this study on the backfill to investigate the sulphurs impact on the cement mixture. Electrical conductivity, pH, and redox potential were investigated and gave similar results, where the higher cement levels (8%, 10%, and 12%) were indistinguishable while the lower cement content (4%) differed significantly from the other levels. This probably indicates that the higher cement levels have a greater resistance to the influence of the sulphur. The most promising results were given when the method was used on enrichment sand alone. The linear lowering of the pH value of the enrichment sand, from pH 4.9 to about pH 3, point to that the enrichment sand contains large amounts of sulphur, as previously chemical analysis has shown. This suggests that the method can best be used in an early stage before the sand is mixed with cement. The strength results on the samples showed a strength after 7 days that was in line with the 90-day strength. However, all 90 day samples had decreased in strength during the time sequence, which may be an effect of the sulphur content, but should be further investigated to be determined. The smaller size of the samples was also experienced as a challenge during the temperature measurements due to small temperature variations and environmental effects. A maturity method for predicting the strength of concrete called "The maturity method" has been investigated in this study. To determine the strength maturity relationship, both the temperature related to time and the equivalent age must be evaluated. The study showed that the method cannot be used on the mine's backfill without first making adjustments related to the lower cement content used in the backfill compared with concrete constructions, since it is not possible to determine the strength growth in the early stage as the method requires.

In the United States, congestive heart failure (CHF) impacts 6.5 million adults and costs about $39 billion year with a projected incidence increasing by 25% by 2030. CHF can be addressed by advancing patient self-care knowledge through interactive patient education. For this project, the Health Beliefs Model guided a strategy to stimulate behavior modification based on perceived benefits of self-care. The purpose of this quality improvement project was to implement an interactive patient education video system, called the Get Well Network, to encourage patient self-care to reduce CHF readmission rates at a veteran's administration hospital. Four evidence-based CHF video order sets were developed with interactive multidisciplinary patient-provider teach back strategies and questions. The topics included: medication adherence, dietary restrictions, smoking cessation, and exercise. During the period of project implementation, all veterans admitted with a diagnosis of CHF were given the opportunity to view the educational videos; the completed viewing rate increased from 3% to 30% during the initial 6 weeks. An attempt was made to retrieve quarterly data on congestive heart failure patient readmission rates from the Veteran's Administration's computerized system. However, recent changes in the ICD coding system have slowed the data gathering process and it continues to be ongoing. This project has the potential for positive social change by increasing veteran knowledge of self-care, thereby reducing the likelihood of CHF readmission.

Subcooled pool boiling on nanotextured surfaces is explored in this study. The experiments are performed in an enclosed viewing chamber. Two silicon wafers are coated with Multiwalled Carbon Nanotubes (MWCNT), 9 microns (Type-A) and 25 microns (Type-B) in height. A third bare silicon wafer is used for control experiments. The test fluid is PF-5060, a fluoroinert with a boiling point of 56°C (Manufacturer: 3M Co.). The apparatus is of the constant heat flux type. Pool boiling experiments in nucleate and film boiling regimes are reported in this study. Experiments are carried out under low subcooling (5 °C and 10 °C) and high subcooling conditions (20°C to ~ 38°C). At approximately 38°C, a non-departing bubble configuration is obtained on a bare silicon wafer. Increase in subcooling is found to enhance the critical heat flux (CHF) and the CHF is found to shift towards higher wall superheats. Presence of MWCNT on the test surface led to an enhancement in heat flux. Potential factors responsible for boiling heat transfer enhancement on heater surfaces coated with MWCNT are identified as follows: a. Enhanced surface area or nano - fin effect b. Higher thermal conductivity of MWCNT than the substrate c. Disruption of vapor-liquid vapor interface in film boiling, and of the “microlayer” region in nucleate boiling d. Enhanced transient heat transfer caused by local quasi-periodic transient liquid-solid contacts due to presence of the “hair like” protrusion of the MWCNT e. Enhancement in the size of cold spots f. Pinning of contact line, leading to enhanced surface area underneath the bubble leading to enhanced heat transfer Presence of MWCNT is found to enhance the phase change heat transfer by approximately 400% in nucleate boiling for conditions of low subcooling. The heat transfer enhancement is found to be independent of the height of MWCNT in nucleate boiling regime in the low subcooling cases. About 75%-120% enhancement in heat transfer is observed for surfaces coated with MWCNT under conditions of high subcooling in the nucleate boiling regime. Surfaces coated with Type-B MWCNT show a 75% enhancement in heat transfer in the film boiling regime under conditions of low subcooling.

<p> CHF and Post-CHF tests were performed in water at 9.7 MPa using two vertical test assemblies having identical, internally heated annular flow channels, one heated directly, the other indirectly. Experiments were conducted to determine the effect of these methods of heating on CHF and Post-CHF heat transfer. </p> <p> For the range of the test conditions investigated, the results show that the direct and indirect heaters have similar CHF performance. At heat fluxes above CHF and mass fluxes of 2.0 and 3.5 Mg.s^-1 .m^-2 , the indicated maximum wall temperatures of the heaters were similar, but at the highest mass flux for the tests, 5.0 Mg.s^-1 .m^-2 , the indirect heater had lower indicated maximum wall temperatures than the direct heater for a given heat flux above CHF. </p> <p> A multi-fluid model, of the type used previously in the prediction of CHF, was derived and tested against the experimental data. The model, which considers droplet entrainment, deposition and evaporation in the annular flow regime, assumes dryout to occur when the liquid film flow on the inner rod approaches zero. The CHF predictions were in fairly good agreement with the experimental results. In general, the model under-predicted CHF at low inlet subcoolings and over-predicted CHF at high inlet subcooling. The error trend is consistent with that of the CHF prediction models of other researchers. </p> <p> In addition to the CHF prediction model, a Post-CHF model to predict the vapour temperatures, and hence, the heated wall temperature is also presented in the report. The theory is based on a physical model of heat transfer in the liquid deficient regime. In the model, heat in the dry region is assumed to transfer from the heated wall to superheat the steam and some of this heat, in turn, is used to evaporate the droplets which are entrained in the vapour core. Droplet entrainment and deposition at the shroud (outer tube) film-vapour interface are modelled. Heat transfer enhancement due to increased turbulence downstream of the rod centering spacers is incorporated through an empirical correlation. The predicted results were compared to the direct heater experiments. In general, the predicted wall temperatures were in agreement with those in the experiments. </p> / Thesis / Master of Engineering (MEngr)

A ansiedade e a depressão são as condições psicopatológicas mais comuns na atualidade. As pesquisas científicas em neurociência, psicologia, psiquiatria e medicina geral procuram encontrar diferentes formas para o tratamento e prevenção. No entanto, a maioria das pesquisas não leva em conta as diferenças individuais ou história do individuo. Quase toda a investigação farmacológica é feita em populações heterogêneas de animais, conduzindo assim à \"média\" dos dados. Recentemente, no Laboratório de Neurociência Comportamental na Pontifícia Universidade Católica do Rio de Janeiro (PUC-RJ), duas novas linhagens de ratos Wistar foram selecionadas fenotipicamente da resposta emocional de congelamento em um teste de medo condicionado . Uma das linhagens, denominada Carioca High ConditionedFreezing (CHF), apresenta uma resposta significativamente aumentada de congelamento no teste, enquanto que a outra (Carioca Low Conditioned-Freezing, CLF) mostra uma resposta de congelamento baixa. Em todos os experimentos utilizamos a linhagem controle (Random, RND) Wistar resultado de cruzamento aleatório entre ratos Wistar. Aqui apresentamos dados de diversos experimentos que avaliaram as diferenças em condições basais e vulnerabilidade ao estresse entre as duas linhagens e a linhagem RND. A concentração plasmática de corticosterona dos ratos foi comparada entre as duas linhagens e o grupo RND, primeiramente no nível basal e posteriormente após a exposição ao mesmo teste, onde foram expostos ao medo condicionado, como estímulo aversivo. Também foi avaliada a proliferação celular e sobrevivência. A imuno-histoquímica para c-fos foi conduzida com o objetivo de se determinar as diferenças de atividade neural entre as duas linhagens e o grupo RND. Um teste farmacológico com ketanserina, antagonista 5-HT2A, foi realizado e os animais foram avaliados quanto à ansiedade e locomoção, no labirinto em cruz elevado. Todos os nossos resultados mostraram diferenças estatisticamente significativas entre as linhagens selecionadas. Estes resultados sugerem que as diferentes condições basais podem ter impacto sobre a reação de comportamento exibido por cada animal. Assim, o uso de grupos selecionados é melhor para se modelar transtornos de ansiedade e procurar quais são caraterísticas que protegem aos animais que não apresentam os sintomas modelados. A partir dos nossos resultados foi evidente que os perfis comportamentais e neuroquímicos dos três grupos CHF, CLF e RND foram qualitativamente e quantitativamente diferentes. Na linha de base após ser fenotipados foi observado que existem diferenças na proliferação celular. Após a reexposição ao contexto observaram-se diferenças na concentração de corticosterona e na ativação neuronal. O estresse crônico levou a respostas diferenciais no número de neurônios imaturos, e o teste farmacológico levou a respostas diferencias tanto a nível local como sistêmico. Os dados obtidos podem ajudar a um melhor entendimento às bases neurobiológicas de aspectos associados às psicopatologias como ansiedade e depressão que estão relacionadas com a vulnerabilidade ao estresse. / Anxiety and depression are the most common psychopathological conditions today. Scientific research in neuroscience, psychology, psychiatry and general medicine seeks to find different ways for treatment and prevention. However, most research does not take into account individual differences and history. Almost all pharmacological research is done in heterogeneous populations of animals, thereby leading to the \"average\" data. Recently, in the Laboratory of Behavioral Neuroscience at the Pontifical Catholic University of Rio de Janeiro (PUC - RJ), two new strains of rats were selected phenotypically by their emotional response (freezing) in a test of cond itioned fear. One of the lines, so called \"Carioca High Conditioned - Freezing\" (CHF) has an increased freezing in the test , whereas the other (\"Carioca Low -Conditioned Freezing \" CLF) shows low freezing response . In all experiments we used the Wistar control strain (RND) derived from random bred between Wistar rats. Here we present data from several experiments evaluating the differences in basal conditions and vulnerability to stress between the two strains and RND strain. The plasma corticosterone of rats was compared between the two lines and the RND group, first at baseline and then after exposure to the same test where the y were exposed to conditioned fear as aversive stimulus. We also analyzed the cell proliferation and survival in the hippocampus after chronic stress. Immunohistochemistry for c -fos was conducted in order to determine the differences in neural activity between the two strains and the RND group. A pharmacological test with ketanserin, 5 -HT2A antagonist, was performed and the animals were assessed for anxiety and locomotion in the elevated plus maze. All our results showed statistically significant differences between the selected strains. These results suggest that different baseline conditions may have an impact on the behavior exhibited by each animal. Thus the use of selected groups is better approach in order to model anxiety disorders and to determine which features prevent animal from presenting symptoms. It is evident that the neurochemical and behavioral profiles of the three groups CHF, CLF and RND were different qualitatively and quantitatively. At baseline after been phenotyped it has been observed that there are differences in cell proliferation and corticosterone concentration. After re-exposure to the context differences were observed in the concentration of corticosterone and neuronal activation. Chronic stress has led to differential responses in the number of immature neurons. And the pharmacological test led to differential responses at both local and systemic. The data obtained are useful for a better understanding of the neurobiological aspects associated with psychopathologies such as anxiety and depression that are associated with vulnerability to stress.

Every year, thousands of congestive heart failure (CHF) patients are readmitted to the hospital within 30 days of discharge. There is a gap in practice in the care continuum of patients with CHF within the transition from hospital to home. One of the factors known to increase a patient's risk for readmission is the lack of patient engagement and self-efficacy regarding the treatment plan. The purpose of this project was to implement a transition of care practice guideline that consisted of the use of a risk identification tool, a customized care plan for patients at high risk for readmission, and a discharge checklist crafted specifically for CHF patients who are at risk for readmission. The practice initiative utilized the Iowa model of Evidence Based Practice as a framework and the teach-back method for discharge education. A sample of 193 patients admitted during a 1-month timeframe fit the inclusion criteria and was generated from the electronic health record. Descriptive statistics were used to analyze the data collected during implementation. In fact, of the 106 CHF patients who benefited from the CHF checklist only 2 required readmission within 30 days, a 1.8% 30 day readmission rate. As compared to the 22% readmission rate experienced in 2017, this represented a considerable improvement, albeit preliminary. Efforts to improve the lives of patients and their families will ultimately serve society well, making a significant contribution to positive social change. Providing comprehensive discharge education to patients using the teach-back method to assess the retention of knowledge will help close the gap in the transition of care between hospital and home, ultimately reducing CHF readmissions.

A ansiedade e a depressão são as condições psicopatológicas mais comuns na atualidade. As pesquisas científicas em neurociência, psicologia, psiquiatria e medicina geral procuram encontrar diferentes formas para o tratamento e prevenção. No entanto, a maioria das pesquisas não leva em conta as diferenças individuais ou história do individuo. Quase toda a investigação farmacológica é feita em populações heterogêneas de animais, conduzindo assim à \"média\" dos dados. Recentemente, no Laboratório de Neurociência Comportamental na Pontifícia Universidade Católica do Rio de Janeiro (PUC-RJ), duas novas linhagens de ratos Wistar foram selecionadas fenotipicamente da resposta emocional de congelamento em um teste de medo condicionado . Uma das linhagens, denominada Carioca High ConditionedFreezing (CHF), apresenta uma resposta significativamente aumentada de congelamento no teste, enquanto que a outra (Carioca Low Conditioned-Freezing, CLF) mostra uma resposta de congelamento baixa. Em todos os experimentos utilizamos a linhagem controle (Random, RND) Wistar resultado de cruzamento aleatório entre ratos Wistar. Aqui apresentamos dados de diversos experimentos que avaliaram as diferenças em condições basais e vulnerabilidade ao estresse entre as duas linhagens e a linhagem RND. A concentração plasmática de corticosterona dos ratos foi comparada entre as duas linhagens e o grupo RND, primeiramente no nível basal e posteriormente após a exposição ao mesmo teste, onde foram expostos ao medo condicionado, como estímulo aversivo. Também foi avaliada a proliferação celular e sobrevivência. A imuno-histoquímica para c-fos foi conduzida com o objetivo de se determinar as diferenças de atividade neural entre as duas linhagens e o grupo RND. Um teste farmacológico com ketanserina, antagonista 5-HT2A, foi realizado e os animais foram avaliados quanto à ansiedade e locomoção, no labirinto em cruz elevado. Todos os nossos resultados mostraram diferenças estatisticamente significativas entre as linhagens selecionadas. Estes resultados sugerem que as diferentes condições basais podem ter impacto sobre a reação de comportamento exibido por cada animal. Assim, o uso de grupos selecionados é melhor para se modelar transtornos de ansiedade e procurar quais são caraterísticas que protegem aos animais que não apresentam os sintomas modelados. A partir dos nossos resultados foi evidente que os perfis comportamentais e neuroquímicos dos três grupos CHF, CLF e RND foram qualitativamente e quantitativamente diferentes. Na linha de base após ser fenotipados foi observado que existem diferenças na proliferação celular. Após a reexposição ao contexto observaram-se diferenças na concentração de corticosterona e na ativação neuronal. O estresse crônico levou a respostas diferenciais no número de neurônios imaturos, e o teste farmacológico levou a respostas diferencias tanto a nível local como sistêmico. Os dados obtidos podem ajudar a um melhor entendimento às bases neurobiológicas de aspectos associados às psicopatologias como ansiedade e depressão que estão relacionadas com a vulnerabilidade ao estresse. / Anxiety and depression are the most common psychopathological conditions today. Scientific research in neuroscience, psychology, psychiatry and general medicine seeks to find different ways for treatment and prevention. However, most research does not take into account individual differences and history. Almost all pharmacological research is done in heterogeneous populations of animals, thereby leading to the \"average\" data. Recently, in the Laboratory of Behavioral Neuroscience at the Pontifical Catholic University of Rio de Janeiro (PUC - RJ), two new strains of rats were selected phenotypically by their emotional response (freezing) in a test of cond itioned fear. One of the lines, so called \"Carioca High Conditioned - Freezing\" (CHF) has an increased freezing in the test , whereas the other (\"Carioca Low -Conditioned Freezing \" CLF) shows low freezing response . In all experiments we used the Wistar control strain (RND) derived from random bred between Wistar rats. Here we present data from several experiments evaluating the differences in basal conditions and vulnerability to stress between the two strains and RND strain. The plasma corticosterone of rats was compared between the two lines and the RND group, first at baseline and then after exposure to the same test where the y were exposed to conditioned fear as aversive stimulus. We also analyzed the cell proliferation and survival in the hippocampus after chronic stress. Immunohistochemistry for c -fos was conducted in order to determine the differences in neural activity between the two strains and the RND group. A pharmacological test with ketanserin, 5 -HT2A antagonist, was performed and the animals were assessed for anxiety and locomotion in the elevated plus maze. All our results showed statistically significant differences between the selected strains. These results suggest that different baseline conditions may have an impact on the behavior exhibited by each animal. Thus the use of selected groups is better approach in order to model anxiety disorders and to determine which features prevent animal from presenting symptoms. It is evident that the neurochemical and behavioral profiles of the three groups CHF, CLF and RND were different qualitatively and quantitatively. At baseline after been phenotyped it has been observed that there are differences in cell proliferation and corticosterone concentration. After re-exposure to the context differences were observed in the concentration of corticosterone and neuronal activation. Chronic stress has led to differential responses in the number of immature neurons. And the pharmacological test led to differential responses at both local and systemic. The data obtained are useful for a better understanding of the neurobiological aspects associated with psychopathologies such as anxiety and depression that are associated with vulnerability to stress.