<p>Neurography is the most objective and reliable measure of the peripheral nerve function, and it is used to diagnose both local and generalized neuropathies. Neurography can measure both motor and sensory nerve functions. The principle for sensory neurgraphy is to stimulate over the nerve and record proximal or distal from the stimulated electrode.</p><p>At the Department of Clinical Neurophysiology, University Hospital Uppsala, a problem has been identified, in that young adult patients tend to show unexpected abnormal neurography values in relation to the expected, indicated by the reference limits, without clinical correlates. This concerns foremost the sensory amplitudes in median and ulnar nerves. The hypothesis is that the requirement of young adults’ amplitudes is too high. A reference material better including more subjects in this age group may solve the problem.</p><p>Sensory nerve conduction studies were performed in 33 subjects, aged 15-30. The nerve functions were tested on median, ulnar and radial nerves. Surface electrodes were used for both recording and stimulation.</p><p>The result shows that the presently used reference material for some nerves indeed has too high requirement for young adults. After increasing the reference material for younger age groups, the new reference limits has been changed and this should cause fewer false positive findings.</p>

The overall goal of this work is to provide a systematic methodology by which the difficulties associated with the inverse heat conduction problem (IHCP) can be resolved. To this end, two inverse heat conduction methods are presented. First, a space-marching IHCP method (discrete space, discrete time) utilizing a Gaussian low-pass filter for regularization is studied. The stability and accuracy of this inverse prediction is demonstrated to be more sensitive to the temporal mesh than the spatial mesh. The second inverse heat conduction method presented aims to eliminate this feature by employing a global time, discrete space inverse solution methodology. The novel treatment of the temporal derivative in the heat equation, combined with the global time Gaussian low-pass filter provides the regularization required for stable, accurate results. A physical experiment used as a test bed for validation of the numerical methods described herein is also presented. The physics of installed thermocouple sensors are outlined, and loop-current step response (LCSR) is employed to measure and correct for the delay and attenuation characteristics of the sensors. A new technique for the analysis of LCSR data is presented, and excellent agreement is observed between this model and the data. The space-marching method, global time method, and a new calibration integral method are employed to analyze the experimental data. First, data from only one probe is used which limits the results to the case of a semi-infinite medium. Next, data from two probes at different depths are used in the inverse analysis which enables generalization of the results to domains of finite width. For both one- and two-probe analyses, excellent agreement is found between the actual surface heat flux and the inverse predictions. The most accurate inverse technique is shown to be the calibration integral method, which is presently restricted to one-probe analysis. It is postulated that the accuracy of the global time method could be improved if the required higher-time derivatives of temperature data could be more accurately measured. Some preliminary work in obtaining these higher-time derivatives of temperature from a voltage-rate interface used in conjunction with the thermocouple calibration curve is also presented.

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According to classical linearized resistive magnetohydrodynamics theory, pressuredriven modes are unstable in the reversed-field pinch (RFP) due to unfavorable magnetic field line curvature. The result is based on the assumption of an adiabatic energy equation where anisotropic thermal conduction effects are ignored as compared to convection and compression. In this thesis the effects of heat conduction in the energy equation have been studied. We have examined these effects on the linear stability of pressure-driven resistive modes using boundary value theory (Δ´ ) and a novel initial-value full resistive MHD code employing the Generalized Weighted Residual Method (GWRM). In the Δ´ method, a shooting technique is employed by integrating from the resistive layer to boundaries. The GWRM method, on the other hand, is a time-spectral Galerkin method in which the fully linearized MHD equations are solved. For detailed computations, efficiency requires the temporal and spatial domains to be divided into subdomains. For this purpose, a number of challenging test cases including linearized ideal MHD equations are treated. Numerical and analytical investigations of equilibria reveal that thermal conduction effects are not stabilizing for reactor relevant values of Lundquist number, S0, and normalized pressure, βθ, for tearing-stable plasmas. These studies show that growth rate scales as  γ~_ S0−1/5 , which is weaker than for the adiabatic case, γ~_ S0−1/3. A numerical study of optimized confinement for an advanced RFP scenario including ohmic heating and heat conduction, is also part of this thesis. The fully nonlinear resistive MHD code DEBSP has been employed. We have identified, using both Δ´ and GWRM methods, that the observed crash of the high confinement is caused by resistive, pressure-driven modes. / <p>QC 20130503</p>

Ce travail de thèse présente les résultats obtenus lors de l'étude des mécanismes élémentaires à l'origine de la forte conduction protonique mesurée dans le cas de clathrates hydrates d'acides forts. Une méthodologie combinant diffusion neutronique, résonance magnétique nucléaire et simulation de dynamique moléculaire "ab-initio" a permis de modéliser les différents processus dynamiques impliqués, se produisant sur des temps allant de la nanoseconde à la femtoseconde. Le modèle proposé explique la forte conduction de ces systèmes aqueux par la délocalisation à longue distance de leurs protons résultant d'un mécanisme de type Grotthuss gouverné par la relaxation des molécules aqueuses environnant les protons en excès.

No description available.

The heat dissipation and thermal performance of ventilated brake discs strongly depends on the aerodynamic characteristics of the air flow through the rotor passages. In this thesis, the thermal convection is analyzed using an analytical method, and the velocity distribution, temperature contours and Nusselt number are determined. Then numerical models for different rotors, pillar post rotors and vane rotors are generated and numerical simulations are conducted to determine the desired parameters. To analyze more realistic vane and pillar post rotor models, commercial CFD software packages, Fluent and Gambit, are used to simulate the heat flux rate, air flow rate, velocity distributions, temperature contours, and pressure distributions inside the rotors. Furthermore, sensitivity studies have been performed, to determine the effects of a different number of vanes or pillar posts, inner and outer radii and various angles of vanes. To automate the tedious and repetitive design process of the disc rotor, a design synthesis framework, iSIGHT, is used to integrate the geometrical modeling using GAMBIT and numerical simulations based on FLUENT. Through this integrated design synthesis process, the disc rotor geometrical optimization is performed using design of experiment studies. / UOIT

SecA is a central component of the general secretion system that is essential for growth and virulence of bacteria. A series of fluorescein analogs were tested against ATPase activities of Escherichia coli SecA. Rose Bengal (RB) and Erythrosin B are potent inhibitors abolishing the activities of three forms of SecA ATPase with IC50 in µM range. Both inhibit SecA intrinsic ATPase with two mechanisms depending on ATP concentrations, indicating they influence the two non-identical nucleotide binding sites differently. RB shows different inhibitory effects against three forms of SecA ATPase activities, suggesting that the inhibition is related to the conformation of SecA. RB with IC50 at sub-µM level is the most potent inhibitor of SecA ATPases and SecA-dependent protein translocation to date. The fluorescein analogs inhibit intrinsic ATPase of Bacillus subtilis SecA similarly, and also exhibit antibacterial effects in E. coli and B. subtilis. Our findings indicate the value of fluorescein analogs as probes for mechanistic studies of SecA and the potential development of new SecA-targeted antimicrobial agents. A series of SecA derivatives with truncated C-terminus within the first long α-helix of the helix-bundle extending the ATPase catalytic domain of N68 was analyzed. These SecA variants interact with lipids, and those containing the C-terminal portion of the long α-helix starting at residues #639 form the ring-like structure in liposomes, indicating the critical domains for forming the protein-conducting channel. The presence and length of the C-domain influence the response to RB of NBDII mutants and C-terminal truncates of SecA. Thus this region may interact with the inhibitors and is involved in the structure and regulation of SecA ATPase activity. B. subtilis SecA was analyzed for interspecies comparison. Despite sharing high homology, this SecA homolog cannot complement E. coli mutants with SecA defect. Phospholipids do not stimulate ATPase activities of B. subtilis SecA, but induce its conformational changes, leading to the lipid-specific domains and ring-like structures similar to E. coli SecA. These pore-ring structures may represent part of the protein-conducting channels. Therefore, the potential structural roles of SecA in the protein translocation machinery may be universal in both Gram-negative and Gram-positive bacteria.

The low thermal conductivity of gallium arsenide compared to silicon results in self-heating effects in GaAs MESFETs that limit the electrical performance of such devices for high power applications. To date, analytical thermal models of self heating in GaAs MESFETs are based on the assumption of a uniformly heated channel. This thesis presents a two dimensional analysis of the electrothermal effect of this device based on the two dimensional power density distribution in the channel under various bias conditions. The numerical simulation is performed using the finite difference technique. The results of the simulation of an isothermal MESFET without heat effects is compared with various one dimensional analytical models in the literature. Electro thermal effects into the two-dimensional isothermal MESFET model allowed close examination of the temperature profile within the MESFET. The large gradient in power distribution results in a localized heat source within the channel which increases the overall channel temperature, which shows that the assumption of a uniformly heated channel is erroneous, and may lead to an underestimation of the maximum channel temperature. / Graduation date: 1992

Organic semiconductors are very attractive for thin film Organic Photodetectors (OPDs) since they possess a number of desirable attributes for optical sensing including high absorption coefficients over visible and ultraviolet wavelengths and compatibility with large-area deposition processes such as ink-jet, screen printing, and solution processing. OPDs, in general, utilize a vertical device architecture where the photoactive organic semiconductor layers are sandwiched between top and bottom electrodes that provide electrical contact. More recently, an interest in utilizing a lateral device architecture instead of the vertical one, has emerged. In this architecture, the two contacts are positioned on the two sides of the photoactive material with respect to the direction of the incoming signal, separated by a small gap. However, the factors governing lateral OPDs’ photo-response are still not well understood. In this thesis, we fabricate top-contact lateral OPDs using a thermal evaporation only fabrication process. We study the factors governing both the dark and photo currents of lateral OPDs. The effect of the wide gap between the two electrodes on the current-voltage characteristics is discussed and the role of space charge limited conduction is investigated. The contributions in the photoresponse of light scattering through the active layers as well as the back reflection of light at the metallic contacts are emphasized. The reproducibility over repeated operation cycles of both dark and photo currents values is explored. Exposure to light of the lateral OPD is found to lead to a significant increase in the dark current. The role of the conductivity enhancement in the channel due to light-induced trap filling is investigated. External quantum efficiency and detectivity estimates are given for deep ultraviolet lateral (DUV) OPDs. A comparison with vertical DUV OPDs performances is provided. Finally, the use of a phosphorescent sensitizer doped in the absorbing bottom layer to improve top-contact lateral OPDs efficiency is discussed.