oday, globalization has become a phenomenon of all the industry in the world, business need to quickly response to the supply chain changes, or could obiously harm to iself. Artificial industry in Taiwan, orders from downstream members are huge and with large diversity, it Is important to build an alignment to the sales department and the production department. To decrease the information gaps between sales department and the production department, there are mechanisms whichh could be apply into this industry In Taiwan. This study shows the difference of apply two kinds of sale / production alignment machanism, and compare the performance of those two to the processes nowaday through simulation tools.

Face the change of globalization business, business opportunities far and wide. In contrast, corporate challengers, is no longer just a regional rival, but the strong competitors from different countries. Now, although the market is large, but also a substantial growth of the overall market supply, the supply quickly exceeded demand. In saturated markets, companies how to overcome or co-competitors to grab a larger market share, profit? For enterprises, existence of the business mission is to provide products, services, customers. Without customers, there is no demand, companies will not be able to survive. Therefore, in addition to providing standard, high quality products, we must be able to respond more quickly to customer needs, get the trust and improve customer satisfaction. Enterprise subject to different tangible and intangible constraints, How to play the best of ability, flexibility and rapid response to customer demand among the existing constraints? Improve operational efficiency, reduce inventory costs, efficient delivery and with the best service in the competition for maximum profit. This study base on many constraints in the continuous industry using thought tool of theory of constraints to break the bottleneck and response customer's demand. Through the ERP combined with ATP / CTP mechanism to improve the order promising process. Effectively improve service efficiency, shorten customer product delivery, while enhancing the overall supply chain efficiency, enhance corporate competitiveness and profitability.

The work deals with processing of radio received signal strength in IEEE 802.15.4 which communicates in 2.4 GHz ISM band. The signal is processed by the three approximation methods. They are tested for their effectiveness for measuring in different radio environments. Furthermore, the work deals with calculation of the most efficient coefficients for distance calculating by radio transmission fucntions. It defines the issues of such solutions on practical examples. The work also deals with the experimental algorithm for implementing dynamic calibration of the coefficients. It describes the design, processing and verification of this system in practice.

<p>A model to predict carpal tunnel syndrome (CTS) risk would improve ergonomic assessments and help reduce the incidence of occupational CTS and its associated costs. Research spanning over sixty years has shown that deviated wrist, forearm, and hand posture has on the hydrostatic pressure within the carpal tunnel (also known as carpal tunnel pressure, CTP). Elevated CTP is a mechanism of the development, or aggravation of CTS symptoms. The purpose of this thesis was to develop a model to predict CTS risk, based on CTP, and incorporate the model into an ergonomic tool for use by ergonomists. An extensive literature review identified additional studies that investigated the effects of pronation/supination, finger posture, and fingertip loading on CTP. The effect of wrist, forearm, and hand posture was then incorporated into the model via a series of regression equations developed for each plane of movement. The effect of fingertip loading (independent to the posture effects) was included using a multiplier based on the hand posture and load magnitude. To provide a user-friendly tool for ergonomists, a graphical-user-interface was developed to predict CTS risk based on the developed model. Input variables were wrist, hand, and forearm posture, and fingertip loading. CTP program estimated CTP, and compared the predicted pressure to a known threshold beyond which median nerve function has been shown to degrade. The tool was then evaluated by comparing the output of the tool (CTS risk) to the incidence of CTS in a large automotive manufacturing environment. There was no significant difference between the two groups (workers completing jobs with an incidence of CTS and workers completing jobs with no incidence of CTS). The tool marks an important first step v towards providing ergonomists with a much-needed tool to predict CTS risk based on posture, frequency, and fingertip force.</p> / Master of Science (MSc)

All living cells are dependent on nucleic acids for their survival. The genetic information stored in DNA is translated into functional proteins via a messenger molecule, the ribonucleic acid (RNA). Since DNA and RNA can be considered as polymers of nucleotides (NTPs), balanced pools of NTPs are crucial to nucleic acid synthesis and repair. The de novo reduction of ribonucleoside diphosphates (NDPs) to deoxyribonucleoside diphosphates (dNDPs), the precursors for DNA synthesis, is catalyzed by the enzyme ribonucleotide reductase (RNR). In cycling cells the dominant form of mammalian RNR consists of two proteins called R1 and R2. A proteasome-mediated degradation completely deprives postmitotic cells of R2 protein. The nonproliferating cells use instead a p53 inducible small RNR subunit, called p53R2 to synthesize dNTPs for mitochondrial DNA replication and DNA repair. To address the ongoing controversy regarding the localization and subsequently function and regulation of RNR subunits, the subcellular localization of all the mammalian RNR subunits during the cell cycle and after DNA damage was followed as a part of this thesis. Irrespective of the employed methodology, only a cytosolic localization could be observed leading to a conclusion that the dNTPs are synthesized in the cytosol and transported into the nucleus or mitochondria for DNA synthesis and repair. Thus, our data do not support the suggestion that nuclear translocation is a new additional mechanism regulating ribonucleotide reduction in mammalian cells. In an attempt to find a cure for African sleeping sickness, a lethal disease caused by a human pathogen, Trypanosoma brucei, nucleotide metabolism of the parasite was studied. The trypanosomes exhibit strikingly low CTP pools compared with mammalian cells and they also lack salvage of cytidine/cytosine making the parasite CTP synthetase a potential target for treatment of the disease. Following expression, purification and kinetic studies of the recombinant T. brucei CTP synthetase it was found that the enzyme has a higher Km value for UTP than the mammalian CTP synthetase. In combination with a lower UTP pool the high Km may account for the low CTP pool in trypanosomes. The activity of the trypanosome CTP synthetase was irreversibly inhibited by the glutamine analog acivicin, a drug extensively tested as an antitumor agent. Daily injections of acivicin to trypanosome-infected mice were sufficient to suppress the parasite infections. The drug was shown to be trypanocidal when added to cultured bloodstream T. brucei for four days at 1 uM concentration. Therefore, acivicin may qualify as a drug with “desirable” properties, i.e. cure within 7 days, according to the current Target Product Profiles of WHO and DNDi. Trypanosomes lack de novo purine biosynthesis and are therefore dependent on exogenous purines such as adenosine that is taken up from the blood by high-affinity transporters. We found that besides the cleavage-dependent pathway, where adenosine is converted to adenine by inosine-adenosine-guanosine-nucleoside hydrolase, T. brucei can also salvage adenosine by adenosine kinase (AK). The efficient adenosine transport combined with a high-affinity AK yields a strong salvage system in T. brucei, but on the other hand makes the parasites highly sensitive to adenosine analogs such as adenine arabinoside (Ara-A). The cleavage-resistant Ara-A was shown to be readily taken up by the parasites and phosphorylated by the TbAK-dependent pathway, inhibiting trypanosome proliferation and survival by incorporation into nucleic acids and by affecting nucleotide levels in the parasite.

Nowadays, many companies attempt to adapt their production planning and strategy to make order fulfillment more flexible. In manufacturing, the capacity and capability constraints are key factors which need efficient production planning for controlling service level and minimizing inventory cost. This thesis focuses on looking for the economic and efficient strategies for Capability to Promise or CTP handling. This strategy is proposed to work for Low Volume/High Mixed product manufacturing. Moreover, SAP is used as Enterprise Resource Planning (ERP) system for steering the CTP handling strategies in order to increase automated order handling regarding cost efficiency. The results of this research are both concepts and implementations on how to set CTP handling by using SAP, regarding the demand uncertainty environment in Make to Order (MTO) fulfillment.

Abstract Since the launch and hot market of innovative products such as iPod, iPhone and iPad, it has created a PND operational interface revolutionary wave. The beloved keyboard, mouse or Passive Touch Panel are gradually replaced by Capacitive Touch Panel(CTP) which became one of the hottest trends in consumer electronic products. No matter in transmittance, hardness, response time, operating temperature resistance, UV resistance or beauty of outlook, CTP products surpass traditional Passive Touch Panel. The market of CTP products is so huge but there is big difference of respective company¡¦s performance. Some companies earn 2 or 3 times of company capital per year but some companies still are at a net loss stage. It¡¦s worth to study why there is a significant difference of their business performance. Further, it is beneficial to study the topic of what are the key successful factors of these outstanding companies. By selecting six representitive samples of CTP companies to research, we will study the development of this industry, the evolution of product technology and the difference of business performance, especially focusing on their sales scale, future growth rate, customer potential growth, ROE, ROA, EPS, EVA and MVA to analyze and compare. We confirm TPK Holding Co., Ltd. and Young Fast Optoelectronics Co., Ltd. are leaders among Taiwan CTP industry. We will study the key successful factors of this industry through interviews with senior management and researchers of this industry. The conclusion of this study is as follows, 1. Glass-type CTP will be the mainstream of CTP product structure, especially in the consumer electronic products such as smartphone and tablet computers. 2. On Glass Solution, Flexible Subtrate and In Cell technology will be the future development of CTP products. 3. If compared with other financial indicators, Economic Value Added (EVA) will fully evaluate and predict the corporate value. 4. There are 7 key successful factors of CTP panels: I. Innovative ability of advanced products and production process technology. II. Emphasize the patent layout to lead the advanced technology. III. Capacity and yield rate. IV. Main customers¡¦ ability to create market. V. Rapid and complete technology supported ability. VI. Provide value added service and products which surpassed other competitors. VII. Establish huge human resource and sound financial structure. Key words¡GCapacitive Touch Panel(CTP)¡BBusiness Performance¡BEconomic Value Added (EVA)¡BMarket Value Added (EVA)¡BKey Successful Factors(KSF)

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Testing often takes between 35 and 50 percent of the total costs of software development projects. Still, the role of testing tends to be underestimated. High costs that are being spent on software testing make a reason for looking for systematical approaches for making the testing processes efficient. Test process improvement models offer such approaches. These models are subject of this thesis. Implementation of process improvement models can be an expensive, long-term activity. Therefore, reasons need to be found, why is important to use such models. Reasons and motivations for using improvement models are demonstrated in the first part of this thesis. It turned out that software testing has, by its historical development, come to the state, when it contains so much theory that companies have a problem absorbing all the knowledge to make testing processes efficient. Therefore, improvement models offer a solution to this problem. This thesis is primarily focused on Test Maturity Model Integration (TMMi), which is being analyzed thoroughly. The work searches for possibilities and limitation of using the model and it summarizes current experiences with the model. Because the TMMi model does not contain a practical assessment method, such method is proposed in this thesis. The assessment method will help organizations using the model. Beside TMMi, the thesis provides an introduction into three other models: Test Process Improvement (TPI), Capability Maturity Model Integration (CMMI) and Critical Testing Processes (CTP). All four models are subject to a comparison based on specified criteria. Results of the comparison are analyzed to identify for which situations individual models suit best. The comparison will help organizations to choose the right model for their needs.

Cash assistance has emerged as a vital tool for supporting household recovery in Nepal after multiple disasters, including the 2015 earthquake, 2018 drought, and COVID-19 pandemic. This research engages with organizational learning theory to explore how cash programs evolved overtime and identify the challenges and opportunities encountered in program implementation. Using semi-structured interviews, I recorded the experiences of individuals from NGOs, INGOs, and donor agencies involved in managing these programs in Nepal. While initial skepticism from the government, limited resources, and beneficiaries' lack of access to financial institutions presented obstacles, cash programs empowered individuals to meet their needs and revitalized local economies. The research identifies that technological integration, use of market analysis, and collaboration with financial institutions as evidence of learning from past programs to inform new programs; however, government resistance remained a barrier. Interview participants emphasized the importance of collaboration, innovation, and adaptation to improve future cash programs and, build a more resilient Nepal that is better prepared for future disasters.