<p>Detta examensarbete har utförts i samarbete med NAtryck i Örebro och syftar till att kontrollera stabiliteten hos deras sättare av märke Agfa Polaris XT och därmed avgöra om ett automatiskt kontrollerande system vore lönsamt i inköp. Kontrollen har skett genom kontinuerliga mätningar av tonvärden på plåt (efter exponering och framkallning men innan tryckning) under en lång tidsperiod. CtP-processens bidrag till den totala punktförstoringen har också studerats med hjälp av tre provtryckningar där även slutsatser om plåtslitagets inverkan dragits. Ett program för att hantera de fel som uppstår i sättaren har också konstruerats.</p><p>Resultaten visar att CtP-processen hos NAtryck är stabil och att medelvärdet av variationerna hos tonvärdena understiger två procent för båda rastreringsmetoderna som tryckeriet använder. De parametrar som påverkar processen mest är temperatur hos sättaren samt rengöring och byte av framkallningsvätska i framkallaren. En högre temperatur och äldre framkallningsvätska ger högre värden. Bidraget till den totala punktförstoringen från sättare och framkallare är ca femton procent i genomsnitt och mellan 0 och 5 procent vid fyrtioprocentig yttäckning. Om inget plåtslitage skulle inträffa vore denna siffra betydligt högre.</p><p>Slutsatsen är att ett inköp av ett automatiskt kontrollerande system vore olönsamt då processen redan håller acceptabel nivå. Sedan arbetet avslutats har även en ny sorts plåtar börjat användas som ger en än högre stabilitet.</p> / <p>This thesis has been done in collaboration with NAtryck in Örebro with the purpose to investigate the stability in their CtP-process. This has been done through continuous measurements of tone values on plates (after exposing and processing and before printing) during an extensive time period. The contribution from the CtP to the total amount of dot gain has also been investigated by conducting three test prints where conclusions about the degrading of the plates also have been made. A program that deals with errors in the CtP has been constructed.</p><p>The results show that the CtP-process is stable and that the mean value of the variations is below two percent for both screening methods used. The parameters that affect the result are the temperature and the cleaning and fluid of the developer. A higher temperature and older fluid give higher values. The contribution to the total dot gain is about fifteen percent in average and between zero and five percent at forty percent area coverage. If there were no degrading of the plate in the press this number would be much higher.</p><p>The conclusion is that an automatic controlling system would not be profitable. Since this work has been concluded a new type of plates has been taking in to production that resulted in even higher stability.</p>

Detta examensarbete har utförts i samarbete med NAtryck i Örebro och syftar till att kontrollera stabiliteten hos deras sättare av märke Agfa Polaris XT och därmed avgöra om ett automatiskt kontrollerande system vore lönsamt i inköp. Kontrollen har skett genom kontinuerliga mätningar av tonvärden på plåt (efter exponering och framkallning men innan tryckning) under en lång tidsperiod. CtP-processens bidrag till den totala punktförstoringen har också studerats med hjälp av tre provtryckningar där även slutsatser om plåtslitagets inverkan dragits. Ett program för att hantera de fel som uppstår i sättaren har också konstruerats. Resultaten visar att CtP-processen hos NAtryck är stabil och att medelvärdet av variationerna hos tonvärdena understiger två procent för båda rastreringsmetoderna som tryckeriet använder. De parametrar som påverkar processen mest är temperatur hos sättaren samt rengöring och byte av framkallningsvätska i framkallaren. En högre temperatur och äldre framkallningsvätska ger högre värden. Bidraget till den totala punktförstoringen från sättare och framkallare är ca femton procent i genomsnitt och mellan 0 och 5 procent vid fyrtioprocentig yttäckning. Om inget plåtslitage skulle inträffa vore denna siffra betydligt högre. Slutsatsen är att ett inköp av ett automatiskt kontrollerande system vore olönsamt då processen redan håller acceptabel nivå. Sedan arbetet avslutats har även en ny sorts plåtar börjat användas som ger en än högre stabilitet. / This thesis has been done in collaboration with NAtryck in Örebro with the purpose to investigate the stability in their CtP-process. This has been done through continuous measurements of tone values on plates (after exposing and processing and before printing) during an extensive time period. The contribution from the CtP to the total amount of dot gain has also been investigated by conducting three test prints where conclusions about the degrading of the plates also have been made. A program that deals with errors in the CtP has been constructed. The results show that the CtP-process is stable and that the mean value of the variations is below two percent for both screening methods used. The parameters that affect the result are the temperature and the cleaning and fluid of the developer. A higher temperature and older fluid give higher values. The contribution to the total dot gain is about fifteen percent in average and between zero and five percent at forty percent area coverage. If there were no degrading of the plate in the press this number would be much higher. The conclusion is that an automatic controlling system would not be profitable. Since this work has been concluded a new type of plates has been taking in to production that resulted in even higher stability.

This thesis deals with Canadian traveller problem (CTP), which can be defined as the shortest path problem in a stochastic environment. The overview of different CTP variants is presented in theoretical part of this thesis, as well as known solutions to these variants. In the next parts, the thesis focuses on the stochastic variation of CTP (SCTP). For this variant chosen solutions (strategies) are discussed more in depth. At the same time, the original strategies named UCTO and UCTP are presented. Further, the thesis deals with the description of a window application implemented in Java, which has been developed to validate and test the functionality of selected strategies. The final part contains experiments and comparison of selected strategies.

Tese (doutorado)—Universidade de Brasília, Faculdade de Arquitetura e Urbanismo, 2016. / Submitted by Camila Duarte (camiladias@bce.unb.br) on 2016-07-20T16:28:11Z No. of bitstreams: 1 2016_GustavodeLunaSales.pdf: 6698120 bytes, checksum: 0e96c1b5bde43be2b8976e3584d413ad (MD5) / Approved for entry into archive by Raquel Viana(raquelviana@bce.unb.br) on 2017-02-23T14:50:54Z (GMT) No. of bitstreams: 1 2016_GustavodeLunaSales.pdf: 6698120 bytes, checksum: 0e96c1b5bde43be2b8976e3584d413ad (MD5) / Made available in DSpace on 2017-02-23T14:50:54Z (GMT). No. of bitstreams: 1 2016_GustavodeLunaSales.pdf: 6698120 bytes, checksum: 0e96c1b5bde43be2b8976e3584d413ad (MD5) / A presente tese aborda o desenvolvimento do Diagrama de Ventilação Natural (DVN) – ferramenta de análise do potencial da ventilação natural, para favorecer a Qualidade Interna do Ar (QIA) e o Conforto Térmico Passivo (CTP) em projetos de habitações. Parte-se da hipótese de que é possível desenvolver uma ferramenta que proporcione uma análise mais simples, amigável e rápida em comparação com as atuais ferramentas disponíveis, e que seja aplicável durante as primeiras etapas do processo de projetação – mais especificamente, na etapa do Estudo Preliminar (EP). Para tanto, foram levantados na bibliografia sobre o tema os principais fatores externos e internos ao projeto que influenciam o potencial da ventilação natural em termos de QIA e o CTP. Posteriormente foram levantados os parâmetros legais mínimos exigidos pelos Códigos de Edificações e Normas Técnicas referentes à ventilação natural que, juntamente com os fatores externos e internos de projeto, foram transformados em variáveis a serem analisadas pelo DVN. Por fim, foram analisados os principais modelos que atualmente estão disponíveis para a análise da ventilação natural no projeto de arquitetura – modelos analíticos e empíricos, modelos em escala, modelo multizona e de zona, modelos computacionais de dinâmica dos fluidos. Essa análise identificou as principais deficiências das ferramentas/modelos atuais em termos de aplicação durante a etapa de Estudo Preliminar de Projeto – sendo essas: custo de aplicação, nível de habilidade técnica exigido do usuário, e interface pouco amigável. Assim, para suprir as deficiências apontadas, foi identificado que a ferramenta a ser desenvolvida deveria ser fundamentada nos princípios dos modelos gráficos – que visam justamente à simplificação do problema a ser estudado, a análise das principais variáveis influentes e a obtenção de um diagnóstico/resultado estimado por meio da combinação das variáveis identificadas. Após a estruturação do DVN, foi desenvolvida a ferramenta com linguagem simples, amigável e acessível gratuitamente na rede mundial de computadores. O DVN possibilita a quantificação do potencial da ventilação natural em favorecer a QIA e o CTP, fornece o número de renovações de ar por hora estimado para os ambientes de quarto, sala, cozinha e banheiro, além de informar ao usuário quais os aspectos que o EP cumpre em termos normativos/legais e quais as diretrizes para a melhoria de possíveis problemas. / This thesis describes the development of Natural Ventilation Diagram (NVD) - an analysis tool of the potential of natural ventilation to provide the Indoor Air Quality and Passive Thermal Comfort in the design of residential buildings. It starts with the hypothesis that it is possible develop a tool that provides more simple, user friendly, and faster analysis in comparison with the current available tools - and that is applicable during the first stages of the design process. Have been raised in the literature the major internal and external factors that influence the potential of natural ventilation associated with IAQ and PTC. Afterwards have been identified the minimum legal standards required by the Building Codes and Technical Standards relating to natural ventilation. The legal parameters and external and internal factors were transformed into variables that the user can analyze by the NVD. Finally, were analyzed the main models that are currently available for the analysis of natural ventilation in architectural design – empirical and analytical models, scale models, multizonal and zonal models, computacional computational fluid dynamics models. This analysis identified the main weaknesses of the tools / current models in terms of application for the Preliminary Design stage process - related to the cost of implementation, technical skill level required of the user, and unfriendly interface. Therefore, to fulfill the identified deficiencies, it was identified that the tool to be developed should be based on the principles of graphical models. The graphics models aim at simplification of the problem to be studied, the analysis of main influential variables and obtaining a diagnostic/result estimated by the combination of the identified variables. After structuring of NVD, it was developed the tool with simple language, friendly and available free on the World Wide Web. The NVD enable quantification of natural ventilation potential, provides an estimation of the number of air change per hour for rooms, living room, kitchen and bathroom. As well as inform the user which aspects meets in regulatory / legal terms and what the guidelines for the improvement of potential problems. / En esta tesis se describe el desarrollo del Diagrama de Ventilación Natural (DVN) - una herramienta de análisis del potencial de ventilación natural para promover la Calidad del Aire Interior (CAI) y el Confort Térmico Pasivo (CTP) en proyectos de viviendas. La posibilidad de desarrollar una herramienta que proporciona un análisis simple de usar y rápido de usuario, en comparación con las herramientas actuales disponibles, y que es aplicable durante las primeras etapas del proceso de projetação es la hipótesis inicial. En un primer momento ha planteado en la literatura sobre el tema de los principales factores externos e internos que influyen en la ventilación potencial del proyecto. Después de los estándares legales mínimos aumentaron requeridos por los códigos de construcción y normas técnicas relativas a la ventilación natural. Todos estos parámetros planteados fueron transformadas en variables para ser analizados por la herramienta propuesta. Por último, los principales modelos que están actualmente disponibles se analizaron para el análisis de la ventilación natural en el diseño arquitectónico - modelos analíticos y empíricos, modelos a escala, multi-zona y el modelo de zona, los modelos informáticos de dinámica de fluidos. Este análisis identifica las principales deficiencias de las / los modelos actuales herramientas en términos de aplicación durante la etapa de diseño preliminar del estudio - a saber: el costo de aplicación, nivel de habilidad técnica requerida del usuario, y la interfaz poco amigable. Para satisfacer las deficiencias identificadas, se identificó que la herramienta que se desarrollen deben estar basadas en los principios de los modelos gráficos. Después de estructuración de lo DVN, se desarrolló la herramienta con un lenguaje sencillo, amable y disponible gratuitamente en la World Wide Web. Lo que permite la cuantificación de la potencial de la ventilación natural en la calidad del aire favor y confort térmico; proporciona el número de renovaciones de aire por hora para la sala de estar, cocina y baño, así como informar al usuario qué aspectos se reúne en términos normativos / legales y cuáles son las pautas para la mejora de los problemas potenciales.

<p>Disertacija daje pregled novih i relevantnih istraživanja i stavova<br />u naučnoj zajednici na temu štamparskih formi i uticaja procesa<br />štampe na trošenje neštampajućih elemenata. U disertaciji je<br />ukazano na kontinualno praćenje topografskih promena<br />neštampajućih elemenata štamparskih formi kako bi se kontrolisao<br />period eksploatacije a time i proces reprodukcije. Takođe daje<br />prilog novim istraživanjima sa analizom velikog broja<br />eksperimentalnih uzoraka sa dobijenim izmerenim podacima i<br />odgovarajućim korelacijama i predstavlja napredak u shvatanju<br />mehanizma trošenja neštampajućih površina štamparskih formi i<br />njihov uticaj na tribološke promene u odnosu na strukturu osnove<br />aluminijuma i sloja aluminijum oksida.</p> / <p>Dissertation gives an overview of the current state, research and theories of<br />printing forms and influence of printing process on wearing of non-printing<br />elements within the science community. The dissertation points out the continuous<br />monitoring of topographic changes of printing form non-printing elements to control<br />the exploitation of a period of time and the process of reproduction. This work<br />contributes to new research with the analysis of large number of experimental<br />samples and calculated correlations and represents an advance in the<br />comprehension of the surface wear mechanism of printing form non-printing<br />elements and their influence on the tribological changes to the structure of the<br />base layer of aluminium and aluminium oxide.</p>

O câncer de pulmão é um dos mais incidentes e letais, e, assim, a busca de novos fármacos é necessária. Atualmente o desenvolvimento de fármacos conta com abordagens computacionais que otimizam este processo. Dado que a fosfatidiletanolamina desempenha importantes papeis fisiológicos e uma das enzimas envolvidas na sua síntese, a CTP:fosfoetanolamina-citidilil-transferase (Pcyt2) é frequentemente superexpressa em células de câncer de pulmão, no presente trabalho, foram avaliados o potencial terapêutico de CHY-1, um análogo da miltefosina desenvolvido como inibidor da enzima Pcyt2, e os mecanismos inerentes à sua atividade antitumoral. O CHY-1 apresentou citotoxicidade superior ao seu protótipo e a outro inibidor da enzima Pcyt2, a meclizina. Além disso, as células malignas foram mais sensíveis ao CHY-1 do que as células não-tumorigênicas. Em conclusão, o presente trabalho evidencia o potencial do CHY-1 como um inibidor da enzima Pcyt2 e candidato a fármaco com atividade preferencial para câncer de pulmão. / Lung cancer is one of the most incident and lethal cancers, thus, the pursuit for new drugs is necessary. Nowadays, new drugs development has computational tools that improves this process. Once that phosphatidylethanolamine plays several important physiological roles and one of the enzymes of its production pathway, CTP:phosphoethanolamine cytidylyltransferase (Pcyt2), is usually overexpressed in lung cancer cells, therefore, this study aimed was to evaluate the antitumor effects of CHY-1, a miltefosine analogue developed as an inhibitor of Pcyt2 enzyme, and to investigate the mechanisms related to its antitumor action. CHY-1 was more cytotoxicity than its prototype, miltefosine, and was more cytotoxic than another inhibitor Pcyt2 enzyme, meclizine. Morevover, malignant cells were more sensitive to CHY-1 effects than non-tumorigenic cells. In conclusion, this work presents CHY-1 as an inhibitor of Pcyt2 enzyme and new candidate a drug with preferential activity on NSCLC cells.

O câncer de pulmão é um dos mais incidentes e letais, e, assim, a busca de novos fármacos é necessária. Atualmente o desenvolvimento de fármacos conta com abordagens computacionais que otimizam este processo. Dado que a fosfatidiletanolamina desempenha importantes papeis fisiológicos e uma das enzimas envolvidas na sua síntese, a CTP:fosfoetanolamina-citidilil-transferase (Pcyt2) é frequentemente superexpressa em células de câncer de pulmão, no presente trabalho, foram avaliados o potencial terapêutico de CHY-1, um análogo da miltefosina desenvolvido como inibidor da enzima Pcyt2, e os mecanismos inerentes à sua atividade antitumoral. O CHY-1 apresentou citotoxicidade superior ao seu protótipo e a outro inibidor da enzima Pcyt2, a meclizina. Além disso, as células malignas foram mais sensíveis ao CHY-1 do que as células não-tumorigênicas. Em conclusão, o presente trabalho evidencia o potencial do CHY-1 como um inibidor da enzima Pcyt2 e candidato a fármaco com atividade preferencial para câncer de pulmão. / Lung cancer is one of the most incident and lethal cancers, thus, the pursuit for new drugs is necessary. Nowadays, new drugs development has computational tools that improves this process. Once that phosphatidylethanolamine plays several important physiological roles and one of the enzymes of its production pathway, CTP:phosphoethanolamine cytidylyltransferase (Pcyt2), is usually overexpressed in lung cancer cells, therefore, this study aimed was to evaluate the antitumor effects of CHY-1, a miltefosine analogue developed as an inhibitor of Pcyt2 enzyme, and to investigate the mechanisms related to its antitumor action. CHY-1 was more cytotoxicity than its prototype, miltefosine, and was more cytotoxic than another inhibitor Pcyt2 enzyme, meclizine. Morevover, malignant cells were more sensitive to CHY-1 effects than non-tumorigenic cells. In conclusion, this work presents CHY-1 as an inhibitor of Pcyt2 enzyme and new candidate a drug with preferential activity on NSCLC cells.

Bakgrund: Sedan slutet av 1960-talet har flera studier kunnat påvisa drift i aktiepriset efter att ett bolag publicerat en kvartalsrapport, något som benämns som Post-earningsannouncement drift (PEAD). När bolagets resultat varit bättre än det marknaden förväntade sig har aktiepriset fortsatt stiga under en längre period, vilket går emot etablerade hypoteser om en effektiv marknad. Det motsatta har skett när bolaget publicerat ett sämre resultat än vad marknaden förväntat sig. Eftersom den svenska marknaden är relativt outforskad och att den kontinuerligt förändras är det intressant att undersöka om den anomali som nyss beskrivits fortsatt existerar på Stockholmsbörsen, om den går att använda som lönsam investeringsstrategi och huruvida det finns skillnader i aktieprisdrift mellan branscher eftersom det aldrig tidigare studerats. Syfte: Syftet med studien är att analysera huruvida PEAD förekommer på Nasdaq Stockholmsbörsen och om det existerar skillnader i aktieprisdrift mellan branscher under perioden 2014–2018. Studien avser vidare studera om det är möjligt att utforma en lönsam investeringsstrategi baserad på PEAD. Metod: För att uppnå studiens syfte tillämpades en deduktiv ansats och en kvantitativ metod. För att analysera PEAD på Stockholmsbörsen baserades portföljer på Unexpected Earnings (UE) och två modeller benämnda Buy-and-hold-abnormal returns (BHAR) och Calendar-Time regression model (CTP) användes för att illustrera och testa portföljernas avkastning. Resultat: Studiens resultat tyder på att PEAD fortfarande existerar på Stockholmsbörsen, men att resultatet skiljer sig något från tidigare studier. En drift i positiv riktning påvisas i innevarande studie i portföljer av bolag som publicerat såväl bättre som sämre resultat än vad marknaden förväntat sig. I tidigare studier har portföljer av bolag som publicerat sämre resultat än marknaden förväntat sig istället haft en negativ. Vidare visar resultatet att det återfunnits skillnader i drift mellan undersökta branscher och att PEAD sannolikt inte är en lönsam investeringsstrategi. / Background: Since the end of 1960 several studies has indicated a delay in stock price movements after the publishing of a company's interim report. When the earnings of a company were higher than expected, the stock price continued to rise for an extended period, which contradicts the different hypothesis of efficient markets. The opposite effect was observed when the earnings were lower than expected. Due to the limited number of studies regarding PEAD conducted on the Swedish stock market, and the fact that the stock markets are constantly changing, it is interesting to examine and analyze if the anomaly still exists on Stockholmsbörsen. Another point of interest to research is whether it would be possible to earn abnormal returns through a PEAD investment strategy and analyze if there are differences in drift depending on the industry. Aim: The aim of this study is to analyze whether PEAD exists on Nasdaq Stockholmsbörsen and if differences in stock price drift exists between industries during the period 2014-2018. The study further means to study whether it is possible to implement a profitable investment strategy based on PEAD. Methodology: In order to reach the aim of the study a quantitative method and deductive approach were used. In order to analyze PEAD on the Swedish stock market portfolios based on Unexpected Earnings (UE) were formed and two models named Buy-and-hold-abnormal returns (BHAR) and Calendar-Time regression model (CTP) were used in order to illustrate and test the portfolio returns. Results: The results of the study indicated that PEAD exists on Stockholmsbörsen, but that the results differ from previous studies. A positive drift was observed in both the portfolios which were based on positive and negative earnings surprises in relation to the market's expectations. In previous studies the portfolio based on companies which reported negative earnings surprise had a negative drift, which differs from this study’s results. Furthermore, this study’s results indicate that an investment strategy based on PEAD is not profitable and that differences in drift could be observed depending on the industry.

Subcellular sequestration of proteins within membrane bound compartments is widely acknowledged to be an important mode of enzymatic regulation. Recently a novel paradigm for metabolic enzyme compartmentalisation has become apparent with the identification of several proteins which are able to form filamentous structures in vivo. Multiple studies independently identified the essential de novo pyrimidine biosynthesis enzyme CTP synthetase as a major constituent of a novel filamentous structure which has been termed “the cytoophidium”. Cytoophidia have been observed to form in multiple organisms including bacteria (C. crescentus), yeast (S. cerevisiae) and fruit fly (D. melanogaster) as well as in human cultured cells. In this thesis I describe the development and results of a high throughput genomescale screen to identify factors involved in cytoophidia biogenesis. Observations of tissue specific CTPS distribution lead to the identification of the well-conserved growth regulator dm/dMyc as an essential factor for CTPS regulation in vivo. These results provide new insights into the coordination of cellular growth and metabolic regulation during normal development and indicate the potential of CTPS/cytoophidia as a future therapeutic target.

The following degree project deals with the production of an ICC-profile, this in the form ofproducing ICC-profiles for VTAB Backa. The company previously had their own profile butthey weren’t satisfied, so earlier this year they started using the TU standard profile, but theyalso wanted a complement to this in form of a profile created for solely their printing press.The separation settings used when creating the new profiles were based on information fromTU and their profile. Two basic profiles were created and then edited to obtain a better result.The test printings made with the edited profiles showed that the less adjustments that are made,the better. It was also discovered that the TU standard profile eliminates the highlight toneswhiles the new profiles are somewhat darker. VTAB Backa has at the end of this degree projectdesided to conduct more test printings before making their decision.