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published_or_final_version / Dentistry / Master / Master of Dental Surgery

Orientador: Fredererico Canato Martinho / Co-orientador: Márcia Carneiro Carneiro Valera / Banca: Ana Paula Martins Gomes / Banca: Izabel Coelho Gomes Camões / Resumo: Os objetivos do presente estudo são: 1) Estudar o perfil inflamatório das lesões periapicais de dentes com infecções endodônticas primárias através dos níveis das citocinas inflamatórias: IL-1beta, IL-6, TNF-alfa; correlacionando com a presença de sintomatologia clínica; 2) Investigar os níveis das metaloproteinases [MMP-1, -2 e -9], inibidores de metaloproteinase [TIMP-1 e -2] e complexos MMP/TIMP [MMP1/TIMP1, MMP1/TIMP2, MMP2/TIMP1, MMP2/TIMP2, MMP9/TIMP1 e MMP9/TIMP2], presentes nos tecidos periapicais de dentes com infecções endodônticas primárias e lesão periapical; correlacionando com a presença de sintomatologia clínica e reabsorção óssea; 3) Correlacionar os níveis das citocinas inflamatórias [IL-1beta, IL-6 e TNF-alfa] e seus antagonistas [IL1-RA, IL6-RA, sTNF-R1], presentes nos tecidos periapicais; 4) Estudar a efetividade de diferentes medicações intracanal no controle do processo inflamatório periapical, através do monitoramento dos níveis de citocinas inflamatórias, [IL-1beta, IL-6, TNF-alfa], MMP's [MMP-1, -2 e -9], TIMP's [TIMP-1 e -2] e complexos [MMP1/TIMP1, MMP1/TIMP2, MMP2/TIMP1, MMP2/TIMP2 MMP9/TIMP1, MMP9/TIMP2] coletadas dos tecidos periapicais. Vinte dentes unirradiculares com necrose pulpar e lesão periapical foram selecionados. Após o preparo biomecânico (PBM) os dentes foram divididos aleatoriamente em 2 grupos de acordo com a medicação intracanal utilizada: Ca(OH)2+SSL [Ca(OH)2 + solução salina fisiológica]; e Ca(OH)2+CLX [Ca(OH)2 + clorexidina gel 2%]. Para a análise dos biomarcadores inflamatórios, foram realizadas coletas utilizando cones de papel estéril/apirogênico, ultrapassando 2 mm além ápice para obtenção do fluído intersticial. As coletas foram realizadas em dois momentos operatórios : coleta após PBM (Coleta inicial-CIF1) e coleta após 14 dias de medicação intracanal (Coleta final-CFF2). Citocinas... / Abstract: The aim of this study was: 1) To investigate the inflammatory profile of apical periodontitis disease present in primarily infected root canals determined by the levels of inflammatory cytokines : IL-1beta, IL-6, TNF-alfa; and to correlate with the presence of clinical features; 2) To investigate the levels of metalloproteinases [MMP-1, -2, -9], metalloproteinase inhibitors [TIMP-1 e -2] ; complexes MMP/TIMP [MMP1/ TIMP1, MMP1/TIMP2, MMP2/TIMP1, MMP2/TIMP2, MMP9/TIMP1 e MMP9/TIMP2], present in apical peridontitis disease from teeth with primary endodontic infection; and to correlate with the presence of clinical features; 3) To correlate the levels of IL-1beta, IL-6, TNF-alfa with their respectively antagonists - IL1-RA, IL6-RA, s TNF-R1, all present in apical peridontitis; 4) To evaluate the effectiveness of different root canal medications in the inflammatory process by monitoring the levels of inflammatory cytokines [IL-1beta, IL-6, TNF-alfa], MMP's [MMP-1,-2,-9]; TIMP [TIMP-1 and -2] and complexes [MMP1/TIMP1, MMP1/TIMP2, MMP2/TIMP1, MMP2/TIMP2, MMP9/TIMP1 e MMP9/TIMP2] in apical periodontitis. Twenty patients with single-rooted teeth that had necrotic pulp and periapical periodontitis will be selected. After BMP teeth will be randonly devided into 2 groups according to the root canal medication selection: Ca(OH)2+SSL [Ca(OH)2 + Saline Solution]; e Ca(OH)2+CHX [Ca(OH)2 + chlorhexidine gel 2%]. Samples will be collected from intersticial fluid by using sterile/ apyrogenic paper points. Samples will performed at two diferente times: After chemomechaical preparation (S1) and after 14 of root canal medication (S2). Inflammatory cytokines, metalloproteinases and their antagonists will be dosage by ELISA-assay. The levels of inflammatory cytokines, metalloproteinases and their antagonists will be typed on a spreadsheet and statiscally analyzed by SPSS for Windows and Statistic packpage 9.0. ... / Mestre

Pour atteindre avec la 4G des débits théoriques supérieurs à 100 Mb/s et espérer pouvoir multiplier par 20 l’efficacité énergétique des futurs réseaux 5G, toute la richesse du canal de propagation doit être exploitée. Cet axe de recherche innovant d’optimisation de la couche physique de la communication se base sur la caractérisation multidimensionnelle « temps réel » du canal. Cette notion de "temps réel" signifie que toutes les dimensions spatiales (à l'émission et à la réception), temporelle, fréquentielle et polarimétrique seront explorées simultanément pour s'assurer des conditions de stationnarité du canal pendant la mesure. Le sondeur associé, objet de la thèse, doit également être capable de s’adapter à différents scénarii de propagation, y compris à un contexte de haute mobilité pour une liaison sol-sol entre trains à grande vitesse par exemple. Le système qui a ainsi été développé à l'aide de composants numériques programmables, fournit avec un temps de latence inférieur à quelques dizaines de µs et sans post traitement, 128 fonctions de transfert associées à un canal MIMO (8,16) dans 80 MHz de bande, la durée du signal transmis étant de 150 µs. Sa reconfigurabilité aisée lui confère l'originalité d'être multi fonctions pour s'adapter aux challenges à venir. Citons par exemple la cybersécurité des communications sans fil pour laquelle l'équipement aura les rôles de système de communication, de générateur d'interférences et de sondeur de canal.Dans le cadre de la localisation, via leur téléphone portable de personnes situées en forêt, les résultats des campagnes de mesures menées avec le sondeur soit au sol, soit embarqué dans un ULM, sont également décrits. / To be able to reach a bit rate higher than 100Mb/s with 4G systems and to multiply by 20 the energy efficiency of future 5G networks, all the propagation channel richness must be exploited. This innovative research area dealing with the physical layer optimization is based on the multidimensional channel characterization in "real time". This concept of “real time” means that space, time, frequency and polarimetric dimensions are explored simultaneously to ensure stationarity conditions of the channel during measurements. The channel sounder, subject of the thesis, must also be able to adapt to different scenarios of propagation, including a context of high mobility as, for example, in the case of a communication between high-speed trains. The system that has been developed, based on programmable digital components, allows measuring in a 80Mz bandwidth, 128 transfer functions associated with a (8,16) MIMO channel in less than a few tens of µs and without post-processing. The duration of the transmitted signal is 150 µs. Another originality of this sounder is its easy reconfigurability and its multi-function ability. For example, for studying cyber security of wireless communications, it would play the role of communication system, interference source and channel sounder. In the frame of localization of people in forest owing to their mobile phone, results of channel characterization conducted with the sounder placed either on the ground, or in an ULM, are also described and analyzed.

In this thesis, I propose that Mexican water works during the Porfiriato influenced the development of modernity because of hydrology’s link between society and environment. These two canals in particular provide a window on the relationship between the state and environment that connects the two in the efforts of state formation. The Gran Canal and the Canal de la Viga both worked as tools for social and political construction for Mexicans to imagine modernity for themselves and for their country.

Thesis (M.S.)--West Virginia University, 2001. / Title from document title page. Document formatted into pages; contains vii, 23 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 15-21).

Thesis (M.S.)--West Virginia University, 2003. / Title from document title page. Document formatted into pages; contains ix, 57 p. : ill. (some col.). Vita. Includes abstract. Includes bibliographical references (p. 43-46).

Thesis (M.S.)--University of Michigan, 1980.

Thesis (M.S.)--University of Michigan, 1989.