Yes / Cavitation is an important phenomenon in solid-phase deformation of polymers, which either has potential adverse effects on physical properties or creates potential opportunities for new properties. In either case, it needs to be better understood to help achieve better control of cavitation and its effects. Cavitation associated with solid-phase deformation in a β-nucleated isotactic polypropylene was found to depend on the solid-phase deformation route employed. Compared with samples obtained by free tensile stretching, cavitation was suppressed in samples deformed via die-drawing, although an almost identical β-to α-phase transition was observed for both deformation routes. Even when die-drawn samples were subsequently deformed to large strains by free stretching, there was still no comparable cavitation compared with the single free tensile-stretching route. The die-drawing process appears to suppress cavitation by fundamentally diminishing the number of growable nuclei of cavities, rather than merely hindering the growth of cavities. A relationship between cavitation intensity and the fractions of lamellae along specific directions has been established. During subsequent free stretching of die-drawn samples, newly created cavities were suggested to be initiated within the crystalline layers. The reduction of the cavity nuclei in the die-drawing process originated from the stabilization of the connections between the crystalline blocks within the lamellae. / This work is supported by the National Natural Science Foundation of China (21704102 and 51525305), Newton Advanced Fellowship of the Royal Society, United Kingdom (NA 150222) and ExxonMobil.

The relationship between cells and their environment is one of dynamic reciprocity, whereby cells can influence their surrounding and the surroundings can influence the cells. One example of this relationship arises from the effect of the mechanical properties of an environment on a cell and of a cell on its environment. Inspired by this relationship, we investigate 1) the local environment of biological materials, both native and synthetic, and 2) the forces that cell sheets exert on surfaces. We do this by developing techniques that focus on local mechanical properties and experimental strategies that provide insight into intercellular mechanics. We first focus on determining local mechanical properties of hydrogel materials by developing the Cavitation Rheology technique. This process involves inducing a cavitation event at the tip of a syringe needle. We develop theory to show that the critical pressure to cavitate can be directly related to the modulus of the material (Chapter 2). This allows us to experimentally determine the mechanical properties at arbitrary locations throughout a material scaffold over a range of length scales defined by the needle radius (Chapter 3). We then demonstrate that we can viturally elminate the energy contribution from the creation of new surface area to the critical pressure by cavitating with a media of lower surface energy (Chapter 4). In chapter 5, we show that Cavitation Rheology can be used on native biological tissues and we go on to demonstrate the importance of measuring the mechanical properties in vivo. We then focus on understanding the force development of cells as they grow to confluency on a dynamic substrate (Chapter 6). We demonstrate the method of living microlenses to measure the collective strains cell sheets attain by growing cells on a thin polystyrene film supported by a surface of microwells. The cells cause the film to buckle and the resultant buckling can be directly related to the strain. We use this technique to study the strains exerted by various cell types and to determine the importance of the cell-cell junctions on the strain development.

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Cavitation is detrimental to the performance of ships and submarines, causing noise, erosion, and vibration. This study seeks to understand cavitation inception and delay on a typical ducted propulsor by utilizing the SimCenter's unstructured simulation and design system: U2NCLE. Specifically, three fundamental questions are addressed: 1. What are the macroscale flow physics causing cavitation inception? 2. How does cavitation inception scale with Reynolds number? 3. How can tip-leakage vortex cavitation inception be suppressed? To study the physics of cavitation inception, a ducted propulso simulation is developed and extensively validated with experimental results. The numerical method is shown to agree very well with experimental measurements made in the vortex core. It was discovered that the interaction of the leakage and trailing edge vortices cause the pressure to drop to a local minimum, providing ideal conditions for inception to occur. However, experimental observation shows that inception does not occur at the minimum pressure location, but rather at the point where the two vortices completely coalesce. At the point of coalescence, the simulation reveals that the streamwise core velocity decelerates, causing the air nuclei to stretch and burst. A Reynolds number scaling analysis is performed for the minimum pressure and maximum velocity in the vortex core. First, the numerical method is validated on a flate plate at various Reynolds numbers to assess the ability of typical turbulence models to predict Reynolds numbers ranging from one million to one billion. This scaling analysis methodology is then applied to the propulsor simulation, revealing that the minimum pressure in the vortex core is much less dependent on Reynolds number than was previously hypothesized. Lastly, to investigate means of delaying cavitation inception, the propulsor is parameterized and studied using design optimization theory. Concepts of vortex alleviation evident in nature are used to suggest suitable parameterizations. Also, dimension reduction is used to reduced the number of design variables. Finally, the concepts are implemented, evaluated, and shown to completely decouple the two vortices causing cavitation inception. Moreover, the minimum pressure in the vortex core is significantly increased.

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An extensive literature review and experimental study were performed to investigate whether cavitation and dissolved gases exiting solution from soil pore water are the cause of the erratic undrained behavior often observed in triaxial tests on saturated, dilatant silts. The literature indicates that ground water contains various amounts of dissolved gases and that gases dissolved in soil pore water will have sufficient time to exit solution to some extent, due to the pore pressure reductions which occur during sampling and unconsolidated-undrained triaxial tests. The exit of dissolved gases from solution would increase the soil volume and affect its undrained behavior. Experiments were performed on saturated silts to measure the pore pressure reductions which occur during sampling and unconsolidated-undrained triaxial tests. The amount of dissolved air that could come out of solution and the desaturation that a saturated soil sample could experience were also estimated. Gas bubble formation and growth within the pores of a saturated silt could affect intergranular forces and influence the stress-strain behavior of the soil in undrained tests. Variations in the amount of dissolved gas exiting solution and forming bubbles from one specimen to another could be the cause of the erratic undrained behavior often observed for saturated silts. Bubble growth within the soil pores is believed to have lead to abrupt strain-softening in a number of the undrained tests performed in this research. Variations in specimen disturbance may also contribute to the erratic behavior observed in undrained tests on silts. Disturbance levels and their influence on soil behavior are difficult to quantify. Due to the unusual properties of water under negative pressure, the initial value of pore water pressure within the soil appears to have a direct influence on the undrained strength of the soil. As a result, laboratory pore water pressures should be similar to in-situ pore water pressures, in order to give reasonable undrained strength measurements. The findings of this research are believed to be worthy of further study. / Ph. D.