In this master thesis work calcination parameters' impact on the resulting quicklimes slaking reactivity is investigated. This is done by calcination of three different sedimentary limestones in an N2 atmosphere according to a design of experiment matrix. The limestones are from Wolica Poland, Slite Sweden and Jutjärn Sweden. The temperatures and residence times are varied between 1000ºC, 1050ºC, and 1100ºC for 5 min, 27.5 min, and 60 min. There were seven experiments per limestone sample. The calcination experiments were conducted in an electrical muffle furnace.When the limestone samples were calcined, the resulting quicklimes slaking reactivity was tested according to standard SS-EN 459-2:2010 Building lime - Part 2: Test methods. Four different parameters were used to determine the slaking reactivity, these were the maximum temperature, how much the temperature increases under the initial 30 s, the time it takes for the temperature to reach 60ºC, and the time for the slaking to become 80% finished.From the slaking reactivity experiments, the calcination parameters to produce the most reactive quicklime for the limestone from Wolica and Jutjärn are 1000ºC for 60 min, and for the limestone from Slite 1100ºC for 5 min. For all three limestones the least reactive quicklime was received by calcining at 1100ºC for 60 min. The most and least reactive quicklimes were analyzed in SEM, where it could be seen that the least reactive quicklime samples were coarser compared to the most reactive samples. Depending on what slaking reactivity parameter is of interest, the calcination settings should be different and can be an indication for operation parameters for industrial kilns. The statistical analysis on the experimental model showed that the experiment had a poor statistical fit for most of the experiment. This could be due to that the model possibly was too simple to describe the calcination parameters complex impact on the slaking reactivity.

In recent years, medical treatments against respiratory tract infections (RTIs) based on trypsin from Atlantic cod targeting the surface proteins on viral particles have been approved. However, the stability and compatibility in the human body of human trypsin would be expected to be greater than that from cod. In this study, the process of producing human trypsin recombinantly in E. coli in a fed batch bioreactor was optimised using a Design of Experiment (DOE) method with four 2-level factors and two responses. The factors considered were temperature, carbon source, induction time point and feeding rate, and the two responses were yield and purity. The study was done in 8 consecutive runs in the bioreactor, with controlled changes made to the factors for each run. The responses were measured and analysed for significance and optimisation of factors. The optimal settings for the highest yield with a purity of at least 80% were found to be at 18 °C, glucose based feed at a restricting feed rate and induction at a low OD600. Only the induction time has a significant effect on purity, and no factor had a stand-alone significant effect on yield. These findings provide a baseline for further studies on purification and further production of trypsin recombinantly in E. coli at a larger industrial scale. The highest yield achieved was 7.9 g trypsin per litre media, almost 80 times higher than comparable methods using shake flasks. However, the sample with over 80% purity was 6.3 g trypsin per litre media.

In this report, modifications and experimental tests with an early stage test rig intended for producing a commercial solution to fractionating pyrolysis oil are described. The idea is to use centrifugal force to separate the formed aerosols from condensible gases with a lower volatility. A stacked disc centrifuge prototype built to work at high temperature was used. The experiment was done with a single component, 1-Methylnaphtalene (1-MN) to evaluate the functionality of the test rig. No separation was achieved, concluding that further work need to be done at different operating parameters with 1-Methylnaphtalene prior to including more components. The reason for the negative separation result is probably due to that the saturation ratio was to low resulting in that no aerosol was formed during the experiments. Further work includes improving the stability of the inlet stream to the centrifuge. Perform more experiments with other process parameters, recommendation is to decreasing the temperature at the inlet to the centrifuge to increase the saturation ratio. It is also suggested that an optical in situ measuring devise is added to the test rig to facilitate operation.

Volatile sulfur compounds are cause of concern because, when present in high concentrations, they constitute a danger for health because of their strong toxicity. Furthermore, for low concentrations, they are often a cause of complaint, because of their low odor threshold. In this context, the purpose of this Thesis is to evaluate a new technology for the abatement of sulfur-based malodorous compounds. The investigated technology consists in the use of ozone generating low-pressure UV mercury lamps, operating at room temperature. Hydrogen sulfide is often found in industrial processes, (e.g. WWTPs (Wastewater Treatment Plants), leather production, sewage treatment, garbage disposal, etc). Moreover, it presents both a very high toxicity a low odor threshold. Thus, due to its high representativeness of the case, hydrogen sulfide was chosen as reference compound for the purposes of this project. In order to evaluate a wide range of cases, several experiments using different residence times, humidity contents and inlet concentrations of the pollutant were conducted. The obtained results show that this technology generally presents discrete conversion efficiencies, although not suffcient to be used as freestanding process. For this reason, a pretreatment is revealed to be necessary. The best conversion efficiency was obtained for low flow rates and high moisture content. At the end of the project, as side-study, a possible pretreatment using an adsorbent bed constituted by granular ferric oxide was evaluated.

I strävan efter att minska textilindustrins omfattande miljöpåverkan utvecklas nya metoder för textilåtervinning. Idag återvinns bomullstyg av Renewcell på deras anläggning i Kristinehamn. Den återvunna produkten, Circulose®, är en dissolvingmassa som kan användas för att spinna nya viskosfibrer som man i sin tur kan använda för att göra nya kläder. Föreliggande arbete är en förstudie om möjligheten att optimera Renewcellls återvinningsprocess. Arbetet inkluderar en optimering av massaprocessen vilket resulterar i en mer effektiv process som minskar förbrukningen av processkemikalier. / To reduce the extensive environmental impact of the textile industry, new methods for textile recycling are being developed. Today, cotton-based fabric is recycled by Renewcell at their facility in Kristinehamn. The recycled product, Circulose®, is a dissolving pulp that can be used to spin new viscose fibers, which in turn can be used to make new clothes. The present work is a feasibility study on the possibility of optimizing Renewcell's recycling process. The work includes an optimization of the pulp process, which results in a more efficient process with a reduced consumption of process chemicals.

Avloppsreningsanläggningar är idag utformade för att rena bort föroreningar i form av organiskt material, suspenderade fasta ämnen och växtnäringsämnen (exempelvis fosfater och nitrater). Myndighet i Sverige har satt upp restriktioner och lagar gällande hur mycket av de olika föroreningarna som det är okej att utgående vatten innehåller. En typ av föroreningar som dock inte blivit undersökt och som inte har lika tydliga restriktioner och utsläppslagar är utsläpp av läkemedelsrester och aktiva läkemedelssubstanser. Den största andelen av läkemedelsrester som återfinns i avloppsvatten är på grund av mänsklig konsumtion. Människan har under evolutionen alltid strävat efter att hitta nya metoder för att leva längre, må bra och undvika smärta. Under de senaste årtiondena har konsumtionen av läkemedel ökat, detta på grund av behandling av åldersrelaterade och kroniska sjukdomar, i kombination med en ändrad och mer generös receptutskrivning från sjukhusen.  Läkemedlen som vi konsumerar kommer inte att brytas ner helt av våra kroppar, och restprodukterna kommer utsöndras vida urinen. Urinen kommer sedan, vi avloppen, komma till ett av de lokala avloppsreningsverken, som idag inte har förmåga att rena bort de aktiva läkemedelssubstanserna från vattnet. Det kommer sedan att påverka omgivande vattendrag, djurliv och på lång sikt även ekosystemen.  Tidigare studier har genomförts med syfte att hitta miljövänliga och hållbara metoder för att rena vattnet från mikroföroreningar och läkemedelsrester. En av teknikerna som undersökts är oxidation och adsorption processer. Ett sätt att genomföra oxidation är genom ozonering, som genom sin höga oxidationspotential och miljövänliga slutprodukter i form av bland annat syre gör den till ett miljövänligt alternativ. Vad gäller adsorption processer så är aktivt kol en av de vanligaste teknikerna som används idag och det har visat på goda resultat. Ett vanligt förekommande problem med aktiva kolfilter är att det måste bytas ut när det blivit mättade vilket både kostar pengar, arbetskostnader och en avstannad vattenprocess.  Denna avhandling behandlar utvärdering och process optimering av vattenrening vid behandling av ozon med avseende att rena vatten från aktiva läkemedelssubstanser. För att göra detta har två pilotanläggningar för vattenrening, placerade på två olika platser i Sverige (plats 1 och plats 2) undersökts och optimerats. Båda systemen är utrustade med ett sandfiltersteg, ozonerigssteg anst ett avslutade poleringssteg i form av aktivkolbädd. De två olika systemen är kopplade så inkommande vatten är utgående vatten från likat avloppsreningsverk. Undersökta variabler är injicerad ozonhalt (uteffekt baserat på ozongeneratorns kapacitet) och i ett av fallen, vattenflödet genom systemet. Syftet med arbetet var att hitta optimala driftförhållande med avseende på reducerad mängd läkemedelssubstanser i vatten och energiförbrukning.  Resultaten visade att den parameter som influerade resultatet mest var mängden ozon som injicerades till systemet. Systemet som var installerat på plats 2 var det mest effektiva baserat på både energiförbrukning per m3 vatten och med avseende på reningsgraden på vattnet. Systemet rena vattnet från läkemedelssubstanser upp till mellan 95–100%, vid ett vattenflöde på 16 m3/h och en uteffekt av ozongeneratorn på 75%.  Systemet på plats 1 hade en halverad ozonkapacitet jämfört med systemet på plats 2 och visade inte på fullt lika effektiv rening. Vattnet som bäst renat till 80%, vid ett vattenflöde på 2,5 m3/h och en uteffekt av ozongeneratorn på 100% (motsvarar 50% på plats 2). / Wastewater treatment plants today are designed to reduce pollutants in the form of organic material, suspended solids, plant nutrients (phosphates and nitrates) and microbes from the water. Governments have set up restrictions and laws around in what amount release of different pollutants is acceptable or not. But one type of pollutant that have not been investigated to the same degree is the micropollutants such as pharmaceuticals or active pharmaceutical ingredients (APIs). The biggest amount of APIs release to water is due to human consumption of medicine. Humans have during the evolution strived to find new ways to live longer, stay healthier and avoid pain. Over the last decade there has been an increased consumption of medicine, due to the need to treated ageing related and chronic diseases, together with a change in the clinical practice leading to a more generous prescription approach.  The APIs that we consume will not be totally decomposed in our body, which means that we sooner or later will exude it in form of example urine. The urine will end up in the local WWTP, which today, does not have the ability to reduce APIs in large amount. Due to this, release of APIs to surrounding watercourse will come to affect the animals and eco-system.  Many studies have been done with a goal to find an environmentally friendly way to reduce micropollutants from the wastewater. One of the techniques that has been investigated is oxidation (e.g., ozonation) and adsorption (e.g., activated carbon) processes. Ozonation is an ideal technique due to the high oxidation potential of ozone, environmentally friendly end-products (e.g. oxygen) and low sludge production. Several reports elucidated that application of ozonation for wastewater can have a reducing effect of APIs, and a more studied technique for removal of micropollutants and APIs is activated carbon (AC). But AC has some common struggle, one example is that it works as a filter and that it due to adsorption can be saturated.  The project contained evaluation and process optimization of water purification by oxidation with ozone with aim to purifying water from APIs. To do this, two pilot plants for water purification, located in two different locations in Sweden (location 1 and location 2) will be evaluated and optimized. Both systems are equipped with a sand filter, ozonation step and a polishing step of activated carbon. The two different systems are connected so that incoming water to the system, is outgoing water from a local wastewater treatment plant. The variables evaluated are injected ozone concentration (output power based on the capacity of the ozone generator) and in one of the cases, the water flow through the system. The purpose of the work was to find optimal operating conditions regarding reduced amount of drug substances in water and energy consumption.  The system installed at location 2 is the most effective system from a perspective of both micropollutants reduced and energy used per m3. The API reduction is between 95-100% for the outgoing water and the ozonation step stands for 95-100% of that reduction, which increases the lifetime of the GAC filter. For optimal process settings a water flow of 16 m3/h and an out effect of 75% from the ozone generator was determined.  At location 1 the APIs reduction achieved was 80% after ozonation and 100% after the GAC filtration, and the process settings were 100% out effect (correspond to 50% at location 2) on the ozone generator and a water flow of 2.5 m3/h.

Process scale-up studies are, generally, non-linear. This basically means that it is not possible to take a chemical process in the laboratory and bring it to a pilot or production plant by simply increasing the quantities of chemicals and the equipment size proportionally. There are many physico-chemical processes involved (such as reaction kinetics, fluid mechanics and thermodynamics), plus over the years a myriad of different equipment (stirrers, baffles, jackets...) have been developed with different geometrical and performance characteristics. Therefore, scale-up studies involve engineering issues, economic considerations, and risks assessment to reduce them to acceptable levels for the successful commercial scale implementation. Mixing and heat transfer assessments are often required when scaling a process, troubleshooting poor performance or transferring from one plant to another. This is because the rates of these physico-chemical processes are a function of the details of the equipment set-up and operating conditions, so they can vary widely from one vessel to another. Due to this series of drawbacks and the large number of parameters involved, there is the increasing interest to make use of scientific approaches in the early stages of process development, both modelling and simulation tools along with experimentation to try to predict the behaviour of chemical processes on a larger scale and, consequently, reduce costs and efforts from the beginning. This project was aimed at implementing a method to characterize production equipment and calculate its heat transfer coefficient experimentally from a thermal test. Both the created database, which contains information of about 70 reactors, and the heat transfer coefficient values are then used in different case studies with the objective of predicting the behaviour of the chemical processes examined at different scales: laboratory, pilot and production. The scale-up parameters calculation is detailed for each project with emphasis on the results and conclusions regarding the mixing and heat transfer performances.

An important process-design problem in multicomponent separations is separation sequencing, which is concerned with the selection of the best method and sequence for a separation system. Essentially all of the published work on this subject has been limited to high-recovery or sharp separations, in which each component to be separated appears in one and only one product stream. In industrial practice, however, it is often useful to permit components that are being separated to appear in two or more product streams. This type of separation results in products that have overlapping components and is called nonsharp or sloppy separations. The present work proposes and demonstrates a simple and practical approach to the systematic synthesis of sloppy multicomponent separation sequences. The task of synthesizing sloppy multicomponent separation sequences is inherently more complicated than that of synthesizing sharp separation sequences as identification of infeasible splits and stream splitting, and transformation of infeasible product sets into equivalent feasible product sets are examples of some difficult tasks involved. A successful synthesis strategy calls for the development of an effective and flexible framework for representing the synthesis problem and for analyzing the feasibility of component splits. In this thesis, we propose a "component assignment diagram (CAD)" for problem representation. It is shown that the use of a CAD allows the design engineer to consider many alternative solutions (or sequences) and eliminate all infeasible component splits. Further, a "separation specification table (SST)" is proposed for feasibility analysis. In particular, the use of an SST provides a means to : (i) properly define and specify key and nonkey components; (ii) quickly identify feasible and infeasible splits; (iii) effectively deal with fuel products with unmatched compo- nent specifications; and (iv) systematically consider sloppy separations with multiple split points. One difficult problem arising from the design of multicomponent distillation columns for sloppy separations is to appropriately specify the distributions of non-key components in both overhead and bottoms products. Despite the importance of these specifications, there is very little information available on this subject in the literature. This thesis reports the results from a comparative study of rigorous simulation and shortcut modeling of multicomponent distillation columns for sloppy separations. One objective was to obtain improved quantitative understanding and practical design insights into the characteristics of nonkey distributions through a shortcut modeling based upon the Fenske equation. One method proposed in this work for synthesizing sloppy multicomponent products is a heuristic method that involves a two-phase approach. The first phase is concerned with the feasibility analysis of splits pertinent to a CAD with the aid of an SST. The second phase is to specify systematically a subsequent split by applying heuristics, an activity that involves the sequential application of several "rank-ordered" heuristics. A unifying approach is proposed and demonstrated for the synthesis of sloppy multicomponent product sets. Its objective is to generate equally good initial separation schemes, featuring as many as three characteristically different sequences, including all-sharp, all-sloppy, and both sharp and sloppy (i.e., mixed separation). The proposed methods have been applied to a number of industrial separation problems. The results show that the new methods offer an extremely useful means for design engineers to generate a number of good initial sequences for obtaining sloppy multicomponent product sets prior to the ultimate separator optimization and heat integration. / Ph. D.

Efterfrågan på litiumjonbatterier (LiB) har ökat genom åren i takt med att kortlivade elektriska apparater och elfordon har blivit alltmer populära. Det är av stort intresse att återvinna dessa batterier när de har blivit uttjänta, men återvinningskapaciteten för LiB är väldigt undermåttlig. Dessutom är de nuvarande återvinningsmetoderna som finns tillgängliga inte särskilt miljövänliga. Denna rapport undersöker en miljövänlig potentiell återvinningsprocess för litiumjonbatterier föreslagen av Dr. Kai Zhang och Dr. Xiong Xiao. Processen är en kontinuerlig, sluten, hydrometallurgisk process som använder ultraljudsassisterad lakning med organiska syror, tillsammans med en ny värmeväxlingsmetod för att förbättra processens energieffektivitet. Syftet med projektet är att ge en bakgrund till återvinning av litiumjonbatterier, samt att utvärdera den nuvarande marknaden för återvinning av litiumjonbatterier för att identifiera behovet av nya återvinningsprocesser. Vidare var syftet också att undersöka möjligheten att omvandla lågtempererad spillvärme som genereras från processen till energi med en reaktiv vätska. Den reaktiva vätskan bestod av N2O4 somdeltog i reversibla reaktioner. Ekonomin för processen utvärderades genom att uppskatta energiförbrukningen och förbrukningen av kemikalier samt svart massa. Återvinning av lågtempererad spillvärme uppnåddes med den reaktiva vätskan som presterade bättre än när den jämfördes med en identisk men icke-reaktiv vätska. Dock identifierades flera områden som behöver förbättras för ytterligare optimering. Det konstaterades att processen inte skulle vara lönsam om försäljning av återvunna metaller var den enda intäktskällan. En återvinningsavgift föreslogs för att göra vinst. Det finns flera osäkerheter kring processens genomförbarhet och ytterligare forskning och experimentell testning krävs. / The demand for lithium-ion batteries (LiB) have increased over the years, as short-lived electric devices and electric vehicles are becoming more popular. It is of great interest to recycle these batteries when they have reached their end of life, however the recycling capacity of LiB is seriously lacking. Also, the current recycling methods available are not particularly environmentally friendly. This report examines a potential environmentally friendly lithium-ion battery recycling process proposed by Dr. Kai Zhang and Dr. Xiong Xiao. The process is a continuous closed-loop hydrometallurgical process that utilizes ultrasonic assisted leaching with organic acids, along with a novel heat exchange method to improve the energy efficiency of the process. The aim of the project is to give a background to lithium-ion battery recycling, along with evaluating the current lithium-ion battery recycling market, to identify the need of new lithium-ion battery recycling processes. Furthermore, the aim was also to investigate the possibility in converting low-temperature waste heat generated from the process into power by utilizing a reactive fluid. The reactive fluid consisted of N2O4 involved in reversible reactions. The power consumption and consumption of chemicals and black mass of the process was estimated, and from this the economics of the process was evaluated. Low-temperature waste heat recovery was achieved with the reactive fluid, which performed better than when compared to an identical but frozen fluid. However, several areas in need of improvement were identified for further optimization. The process was concluded to not be profitable if only sales from recycled metals were to be the sole source of revenue. Charging a recycling fee was proposed to make profit. There are several uncertainties concerning the feasibility of the process and further research and experimental testing is required.

I takt med att behovet av att minska utsläppen av växthusgasen ökar, ökar även intresset för negativa utsläpp. En lovande teknik för att uppnå negativa utsläpp är koldioxidlagring från biomassa, även kallad BECCS (Bio-Energy Carbon Capture and Storage). Trots teknologins mognad är de stora energibehoven vid lösningsmedelsregenerering ett hinder för storskalig implementering. I den här studien utforskas den relativt okända kinetiken för lösningsmedelsregenerering av kaliumkarbonat i ett steg för att optimera processen. Dessutom undersöks möjligheten att använda vanadin(V)oxid som katalysator för att förbättra desorptionshastigheten. Experimentella analyser utfördes i en sats-reaktor och gick ut på att undersöka förändringen av lösningsmedlets loading över tid genom regelbundna titreringar. Utöver detta undersöks den påverkan som temperatur och omrörning har på desorptionshastigheten. Experimenten utförs vid atmosfärstryck och temperaturer från 80°C till 100°C. Resultaten visade på god repeterbarhet trots svårigheter med temperaturöverskridningar. Desorptionshastigheten var lägre vid 80°C och 90°C än vid 100°C, men de logaritmiska hastighetskonstanterna följde inte en linjär relation mot temperaturinverserna vilket antyder att reaktionen är begränsad av massöverföring. Vidare påverkade inte användandet av en katalysator desorptionskinetiken märkbart, vilket än en gång antyder ett massöverföringsberoende. Slutligen visades ingen märkbar skillnad i desorptionshastighet trots olika omrörningshastigheter. Detta beror troligen på den redan höga massöverföringen som sker vid kokpunkten. Sammanfattningsvis bidrar denna studie med insikter för att förbättra effektiviteten hos regenereringen av lösningsmedel vid BECCS, vilket är avgörande för att motverka utsläppen och möta utmaningarna med klimatförändringarna.