Thesis (Ph.D)--Baylor University, 2007. / Includes bibliographical references (p. 137-142).

Thesis--Catholic Univ. of America. / Includes bibliographical references (p. 70-73).

Thesis (M.S.)--West Virginia University, 2006. / Title from document title page. Document formatted into pages; contains vii, 60 p. : ill. Includes abstract. Includes bibliographical references.

No description available.

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by Lai Wai Kai. / Thesis (M.Sc.)--Chinese University of Hong Kong, 1996. / Includes bibliographical references (leaves 70-74). / Acknowledgement --- p.iv / Abstract --- p.v / Figures and Tables --- p.vii / Abbreviations used in this study --- p.ix / Contents / Chapter 1. --- Introduction --- p.1 / Chapter 1.1 --- Biochemistry of cobalamin --- p.2 / Chapter 1.1.1 --- Biological functions of cobalamin --- p.2 / Chapter 1.1.2 --- Causes of cobalamin deficiency --- p.4 / Chapter 1.1.3 --- Significances of cobalamin deficiency --- p.7 / Chapter 1.1.4 --- Assessment of cobalamin deficiency --- p.8 / Chapter 1.2 --- Biochemistry of Methylmalonic acid (MMA) --- p.10 / Chapter 1.2.1 --- Elevation of MMA in biological fluids --- p.11 / Chapter 1.2.2 --- Significances of measurement of MMA --- p.11 / Chapter 1.2.3 --- Methods of measurement of urinary MMA --- p.13 / Chapter 2. --- Objectives of this project --- p.16 / Chapter 3. --- Materials and Methods / Chapter 3.1 --- Study subjects --- p.18 / Chapter 3.2 --- Sample collection --- p.18 / Chapter 3.3 --- Biochemical and haematological analysis --- p.18 / Chapter 3.4 --- Measurement of urinary creatinine concentration --- p.19 / Chapter 3.5 --- Measurement of serum cobalamin concentration --- p.20. / Chapter 3.6 --- GC-MS determination of urinary MMA --- p.21 / Chapter 3.7 --- Statistical analysis --- p.24 / Chapter 4. --- Results / Chapter 4.1 --- Clinical features of subjects --- p.28 / Chapter 4.2 --- General blood analysis --- p.28 / Chapter 4.3 --- Serum cobalamin analysis --- p.30 / Chapter 4.4 --- Urinary MMA analysis --- p.33 / Chapter 4.5 --- Relationship between urinary MMA excretion and age --- p.53 / Chapter 4.6 --- Relationship between urinary MMA excretion and serum cobalamin concentrations --- p.53 / Chapter 5. --- Discussions / Chapter 5.1 --- Serum cobalamin analysis --- p.62 / Chapter 5.2 --- Urinary MMA analysis --- p.62 / Chapter 5.3 --- Relationship between urinary MMA excretion and age --- p.66 / Chapter 5.4 --- Relationship between urinary MMA excretion and serum cobalamin concentration --- p.66 / Chapter 5.5 --- Relationship between urinary MMA excretion and diet --- p.68 / Chapter 6. --- Conclusions --- p.69 / Chapter 7. --- References --- p.70

Diss. (sammanfattning) Stockholm : Karol. inst., 2003. / Härtill 4 uppsatser.

Within the framework of this diploma thesis, the sorptive capability of a lignite as a natural adsorbent was applied on an aqueous solution of pentachlorophenol. The aqueous solution of this substance, which is very dangerous for the environment, was prepared in various concentration ranges according to reached solubility. The solubility is noticed in different literatures variously and then is not applicable. That is why it was necessary to find out the ”real“ solubility. The aqueous solution of pentachlorophenol of given concentration was subsequently put to adsorption with exactly defined quantity of the lignite and as a result the adsorptive isotherms were obtained. These isotherms represent the adsorption capability in dependence on the adsorption duration, quantity of used lignite and concentration of pentachlorophenol solution. By the adsorption with duration longer than one hour, the quantity of adsorbed PCP does not increase markedly.

PURPOSE: To explore the use of crystal inter-planar d-spacings and slip-plane interaction energies for predicting and characterising mechanical properties of crystalline solids. METHODS: Potential relationships were evaluated between mechanical properties and inter-planar d-spacing, inter-planar interaction energy, and dispersive surface energy as determined using inverse gas chromatography (IGC) for a set of pharmaceutical materials. Inter-planar interaction energies were determined by molecular modelling. RESULTS: General trends were observed between mechanical properties and the largest inter-planar d-spacing, inter-planar interaction energies, and IGC dispersive surface energy. A number of materials showed significant deviations from general trends. Weak correlations and outliers were rationalised. CONCLUSIONS: Results suggest that the highest d-spacing of a material could serve as a first-order indicator for ranking mechanical behaviour of pharmaceutical powders, but with some reservation. Inter-planar interaction energy normalised for surface area shows only a weak link with mechanical properties and does not appear to capture essential physics of deformation. A novel framework linking mechanical properties of crystals to the distinct quantities, slip-plane energy barrier and inter-planar interaction (detachment) energy is proposed.

O desenvolvimento de formas comuns de diabetes ocorre a partir da interação de fatores ambientais e genéticos. Como consequências da falta de controle glicêmico nesses pacientes várias complicações são geradas. Estudos metabolômicos para diabetes mellitus tipo 2 no soro/plasma relataram mudanças em vários metabólitos, os quais podem ser considerados possíveis alvos para futuras pesquisas mecanicistas. Como o diabetes mellitus tipo 2 é uma doença que altera o perfil metabólico em vários níveis, este trabalho teve como objetivo comparar os indivíduos com diabetes mellitus tipo 2 e com indivíduos não-diabéticos. Além disso, foram explorados o design exclusivo de um estudo de base familiar para trazer uma melhor compreensão da relação causal de metabólitos identificados e o diabetes. No presente estudo, metabolômica de base populacional foi realizada em 939 amostras de soro de indivíduos participantes do Projeto Corações de Baependi. Os participantes foram separados em dois grupos: diabéticos (77 indivíduos) e não-diabéticos (862 indivíduos). Com a técnica de GC/MS, normalização e análise estatística utilizadas, foi possível identificar metabólitos diferencialmente alterados em soro de diabéticos e não-diabéticos. Foram identificados 72 metabólitos com diferentes concentrações médias em indivíduos com diabetes mellitus tipo 2, em comparação com indivíduos saudáveis. Foi possível recapitular as principais vias que são alteradas no indivíduo diabético e a identificação de metabólitos sugestivos de estarem elevados no diabetes. Os dados de hereditariedade puderam ser utilizados para uma melhor compreensão da relação causal das associações observadas e ajudar a priorizar metabólitos associados ao diabetes para trabalhos futuros / The development of common forms of diabetes comes from the interaction between environmental and genetic factors, and the consequences of poor glycemic control in these patients can result in several complications. Metabolomics studies for type 2 diabetes mellitus in serum/plasma have reported changes in numerous metabolites, which might be considered possible targets for future mechanistic research. As type 2 diabetes is a disease that changes the metabolic profile in several levels, this work aimed to compare type 2 diabetes mellitus and non-diabetic participants of a family-based epidemiological study. In addition, we exploited the unique design of a family-based study to bring a better understanding of the causal relationship of identified metabolites and diabetes. In the current study, population based metabolomics was applied in 939 participants of \"the Baependi Heart Study\". Participants were separated into two groups: diabetic (77 individuals) and non-diabetic (862 individuals). By GC/MS technique, normalization and statistical analysis, it was possible to identify differentially concentrated metabolites in serum of diabetics and non-diabetics. 72 metabolites were identified as up regulated in type 2 diabetes mellitus subjects compared to non-diabetic individuals. It was possible to recapitulate the main pathways that are changed in the diabetic subject and the identification of metabolites suggestive of being upstream of diabetes. Heritability data was used to derive a better understanding of the causal relationship of the observed associations and help to prioritize diabetes-associated metabolites for further work