This thesis describes coping in pacients with chronic musculoskeletal pain. It focuses especially on the cognitive evaluation of pain and coping strategies. Furthermore it deals with the emotional changes in chronic pain. The theoretical part consists of the development of access to pain and the overview of some current knowledge of biological and psychosocial determinant of pain. Emphasis is placed on a holistic, biopsychosocial approach to the issue. Empirical part consists of research aimed at assesing the important factors that contribute to cope life with pain, as in terms of personal dispositions of an individual, so in terms of environmental influence. The main aim of the research is to identity the most used coping strategies and to assess their effectiveness. Keywords: chronic disease, chronic pain, coping resources, coping strategies

Dans le présent travail, le rôle de la glie dans l’expression de la douleur cancéreuse et de la douleur neuropathique a été étudié de façon comparative. Le modèle animal de douleur cancéreuse a été obtenu par injection osseuse dans le tibia, chez la rate Sprague-Dawley, de cellules de carcinome mammaire de type MRMT-1. Le modèle de douleur neuropathique a été obtenu chez le rat Wistar par ligature des nerfs spinaux L5 et L6. Les données obtenues par l’analyse du comportement douloureux en réponse à la stimulation par des filaments de von Frey ont permis de quantifier l’allodynie et l’hyperalgésie mécaniques statiques. La douleur chronique, hors stimulation nociceptive, a été mesurée à l’aide d’un test d’impotence. Les agents pharmacologiques ont été administrés par voie intrapéritonéale ou par voie intrathécale, à l’aide d’un cathéter implanté de façon chronique. L’analyse des comportements nociceptifs après stimulation par filaments de von Frey montre que l’inhibition fonctionnelle transitoire de la glie spinale par le fluorocitrate est sans effet sur la douleur dans les deux modèles. Dans les deux modèles, l’expression des réponses douloureuses dépend de l’activation des récepteurs NMDA spinaux. L’administration par voie intrathécale d’une seule dose de D-aminoacide oxydase, qui dégrade la D-sérine, co-agoniste endogène du récepteur NMDA, réduit l’allodynie et l’hyperalgésie chez les rats neuropathiques et l’allodynie chez les rats cancéreux. Les effets d’un traitement chronique par le fluoroacétate chez les rats neuropathiques sont réversés par l’administration intrathécale de D-sérine. La D-sérine altère légèrement le seuil nociceptif chez les rats cancéreux. Aucun des agents pharmacologiques utilisés ne réverse la réduction d’appui du membre lésé chez les rats cancéreux ou neuropathiques. Ces résultats montrent que, chez le rat, la douleur neuropathique comme la douleur osseuse cancéreuse dépend de la co-activation des récepteurs NMDA spinaux par un de ses ligands endogènes, la D-sérine, mais que seule la douleur neuropathique requiert une glie spinale fonctionnelle. Ils suggèrent donc un rôle différentiel de la glie dans la physiopathologie de ces deux types de douleur chronique / The present work has investigated the role of glia upon pain symptoms in a well established peripheral neuropathic pain model and a bone cancer pain model. The neuropathic pain model was obtained by right L5-L6 spinal nerve ligation in male Wistar rats. Bone cancer pain was induced by injecting MRMT-1 rat mammary gland carcinoma cells into the right tibia of Sprague-Dawley female rats. Mechanical allodynia and hyperalgesia were quantified using von Frey hairs and ambulatory incapacitance using dynamic weight bearing. Drugs were administered either acutely or chronically using osmotic pumps, through intrathecal catheters chronically implanted in experimental animals. Using von Frey hair stimuli, we found that transient inhibition of glia metabolism by intrathecal injection of fluorocitrate was ineffective in both models. In both models, pain symptoms required spinal NMDA receptor activation. Intrathecal administration of a single dose of D-aminoacid oxidase, which degrades D-serine, a co-agonist of NMDA receptors, reduced mechanical allodynia and hyperalgesia in neuropathic rats and allodynia in cancer rats. The effect of chronic fluoroacetate in neuropathic rats was reversed by acutely administered intrathecal D-serine, which had only a slight effect in cancer rats. None of these compounds altered the functional disability shown by neuropathic or cancer animals and measured by the dynamic weight bearing apparatus. These results show that neuropathic pain and cancer pains depend upon D-serine co-activation of spinal NMDA receptors but only neuropathic pain requires functional spinal cord glia in the rat. Glia may thus play different roles in the development and maintenance of chronic pain in these two situations.

A significant subset of mild traumatic brain injury (mild TBI) and chronic pain (CP) patients report, and sometimes show objective evidence of, persisting cognitive problems. Despite differences in injury mechanisms, there is considerable overlap in the types of persisting cognitive symptoms that are reported by the two populations. Psychogenic, rather than physiogenic, factors are thought to play an important role in the maintenance of these persisting symptoms. The current investigation examined the contributions somatization, depression, and anxiety had on an objective measure of “working attention.” In order to best elucidate the influences these psychological factors had on attentional performance, only individuals who passed well-validated and popular indicators of cognitive and self-report validity were included in the study. Two hundred and forty-nine individuals (n = 116 TBI; n = 133 CP) met the inclusionary criteria for the study. Psychological factors were assessed using Scales 1 (Hypochondriasis), 2 (Depression), 3 (Hysteria), and 7 (Psychasthenia) of the Minnesota Multiphasic Personality Inventory-II. “Working attention” was measured using the demographically-adjusted T-scores for the Working Memory and Processing Speed Indexes of the Wechsler Adult Intelligence Scale- 3. Results indicated that a high rate of psychological complications was observed in the mild TBI and CP groups but not the moderate-severe traumatic brain injury (M/S TBI) comparison group. Analysis indicated that psychological elevations were not significantly related to spontaneously-reported symptoms or working attention deficits for the mild TBI group but were for the CP and M/S TBI groups. The current results are important for understanding the psychological complications that may occur in individuals exhibiting persisting cognitive problems in these clinical populations.

<p>Background: Sickle Cell Disease (SCD) is a genetic hematological disorder that affects more than 7 million people globally (NHLBI, 2009). It is estimated that 50% of adults with SCD experience pain on most days, with 1/3 experiencing chronic pain daily (Smith et al., 2008). Persons with SCD also experience higher levels of pain catastrophizing (feelings of helplessness, pain rumination and magnification) than other chronic pain conditions, which is associated with increases in pain intensity, pain behavior, analgesic consumption, frequency and duration of hospital visits, and with reduced daily activities (Sullivan, Bishop, & Pivik, 1995; Keefe et al., 2000; Gil et al., 1992 & 1993). Therefore effective interventions are needed that can successfully be used manage pain and pain-related outcomes (e.g., pain catastrophizing) in persons with SCD. A review of the literature demonstrated limited information regarding the feasibility and efficacy of non-pharmacological approaches for pain in persons with SCD, finding an average effect size of .33 on pain reduction across measurable non-pharmacological studies. Second, a prospective study on persons with SCD that received care for a vaso-occlusive crisis (VOC; N = 95) found: (1) high levels of patient reported depression (29%) and anxiety (34%), and (2) that unemployment was significantly associated with increased frequency of acute care encounters and hospital admissions per person. Research suggests that one promising category of non-pharmacological interventions for managing both physical and affective components of pain are Mindfulness-based Interventions (MBIs; Thompson et al., 2010; Cox et al., 2013). The primary goal of this dissertation was thus to develop and test the feasibility, acceptability, and efficacy of a telephonic MBI for pain catastrophizing in persons with SCD and chronic pain. </p><p>Methods: First, a telephonic MBI was developed through an informal process that involved iterative feedback from patients, clinical experts in SCD and pain management, social workers, psychologists, and mindfulness clinicians. Through this process, relevant topics and skills were selected to adapt in each MBI session. Second, a pilot randomized controlled trial was conducted to test the feasibility, acceptability, and efficacy of the telephonic MBI for pain catastrophizing in persons with SCD and chronic pain. Acceptability and feasibility were determined by assessment of recruitment, attrition, dropout, and refusal rates (including refusal reasons), along with semi-structured interviews with nine randomly selected patients at the end of study. Participants completed assessments at baseline, Week 1, 3, and 6 to assess efficacy of the intervention on decreasing pain catastrophizing and other pain-related outcomes. </p><p>Results: A telephonic MBI is feasible and acceptable for persons with SCD and chronic pain. Seventy-eight patients with SCD and chronic pain were approached, and 76% (N = 60) were enrolled and randomized. The MBI attendance rate, approximately 57% of participants completing at least four mindfulness sessions, was deemed acceptable, and participants that received the telephonic MBI described it as acceptable, easy to access, and consume in post-intervention interviews. The amount of missing data was undesirable (MBI condition, 40%; control condition, 25%), but fell within the range of expected missing outcome data for a RCT with multiple follow-up assessments. Efficacy of the MBI on pain catastrophizing could not be determined due to small sample size and degree of missing data, but trajectory analyses conducted for the MBI condition only trended in the right direction and pain catastrophizing approached statistically significance. </p><p>Conclusion: Overall results showed that at telephonic group-based MBI is acceptable and feasible for persons with SCD and chronic pain. Though the study was not able to determine treatment efficacy nor powered to detect a statistically significant difference between conditions, participants (1) described the intervention as acceptable, and (2) the observed effect sizes for the MBI condition demonstrated large effects of the MBI on pain catastrophizing, mental health, and physical health. Replication of this MBI study with a larger sample size, active control group, and additional assessments at the end of each week (e.g., Week 1 through Week 6) is needed to determine treatment efficacy. Many lessons were learned that will guide the development of future studies including which MBI strategies were most helpful, methods to encourage continued participation, and how to improve data capture.</p> / Dissertation

L´existence d´état douloureux, chronique et sans substrat organique, de maladies de la douleur, sont signalés depuis le XIX siècle. La douleur, comme perception, est une expérience subjective qui intègre des sensations variées. Les différents syndromes de douleur chronique ont la douleur comme symptôme principal et se caractérisent par un ensemble de signes qui ne correspondent pas à un modèle de cause organiques non localisées. Alors que la douleur aigüe est un indicateur précieux dans l´établissement d´un diagnostic, la douleur chronique, pour avoir perdu son caractère de signald´alarme, nous renvoie à une multiplicité de déterminations d´ordre somatique, psychologique et/ou ambiant. L´apport de la psychanalyse, en partenariat avec la médecine se révèle utile dans l´appréhension du sens des symptômes dans laparticularité du cas et en relation avec la singularité du sujet. À la place de soutenir l´idée qu´il est nécessaire, à tout prix, d´éradiquer définitivement un syndrome douloureux quel qu´il soit et la souffrance psychique qui y est associée, il nous semble utile de prendre en considération ce qui est en jeu en termes structurel et inconscient. En d´autres mots, faire « parler » le corps, d´une douleur (psychique) impossible à symboliser. Possiblement, une douleur d´amour, c´est la supposition de base de notre hypothèse / The existence of painful condition, chronic and without organic substrate, disease of pain, are reported from the nineteenth century. Pain, such as perception, which is a subjective experience includes various sensations. Different chronic pain syndromes have pain as the main symptom and is characterized by a set of signs that do not correspond to a modelof organic causes unlocated. While acute pain is a valuable indicator in establishing a diagnosis, chronic pain, to have lost its character as a warning, we refer to a multiplicity of determinations order somatic, psychological and / or ambient. The contribution of psychoanalysis, in partnership with the medicine is useful in understanding the meaning of symptoms in the particularity of the case and in relation to the singularity of the subject. Instead of supporting the idea that it is necessary, at any cost, permanently eradicate a painful syndrome whatsoever and mental suffering associated with it, it is useful to consider what is involved in structural terms and unconscious. In other words, to "speak" the body, pain (psychic) Unable to symbolize. Possibly pain of love is the basic assumption of our hypothesis / A existência de condição dolorosa crônica e sem substrato orgânico , a doença de dor, são relatados a partir do século XIX. Dor, tais como percepção, que é uma experiência subjetiva inclui várias sensações . Diferentes síndromes de dor crônica tem a dor como o principal sintoma e é caracterizada por um conjunto de sinais que não correspondem a um modelo de causas orgânicas não localizados. Enquanto a dor aguda é um indicador valioso para estabelecer um diagnóstico, dor crônica, ter perdido seu caráter de advertência, nos referimos a uma multiplicidade de determinações ordem somática ,psicológica e / ou ambiente . A contribuição da psicanálise, em parceria com o medicamento é útil na compreensão do significado dos sintomas na particularidade do caso e em relação à singularidade do sujeito. Em vez de apoiar a ideia de que é necessário , a qualquer custo, eliminar permanentemente uma síndrome dolorosa que seja e sofrimento mental associado a ele, é útil considerar o que é envolvido em termos estruturais e inconsciente. Em outras palavras, para "falar" do corpo, dor ( psíquica ) Não é possível simbolizar . Possivelmente dor do amor é o pressuposto básico da nossahipótese

INTRODUÇÃO: A dor, fenômeno multidimensional, é compreendida como experiência pessoal e subjetiva, influenciada por fatores que abrange o ser humano em sua totalidade e deve ser avaliada a fim de ser adequadamente manejada com excelência técnico-científica. OBJETIVOS: O objetivo geral deste estudo foi realizar adaptação transcultural da Escala Multidimensional de Avaliação de Dor (EMADOR) e os específicos foram traduzir a EMADOR para a língua inglesa; validar a EMADOR para a cultura americana na sua forma aparente e de conteúdo; aplicar a EMADOR adaptada e validada para a cultura americana em indivíduos com dor; aplicar a EMADOR em indivíduos brasileiros com dor; Descrever os dados sócios demográficos (idade e gênero) e clínicos (uso de medicamento e tipo de dor) das amostras norte americana e brasileira; Verificar o grau de atribuição dos descritores de dor crônica e de dor aguda da amostra americana; Verificar o grau de atribuição dos descritores de dor crônica e de dor aguda da amostra brasileira; Identificar as dimensões dos descritores atribuídos pelos participantes de ambas às amostras, norte americana e brasileira; Identificar semelhanças e diferenças da percepção da dor crônica e aguda entre as amostras norte americana e brasileira. MÉTODO: Realizou-se estudo de adaptação transcultural de instrumento, utilizando-se método proposto por Beaton e seus colaboradores, constituído pelas etapas de tradução, retrotradução, comitê de revisores, validação aparente e de conteúdo e teste piloto. Utilizou-se o método psicofísico de estimação de categoria na aplicação da EMADOR. A análise de dados foi realizada descritivamente. Foram calculados alpha de cronbach para analisar a fidedignidade da escala e o teste de Mann Whitney para verificar diferenças estatísticas entre as amostras. RESULTADOS: Na tradução, retrotradução e comitê de revisores os descritores de dor foram alterados de modo a manter o maior nível de similaridade entre as versões em português e em inglês (Multidimensional Pain Evaluation Scale - MPES). Na validação aparente e de conteúdo, os descritores de dor da MPES foram apresentados cardinalmente e algumas definições foram alteradas. A maioria dos participantes era do gênero feminino e grande parte fazia uso de medicação para alívio da dor. Quanto à aplicação da escala nos Estados Unidos, participaram 90 norte americanos, sendo 41 cuidadores de idosos e 49 estudantes universitários do curso de enfermagem, dos quais 49 (54,4%) apresentaram dor aguda e 41(45,6%) dor crônica. Os descritores de maior atribuição e suas respectivas dimensões para dor crônica foram \"Chata\" (Afetiva/Cognitiva), \"Incômoda\" (Afetiva/Cognitiva), \"Dolorosa\" (Afetiva/Sensitiva), \"Desagradável\" (Afetiva/Cognitiva) e \"Irritante\" (Afetiva/Cognitiva) e para dor aguda \"Dolorosa\" (Afetiva/Sensitiva), \"Irritante\" (Afetiva/Cognitiva), \"Desconfortável\" (Afetiva/Cognitiva), \"Desagradável\" (Afetiva/Cognitiva), \"Estafante\" (Afetiva/Cognitiva). Quanto à aplicação da escala no Brasil, participaram 97 brasileiros, sendo 28 cuidadores de idosos e 69 estudantes de graduação do curso de enfermagem, dos quais 39 (40,21%) apresentavam dor crônica e 58 (59,79%) dor aguda. Os descritores de maior atribuição e suas respectivas dimensões para dor crônica foram \"Desconfortável\" (Afetiva/Sensitiva), \"Incômoda\" (Afetiva/Cognitiva), \"Dolorosa\" (Afetiva/Sensitiva), \"Chata\" (Afetiva/Cognitiva) e \"Desagradável\" (Afetiva/Cognitiva) e para dor aguda \"Desconfortável\" (Afetiva/Cognitiva), \"Desagradável\" (Afetiva/Cognitiva), \"Importuna\" (Afetiva/Cognitiva), \"Irritante\" (Afetiva/Cognitiva) e \"Que Perturba\" (Afetiva/Cognitiva). CONSIDERAÇÕES FINAIS: A experiência dolorosa pode ser percebida em suas múltiplas dimensões, seja afetiva, cognitiva e sensitiva. Como experiência pessoal, é por meio da linguagem que as características das sensações dolorosas podem ser expressas, diferenciando-se, significativamente umas das outras. A adaptação transcultural da EMADOR/MPES para a cultura americana bem como sua aplicação nos Estados Unidos e no Brasil pode contribuir para enfermeiros e equipe de saúde em geral ter consciência da complexidade e da multidimensionalidade existente na dor em diferentes situações e perspectivas subjetivas, além de possibilitar avaliação fidedigna do fenômeno de modo a promover melhorias na assistência, e avanços na pesquisa e no ensino, propiciando manejos que respeitem o ser humano com dor. / INTRODUCTION: Pain, a multidimensional phenomenon, is understood as personal and subjective experience, influenced by factors that cover the whole human and must be evaluated in order to be adequately managed with technical and scientific excellence. OBJECTIVES: The general objective of this study was to perform transcultural adaptation of the Multidimensional Pain Evaluation Scale (MPES) and the specific ones were to translate the MPES into the English language; to validate the MPES for the north american culture in its apparent and content form; to apply the MPES adapted and validated for the north american culture in people with pain; to apply the MPES to brazilian people with pain; to describe the demographic data (age and gender) and clinical data (drug use and type of pain) of the north american and brazilian samples; to verify the degree of attribution of the chronic and acute pain descriptors of the north american sample; to verify the degree of attribution of chronic and acute pain descriptors of the brazilian sample; to identify the dimensions of the descriptors attributed by the participants of both samples, north american and brazilian; to identify similarities and differences in the perception of chronic and acute pain between the north american and brazilian samples. METHOD: A cross-cultural adaptation study was carried out using a method proposed by Beaton and his collaborators consisting of translation, retro-translation, review committee, apparent and content validation, and pilot testing. It was use the psychophysical method of category estimation in the MPES application. Data analysis was performed descriptively. Chronbach\'s alpha was calculated to analyze the reliability of the scale and the Mann Whitney test to verify statistical differences between the samples. RESULTS: In the translation, back-translation and review committee the pain descriptors were altered in order to maintain the highest level of similarity between the versions. In the apparent and content validation, the pain descriptors of the MPES were presented cardinally and some definitions were altered. The most of the participants were female and most of them used pain relief medication. As far as the application of the scale in the United States, 90 north americans were attended, 41 elderly caregivers and 49 undergraduate nursing students, of which 49 (54.4%) had acute pain and 41 (45.6%) had chronic pain. The descriptors of higher attribution and their respective dimensions for chronic pain were \"Annoyng\" (Affective / Cognitive), \"Disconforting\" (Affective / Cognitive), \"Painful\" (Affective / Sensitive), \"Unpleasant\" (Affective / Cognitive),\"Irritating \"(Affective / Cognitive) and to acute pain were \"Painful\" (Affective / Sensitive), \"Irritating\" (Affective / Cognitive), \"Uncomfortable\" (Affective / Cognitive), \"Unpleasant\" (Affective / Cognitive) and \"Exhausting\" (Affective / Cognitive) Regarding the application of the scale in Brazil, 97 Brazilians participated: 28 elderly caregivers and 69 nursing undergraduate students, of whom 39 (40.21%) had chronic pain and 58 (59.79%) had acute pain. The most attributable descriptors and their respective dimensions for chronic pain were \"Uncomfortable\" (Affective / Sensitive), \"Disconforting\" (Affective / Cognitive), \"Painful\" \"(Affective / Sensitive), \"Annoyng\" (Affective / Cognitive) and \"Unpleasant\" (Affective / Cognitive) and to acute pain were \"Uncomfortable\" (Affective / Cognitive), \"Unpleasant\" (Affective / Cognitive), \"Nagging\" (Affective / Cognitive), \"Irritating\" (Affective / Cognitive) and \"Disturbing\" (Affective / Cognitive). CONCLUSIONS: The painful experience can be perceived in its multiple dimensions, be it affective, cognitive and sensitive. As personal experience, it is through language that the characteristics of painful sensations can be expressed, differing significantly from one another. The cross-cultural adaptation of MPES to north american culture as well as its application in the United States and Brazil can contribute to nurses and health staff in general to be aware of the complexity and multidimensionality of pain in different situations and subjective perspectives, reliable in order to promote improvements in care, and advances in research and teaching, providing management that respects the human with pain.

Introdução: A osteoartrite (OA) do quadril manifesta-se clinicamente pela dor e o comprometimento da amplitude de movimento articular. Quando há falha no tratamento clínico, fundamentado no controle de sintomas e na recuperação da funcionalidade, pode ser indicada a artroplastia de quadril. Em paciente sem condições clínicas ou socioeconômicas para a realização cirúrgica, ou para os pacientes que estão em reabilitação, uma alternativa para o gerenciamento dos sintomas é o bloqueio do ramo anterior do nervo obturatório (RAO), que pode ser realizado com lidocaína ou fenol. Devido às suas características farmacológicas, acredita-se que o efeito do bloqueio com fenol pode ter uma duração maior e ser clinicamente mais vantajoso. Objetivos: Comparar os resultados do bloqueio do RAO com fenol versus lidocaína para o tratamento da dor e melhora da funcionalidade em pacientes com osteoatrite grave do quadril que apresentaram falhas no tratamento conservador. Metodologia: 44 pacientes com OA grave do quadril e indicação de artroplastia total dessa articulação foram aleatorizados em dois grupos e submetidos ao bloqueio do RAO guiado por eletroestimulação com fenol 5% (GF) ou lidocaína 2% (GL). Os pacientes foram avaliados por meio da escala visual analógica (EVA), Western Ontario andMcMasterUniversitiesOsteoarthritis Index (WOMAC), e dolorimetria de pressão no imediatamente antes do bloqueio e ao final de um e de quatro meses. Resultados: No GF o valor médio inicial de dor antes do bloqueio (8,8± 1,5) evoluiu para 5,8±2,9 em um mês e 5,9±2,9 após quatro meses, enquantopara o GL a evolução foi de 9,0±1,2 para 7,0±2,8 e finalmente para 6,0±3,2. Assim como para os outros parâmetros (WOMAC e dolorimetria), a redução dos valores ao final de quatro meses foram estatisticamente significantes, mas não houve diferenças entre os grupos. Dez pacientes relataram valores de dor EVA < 3 até o quarto mês de observação e um paciente tornou-se completamente sem dor nesse período. Três pacientes não relataram melhora alguma da dor ou da funcionalidade. Não ocorreram efeitos colaterais como sangramentos, dor pelo procedimento ou do tipo neuropática. Conclusão: O uso de lidocaína ou fenol para o bloqueio do RAO é igualmente eficaz no tratamento da dor crônica na OA de quadril por até quatro meses, podendo resultar em melhora da funcionalidade. Não ocorreram efeitos adversos com o procedimento / Introduction: Hip osteoarthritis (OA) is clinically manifested by pain and reduced joint range of motion. When conservative treatment based on symptom control and functional recovery fails, hip arthroplasty may be indicated. In a patient without clinical or socioeconomic conditions for the surgical treatment, or under rehabilitation interventions, an alternative for the management of the symptoms is the blockage of the anterior branch of obturator nerve (ABO), which can be performed with lidocaine or phenol. Due to its pharmacological characteristics, the effect of phenol blockade may last longer and be clinically more advantageous. Objectives: To compare the results of ABO blockade with phenol versus lidocaine for the treatment of pain and improvement of functioning in patients with severe hip osteoarthritis who presented with failures in conservative treatment. Method: 44 patients scheduled for total hip replacement due to severe hip OA were randomized into two groups for ABO blockade guided by electrostimulation with phenol 5% (GF) or 2% lidocaine (GL). Patients were evaluated using visual analogue scale (VAS), Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and pressure pain dolorimetry immediately before the blockade and at the end of one and four months. Results: In the GF, initial mean VAS was 8.8 ± 1.5 and evolved to 5.8 ± 2.9 in one month and 5.9 ± 2.9 after four months, whereas for GL VAS evolved from 9.0 ± 1.2 to 7.0 ± 2.8 and finally to 6.0 ± 3.2. As for the other parameters (WOMAC and painimetry), the reduction of the values at the end of four months were statistically significant, but there were no differences between the groups. Ten patients reported VAS < 3 duringthe four months of observation and one patient became completely painless. However, three patients reported no improvement in pain or functioning. There were no side effects such as bleeding, inflammatory or neuropathic pain. Conclusion: The use of lidocaine or phenol for ABO blockade is equally efficient in the treatment of chronic hip pain in OA for up to four months and may result in improved functioning. There were no adverse effects with the procedure

No description available.

A Dor Crônica por Afecções Musculoesqueléticas (DCAME) é uma doença que, além de atingir o sistema osteomuscular, principalmente de mulheres da faixa etária entre 45 a 64 anos, frequentemente acarreta desordens psicológicas, sociais e espirituais e é influenciada por elas, podendo ainda desenvolver grande carga de desgosto para os doentes quando não diagnosticada e tratada adequadamente. Assim, dentre os aspectos citados, destaca-se o Bem-Estar Espiritual (BEE) como uma expressão da espiritualidade prática que, embora recentemente abordada em estudos científicos foi, desde o início da humanidade, apontada como uma dimensão importante no processo saúde-doença, por possibilitar, além de outros benefícios, o restabelecimento mais rápido da saúde. Foi neste contexto que se tornou necessário compreender e refletir sobre os significados do BEE que permearam a vivência de mulheres portadoras de DCAME e as formas pelas quais o BEE foi manifestado por esta população, para facilitar o esclarecimento tanto das causas da dor atribuídas por elas quanto das formas de manejo e dos impactos ocasionados pela dor. Desta forma, este estudo, que foi realizado na Clínica de Dor do Hospital das Clínicas de Ribeirão Preto (CDHCRP) e conduzido de acordo com as normatizações da Comissão Nacional de Ética em Pesquisa (CONEP), utilizou-se de abordagem qualitativa. Neste trabalho, após seleção por amostragem por conveniência, 11 sujeitos foram selecionados e entrevistados individualmente numa sala reservada a este fim, sendo um guia à entrevista um roteiro norteador de entrevista semiestruturada com questões fechadas para identificação e delineamento sociodemográfico e questões abertas para a apreensão dos significados de BEE bem como dos conhecimentos acerca das causas, dos impactos e das formas de alívio da dor. Os dados coletados foram gravados em um aparelho de MP3 e transcritos na íntegra para o início da análise dos dados que foi feita por meio da Análise Temática (AT), uma das técnicas da Análise de Conteúdo (AC) e possibilitaram o surgimento de quatro temas: Significados e Manifestações do BEE; Modelos explicativos para a dor; Formas de manejo da doença e Impactos da dor crônica. A partir destes temas, algumas interpretações acerca do BEE puderam ser destacadas. Relatado como um aspecto humano de difícil definição, o BEE pôde ser manifestado de diferentes maneiras. As formas apresentadas foram o bom relacionamento consigo mesmo, com o outro e com Deus, o desenvolvimento de esperança, da confiança, da fé em si e no tratamento que realizaram, o conforto físico, a ocupação, o lazer, o aprendizado e a empatia no contato com o outro. Neste trabalho, algumas causas manifestadas foram as de origem psicossocial, as sobrecargas físicas e comportamentos que perpetuam o problema, além da dor como resposta a um pecado. Destacadas algumas causas, o trabalho apontou para a utilização das preces como coadjuvante do tratamento médico convencional por todas as entrevistadas e da técnica Reiki. Tendo em vista o exposto, a DCAME mesmo impactando de forma negativa na vida das entrevistadas, desenvolvendo inclusive o medo da perda da autonomia e independência, possibilitou a modificação de suas visões de mundo, sendo fonte de descoberta de valores humanos tais como a coragem, a resiliência, a valorização da vida bem como da empatia pelo sofrimento alheio. Em suma, este estudo destacou a importância da DCAME enquanto doença multidimensional que leva o indivíduo a experimentar necessidades espirituais importantes, sendo o incentivo a busca da integralidade no contexto hospitalar para o correto manejo do problema mais do que uma emergência para a saúde pública. / Chronic Musculoskeletal Pain (CMP) is a disease that, in addition to achieving the musculoskeletal system, especially the women aged 45 to 64 years, often entails psychological, social and spiritual disorders and is influenced by them and may develop big load of grief for patients when not diagnosed and treated properly. Thus, among the aspects mentioned, Spiritual Well-Being (SWB) as an expression of practical spirituality which, although recently has been addressed in scientific studies, since the beginning of mankind, considered as an important dimension in the health-disease process, by allowing, among other benefits, the most rapid restoration of health. In this context, it has become necessary to understand and reflect on the meanings of SWB that permeated the experience of women with CMP and the ways in which the SWB was expressed by this population, both to facilitate the clarification of the causes of pain attributed by them as forms of management and the impacts caused by pain. Thus, this study, which was conducted at the Pain Clinic of the University Hospital of Ribeirão Preto (PCUHRP) and conducted according to the regulations of the National Committee of Ethics in Research (NCER), used a qualitative approach. In this work, after being selected by convenience sampling, 11 subjects were selected and individually interviewed in a room reserved for this purpose, with a guide to interview a guiding semi- structured interview with closed questions and to identify sociodemographic and open design issues for the seizure of SWB meanings and knowledge about the causes, impacts and forms of pain relief. Data were recorded on an MP3 player and transcribed to the top of the data analysis that was done by means of the Thematic Analysis (TA), one of the techniques of Content Analysis (CA) and made possible the emergence of four themes: Meanings and Manifestations of SWB; Explanatory models for pain; Forms of disease management and Impacts of chronic pain. From these themes, some interpretations of the SWB could be highlighted. Reported as a human aspect difficult to define, SWB could be manifested in different ways. The forms submitted were good relationship with oneself, with others and with God, the development of hope, trust, and faith in themselves and who performed the treatment, physical comfort, occupation, leisure, learning and empathy contact with each other. In this work, some causes were expressed psychosocial origin, physical burdens and behaviors that perpetuate the problem, in addition to pain in response to a sin. Highlighted some causes, the paper points out the use of prayer as an adjunct to conventional medical treatment for all interviewees and Reiki technique. In view of the above, the same CMP negatively impacting on the lives of the interviewees, including developing the fear of loss of autonomy and independence, enabled the modification of their worldviews, a source of discovery of human values such as courage, resilience, valuing life and empathy for others\' suffering. In summary, this study highlighted the importance of CMP as multidimensional disease that causes the individual to experience significant spiritual needs, and encouraging the pursuit of comprehensive health care in the hospital setting to the correct handling of the problem more than a public health emergency.

Introdução: A dor é uma experiência emocional e sensorial desagradável, associada ao dano real ou potencial de alguma região do corpo. Segundo a International Association for the Study of Pain, ela é sempre subjetiva, pois sua percepção é aprendida com a vivência pessoal de cada indivíduo. Estima-se que a hérnia de disco atinge de 2 a 3% da população brasileira, considerando uma prevalência de 2,5 em mulheres e 4,8% em homens, acima de 35 anos. Ao longo da vida, o sujeito pode entrar em contato com o desamparo inerente à natureza humana em vivências traumáticas e pós-traumáticas, remetendo-o à impotência do recém-nascido humano, como no exemplo de uma vivência de dor. Este projeto também pretende abarcar alguns princípios básicos das Neurociências e aproximar-se das possíveis relações da ocitocina na experiência subjetiva de desamparo e, posteriormente, na percepção da dor. Objetivo: Compreender a experiência subjetiva de desamparo em pessoas com dor crônica decorrente de hérnia de disco lombar e estudar a interação da ocitocina na vivência de desamparo e percepção da dor. Método: Tratou-se de estudo clínico randomizado controlado composto por 10 participantes do sexo masculino, idade entre 35 e 59 anos e com diagnóstico médico de hérnia de disco lombar. Foram realizadas, nesta ordem, anamnese, entrevista clínica semi-dirigida, e aplicação da Escala Visual Analógica de Dor (EVA) e do Teste de Apercepção Temática (TAT). Na reavaliação, entrevista clínica semi-dirigida e reaplicação da EVA e do TAT. No primeiro encontro, além da avaliação, foi fornecido aos participantes, por um médico treinado da equipe médica, ocitocina (no grupo experimental) ou soro fisiológico (grupo controle) na forma de spray nasal, para ser ministrado diariamente por 28 dias, até o dia da reavaliação psicológica dos mesmos participantes. A escolha do tipo de intervenção que os participantes receberam foi randomizada e duplo cega. Considerações: Mesmo inicialmente vivida em suas primeiras vezes em estágios muito primitivos do desenvolvimento, a experiência subjetiva do desamparo deixa marcas que permanecem presentes em todos os períodos de vida, podendo ser revivida pelo indivíduo em situações como a da dor. A dor compele ao indivíduo isolamento social, mas também pela dificuldade em conseguir se expressar ao outro e perceber-se compreendido. Com a redução dos sentimentos de isolamento e negativismo e do abrandamento da percepção de dor pelo uso de ocitocina, observou-se uma correlação positiva da ocitocina com a redução dos sentimentos de isolamento, negativismo com abrandamento da percepção de dor e do sentimento de desamparo. Por outro lado, os resultados corroboram achados de nossas pesquisas, ou seja, a maneira da pessoa lidar com sua dor expressa a sua forma de lidar com a vida e com o mundo. Estes dados contribuem na busca de estratégias para lidar com o fenômeno álgico / Introduction: Pain is an unpleasant emotional and sensory experience associated with actual or potential damage to a region of the body. According to the International Association for the Study of Pain, it is always subjective because its perception is learned from the personal experience of each individual. It is estimated that disc herniation affects 2 to 3% of the Brazilian population, considering a prevalence of 2.5 in women and 4.8% in men, over 35 years. Throughout life, the subject can come into contact with the inherent helplessness of human nature in traumatic and post-traumatic experiences, referring to the impotence of the human newborn, as in the example of an experience of pain. This project also intends to cover some basic principles of neurosciences and to approach the possible relations of oxytocin in the subjective experience of helplessness and, later, in the perception of pain. Objective: To understand the subjective experience of helplessness in people with chronic pain due to lumbar disc herniation and to study the interaction of oxytocin in the experience of helplessness and pain perception. Method: This was a randomized controlled clinical study composed of 10 male participants, aged between 35 and 59 years and with a medical diagnosis of lumbar disc herniation. Anamnesis, a semi-guided clinical interview, and the application of the Visual Analog Pain Scale (EVA) and the Thematic Apperception Test (TAT) were performed. In the re-evaluation, semi-directed clinical interview and reapplication of EVA and TAT. At the first meeting, in addition to the evaluation, the participants were given, by a physician trained in the medical team, oxytocin (in the experimental group) or saline (control group) as a nasal spray, to be administered daily for 28 days, until the day of the psychological reevaluation of the same patients. The type of intervention the participants received was randomized and double blind. Considerations: Even when initially experienced in its earliest stages in very primitive stages of development, the subjective experience of helplessness leaves marks that remain present in all periods of life, and can be revived by the individual in situations such as pain. Pain compels the individual to be socially isolated, but also because of the difficulty in being able to express himself to the other and to perceive himself understood. With the reduction of the feelings of isolation and negativism and the slowing of the perception of pain by the use of oxytocin, a positive correlation of the oxytocin with the reduction of the feelings of isolation, negativism with slowing of the perception of pain and the feeling of helplessness was observed. On the other hand, the results corroborate findings of our research, that is, the way the person deals with their pain expresses the way of dealing with life and with the world. These data contribute to the search for strategies to deal with the pain phenomenon