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The Global ETD Search service is a free service for researchers
to find electronic theses and dissertations. This service is
provided by the
Networked Digital Library of Theses and Dissertations.
Our metadata is collected from universities around the world. If you manage a university/consortium/country archive and want to be added, details can be found on the NDLTD website.
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Showing 1 to 6 of 6 (0.077 seconds)Spelling suggestions: "subject:"compartmentalizing"" "subject:"compartmentalising""
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Synthesis of Caseinolytic Protease Agonists Towards the Synthesis of the Natural AcyldepsipeptidesCossette, Michele 30 November 2011 (has links)
Caseinolytic protease (ClpP) is a cylindrical protease forming the core of protein degradation machinery in eubacteria. ClpP is tightly regulated and is non-functional without a member of the Clp-ATPases. A new class of antibiotics, termed ADEPs, bind to ClpP and allow for activation without the Clp-ATPases; leading to cell death.
A more efficient synthetic route to the ADEPs utilizing solid-phase peptide synthesis was investigated. A linear peptide was synthesized, however attempts to close the depsipeptidic macrocycle via macrolactonization failed. Further attempts of assembling a branched depsipeptide for ring closure via a macrolactamization resulted in products that were not stable to cleavage conditions.
A group of molecules termed Activators of Self-Compartmentalizing Proteases (ACP) were identified through a screen for activity towards ClpP. Compound ACP1 was synthesized along with twelve analogs and their activity towards ClpP evaluated. The project resulted in a compound with a higher activity than its natural product counterpart.
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| 2 |
Wonder-women: case studies of pregnant university students - change and transition.Poffley, Cara Unknown Date (has links)
Changes have occurred within educational settings over the past 30 years, creating a more equal learning environment for women. Despite the fact that women aged 18-39 years now outnumber men within New Zealand universities, there is still evidence of inequality for pregnant university students.A qualitative case-study approach was used to explore and describe the stages and patterns of transition from being a university student to becoming a pregnant university student. Each woman demonstrated the complexity of the transitions. The pregnant body and becoming visible were factors that impacted on all five women who participated in this study. The case studies describe how pregnancy intervened in the experience of being a student.Various coping mechanisms were employed by these pregnant university students. The research suggests that they find balance through compartmentalizing aspects of their lives. They attribute educational and personal outcomes to luck. These strategies have enabled these women to aim for educational or personal success. Yet it remains clear that the university does not provide adequate support for these pregnant university students. Policies and resources need to be established to aid pregnant university students in this process of transition.
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| 3 |
Synthesis of Caseinolytic Protease Agonists Towards the Synthesis of the Natural AcyldepsipeptidesCossette, Michele 30 November 2011 (has links)
Caseinolytic protease (ClpP) is a cylindrical protease forming the core of protein degradation machinery in eubacteria. ClpP is tightly regulated and is non-functional without a member of the Clp-ATPases. A new class of antibiotics, termed ADEPs, bind to ClpP and allow for activation without the Clp-ATPases; leading to cell death.
A more efficient synthetic route to the ADEPs utilizing solid-phase peptide synthesis was investigated. A linear peptide was synthesized, however attempts to close the depsipeptidic macrocycle via macrolactonization failed. Further attempts of assembling a branched depsipeptide for ring closure via a macrolactamization resulted in products that were not stable to cleavage conditions.
A group of molecules termed Activators of Self-Compartmentalizing Proteases (ACP) were identified through a screen for activity towards ClpP. Compound ACP1 was synthesized along with twelve analogs and their activity towards ClpP evaluated. The project resulted in a compound with a higher activity than its natural product counterpart.
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| 4 |
Wonder-women: case studies of pregnant university students - change and transition.Poffley, Cara Unknown Date (has links)
Changes have occurred within educational settings over the past 30 years, creating a more equal learning environment for women. Despite the fact that women aged 18-39 years now outnumber men within New Zealand universities, there is still evidence of inequality for pregnant university students.A qualitative case-study approach was used to explore and describe the stages and patterns of transition from being a university student to becoming a pregnant university student. Each woman demonstrated the complexity of the transitions. The pregnant body and becoming visible were factors that impacted on all five women who participated in this study. The case studies describe how pregnancy intervened in the experience of being a student.Various coping mechanisms were employed by these pregnant university students. The research suggests that they find balance through compartmentalizing aspects of their lives. They attribute educational and personal outcomes to luck. These strategies have enabled these women to aim for educational or personal success. Yet it remains clear that the university does not provide adequate support for these pregnant university students. Policies and resources need to be established to aid pregnant university students in this process of transition.
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| 5 |
The sacred and the secular with special reference to Francis Schaeffer's thinkingPotgieter, Raymond Michiel 11 1900 (has links)
Francis Schaeffer presented a Christian world and life-view encompassing the totality of
reality as an alternative to a fragmented view of reality. Refinements of dualism are
examined from within a theological context giving substance to his understanding of
modern world and life-view trends. Dualisms may be traced from the dawn of history of
religion. It was Thomas Aquinas who profoundly influenced Western thought into a
secular compartment through a synthesis of Christian dogma with Aristotelian
presuppositions. The reign of the sacred diminished and a predominantly secular
pathway may be traced through disciplines such as philosophy, arts, science and
theology. This dissertation suggests that a dualistic analysis of reality is limited in its
application. A model is suggested which traces all of reality to its ultimate source, God.
The Fall brought about a dialectic which is found within the totality of a Christian world
and life-view. / Philosophy, Practical & Sytematic Theology / M. Th. (Systematic Theology.
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| 6 |
The sacred and the secular with special reference to Francis Schaeffer's thinkingPotgieter, Raymond Michiel 11 1900 (has links)
Francis Schaeffer presented a Christian world and life-view encompassing the totality of
reality as an alternative to a fragmented view of reality. Refinements of dualism are
examined from within a theological context giving substance to his understanding of
modern world and life-view trends. Dualisms may be traced from the dawn of history of
religion. It was Thomas Aquinas who profoundly influenced Western thought into a
secular compartment through a synthesis of Christian dogma with Aristotelian
presuppositions. The reign of the sacred diminished and a predominantly secular
pathway may be traced through disciplines such as philosophy, arts, science and
theology. This dissertation suggests that a dualistic analysis of reality is limited in its
application. A model is suggested which traces all of reality to its ultimate source, God.
The Fall brought about a dialectic which is found within the totality of a Christian world
and life-view. / Philosophy, Practical and Sytematic Theology / M. Th. (Systematic Theology.
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